{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T14:33:30Z","timestamp":1775486010765,"version":"3.50.1"},"reference-count":101,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T00:00:00Z","timestamp":1745971200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["1R01ES030341"],"award-info":[{"award-number":["1R01ES030341"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>SUMOylation is a post-translational modification critical for oocyte development and chromatin-associated processes. Environmental exposures and obesity can cause follicle depletion and exposure to 7,12-dimethylbenz(a)anthracene (DMBA) altered ovarian small ubiquitin-like modifiers (SUMO) protein abundance in lean and obese mice. Thus, the hypothesis that exposure to DMBA may alter ovarian protein SUMOylation as a mode of ovotoxicity dampened by obesity was tested. Lean and obese mice (KK.Cg-a\/a and KK.Cg-Ay\/J) were exposed to either corn oil or DMBA (1\u00a0mg\/kg) intraperitoneally for 7d (n\u2009=\u20094\/treatment) and ovaries were flash-frozen on the second day of diestrus. Protein was isolated followed by immunoprecipitation using a SUMO-2\/3 antibody and precipitated proteins were identified via liquid chromatography\u2013tandem mass spectrometry. A total of 114 SUMO-2\/3 ovarian protein targets were identified. Obesity basally altered (P\u2009\u2264\u20090.05) the abundance of 55 SUMOylated proteins with an additional 11 proteins tending (P\u2009\u2264\u20090.1) to be altered. In lean mice, DMBA altered (P\u2009&amp;lt;\u20090.05) the level of SUMOylation profile of 18 proteins with an additional three proteins tending (P\u2009\u2264\u20090.1) to be changed by DMBA exposure. In obese mice, DMBA exposure altered (P\u2009&amp;lt;\u20090.05) the abundance of 29 SUMOylated proteins and seven proteins had a tendency toward being different (P\u2009\u2264\u20090.1). DMBA exposure of lean compared to obese mice affected (P\u2009&amp;lt;\u20090.05) SUMOylation of 43 proteins, and four additional proteins tended (P\u2009\u2264\u20090.1) to differ. These findings suggest that protein SUMOylation is a mode of ovotoxicity which is influenced by physiological status.<\/jats:p>","DOI":"10.1093\/biolre\/ioaf101","type":"journal-article","created":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T21:37:54Z","timestamp":1746049074000},"page":"962-976","source":"Crossref","is-referenced-by-count":2,"title":["Ovarian SUMO-2\/3 targets and their differential response to genotoxic stress induced by 7,12-dimethylbenz(a) anthracene exposure in lean and obese female mice"],"prefix":"10.1093","volume":"113","author":[{"given":"Jaspreet K","family":"Rishi","sequence":"first","affiliation":[{"name":"Department of Animal Science, Iowa State University , 50011 Ames, IA ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Montes","sequence":"additional","affiliation":[{"name":"Department of Plant Pathology, Entomology and Microbiology, Iowa State University , 50011 Ames, IA ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin W","family":"Walley","sequence":"additional","affiliation":[{"name":"Department of Plant Pathology, Entomology and Microbiology, Iowa State University , 50011 Ames, IA ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aileen F","family":"Keating","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Iowa State University , 50011 Ames, IA ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,4,30]]},"reference":[{"key":"2025101516131767200_ref1","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0074-7696(08)61524-7","article-title":"Development of follicles in the mammalian ovary","volume":"124","author":"Hirshfield","year":"1991","journal-title":"Int Rev Cytol"},{"key":"2025101516131767200_ref2","first-page":"707","article-title":"Ovarian follicle 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