{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T03:09:56Z","timestamp":1791688196768,"version":"4.3.4"},"reference-count":220,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T00:00:00Z","timestamp":1746489600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Research and Application of Twin Breeding Technology in Nonspiritual Animals, Sichuan Science and Technology Department","award":["2023JDZH0024"],"award-info":[{"award-number":["2023JDZH0024"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,8,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Non-human primates (NHPs) have become important models for biomedical research due to their similarities to humans in evolution, anatomy, and physiology. It is worth noting that NHPs have important clinical significance in the field of assisted reproductive technology (ART) research and are an important experimental basis for studying human reproductive physiology and pathogenic mechanisms. However, due to the differences in reproductive physiology between the two species, the application of human ART treatment strategies in NHPs often leads to different experimental results. Therefore, this review provides an analysis of the challenges encountered by NHPs in the application of ART and their possible solutions. This article discusses the technical status and difficulties of semen collection, quality assessment, egg collection, artificial insemination, and gamete development in NHP. Based on the analysis of existing technologies, suggestions are put forward to optimize the ART of NHPs, in order to improve the research model system of early embryo development of NHP. This study contributes to a deeper understanding of NHP and human embryo development and provides some potential suggestions for optimizing NHP embryo culture and human infertility treatment. The optimization of NHP-ART has important scientific value and application prospects, and in-depth research can make more contributions to the progress of reproductive biology and clinical treatment. This review summarizes and analyzes the problems and strategies that deserve attention in some NHP-ART technologies, so as to provide a reference for researchers in related fields.<\/jats:p>","DOI":"10.1093\/biolre\/ioaf109","type":"journal-article","created":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T07:58:15Z","timestamp":1746518295000},"page":"257-288","source":"Crossref","is-referenced-by-count":2,"title":["Challenges and strategies in the application of assisted reproductive technology in non-human primates: review"],"prefix":"10.1093","volume":"113","author":[{"given":"Jia","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Institute of Laboratory Animal Sciences, Sichuan Provincial People\u2019s Hospital, School of Medicine, University of Electronic Science and Technology of China , Chengdu ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Institute of Laboratory Animal Sciences, Sichuan Provincial People\u2019s Hospital, School of Medicine, University of Electronic Science and Technology of China , Chengdu ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Lan","sequence":"additional","affiliation":[{"name":"Department of Institute of Laboratory Animal Sciences, Sichuan Provincial People\u2019s Hospital, School of Medicine, University of Electronic Science and Technology of China , Chengdu ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Institute of Laboratory Animal Sciences, Sichuan Provincial People\u2019s Hospital, School of Medicine, University of Electronic Science and Technology of China , Chengdu ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengyi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Institute of Laboratory Animal Sciences, Sichuan Provincial People\u2019s Hospital, School of Medicine, University of Electronic Science and Technology of China , Chengdu ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,5,6]]},"reference":[{"key":"2025081723471013000_ref1","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1016\/j.stemcr.2021.03.021","article-title":"Non-human primates as a model for human development","volume":"16","author":"Nakamura","year":"2021","journal-title":"Stem Cell Rep"},{"key":"2025081723471013000_ref2","doi-asserted-by":"crossref","first-page":"4152","DOI":"10.1073\/pnas.82.12.4152","article-title":"Microtubule configurations during fertilization, mitosis, and early development in 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