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Myeloid cells, including macrophages, monocytes, dendritic cells, and neutrophils, play pivotal roles in shaping the ovarian tissue microenvironment and regulating inflammatory responses. However, a comprehensive understanding of the roles of these cells in the ovarian aging process is lacking. To bridge this knowledge gap, we utilized single-cell RNA sequencing and flow cytometry analysis to functionally characterize CD45+ CD11b+ myeloid cell populations in young (3\u00a0months old) and aged (14\u201317\u00a0months old) murine ovaries. Our dataset unveiled the presence of five ovarian macrophage subsets, including a Cx3cr1lowCd81hi subset unique to the aged murine ovary. Most notably, our data revealed significant alterations in ANNEXIN and TGF\u03b2 signaling within aged ovarian myeloid cells, which suggest a novel mechanism contributing to the onset and progression of aging-associated inflammation and fibrosis in the ovarian tissue. In summary, our study revealed age-related changes in ovarian myeloid cells using single-cell RNA sequencing and flow cytometry, and identified distinct macrophage subsets and signaling alterations that may contribute to the inflammaging process of the ovary.<\/jats:p>","DOI":"10.1093\/biolre\/ioaf122","type":"journal-article","created":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T07:33:20Z","timestamp":1748936000000},"page":"373-386","source":"Crossref","is-referenced-by-count":17,"title":["Single-cell analysis of ovarian myeloid cells identifies age-associated changes in macrophages and signaling dynamics"],"prefix":"10.1093","volume":"113","author":[{"given":"Zijing","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences , Little Rock, AR ,","place":["USA"]},{"name":"Winthrop P Rockefeller Cancer Institute, University of Arkansas for Medical Sciences , Little Rock, AR 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