{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T03:31:26Z","timestamp":1788233486641,"version":"build-2803163510"},"reference-count":57,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T00:00:00Z","timestamp":1749686400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Hubei Provincial Health Commission General Program","award":["WJ2023M049"],"award-info":[{"award-number":["WJ2023M049"]}]},{"name":"Knowledge Innovation Program of Wuhan-Shuguang Project","award":["2022020801020492"],"award-info":[{"award-number":["2022020801020492"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82301817"],"award-info":[{"award-number":["82301817"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key R&D Program of China","doi-asserted-by":"publisher","award":["2020YFA0803900"],"award-info":[{"award-number":["2020YFA0803900"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Ferroptosis, an iron-dependent form of regulated cell death characterized by phospholipid peroxidation, plays a pivotal role in various diseases. However, its involvement in male infertility, particularly in idiopathic non-obstructive azoospermia (iNOA), remains largely unexplored. Idiopathic non-obstructive azoospermia accounts for 10\u201315% of male infertility cases, presenting a significant clinical challenge due to its unknown origins. This study investigated the potential link between ferroptosis and iNOA, revealing excessive activation of both ferroptosis and autophagy in the testes of iNOA patients, along with severe disruption of the blood-testis barrier (BTB). The BTB, formed by tight junctions between Sertoli cells, is essential for maintaining the spermatogenesis microenvironment. Using the ferroptosis inducer erastin, an antagonist of the cystine antiporter Solute Carrier Family 7 Member 11 (SLC7A11), we established a ferroptosis model in mouse Sertoli cells, demonstrating that ferroptosis activation led to cytoskeletal disarray and BTB disruption, accompanied by excessive autophagy activation. Notably, inhibition of autophagy using 3-methyladenine significantly rescued erastin-induced ferroptosis and restored BTB integrity, highlighting a crucial cross-talk between ferroptosis and autophagy in maintaining the spermatogenic microenvironment. Furthermore, through combined transcriptome analysis of iNOA testes and Sertoli cells, we identified RAB3IL1 as a novel regulator of ferroptosis. Mechanistically, Rab3il1 knockdown induced ferroptosis via translocation of SLC7A11, resulting in cytoskeletal defects and BTB damage. Our findings underscore the critical role of the ferroptosis-autophagy axis, regulated by RAB3IL1, in preserving the spermatogenic microenvironment, offering a potential therapeutic target for restoring spermatogenesis in iNOA patients.<\/jats:p>","DOI":"10.1093\/biolre\/ioaf127","type":"journal-article","created":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T08:46:34Z","timestamp":1749717994000},"page":"944-961","source":"Crossref","is-referenced-by-count":5,"title":["RAB3IL1: a key regulator in the autophagy-ferroptosis axis of male infertility"],"prefix":"10.1093","volume":"113","author":[{"given":"Binyu","family":"Ma","sequence":"first","affiliation":[{"name":"Center for Reproductive Medicine, Zhongnan Hospital of Wuhan University , Wuhan, Hubei ,","place":["P.R. China"]},{"name":"Clinical Medicine Research Center of Prenatal Diagnosis and Birth Health in Hubei Province , Wuhan, Hubei ,","place":["P.R. China"]},{"name":"Wuhan Clinical Research Center for Reproductive Science and Birth Health , Wuhan, Hubei ,","place":["P.R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhidan","family":"Hong","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine, Zhongnan Hospital of Wuhan University , Wuhan, Hubei ,","place":["P.R. China"]},{"name":"Clinical Medicine Research Center of Prenatal Diagnosis and Birth Health in Hubei Province , Wuhan, Hubei ,","place":["P.R. China"]},{"name":"Wuhan Clinical Research Center for Reproductive Science and Birth Health , Wuhan, Hubei ,","place":["P.R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Gao","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine, Zhongnan Hospital of Wuhan University , Wuhan, Hubei ,","place":["P.R. China"]},{"name":"Clinical Medicine Research Center of Prenatal Diagnosis and Birth Health in Hubei Province , Wuhan, Hubei ,","place":["P.R. China"]},{"name":"Wuhan Clinical Research Center for Reproductive Science and Birth Health , Wuhan, Hubei ,","place":["P.R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingjing","family":"Wan","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine, Zhongnan Hospital of Wuhan University , Wuhan, Hubei ,","place":["P.R. China"]},{"name":"Clinical Medicine Research Center of Prenatal Diagnosis and Birth Health in Hubei Province , Wuhan, Hubei ,","place":["P.R. China"]},{"name":"Wuhan Clinical Research Center for Reproductive Science and Birth Health , Wuhan, Hubei ,","place":["P.R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuanyi","family":"He","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine, Zhongnan Hospital of Wuhan University , Wuhan, Hubei ,","place":["P.R. China"]},{"name":"Clinical Medicine Research Center of Prenatal Diagnosis and Birth Health in Hubei Province , Wuhan, Hubei ,","place":["P.R. China"]},{"name":"Wuhan Clinical Research Center for Reproductive Science and Birth Health , Wuhan, Hubei ,","place":["P.R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Wang","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine, Zhongnan Hospital of Wuhan University , Wuhan, Hubei ,","place":["P.R. China"]},{"name":"Clinical Medicine Research Center of Prenatal Diagnosis and Birth Health in Hubei Province , Wuhan, Hubei ,","place":["P.R. China"]},{"name":"Wuhan Clinical Research Center for Reproductive Science and Birth Health , Wuhan, Hubei ,","place":["P.R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanzhen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine, Zhongnan Hospital of Wuhan University , Wuhan, Hubei ,","place":["P.R. China"]},{"name":"Clinical Medicine Research Center of Prenatal Diagnosis and Birth Health in Hubei Province , Wuhan, Hubei ,","place":["P.R. China"]},{"name":"Wuhan Clinical Research Center for Reproductive Science and Birth Health , Wuhan, Hubei ,","place":["P.R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,6,12]]},"reference":[{"key":"2025101516135913800_ref1","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/s41585-018-0003-3","article-title":"Genetics of male infertility","volume":"15","author":"Krausz","year":"2018","journal-title":"Nat Rev Urol"},{"key":"2025101516135913800_ref2","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1093\/humrep\/deae057","article-title":"Systematic molecular analyses for 115 karyotypically normal men with isolated non-obstructive azoospermia","volume":"39","author":"Muranishi","year":"2024","journal-title":"Hum Reprod"},{"key":"2025101516135913800_ref3","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/s41585-023-00837-9","article-title":"Molecular mechanisms of cellular dysfunction in testes from men with non-obstructive azoospermia","volume":"21","author":"Piechka","year":"2024","journal-title":"Nat Rev Urol"},{"key":"2025101516135913800_ref4","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"2025101516135913800_ref5","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/s41419-020-2298-2","article-title":"Ferroptosis: past, present and future","volume":"11","author":"Li","year":"2020","journal-title":"Cell Death Dis"},{"key":"2025101516135913800_ref6","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1007\/s13238-020-00789-5","article-title":"Cystine transporter Slc7a11\/Xct in cancer: ferroptosis, nutrient dependency, and cancer therapy","volume":"12","author":"Koppula","year":"2021","journal-title":"Protein Cell"},{"key":"2025101516135913800_ref7","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/s12929-021-00762-2","article-title":"Hbx facilitates ferroptosis in acute liver failure via Ezh2 mediated Slc7a11 suppression","volume":"28","author":"Liu","year":"2021","journal-title":"J Biomed Sci"},{"key":"2025101516135913800_ref8","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1038\/s41419-021-04307-1","article-title":"Nrf2 attenuates ferroptosis-mediated Iir-Ali by modulating Tert and Slc7a11","volume":"12","author":"Dong","year":"2021","journal-title":"Cell Death Dis"},{"key":"2025101516135913800_ref9","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.cell.2011.10.026","article-title":"Autophagy: renovation of cells and tissues","volume":"147","author":"Mizushima","year":"2011","journal-title":"Cell"},{"key":"2025101516135913800_ref10","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.semcancer.2019.03.002","article-title":"Ferroptosis is a type of autophagy-dependent cell death","volume":"66","author":"Zhou","year":"2020","journal-title":"Semin Cancer Biol"},{"key":"2025101516135913800_ref11","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.chembiol.2020.02.005","article-title":"Autophagy-dependent ferroptosis: machinery and regulation","volume":"27","author":"Liu","year":"2020","journal-title":"Cell chemical biology"},{"key":"2025101516135913800_ref12","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1210\/er.2014-1101","article-title":"The mammalian blood-testis barrier: its biology and regulation","volume":"36","author":"Mruk","year":"2015","journal-title":"Endocr Rev"},{"key":"2025101516135913800_ref13","doi-asserted-by":"crossref","first-page":"5683","DOI":"10.1038\/s41467-020-19414-4","article-title":"Single-cell analysis of developing and azoospermia human testicles reveals central role of Sertoli cells","volume":"11","author":"Zhao","year":"2020","journal-title":"Nat Commun"},{"key":"2025101516135913800_ref14","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S1470-2045(02)00776-3","article-title":"An oncological view on the blood-testis barrier","volume":"3","author":"Bart","year":"2002","journal-title":"Lancet Oncol"},{"key":"2025101516135913800_ref15","doi-asserted-by":"crossref","first-page":"e13636","DOI":"10.1111\/and.13636","article-title":"Evaluation of blood-testis barrier integrity in terms of adhesion molecules in nonobstructive azoospermia","volume":"52","author":"Aydin","year":"2020","journal-title":"Andrologia"},{"key":"2025101516135913800_ref16","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1038\/s41419-019-1688-9","article-title":"The alteration of Rhoa geranylgeranylation and Ras Farnesylation breaks the integrity of the blood-testis barrier and results in Hypospermatogenesis","volume":"10","author":"Zhu","year":"2019","journal-title":"Cell Death Dis"},{"key":"2025101516135913800_ref17","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S1535-6108(03)00050-3","article-title":"Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells","volume":"3","author":"Dolma","year":"2003","journal-title":"Cancer Cell"},{"key":"2025101516135913800_ref18","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1073\/pnas.79.6.1889","article-title":"3-methyladenine: specific inhibitor of autophagic\/lysosomal protein degradation in isolated rat hepatocytes","volume":"79","author":"Seglen","year":"1982","journal-title":"Proc Natl Acad Sci USA"},{"key":"2025101516135913800_ref19","doi-asserted-by":"crossref","first-page":"113588","DOI":"10.1016\/j.biopha.2022.113588","article-title":"Effects of 3-methyladenine, an autophagy inhibitor, on the elevated blood pressure and arterial dysfunction of angiotensin ii-induced hypertensive mice","volume":"154","author":"Kwon","year":"2022","journal-title":"Biomedicine & pharmacotherapy \u2014 Biomedecine & pharmacotherapie"},{"key":"2025101516135913800_ref20","doi-asserted-by":"crossref","first-page":"e2498","DOI":"10.1038\/cddis.2016.376","article-title":"Systemic application of 3-methyladenine markedly inhibited atherosclerotic lesion in Apoe(\u2212\/\u2212) mice by modulating autophagy, foam cell formation and immune-negative molecules","volume":"7","author":"Dai","year":"2016","journal-title":"Cell Death Dis"},{"key":"2025101516135913800_ref21","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1080\/15548627.2020.1810918","article-title":"Ferroptosis: machinery and regulation","volume":"17","author":"Chen","year":"2021","journal-title":"Autophagy"},{"key":"2025101516135913800_ref22","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/path.2697","article-title":"Autophagy: cellular and molecular mechanisms","volume":"221","author":"Glick","year":"2010","journal-title":"J Pathol"},{"key":"2025101516135913800_ref23","doi-asserted-by":"crossref","first-page":"12562","DOI":"10.1073\/pnas.1202316109","article-title":"Focal adhesion kinase-Tyr407 and -Tyr397 exhibit antagonistic effects on blood-testis barrier dynamics in the rat","volume":"109","author":"Lie","year":"2012","journal-title":"Proc Natl Acad Sci USA"},{"key":"2025101516135913800_ref24","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/cr.2015.152","article-title":"Nudc regulates actin dynamics and Ciliogenesis by stabilizing cofilin 1","volume":"26","author":"Zhang","year":"2016","journal-title":"Cell Res"},{"key":"2025101516135913800_ref25","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1080\/15548627.2016.1159377","article-title":"Autophagy is required for ectoplasmic specialization assembly in Sertoli cells","volume":"12","author":"Liu","year":"2016","journal-title":"Autophagy"},{"key":"2025101516135913800_ref26","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/S0896-6273(01)00384-1","article-title":"Grab: a physiologic guanine nucleotide exchange factor for Rab3a, which interacts with inositol Hexakisphosphate kinase","volume":"31","author":"Luo","year":"2001","journal-title":"Neuron"},{"key":"2025101516135913800_ref27","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.bbamcr.2018.12.005","article-title":"Grab recruitment by Rab27a-Rabphilin3a triggers Rab3a activation in human sperm exocytosis","volume":"1866","author":"Quevedo","year":"2019","journal-title":"Biochim Biophys Acta, Mol Cell Res"},{"key":"2025101516135913800_ref28","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1038\/s41419-023-06359-x","article-title":"Gss deficiency causes age-related fertility impairment via Ros-triggered ferroptosis in the testes of mice","volume":"14","author":"Zhu","year":"2023","journal-title":"Cell Death Dis"},{"key":"2025101516135913800_ref29","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1080\/19396368.2023.2257352","article-title":"Identification of Ferroptotic genes and phenotypes in idiopathic nonobstructive azoospermia","volume":"69","author":"Liao","year":"2023","journal-title":"Syst Biol Reprod Med"},{"key":"2025101516135913800_ref30","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/s43032-022-01004-y","article-title":"Reduction of Slc7a11 and Gpx4 contributing to ferroptosis in sperm from Asthenozoospermia individuals","volume":"30","author":"Hao","year":"2023","journal-title":"Reproductive sciences (Thousand Oaks, Calif)"},{"key":"2025101516135913800_ref31","doi-asserted-by":"crossref","first-page":"11355","DOI":"10.1021\/acsnano.8b06201","article-title":"Fenton-reaction-Acceleratable magnetic nanoparticles for ferroptosis therapy of orthotopic brain Tumors","volume":"12","author":"Shen","year":"2018","journal-title":"ACS Nano"},{"key":"2025101516135913800_ref32","doi-asserted-by":"publisher","first-page":"10707","DOI":"10.1021\/acs.est.5c04383","volume-title":"Sertoli Cell\u2013Only Syndrome [M]. Statpearls. Treasure Island (FL) ineligible companies. Disclosure: Stephanie Mejias declares no relevant financial relationships with ineligible companies. Disclosure: Kamleshun Ramphul declares no relevant financial relationships with ineligible companies","author":"Leslie","year":"2025"},{"issue":"7","key":"2025101516135913800_ref32a","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1111\/his.15366","article-title":"Interpretation of testicular biopsy for infertility: a practical guide","volume":"86","author":"Al-Hussain","year":"2025","journal-title":"Histopathology"},{"key":"2025101516135913800_ref33","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s00018-023-04723-w","article-title":"Sertoli cell-only syndrome: advances, challenges, and perspectives in genetics and mechanisms","volume":"80","author":"Wang","year":"2023","journal-title":"Cellular and molecular life sciences : CMLS"},{"key":"2025101516135913800_ref34","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.juro.2011.03.156","article-title":"Early versus late maturation arrest: reproductive outcomes of testicular failure","volume":"186","author":"Weedin","year":"2011","journal-title":"J Urol"},{"key":"2025101516135913800_ref35","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1038\/s41419-019-2064-5","article-title":"Ros-mediated autophagy increases intracellular iron levels and ferroptosis by ferritin and transferrin receptor regulation","volume":"10","author":"Park","year":"2019","journal-title":"Cell Death Dis"},{"key":"2025101516135913800_ref36","doi-asserted-by":"crossref","first-page":"2388","DOI":"10.1016\/j.cub.2018.05.094","article-title":"Ampk-mediated Becn1 phosphorylation promotes ferroptosis by directly blocking system X(C)(\u2212) activity","volume":"28","author":"Song","year":"2018","journal-title":"Current biology : CB"},{"key":"2025101516135913800_ref37","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.freeradbiomed.2025.02.011","article-title":"Nrf2 ameliorates defective autophagic processes and thereby inhibits ferroptosis in acute pancreatitis by suppressing Beclin1-Slc7a11 complex formation","volume":"230","author":"Li","year":"2025","journal-title":"Free Radic Biol Med"},{"key":"2025101516135913800_ref38","volume-title":"Advanced science","author":"Chen"},{"key":"2025101516135913800_ref39","doi-asserted-by":"crossref","first-page":"102584","DOI":"10.1016\/j.redox.2022.102584","article-title":"Ferroptosis is critical for phthalates driving the blood-testis barrier dysfunction via targeting transferrin receptor","volume":"59","author":"Zhao","year":"2023","journal-title":"Redox Biol"},{"key":"2025101516135913800_ref40","doi-asserted-by":"crossref","first-page":"113046","DOI":"10.1016\/j.fct.2022.113046","article-title":"Dehp induces ferroptosis in testes via P38\u03b1-lipid Ros circulation and destroys the Btb integrity","volume":"164","author":"Yang","year":"2022","journal-title":"Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association"},{"key":"2025101516135913800_ref41","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.freeradbiomed.2023.02.024","article-title":"The role of ferroptosis mediated by Bmal1\/Nrf2 in nicotine -induce injury of Btb integrity","volume":"200","author":"Zhang","year":"2023","journal-title":"Free Radic Biol Med"},{"key":"2025101516135913800_ref42","doi-asserted-by":"crossref","first-page":"102227","DOI":"10.1016\/j.redox.2021.102227","article-title":"Induction of autophagy via the Ros-dependent Ampk-Mtor pathway protects copper-induced spermatogenesis disorder","volume":"49","author":"Guo","year":"2022","journal-title":"Redox Biol"},{"key":"2025101516135913800_ref43","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1210\/en.2013-1657","article-title":"Perfluorooctanesulfonate (Pfos) perturbs male rat Sertoli cell blood-testis barrier function by affecting F-actin organization via P-Fak-Tyr(407): an in vitro study","volume":"155","author":"Wan","year":"2014","journal-title":"Endocrinology"},{"key":"2025101516135913800_ref44","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2021.12352","article-title":"Erastin-induced ferroptosis causes physiological and pathological changes in healthy tissues of mice","volume":"24:713","author":"Zhao","year":"2021","journal-title":"Mol Med Rep"},{"key":"2025101516135913800_ref45","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1679\/aohc1950.42.51","article-title":"Electron microscopic study on the testicular interstitial cells in the mouse","volume":"42","author":"Ohata","year":"1979","journal-title":"Archivum histologicum Japonicum \u2014 Nihon soshikigaku kiroku"},{"key":"2025101516135913800_ref46","doi-asserted-by":"crossref","first-page":"103312","DOI":"10.1016\/j.redox.2024.103312","article-title":"Plin4 exacerbates cadmium-decreased testosterone level via inducing ferroptosis in testicular Leydig cells","volume":"76","author":"Zhang","year":"2024","journal-title":"Redox Biol"},{"key":"2025101516135913800_ref47","doi-asserted-by":"crossref","first-page":"113515","DOI":"10.1016\/j.ecoenv.2022.113515","article-title":"Tetramethyl bisphenol a inhibits Leydig cell function in late puberty by inducing ferroptosis","volume":"236","author":"Hu","year":"2022","journal-title":"Ecotoxicol Environ Saf"},{"key":"2025101516135913800_ref48","doi-asserted-by":"crossref","first-page":"169927","DOI":"10.1016\/j.scitotenv.2024.169927","article-title":"Glyphosate drives autophagy-dependent ferroptosis to inhibit testosterone synthesis in mouse Leydig cells","volume":"914","author":"Lu","year":"2024","journal-title":"Sci Total Environ"},{"key":"2025101516135913800_ref49","doi-asserted-by":"crossref","first-page":"127807","DOI":"10.1016\/j.jhazmat.2021.127807","article-title":"Di-(2-Ethylhexyl) phthalate exposure leads to ferroptosis via the Hif-1\u03b1\/Ho-1 Signaling pathway in mouse testes","volume":"426","author":"Wu","year":"2022","journal-title":"J Hazard Mater"},{"key":"2025101516135913800_ref50","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1182\/blood.2021015189","article-title":"Grab regulates transferrin receptor recycling and iron uptake in developing erythroblasts","volume":"140","author":"Chen","year":"2022","journal-title":"Blood"},{"key":"2025101516135913800_ref51","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.bbrc.2013.10.043","article-title":"Grab is a binding partner for the Rab11a and Rab11b Gtpases","volume":"441","author":"Horgan","year":"2013","journal-title":"Biochem Biophys Res Commun"},{"key":"2025101516135913800_ref52","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.bbrc.2014.01.149","article-title":"Critical function of Ra-Gef-2\/Rapgef6, a guanine nucleotide exchange factor for Rap1, in mouse spermatogenesis","volume":"445","author":"Okada","year":"2014","journal-title":"Biochem Biophys Res Commun"},{"key":"2025101516135913800_ref53","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.devcel.2005.11.004","article-title":"Rap-Gef Signaling controls stem cell anchoring to their niche through regulating De-cadherin-mediated cell adhesion in the drosophila testis","volume":"10","author":"Wang","year":"2006","journal-title":"Dev Cell"},{"key":"2025101516135913800_ref54","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1210\/en.2002-220893","article-title":"Rab8b Gtpase and junction dynamics in the testis","volume":"144","author":"Lau","year":"2003","journal-title":"Endocrinology"},{"key":"2025101516135913800_ref55","doi-asserted-by":"publisher","author":"Mukhopadhyay","DOI":"10.1073\/pnas.2021475118"},{"key":"2025101516135913800_ref56","doi-asserted-by":"crossref","first-page":"2954","DOI":"10.1158\/0008-5472.CAN-15-2121","article-title":"The Egf receptor promotes the malignant potential of glioma by regulating amino acid transport system xc(\u2212)","volume":"76","author":"Tsuchihashi","year":"2016","journal-title":"Cancer Res"}],"container-title":["Biology of Reproduction"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/biolreprod\/advance-article-pdf\/doi\/10.1093\/biolre\/ioaf127\/63477710\/ioaf127.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/biolreprod\/article-pdf\/113\/4\/944\/63477710\/ioaf127.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/biolreprod\/article-pdf\/113\/4\/944\/63477710\/ioaf127.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T20:14:09Z","timestamp":1760559249000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/biolreprod\/article\/113\/4\/944\/8160906"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,12]]},"references-count":57,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,6,12]]},"published-print":{"date-parts":[[2025,10,14]]}},"URL":"https:\/\/doi.org\/10.1093\/biolre\/ioaf127","relation":{},"ISSN":["0006-3363","1529-7268"],"issn-type":[{"value":"0006-3363","type":"print"},{"value":"1529-7268","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,10]]},"published":{"date-parts":[[2025,6,12]]}}}