{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T21:36:29Z","timestamp":1787866589024,"version":"build-2784847793"},"reference-count":206,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T00:00:00Z","timestamp":1752019200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Department of Life, Health and Environmental Sciences, University of L\u2019Aquila"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Recent findings highlight NAD+ as a central regulator of various cellular processes, including energy metabolism, stress response, and aging. Growing evidence of the benefits associated with dietary NAD+ precursors has elevated NAD+ to a promising therapeutic target for addressing female infertility. This review aims to evaluate existing literature on the mechanisms governing the availability and utilization of NAD+ in the ovaries and its alterations in female reproductive disorders, with a particular focus on ovarian aging and dysfunction including polycystic ovary syndrome and premature ovarian insufficiency. Alongside data from in vivo and in vitro studies on various NAD+ boosters, this review incorporates findings from research on genetic mutations, polymorphisms in human and animal populations, and insights from transgenic animal models. The present work emphasizes that NAD+ deficiency is largely driven by a combination of factors, including heightened consumption, impaired utilization efficiency, and diminished biosynthesis or transport. Based on this analysis, we suggest that the ovary possesses its own unique NAD+ metabolism, but our understanding of its regulatory mechanisms is still in its infancy. Key questions remain unanswered, such as how NAD+ and its precursors are transported into oocytes and ovarian cells, their specific preferences for different NAD+ precursors, as well as the specific changes associated with different ovarian dysfunctions. Finally, we reviewed methods for studying NAD+ metabolism as essential tools for investigating the potential of NAD+ boosting therapies to counteract ovarian aging and dysfunction.<\/jats:p>","DOI":"10.1093\/biolre\/ioaf140","type":"journal-article","created":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T14:31:11Z","timestamp":1752071471000},"page":"463-478","source":"Crossref","is-referenced-by-count":8,"title":["Is NAD+ a key factor in ovarian aging and dysfunction? Insights and uncertainties from current research"],"prefix":"10.1093","volume":"114","author":[{"given":"Valeria","family":"Cordone","sequence":"first","affiliation":[{"name":"Department of Life, Health and Environmental Sciences, University of L\u2019Aquila , L\u2019Aquila ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Vergara","sequence":"additional","affiliation":[{"name":"Department of Life, Health and Environmental Sciences, University of L\u2019Aquila , L\u2019Aquila ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Falone","sequence":"additional","affiliation":[{"name":"Department of Life, Health and Environmental Sciences, University of L\u2019Aquila , L\u2019Aquila 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