{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:59:22Z","timestamp":1787237962185,"version":"build-2736575974"},"reference-count":148,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T00:00:00Z","timestamp":1751846400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Canada Graduate Scholarship from the National Sciences and Engineering Research Council of Canada"},{"name":"Postdoctoral Fellowship Award from the Canadian Institutes of Health Research"},{"DOI":"10.13039\/501100001804","name":"Canada Research Chairs Program","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001804","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Canadian Institutes of Health Research and the Natural Sciences and Engineering Research Council of Canada"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,12,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Maternal excess adiposity during pregnancy is linked to placental malperfusion and inflammatory injury. Obesity-associated placental malperfusion may induce fetoplacental hypoxia, contributing to adverse health outcomes within and beyond the perinatal period. However, direct comparisons of tissue oxygen saturation at the uteroplacental interface in pregnancies complicated by excess adiposity are lacking. Using a mouse model of preconception high-fat, high-sucrose (HFHS) diet-induced excess adiposity, we found that both placental junctional and labyrinth zones at E17.5 were hypoxic compared to chow-fed controls (CON). HFHS placentas had a greater burden of histopathological lesions, including tissue calcification and fibrinoid deposition within the labyrinth zone. Calcified placental tissue coincided with the destruction of vasculosyncytial membranes and macrophage-dense foci, alongside altered expression of immunomodulatory and chemotactic cytokines, which differed in magnitude with fetal sex. While fetal growth was not impaired, fetuses from HFHS pregnancies exhibited higher levels of circulating IL-6, prolactin, CXCL1, and CCL2. Collectively, these data confirm that maternal diet-induced excess adiposity leads to a reduction in placental oxygen saturation, even in the absence of marked growth restriction or fetal demise. While this hypoxic state was not linked to gross morphological abnormalities, it was associated with markers indicative of local malperfusion and inflammation, and an altered fetal inflammatory and endocrine milieu in late gestation. Together, these findings demonstrate that a state of placental hypoxia may contribute to the increased risk of adverse perinatal outcomes and long-term disease programming in pregnancies affected by maternal obesity.<\/jats:p>","DOI":"10.1093\/biolre\/ioaf143","type":"journal-article","created":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T07:51:40Z","timestamp":1751529100000},"page":"1490-1509","source":"Crossref","is-referenced-by-count":8,"title":["Maternal high-fat, high-sucrose diet\u2013induced excess adiposity is linked to placental hypoxia and disruption of fetoplacental immune homeostasis in late gestation"],"prefix":"10.1093","volume":"113","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5896-2622","authenticated-orcid":false,"given":"Christian J","family":"Bellissimo","sequence":"first","affiliation":[{"name":"Department of Biochemistry & Biomedical Sciences, McMaster University , Hamilton, ON ,","place":["Canada"]},{"name":"Centre for Metabolism, Obesity, & Diabetes Research, McMaster University , Hamilton, ON ,","place":["Canada"]},{"name":"Farncombe Family Digestive Research Institute, McMaster University , Hamilton, ON ,","place":["Canada"]},{"name":"Department of Obstetrics & Gynecology, McMaster University , Hamilton, ON ,","place":["Canada"]},{"name":"McMaster Immunology Research Centre, McMaster University , Hamilton, ON ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiane A","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Department of Biochemistry & Biomedical Sciences, McMaster University , Hamilton, ON ,","place":["Canada"]},{"name":"Centre for Metabolism, Obesity, & Diabetes Research, McMaster University , Hamilton, ON ,","place":["Canada"]},{"name":"Farncombe Family Digestive Research Institute, McMaster University , Hamilton, ON ,","place":["Canada"]},{"name":"Department of Obstetrics & Gynecology, McMaster University , Hamilton, ON ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica","family":"Yeo","sequence":"additional","affiliation":[{"name":"Department of Biochemistry & Biomedical Sciences, McMaster University , Hamilton, ON ,","place":["Canada"]},{"name":"Centre for Metabolism, Obesity, & Diabetes Research, McMaster University , Hamilton, ON ,","place":["Canada"]},{"name":"Farncombe Family Digestive Research Institute, McMaster University , Hamilton, ON ,","place":["Canada"]},{"name":"Department of Obstetrics & Gynecology, McMaster University , Hamilton, ON ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrycja A","family":"Jazwiec","sequence":"additional","affiliation":[{"name":"Department of Biochemistry & Biomedical Sciences, McMaster University , Hamilton, ON ,","place":["Canada"]},{"name":"Centre for Metabolism, Obesity, & Diabetes Research, McMaster University , Hamilton, ON ,","place":["Canada"]},{"name":"Farncombe Family Digestive Research Institute, McMaster University , Hamilton, ON ,","place":["Canada"]},{"name":"Department of Obstetrics & Gynecology, McMaster University , Hamilton, ON ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Biochemistry & Biomedical Sciences, McMaster University , Hamilton, ON ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaskiran","family":"Bains","sequence":"additional","affiliation":[{"name":"Department of Biochemistry & Biomedical Sciences, McMaster University , Hamilton, ON ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine M","family":"Kennedy","sequence":"additional","affiliation":[{"name":"Department of Biochemistry & Biomedical Sciences, McMaster University , Hamilton, ON ,","place":["Canada"]},{"name":"Farncombe Family Digestive Research Institute, McMaster University , Hamilton, ON ,","place":["Canada"]},{"name":"Department of Obstetrics & Gynecology, McMaster University , Hamilton, ON ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6823-2957","authenticated-orcid":false,"given":"Dawn M E","family":"Bowdish","sequence":"additional","affiliation":[{"name":"McMaster Immunology Research Centre, McMaster University , Hamilton, ON ,","place":["Canada"]},{"name":"Department of Medicine, McMaster University , Hamilton, ON ,","place":["Canada"]},{"name":"Firestone Institute for Respiratory Health, St. Joseph\u2019s Healthcare Hamilton , Hamilton, ON ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7410-4756","authenticated-orcid":false,"given":"Deborah M","family":"Sloboda","sequence":"additional","affiliation":[{"name":"Department of Biochemistry & Biomedical Sciences, McMaster University , Hamilton, ON ,","place":["Canada"]},{"name":"Centre for Metabolism, Obesity, & Diabetes Research, McMaster University , Hamilton, ON ,","place":["Canada"]},{"name":"Farncombe Family Digestive Research Institute, McMaster University , Hamilton, ON ,","place":["Canada"]},{"name":"Department of Obstetrics & Gynecology, McMaster University , Hamilton, ON ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,7,7]]},"reference":[{"key":"2025121605122704200_ref1","volume-title":"Overweight and obese adults","year":"2018"},{"key":"2025121605122704200_ref2","doi-asserted-by":"crossref","first-page":"10859","DOI":"10.1038\/s41598-017-11432-5","article-title":"Impact of maternal obesity on the incidence of pregnancy complications in France and Canada","volume":"7","author":"Fuchs","year":"2017","journal-title":"Sci Rep"},{"key":"2025121605122704200_ref3","first-page":"292","article-title":"The implications and consequences of maternal obesity on fetal intrauterine growth restriction","volume":"6","author":"Radulescu","year":"2013","journal-title":"J Med Life"},{"key":"2025121605122704200_ref4","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1097\/01.AOG.0000107291.46159.00","article-title":"Maternal morbid obesity and the risk of adverse pregnancy outcome","volume":"103","author":"Cedergren","year":"2004","journal-title":"Obstet Gynecol"},{"key":"2025121605122704200_ref5","doi-asserted-by":"crossref","DOI":"10.3390\/nu13041213","article-title":"Maternal obesity and risk of low birth weight, fetal growth restriction, and macrosomia: multiple analyses","volume":"13","author":"Lewandowska","year":"2021","journal-title":"Nutrients"},{"key":"2025121605122704200_ref6","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1097\/AOG.0000000000003901","article-title":"Maternal obesity and the risk of early-onset and late-onset hypertensive disorders of pregnancy","volume":"136","author":"Bicocca","year":"2020","journal-title":"Obstet Gynecol"},{"key":"2025121605122704200_ref7","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1111\/1471-0528.15661","article-title":"Impact of maternal body mass index and gestational weight gain on pregnancy complications: an individual participant data meta-analysis of European, North American and Australian cohorts","volume":"126","author":"Santos","year":"2019","journal-title":"BJOG"},{"key":"2025121605122704200_ref8","doi-asserted-by":"crossref","first-page":"R47","DOI":"10.1530\/JOE-21-0332","article-title":"Programming of cardiometabolic health: the role of maternal and fetal hyperinsulinaemia","volume":"253","author":"Hufnagel","year":"2022","journal-title":"J Endocrinol"},{"key":"2025121605122704200_ref9","doi-asserted-by":"crossref","first-page":"20220222","DOI":"10.1098\/rstb.2022.0222","article-title":"Early life impacts of maternal obesity: a window of opportunity to improve the health of two generations","volume":"378","author":"Dearden","year":"2023","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"2025121605122704200_ref10","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1161\/HYPERTENSIONAHA.123.21061","article-title":"Long-term impacts of preeclampsia on the cardiovascular system of mother and offspring","volume":"80","author":"Yang","year":"2023","journal-title":"Hypertension"},{"key":"2025121605122704200_ref11","first-page":"170","article-title":"The impact of maternal obesity on maternal and fetal health","volume":"1","author":"Leddy","year":"2008","journal-title":"Rev Obstet Gynecol"},{"key":"2025121605122704200_ref12","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1002\/pd.4932","article-title":"Maternal obesity and neurodevelopmental and psychiatric disorders in offspring","volume":"37","author":"Edlow","year":"2017","journal-title":"Prenat Diagn"},{"key":"2025121605122704200_ref13","doi-asserted-by":"crossref","first-page":"23982128211003484","DOI":"10.1177\/23982128211003484","article-title":"Maternal obesity and developmental programming of neuropsychiatric disorders: an inflammatory hypothesis","volume":"5","author":"Davis","year":"2021","journal-title":"Brain Neurosci Adv"},{"key":"2025121605122704200_ref14","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1152\/physrev.00029.2015","article-title":"Placental origins of chronic disease","volume":"96","author":"Burton","year":"2016","journal-title":"Physiol Rev"},{"key":"2025121605122704200_ref15","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1016\/S0140-6736(18)30312-X","article-title":"Origins of lifetime health around the time of conception: causes and consequences","volume":"391","author":"Fleming","year":"2018","journal-title":"Lancet"},{"key":"2025121605122704200_ref16","doi-asserted-by":"crossref","first-page":"T33","DOI":"10.1530\/JOE-18-0676","article-title":"Periconceptional environment and the developmental origins of disease","volume":"242","author":"Velazquez","year":"2019","journal-title":"J Endocrinol"},{"key":"2025121605122704200_ref17","doi-asserted-by":"crossref","first-page":"44650","DOI":"10.1038\/srep44650","article-title":"Exercise rescues obese mothers\u2019 insulin sensitivity, placental hypoxia and male offspring insulin sensitivity","volume":"7","author":"Fernandez-Twinn","year":"2017","journal-title":"Sci Rep"},{"key":"2025121605122704200_ref18","doi-asserted-by":"crossref","first-page":"3029","DOI":"10.1113\/JP277353","article-title":"High-fat diet intake modulates maternal intestinal adaptations to pregnancy and results in placental hypoxia, as well as altered fetal gut barrier proteins and immune markers","volume":"597","author":"Gohir","year":"2019","journal-title":"J Physiol"},{"key":"2025121605122704200_ref19","doi-asserted-by":"crossref","first-page":"17621","DOI":"10.1038\/s41598-019-54098-x","article-title":"Obesity during pregnancy results in maternal intestinal inflammation, placental hypoxia, and alters fetal glucose metabolism at mid-gestation","volume":"9","author":"Wallace","year":"2019","journal-title":"Sci Rep"},{"key":"2025121605122704200_ref20","first-page":"650","article-title":"Gestational diabetes induces chronic hypoxia stress and excessive inflammatory response in murine placenta","volume":"6","author":"Li","year":"2013","journal-title":"Int J Clin Exp Pathol"},{"key":"2025121605122704200_ref21","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.placenta.2015.12.006","article-title":"Maternal obesity and sex-specific differences in placental pathology","volume":"38","author":"Leon-Garcia","year":"2016","journal-title":"Placenta"},{"key":"2025121605122704200_ref22","doi-asserted-by":"crossref","first-page":"e33370","DOI":"10.1371\/journal.pone.0033370","article-title":"Adverse fetal and neonatal outcomes associated with a life-long high fat diet: role of altered development of the placental vasculature","volume":"7","author":"Hayes","year":"2012","journal-title":"PloS One"},{"key":"2025121605122704200_ref23","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.placenta.2020.10.013","article-title":"The role of obesity and gestational diabetes on placental size and fetal oxygenation","volume":"103","author":"Bianchi","year":"2021","journal-title":"Placenta"},{"key":"2025121605122704200_ref24","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3390\/ijms21113776","article-title":"Maternal obesity and the uterine immune cell landscape: the shaping role of inflammation","volume":"21","author":"St-Germain","year":"2020","journal-title":"Int J Mol Sci"},{"key":"2025121605122704200_ref25","doi-asserted-by":"crossref","first-page":"582748","DOI":"10.1155\/2012\/582748","article-title":"Impact of oxidative stress in fetal programming","volume":"2012","author":"Thompson","year":"2012","journal-title":"J Pregnancy"},{"key":"2025121605122704200_ref26","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1038\/s41574-022-00717-z","article-title":"Fetoplacental oxygen homeostasis in pregnancies with maternal diabetes mellitus and obesity","volume":"18","author":"Desoye","year":"2022","journal-title":"Nat Rev Endocrinol"},{"key":"2025121605122704200_ref27","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.placenta.2023.02.008","article-title":"The impact of maternal diabetes on birth to placental weight ratio and umbilical cord oxygen values with implications for fetal-placental development","volume":"136","author":"Choo","year":"2023","journal-title":"Placenta"},{"key":"2025121605122704200_ref28","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.placenta.2014.01.003","article-title":"Maternal obesity is associated with a lipotoxic placental environment","volume":"35","author":"Saben","year":"2014","journal-title":"Placenta"},{"key":"2025121605122704200_ref29","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1042\/CS20090640","article-title":"Lipotoxicity in obese pregnancy and its potential role in adverse pregnancy outcome and obesity in the offspring","volume":"119","author":"Jarvie","year":"2010","journal-title":"Clin Sci"},{"key":"2025121605122704200_ref30","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1038\/oby.2010.215","article-title":"Pregravid obesity associates with increased maternal endotoxemia and metabolic inflammation","volume":"19","author":"Basu","year":"2011","journal-title":"Obesity"},{"key":"2025121605122704200_ref31","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1113\/JP284139","article-title":"Obesity and gestational diabetes independently and collectively induce specific effects on placental structure, inflammation and endocrine function in a cohort of South African women","volume":"601","author":"Musa","year":"2023","journal-title":"J Physiol"},{"key":"2025121605122704200_ref32","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1210\/jc.2006-2083","article-title":"Longitudinal assessment of maternal endothelial function and markers of inflammation and placental function throughout pregnancy in lean and obese mothers","volume":"92","author":"Stewart","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"2025121605122704200_ref33","doi-asserted-by":"crossref","first-page":"2246","DOI":"10.1038\/s41366-020-0627-2","article-title":"Independent influences of maternal obesity and fetal sex on maternal cardiovascular adaptation to pregnancy: a prospective cohort study","volume":"44","author":"Teulings","year":"2020","journal-title":"Int J Obes (Lond)"},{"key":"2025121605122704200_ref34","doi-asserted-by":"crossref","first-page":"e0234861","DOI":"10.1371\/journal.pone.0234861","article-title":"Cardiac, renal and uterine hemodynamics changes throughout pregnancy in rats with a prolonged high fat diet from an early age","volume":"15","author":"Oltra","year":"2020","journal-title":"PloS One"},{"key":"2025121605122704200_ref35","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1210\/en.2019-00149","article-title":"Maternal high-fat diet consumption and chronic hyperandrogenemia are associated with placental dysfunction in female rhesus macaques","volume":"160","author":"Kuo","year":"2019","journal-title":"Endocrinology"},{"key":"2025121605122704200_ref36","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1038\/s41366-018-0145-7","article-title":"Maternal high-fat diet reversal improves placental hemodynamics in a nonhuman primate model of diet-induced obesity","volume":"43","author":"Salati","year":"2019","journal-title":"Int J Obes (Lond)"},{"key":"2025121605122704200_ref37","doi-asserted-by":"crossref","first-page":"2456","DOI":"10.1210\/en.2010-1332","article-title":"Maternal high-fat diet disturbs uteroplacental hemodynamics and increases the frequency of stillbirth in a nonhuman primate model of excess nutrition","volume":"152","author":"Frias","year":"2011","journal-title":"Endocrinology"},{"key":"2025121605122704200_ref38","doi-asserted-by":"crossref","first-page":"e85560","DOI":"10.1172\/jci.insight.85560","article-title":"Maternal obesity drives functional alterations in uterine NK cells","volume":"1","author":"Perdu","year":"2016","journal-title":"JCI Insight"},{"key":"2025121605122704200_ref39","first-page":"63","article-title":"Obesogenic diet exposure alters uterine natural killer cell biology and impairs vasculature remodeling in mice","volume":"102","author":"Baltayeva","year":"2020","journal-title":"Biol Reprod"},{"key":"2025121605122704200_ref40","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1093\/ajcp\/aqaa035","article-title":"The burden of placental histopathology in stillbirths associated with maternal obesity","volume":"154","author":"Avagliano","year":"2020","journal-title":"Am J Clin Pathol"},{"key":"2025121605122704200_ref41","doi-asserted-by":"crossref","first-page":"e13795","DOI":"10.1111\/apha.13795","article-title":"Diet-induced maternal obesity impacts feto-placental growth and induces sex-specific alterations in placental morphology, mitochondrial bioenergetics, dynamics, lipid metabolism and oxidative stress in mice","volume":"234","author":"Napso","year":"2022","journal-title":"Acta Physiol"},{"key":"2025121605122704200_ref42","doi-asserted-by":"crossref","first-page":"3425","DOI":"10.1007\/s43032-022-00983-2","article-title":"Maternal underweight and obesity are associated with placental pathologies in human pregnancy","volume":"29","author":"Scott","year":"2022","journal-title":"Reprod Sci"},{"key":"2025121605122704200_ref43","doi-asserted-by":"crossref","first-page":"S386","DOI":"10.1016\/j.ajog.2021.11.647","article-title":"Obesity and hypertension are risk factors for villitis of unknown etiology","volume":"226","author":"Rose","year":"2022","journal-title":"Am J Obstet Gynecol"},{"key":"2025121605122704200_ref44","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1177\/1933719115592712","article-title":"The effect of maternal obesity on pregnancy outcome in correlation with placental pathology","volume":"22","author":"Kovo","year":"2015","journal-title":"Reprod Sci"},{"key":"2025121605122704200_ref45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.placenta.2023.10.011","article-title":"Placental pathologic features in obesity","volume":"144","author":"Beneventi","year":"2023","journal-title":"Placenta"},{"key":"2025121605122704200_ref46","doi-asserted-by":"crossref","first-page":"3333","DOI":"10.1113\/JP277698","article-title":"Exercise prevents the adverse effects of maternal obesity on placental vascularization and fetal growth","volume":"597","author":"Son","year":"2019","journal-title":"J Physiol"},{"key":"2025121605122704200_ref47","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1038\/s41366-020-0561-3","article-title":"Impact of maternal obesity on placental transcriptome and morphology associated with fetal growth restriction in mice","volume":"44","author":"Barros","year":"2020","journal-title":"Int J Obes (Lond)"},{"key":"2025121605122704200_ref48","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1113\/JP281902","article-title":"Maternal but not fetoplacental health can be improved by metformin in a murine diet-induced model of maternal obesity and glucose intolerance","volume":"600","author":"Hufnagel","year":"2022","journal-title":"J Physiol"},{"key":"2025121605122704200_ref49","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1093\/biolre\/ioy010","article-title":"Diet-induced obesity alters the maternal metabolome and early placenta transcriptome and decreases placenta vascularity in the mouse","volume":"98","author":"Stuart","year":"2018","journal-title":"Biol Reprod"},{"key":"2025121605122704200_ref50","doi-asserted-by":"crossref","first-page":"E5098","DOI":"10.1073\/pnas.1514498112","article-title":"Uterine activin receptor-like kinase 5 is crucial for blastocyst implantation and placental development","volume":"112","author":"Peng","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2025121605122704200_ref51","article-title":"Diallyl trisulfide promotes placental angiogenesis by regulating lipid metabolism and alleviating inflammatory responses in obese pregnant mice","volume":"14","author":"Wang","year":"2022","journal-title":"Nutrients"},{"key":"2025121605122704200_ref52","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.5858\/2001-125-1258-PC","article-title":"Placental chorangiosis","volume":"125","author":"De La Ossa","year":"2001","journal-title":"Arch Pathol Lab Med"},{"key":"2025121605122704200_ref53","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1038\/labinvest.2008.7","article-title":"Impaired placental neovascularization in mice with pregnancy-associated hypertension","volume":"88","author":"Furuya","year":"2008","journal-title":"Lab Invest"},{"key":"2025121605122704200_ref54","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1186\/s12884-021-03576-0","article-title":"Association of placental chorangiosis with pregnancy complication and prenatal outcome: a case-control study","volume":"21","author":"Vafaei","year":"2021","journal-title":"BMC Pregnancy Childbirth"},{"key":"2025121605122704200_ref55","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s12958-019-0482-y","article-title":"Effects of high-fat diets on fetal growth in rodents: a systematic review","volume":"17","author":"Christians","year":"2019","journal-title":"Reprod Biol Endocrinol"},{"key":"2025121605122704200_ref56","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.placenta.2021.03.018","article-title":"Placental hypoxia: what have we learnt from small animal models?","volume":"113","author":"Siragher","year":"2021","journal-title":"Placenta"},{"key":"2025121605122704200_ref57","doi-asserted-by":"crossref","first-page":"629","DOI":"10.3389\/fphys.2018.00629","article-title":"Near to one\u2019s heart: the intimate relationship between the placenta and fetal heart","volume":"9","author":"Camm","year":"2018","journal-title":"Front Physiol"},{"key":"2025121605122704200_ref58","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1038\/s41467-023-36740-5","article-title":"Defects in placental syncytiotrophoblast cells are a common cause of developmental heart disease","volume":"14","author":"Radford","year":"2023","journal-title":"Nat Commun"},{"key":"2025121605122704200_ref59","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.ydbio.2024.10.009","article-title":"Off to a good start: the importance of the placental exchange surface - lessons from the mouse","volume":"517","author":"Ballasy","year":"2024","journal-title":"Dev Biol"},{"key":"2025121605122704200_ref60","doi-asserted-by":"crossref","first-page":"10756","DOI":"10.1038\/s41598-022-14955-8","article-title":"Analysis of commonly expressed genes between first trimester fetal heart and placenta cell types in the context of congenital heart disease","volume":"12","author":"Wilson","year":"2022","journal-title":"Sci Rep"},{"key":"2025121605122704200_ref61","doi-asserted-by":"crossref","first-page":"4","DOI":"10.21769\/BioProtoc.1254","article-title":"Hypoxia studies with pimonidazole in vivo","volume":"4","author":"Aguilera","year":"2014","journal-title":"Bio Protoc"},{"key":"2025121605122704200_ref62","doi-asserted-by":"crossref","first-page":"3285","DOI":"10.1113\/JP274845","article-title":"Feto- and utero-placental vascular adaptations to chronic maternal hypoxia in the mouse","volume":"596","author":"Cahill","year":"2018","journal-title":"J Physiol"},{"key":"2025121605122704200_ref63","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1113\/jphysiol.2008.163477","article-title":"Maternal nutritional history predicts obesity in adult offspring independent of postnatal diet","volume":"587","author":"Howie","year":"2009","journal-title":"J Physiol"},{"key":"2025121605122704200_ref64","volume-title":"The Guide to Investigation of Mouse Pregnancy","author":"Anne, Croy","year":"2013"},{"key":"2025121605122704200_ref65","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1161\/HYPERTENSIONAHA.111.183939","article-title":"Effects of reduced Gcm1 expression on trophoblast morphology, fetoplacental vascularity, and pregnancy outcomes in mice","volume":"59","author":"Bainbridge","year":"2012","journal-title":"Hypertension"},{"key":"2025121605122704200_ref66","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.devcel.2021.12.005","article-title":"The imprinted Igf2-Igf2r axis is critical for matching placental microvasculature expansion to fetal growth","volume":"57","author":"Sandovici","year":"2022","journal-title":"Dev Cell"},{"key":"2025121605122704200_ref67","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.placenta.2020.03.014","article-title":"Double-label immunohistochemistry to assess labyrinth structure of the mouse placenta with stereology","volume":"94","author":"De Clercq","year":"2020","journal-title":"Placenta"},{"key":"2025121605122704200_ref68","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1093\/biolre\/ioac066","article-title":"Paternal obesity induces placental hypoxia and sex-specific impairments in placental vascularization and offspring metabolism","volume":"107","author":"Jazwiec","year":"2022","journal-title":"Biol Reprod"},{"key":"2025121605122704200_ref69","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v082.i13","article-title":"lmerTest package: tests in linear mixed effects models","volume":"82","author":"Kuznetsova","year":"2017","journal-title":"J Stat Softw"},{"key":"2025121605122704200_ref70","volume-title":"R Companion 3E"},{"key":"2025121605122704200_ref71","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v067.i01","article-title":"Fitting linear mixed-effects models using lme4","volume":"67","author":"Bates","year":"2015","journal-title":"J Stat Softw"},{"key":"2025121605122704200_ref72","volume-title":"Data Visualization for Statistics in Social Science [R package sjPlot version 2.8.14]","author":"L\u00fcdecke","year":"2023"},{"key":"2025121605122704200_ref73","volume-title":"Estimated Marginal Means, aka Least-Squares Means [R package emmeans version 1.8.7]","author":"Lenth","year":"2023"},{"key":"2025121605122704200_ref74","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1038\/nm1429","article-title":"Soluble endoglin contributes to the pathogenesis of preeclampsia","volume":"12","author":"Venkatesha","year":"2006","journal-title":"Nat Med"},{"key":"2025121605122704200_ref75","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jri.2019.07.004","article-title":"The two-stage placental model of preeclampsia: an update","volume":"134-135","author":"Staff","year":"2019","journal-title":"J Reprod Immunol"},{"key":"2025121605122704200_ref76","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1006\/dbio.2002.0773","article-title":"Interactions between trophoblast cells and the maternal and fetal circulation in the mouse placenta","volume":"250","author":"Adamson","year":"2002","journal-title":"Dev Biol"},{"key":"2025121605122704200_ref77","doi-asserted-by":"crossref","first-page":"4158","DOI":"10.1210\/en.2010-1078","article-title":"Maternal obesity promotes a proinflammatory signature in rat uterus and blastocyst","volume":"152","author":"Shankar","year":"2011","journal-title":"Endocrinology"},{"key":"2025121605122704200_ref78","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1210\/jcem.87.4.8397","article-title":"Effect of estrogen versus testosterone on circulating osteoprotegerin and other cytokine levels in normal elderly men","volume":"87","author":"Khosla","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"2025121605122704200_ref79","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1016\/S0022-5347(05)65925-3","article-title":"The influence of sex hormones on renal osteopontin expression and urinary constituents in experimental urolithiasis","volume":"166","author":"Yagisawa","year":"2001","journal-title":"J Urol"},{"key":"2025121605122704200_ref80","doi-asserted-by":"crossref","first-page":"2417","DOI":"10.1007\/s00125-016-4061-x","article-title":"Knockout maternal adiponectin increases fetal growth in mice: potential role for trophoblast IGFBP-1","volume":"59","author":"Qiao","year":"2016","journal-title":"Diabetologia"},{"key":"2025121605122704200_ref81","doi-asserted-by":"crossref","first-page":"13557","DOI":"10.1002\/jcp.28034","article-title":"ROS- and HIF1\u03b1-dependent IGFBP3 upregulation blocks IGF1 survival signaling and thereby mediates high-glucose-induced cardiomyocyte apoptosis","volume":"234","author":"Huang","year":"2019","journal-title":"J Cell Physiol"},{"key":"2025121605122704200_ref82","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1038\/s41420-021-00629-3","article-title":"Insulin-like growth factor binding protein-1 regulates HIF-1\u03b1 degradation to inhibit apoptosis in hypoxic cardiomyocytes","volume":"7","author":"Tang","year":"2021","journal-title":"Cell Death Discov"},{"key":"2025121605122704200_ref83","doi-asserted-by":"crossref","first-page":"5057","DOI":"10.1113\/JP273330","article-title":"Placental phenotype and the insulin-like growth factors: resource allocation to fetal growth","volume":"595","author":"Sferruzzi-Perri","year":"2017","journal-title":"J Physiol"},{"key":"2025121605122704200_ref84","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1038\/ni.3370","article-title":"Interleukin 33 is a guardian of barriers and a local alarmin","volume":"17","author":"Martin","year":"2016","journal-title":"Nat Immunol"},{"key":"2025121605122704200_ref85","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1146\/annurev-immunol-101921-041206","article-title":"IL-4 and IL-13: regulators and effectors of wound repair","volume":"41","author":"Allen","year":"2023","journal-title":"Annu Rev Immunol"},{"key":"2025121605122704200_ref86","doi-asserted-by":"crossref","first-page":"826053","DOI":"10.3389\/fcell.2022.826053","article-title":"Regulation and function of chemokines at the maternal-fetal interface","volume":"10","author":"Zhang","year":"2022","journal-title":"Front Cell Dev Biol"},{"key":"2025121605122704200_ref87","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.4049\/jimmunol.1800963","article-title":"IL-27 promotes human placenta-derived mesenchymal stromal cell ability to induce the generation of CD4+IL-10+IFN-\u03b3+ T cells via the JAK\/STAT pathway in the treatment of experimental graft-versus-host disease","volume":"202","author":"Yi","year":"2019","journal-title":"J Immunol"},{"key":"2025121605122704200_ref88","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1146\/annurev-immunol-032414-112134","article-title":"The immunobiology of interleukin-27","volume":"33","author":"Yoshida","year":"2015","journal-title":"Annu Rev Immunol"},{"key":"2025121605122704200_ref89","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1161\/JAHA.117.007356","article-title":"Atherosclerotic calcification: Wnt is the hint","volume":"7","author":"Albanese","year":"2018","journal-title":"J Am Heart Assoc"},{"key":"2025121605122704200_ref90","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1161\/ATVBAHA.118.311577","article-title":"Osteopontin in vascular disease","volume":"39","author":"Lok","year":"2019","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2025121605122704200_ref91","first-page":"461","article-title":"Osteoprotegerin and vascular calcification: clinical and prognostic relevance","volume":"39","author":"Makarovi\u0107","year":"2015","journal-title":"Coll Antropol"},{"key":"2025121605122704200_ref92","doi-asserted-by":"crossref","first-page":"112131","DOI":"10.1016\/j.celrep.2023.112131","article-title":"Platelet-instructed SPP1+ macrophages drive myofibroblast activation in fibrosis in a CXCL4-dependent manner","volume":"42","author":"Hoeft","year":"2023","journal-title":"Cell Rep"},{"key":"2025121605122704200_ref93","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1111\/apm.12833","article-title":"Maternal vascular malperfusion of the placental bed","volume":"126","author":"Ernst","year":"2018","journal-title":"APMIS"},{"key":"2025121605122704200_ref94","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.placenta.2019.07.011","article-title":"Segmental villous mineralization: a placental feature of fetal vascular malperfusion","volume":"86","author":"Stanek","year":"2019","journal-title":"Placenta"},{"key":"2025121605122704200_ref95","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.5858\/arpa.2017-0212-RA","article-title":"Fetal vascular malperfusion","volume":"141","author":"Fetal","year":"2017","journal-title":"Arch Pathol Lab Med"},{"key":"2025121605122704200_ref96","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.3389\/fphys.2018.01044","article-title":"Placental vascular calcification and cardiovascular health: it is time to determine how much of maternal and offspring health is written in stone","volume":"9","author":"Wallingford","year":"2018","journal-title":"Front Physiol"},{"key":"2025121605122704200_ref97","doi-asserted-by":"crossref","first-page":"e12816","DOI":"10.1111\/aji.12816","article-title":"Lipopolysaccharide-induced maternal inflammation induces direct placental injury without alteration in placental blood flow and induces a secondary fetal intestinal injury that persists into adulthood","volume":"79","author":"Fricke","year":"2018","journal-title":"Am J Reprod Immunol"},{"key":"2025121605122704200_ref98","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s00125-022-05820-4","article-title":"Secular trend for increasing birthweight in offspring of pregnant women with type 1 diabetes: is improved placentation the reason?","volume":"66","author":"Desoye","year":"2023","journal-title":"Diabetologia"},{"key":"2025121605122704200_ref99","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1042\/CS20190266","article-title":"Placental function in maternal obesity","volume":"134","author":"Kelly","year":"2020","journal-title":"Clin Sci"},{"key":"2025121605122704200_ref100","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1093\/biolre\/ioac056","article-title":"Placental structure, function, and mitochondrial phenotype relate to fetal size in each fetal sex in mice","volume":"106","author":"Salazar-Petres","year":"2022","journal-title":"Biol Reprod"},{"key":"2025121605122704200_ref101","doi-asserted-by":"crossref","first-page":"e13861","DOI":"10.1111\/apha.13861","article-title":"Obesogenic diet in mice compromises maternal metabolic physiology and lactation ability leading to reductions in neonatal viability","volume":"236","author":"Lean","year":"2022","journal-title":"Acta Physiol"},{"key":"2025121605122704200_ref102","doi-asserted-by":"crossref","first-page":"100527","DOI":"10.1016\/j.ajogmf.2021.100527","article-title":"Unisex vs sex-specific estimated fetal weight charts for fetal growth monitoring: a population-based study","volume":"4","author":"Monier","year":"2022","journal-title":"Am J Obstet Gynecol MFM"},{"key":"2025121605122704200_ref103","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.earlhumdev.2017.06.009","article-title":"Maternal body mass index impacts fetal-placental size at birth and umbilical cord oxygen values with implications for regulatory mechanisms","volume":"112","author":"Richardson","year":"2017","journal-title":"Early Hum Dev"},{"key":"2025121605122704200_ref104","doi-asserted-by":"crossref","first-page":"2620","DOI":"10.1096\/fj.11-198598","article-title":"Hypoxia induces IGFBP3 in esophageal squamous cancer cells through HIF-1\u03b1-mediated mRNA transcription and continuous protein synthesis","volume":"26","author":"Natsuizaka","year":"2012","journal-title":"FASEB J"},{"key":"2025121605122704200_ref105","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1073\/pnas.0407443102","article-title":"Insulin-like growth factor-binding protein-1 (IGFBP-1) mediates hypoxia-induced embryonic growth and developmental retardation","volume":"102","author":"Kajimura","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2025121605122704200_ref106","doi-asserted-by":"crossref","first-page":"S844","DOI":"10.1016\/j.ajog.2021.11.1356","article-title":"The etiology of preeclampsia","volume":"226","author":"Jung","year":"2022","journal-title":"Am J Obstet Gynecol"},{"key":"2025121605122704200_ref107","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/s41572-023-00417-6","article-title":"Pre-eclampsia","volume":"9","author":"Dimitriadis","year":"2023","journal-title":"Nat Rev Dis Primers"},{"key":"2025121605122704200_ref108","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.placenta.2011.10.003","article-title":"Restriction of placental vasculature in a non-human primate: a unique model to study placental plasticity","volume":"33","author":"Roberts","year":"2012","journal-title":"Placenta"},{"key":"2025121605122704200_ref109","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1136\/bmjdrc-2020-001243","article-title":"Poorly controlled diabetes mellitus alters placental structure, efficiency, and plasticity","volume":"8","author":"Nteeba","year":"2020","journal-title":"BMJ Open Diabetes Res Care"},{"key":"2025121605122704200_ref110","doi-asserted-by":"crossref","first-page":"11","DOI":"10.7554\/eLife.77241","article-title":"VE-cadherin enables trophoblast endovascular invasion and spiral artery remodeling during placental development","volume":"11","author":"Sung","year":"2022","journal-title":"Elife"},{"key":"2025121605122704200_ref111","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1016\/j.immuni.2017.11.018","article-title":"Natural killer cells promote fetal development through the secretion of growth-promoting factors","volume":"47","author":"Fu","year":"2017","journal-title":"Immunity"},{"key":"2025121605122704200_ref112","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1177\/1933719113508815","article-title":"Trophoblast invasion and blood vessel remodeling are altered in a rat model of lifelong maternal obesity","volume":"21","author":"Hayes","year":"2014","journal-title":"Reprod Sci"},{"key":"2025121605122704200_ref113","article-title":"Maternal obesogenic diet disrupts mid-gestation decidual immune and vascular homeostasis without impairing spiral artery remodelling","author":"Bellissimo","year":"2024","journal-title":"BioRxiv"},{"key":"2025121605122704200_ref114","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1038\/s41366-024-01546-y","article-title":"Placental pathology and fetal growth outcomes in pregnancies complicated by maternal obesity","volume":"48","author":"Hietalati","year":"2024","journal-title":"Int J Obes (Lond)"},{"key":"2025121605122704200_ref115","doi-asserted-by":"crossref","first-page":"2246","DOI":"10.1016\/j.ajpath.2019.07.010","article-title":"N-Acetylcysteine resolves placental inflammatory-vasculopathic changes in mice consuming a high-fat diet","volume":"189","author":"Williams","year":"2019","journal-title":"Am J Pathol"},{"key":"2025121605122704200_ref116","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1515\/CCLM.2010.042","article-title":"Plasma osteopontin concentrations in preeclampsia - is there an association with endothelial injury?","volume":"48","author":"Stenczer","year":"2010","journal-title":"Clin Chem Lab Med"},{"key":"2025121605122704200_ref117","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1056\/NEJMra2206346","article-title":"Humoral innate immunity and acute-phase proteins","volume":"388","author":"Mantovani","year":"2023","journal-title":"N Engl J Med"},{"key":"2025121605122704200_ref118","doi-asserted-by":"crossref","first-page":"4847","DOI":"10.1080\/14767058.2020.1869930","article-title":"M1 macrophages involved in the pathogenesis of placental chronic villitis of unknown etiology","volume":"35","author":"Scarini","year":"2022","journal-title":"J Matern Fetal Neonatal Med"},{"key":"2025121605122704200_ref119","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1111\/j.1600-0897.2010.00927.x","article-title":"Focal increases of fetal macrophages in placentas from pregnancies with histological chorioamnionitis: potential role of fibroblast monocyte chemotactic protein-1","volume":"65","author":"Toti","year":"2011","journal-title":"Am J Reprod Immunol"},{"key":"2025121605122704200_ref120","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1080\/14767058.2017.1378329","article-title":"Maternal obesity is associated with chorioamnionitis and earlier indicated preterm delivery among expectantly managed women with preterm premature rupture of membranes","volume":"32","author":"Hadley","year":"2019","journal-title":"J Matern Fetal Neonatal Med"},{"key":"2025121605122704200_ref121","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.placenta.2010.12.023","article-title":"Placental structure and inflammation in pregnancies associated with obesity","volume":"32","author":"Roberts","year":"2011","journal-title":"Placenta"},{"key":"2025121605122704200_ref122","doi-asserted-by":"crossref","first-page":"E419","DOI":"10.1152\/ajpendo.00025.2014","article-title":"Impaired mitochondrial function in human placenta with increased maternal adiposity","volume":"307","author":"Mele","year":"2014","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"2025121605122704200_ref123","doi-asserted-by":"crossref","first-page":"671347","DOI":"10.3389\/fcimb.2021.671347","article-title":"Maternal obesity increases oxidative stress in placenta and it is associated with intestinal microbiota","volume":"11","author":"Hu","year":"2021","journal-title":"Front Cell Infect Microbiol"},{"key":"2025121605122704200_ref124","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1111\/jog.14315","article-title":"Maternal obesity reduces placental autophagy marker expression in uncomplicated pregnancies","volume":"46","author":"Cohen","year":"2020","journal-title":"J Obstet Gynaecol Res"},{"key":"2025121605122704200_ref125","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1080\/15548627.2016.1156822","article-title":"Sexual dimorphism in activation of placental autophagy in obese women with evidence for fetal programming from a placenta-specific mouse model","volume":"12","author":"Muralimanoharan","year":"2016","journal-title":"Autophagy"},{"key":"2025121605122704200_ref126","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/j.molmed.2022.05.013","article-title":"Maternal obesity: new placental paradigms unfolded","volume":"28","author":"Brombach","year":"2022","journal-title":"Trends Mol Med"},{"key":"2025121605122704200_ref127","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1038\/s42255-022-00693-8","article-title":"Maternal diet disrupts the placenta-brain axis in a sex-specific manner","volume":"4","author":"Ceasrine","year":"2022","journal-title":"Nat Metab"},{"key":"2025121605122704200_ref128","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1095\/biolreprod.113.117259","article-title":"Obesity during pregnancy disrupts placental morphology, cell proliferation, and inflammation in a sex-specific manner across gestation in the mouse","volume":"90","author":"Kim","year":"2014","journal-title":"Biol Reprod"},{"key":"2025121605122704200_ref129","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2018\/5427089","article-title":"Inflammation and LPS-binding protein enable the stimulatory effect of endotoxin on prolactin secretion in the ovine anterior pituitary: ex vivo study","volume":"2018","author":"Tomaszewska-Zaremba","year":"2018","journal-title":"Mediators Inflamm"},{"key":"2025121605122704200_ref130","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1210\/endo-125-1-575","article-title":"Interleukin-6 stimulates anterior pituitary hormone release in vitro","volume":"125","author":"Spangelo","year":"1989","journal-title":"Endocrinology"},{"key":"2025121605122704200_ref131","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1093\/molehr\/gaz038","article-title":"Prolactin decreases LPS-induced inflammatory cytokines by inhibiting TLR-4\/NF\u03baB signaling in the human placenta","volume":"25","author":"Olmos-Ortiz","year":"2019","journal-title":"Mol Hum Reprod"},{"key":"2025121605122704200_ref132","doi-asserted-by":"crossref","first-page":"1212736","DOI":"10.3389\/fimmu.2023.1212736","article-title":"Immunomodulatory role of decidual prolactin on the human fetal membranes and placenta","volume":"14","author":"Flores-Espinosa","year":"2023","journal-title":"Front Immunol"},{"key":"2025121605122704200_ref133","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1203\/00006450-198609000-00014","article-title":"Prolactin levels in umbilical cord serum and its relation to fetal adrenal activity in newborns of women with pregnancy-induced hypertension","volume":"20","author":"Parker","year":"1986","journal-title":"Pediatr Res"},{"key":"2025121605122704200_ref134","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1084\/jem.20130295","article-title":"Inflammation in rat pregnancy inhibits spiral artery remodeling leading to fetal growth restriction and features of preeclampsia","volume":"211","author":"Cotechini","year":"2014","journal-title":"J Exp Med"},{"key":"2025121605122704200_ref135","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.4049\/jimmunol.1002679","article-title":"Spontaneous pregnancy loss mediated by abnormal maternal inflammation in rats is linked to deficient uteroplacental perfusion","volume":"186","author":"Renaud","year":"2011","journal-title":"J Immunol"},{"key":"2025121605122704200_ref136","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.3389\/fphys.2019.01030","article-title":"LPS induces preeclampsia-like phenotype in rats and HTR8\/SVneo cells dysfunction through TLR4\/p38 MAPK pathway","volume":"10","author":"Fan","year":"2019","journal-title":"Front Physiol"},{"key":"2025121605122704200_ref137","doi-asserted-by":"crossref","first-page":"105653","DOI":"10.1016\/j.isci.2022.105653","article-title":"Placental macrophage responses to viral and bacterial ligands and the influence of fetal sex","volume":"25","author":"Pantazi","year":"2022","journal-title":"IScience"},{"key":"2025121605122704200_ref138","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1093\/biolre\/ioad072","article-title":"Sex differences in innate and adaptive immunity impact fetal, placental, and maternal health","volume":"109","author":"Baines","year":"2023","journal-title":"Biol Reprod"},{"key":"2025121605122704200_ref139","doi-asserted-by":"crossref","DOI":"10.1126\/science.abf3002","article-title":"Prenatal maternal infection promotes tissue-specific immunity and inflammation in offspring","volume":"373","author":"Lim","year":"2021","journal-title":"Science"},{"key":"2025121605122704200_ref140","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1002\/oby.21816","article-title":"Maternal high-fat diet consumption enhances offspring susceptibility to DSS-induced colitis in mice","volume":"25","author":"Bibi","year":"2017","journal-title":"Obesity"},{"key":"2025121605122704200_ref141","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.bbi.2017.05.015","article-title":"The role of IL-6 in neurodevelopment after prenatal stress","volume":"65","author":"Gumusoglu","year":"2017","journal-title":"Brain Behav Immun"},{"key":"2025121605122704200_ref142","doi-asserted-by":"crossref","first-page":"10695","DOI":"10.1523\/JNEUROSCI.2178-07.2007","article-title":"Maternal immune activation alters fetal brain development through interleukin-6","volume":"27","author":"Smith","year":"2007","journal-title":"J Neurosci"},{"key":"2025121605122704200_ref143","doi-asserted-by":"crossref","first-page":"2566","DOI":"10.1210\/en.2013-1968","article-title":"Maternal obesity and IL-6 lead to aberrant developmental gene expression and deregulated neurite growth in the fetal arcuate nucleus","volume":"155","author":"Sanders","year":"2014","journal-title":"Endocrinology"},{"key":"2025121605122704200_ref144","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1093\/humupd\/dmp046","article-title":"Beyond oxygen: complex regulation and activity of hypoxia inducible factors in pregnancy","volume":"16","author":"Pringle","year":"2010","journal-title":"Hum Reprod Update"},{"key":"2025121605122704200_ref145","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.ccr.2006.08.026","article-title":"Recruitment of HIF-1alpha and HIF-2alpha to common target genes is differentially regulated in neuroblastoma: HIF-2alpha promotes an aggressive phenotype","volume":"10","author":"Holmquist-Mengelbier","year":"2006","journal-title":"Cancer Cell"},{"key":"2025121605122704200_ref146","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.158908","article-title":"HIF1 inhibitor acriflavine rescues early-onset preeclampsia phenotype in mice lacking placental prolyl hydroxylase domain protein 2","volume":"7","author":"Sallais","year":"2022","journal-title":"JCI Insight"},{"key":"2025121605122704200_ref147","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1161\/HYPERTENSIONAHA.122.20739","article-title":"Specific HIF-2\u03b1 (hypoxia-inducible factor-2) inhibitor PT2385 mitigates placental dysfunction in vitro and in a rat model of preeclampsia (RUPP)","volume":"80","author":"Colson","year":"2023","journal-title":"Hypertension"},{"key":"2025121605122704200_ref148","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1113\/JP271057","article-title":"Placental phenotype and resource allocation to fetal growth are modified by the timing and degree of hypoxia during mouse pregnancy","volume":"594","author":"Higgins","year":"2016","journal-title":"J Physiol"}],"container-title":["Biology of Reproduction"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/biolreprod\/advance-article-pdf\/doi\/10.1093\/biolre\/ioaf143\/63686912\/ioaf143.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/biolreprod\/article-pdf\/113\/6\/1490\/63686912\/ioaf143.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/biolreprod\/article-pdf\/113\/6\/1490\/63686912\/ioaf143.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T10:12:55Z","timestamp":1765879975000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/biolreprod\/article\/113\/6\/1490\/8190021"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,7]]},"references-count":148,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2025,7,7]]},"published-print":{"date-parts":[[2025,12,16]]}},"URL":"https:\/\/doi.org\/10.1093\/biolre\/ioaf143","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2024.09.30.615691","asserted-by":"object"}]},"ISSN":["0006-3363","1529-7268"],"issn-type":[{"value":"0006-3363","type":"print"},{"value":"1529-7268","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,12]]},"published":{"date-parts":[[2025,7,7]]}}}