{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T18:39:31Z","timestamp":1775327971355,"version":"3.50.1"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,7,18]],"date-time":"2025-07-18T00:00:00Z","timestamp":1752796800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"SickKids Foundation\/Canadian Institutes of Health Research","award":["SKF-143181"],"award-info":[{"award-number":["SKF-143181"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and objective<\/jats:title>\n                    <jats:p>The placenta is crucial for fetal development; altered function is associated with complications and adverse neonatal outcomes. Our goal was to ascertain changes in the placental transcriptome in relation to neonatal outcome and fetal\/placental sex.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study design<\/jats:title>\n                    <jats:p>Seventy-two mother-baby dyads were included. Demographic, obstetrical, neonatal, and infant health data were obtained through medical charts. Adverse neonatal outcome was defined as the presence of a pulmonary, cardiac, neurological or other health complication. Bulk RNA-sequencing of placental biopsies was obtained. P-value &amp;lt;0.05 was considered statistically significant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Neonates experiencing adverse outcomes were more likely to be premature or have lower birth weights. Analysis of the placental transcriptome revealed a predominant inflammatory profile in pregnancies associated with adverse neonatal outcomes with the top pathways being related to immune and inflammatory responses. Among differently expressed genes (DEGs), 1237 were upregulated and 239 were downregulated in adverse vs no adverse outcomes. Furthermore, sex-specific differences in gene expression were observed and indicated that male and female placentas displayed unique DEGs in association with adverse outcomes. Indeed, no DEG was observed in female placentas when comparing those without vs with adverse neonatal outcomes, as opposed to 1279 DEGs in male placentas, of which 91% were up-regulated in adverse subgroups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings highlight that inflammatory pathways are upregulated in placentas in association with adverse neonatal outcomes, and showcase the importance of the fetal sex in understanding neonatal health. The placenta provides a unique tool for early identification of high-risk infants rapidly after delivery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/biolre\/ioaf158","type":"journal-article","created":{"date-parts":[[2025,7,18]],"date-time":"2025-07-18T11:21:31Z","timestamp":1752837691000},"page":"1266-1273","source":"Crossref","is-referenced-by-count":2,"title":["Adverse neonatal outcomes are associated with a sex-specific placental inflammatory profile"],"prefix":"10.1093","volume":"113","author":[{"given":"Camille","family":"Couture","sequence":"first","affiliation":[{"name":"Sainte-Justine Hospital Research Center , Montreal, QC ,","place":["Canada"]},{"name":"Department of Obstetrics and Gynecology, Mayo Clinic , Rochester, MN ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie-Eve","family":"Brien","sequence":"additional","affiliation":[{"name":"Sainte-Justine Hospital Research Center , Montreal, QC ,","place":["Canada"]},{"name":"Department of Obstetrics and Gynecology, Mayo Clinic , Rochester, MN ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline","family":"Pich\u00e9","sequence":"additional","affiliation":[{"name":"Sainte-Justine Hospital Research Center , Montreal, QC ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Cervantes","sequence":"additional","affiliation":[{"name":"Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic , Rochester, MN ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thuy Mai","family":"Luu","sequence":"additional","affiliation":[{"name":"Sainte-Justine Hospital Research Center , Montreal, QC ,","place":["Canada"]},{"name":"Department of Pediatrics; Universit\u00e9 de Montr\u00e9al , Montreal, Quebec ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5164-5816","authenticated-orcid":false,"given":"Sylvie","family":"Girard","sequence":"additional","affiliation":[{"name":"Sainte-Justine Hospital Research Center , Montreal, QC ,","place":["Canada"]},{"name":"Department of Obstetrics and Gynecology, Mayo Clinic , Rochester, MN ,","place":["USA"]},{"name":"Department of Immunology, Mayo Clinic , Rochester, MN ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,7,18]]},"reference":[{"key":"2025111708522542600_ref1","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1146\/annurev-cellbio-100814-125620","article-title":"Placenta: the forgotten organ","volume":"31","author":"Maltepe","year":"2015","journal-title":"Annu Rev Cell Dev 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