{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T04:05:08Z","timestamp":1776485108428,"version":"3.51.2"},"reference-count":219,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T00:00:00Z","timestamp":1754524800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Vice-Chancellor for Research and Technology at Kerman University of Medical Sciences","award":["IR.KMU.REC.402000531"],"award-info":[{"award-number":["IR.KMU.REC.402000531"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Fertility and sexual performance are directly related to the amounts of gonadal hormones. Gonadal hormones, fertility, and sexual function decrease with age. Klotho, an age-related protein, plays a role in reproduction and sex hormone-related diseases by regulating the amount and function of gonadal hormones. Klotho is a regulator of testosterone and estrogen at both the gene expression level and posttranslational modifications. Klotho is also involved in regulating spermatogenesis, oocyte development, fertilization, and fertility by participating in fibroblast growth factor (FGF) pathways and FGF receptors. On the other hand, gonadal hormones regulate the expression of this protein, and disruption of the related signaling pathways causes infertility, sexual dysfunction, and other sex hormone\u2013related diseases. Gonadal hormones also interact with Klotho in maintaining the function of different body systems and can contribute to diseases like cancer and preeclampsia. Thus, the interaction between gonadal hormones and Klotho is strong, but the areas where the mechanism remains unclear.<\/jats:p>","DOI":"10.1093\/biolre\/ioaf181","type":"journal-article","created":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T11:47:45Z","timestamp":1754567265000},"page":"1044-1060","source":"Crossref","is-referenced-by-count":1,"title":["Klotho-gonadal hormone crosstalk in male and female reproduction"],"prefix":"10.1093","volume":"113","author":[{"given":"Farzaneh","family":"Rostamzadeh","sequence":"first","affiliation":[{"name":"Physiology Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences , Kerman ,","place":["Iran"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahboobeh","family":"Yeganeh-Hajahmadi","sequence":"additional","affiliation":[{"name":"Physiology Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences , Kerman ,","place":["Iran"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasmin","family":"Moosavi-Saeed","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences , Kerman ,","place":["Iran"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,8,7]]},"reference":[{"key":"2025111708512556100_ref1","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1210\/jcem.87.2.8201","article-title":"Age trends in the level of serum testosterone and other hormones in middle-aged men: longitudinal results from the Massachusetts male aging study","volume":"87","author":"Feldman","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"2025111708512556100_ref2","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1017\/CBO9781139649520.008","article-title":"Androgensin postmenopausal women: their practically exclusive intracrine formation and inactivation in peripheral tissues. 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