{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T03:43:46Z","timestamp":1780544626840,"version":"3.54.1"},"reference-count":114,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T00:00:00Z","timestamp":1755129600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Obesity is a rising public health concern in the United States, with significant implications for maternal and fetal health during pregnancy. Maternal obesity is associated with increased risks of miscarriage, reduced implantation and pregnancy rates, fetal anomalies, abnormal fetal growth, stillbirth, preeclampsia, gestational diabetes, hypertensive disorders, labor and wound complications, and maternal depression. Current strategies for managing these risks include pre-pregnancy weight loss, nutritional counseling and weight management during pregnancy, lifestyle modifications, and low-dose aspirin to reduce the risk of preeclampsia. The effects of these interventions remain limited, underscoring the need for novel therapeutic approaches. A growing number of preclinical studies suggest that antioxidants such as coenzyme Q10 and pyrroloquinoline quinone may be promising candidates to mitigate the oxidative stress and mitochondrial dysfunction associated with maternal obesity and its comorbidities. Coenzyme Q10 supports mitochondrial function, ovarian reserve, and placental function while reducing obesity-related complications such as preeclampsia and miscarriage. Pyrroloquinoline quinone enhances mitochondrial biogenesis, regulates fatty acid metabolism, and ameliorates inflammation, with preclinical studies showing improved fertility and pregnancy rates, as well as protective effects against the development of adult metabolic diseases in offspring of pregnancies complicated with obesity. Together, coenzyme Q10 and pyrroloquinoline quinone offer promising nutraceutical strategies to improve fertility and reproductive health, placental function, pregnancy outcomes, and long-term metabolic consequences in offspring. Mechanistic insights gained from the preclinical research may inform future clinical studies to explore the therapeutic potential and synergistic benefits of combined coenzyme Q10 and pyrroloquinoline quinone treatment during human pregnancy complicated by obesity.<\/jats:p>","DOI":"10.1093\/biolre\/ioaf185","type":"journal-article","created":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T11:50:23Z","timestamp":1755085823000},"page":"29-41","source":"Crossref","is-referenced-by-count":1,"title":["A role for the antioxidants coenzyme Q10 and pyrroloquinoline quinone in mitigating obesity-associated reproductive dysfunction"],"prefix":"10.1093","volume":"114","author":[{"given":"Marisol","family":"Castillo-Castrejon","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Oklahoma Health Sciences Center , Oklahoma City, OK ,","place":["United States"]},{"name":"Department of Pathology, University of Oklahoma Health Sciences Center , Oklahoma City, OK ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather E","family":"McClurg","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Oklahoma Health Sciences Center , Oklahoma City, OK ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta F","family":"Maxted","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Oklahoma Health Sciences Center , Oklahoma City, OK ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dean A","family":"Myers","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Oklahoma Health Sciences Center , Oklahoma City, OK ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7929-4886","authenticated-orcid":false,"given":"Karen R","family":"Jonscher","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Oklahoma Health Sciences Center , Oklahoma City, OK ,","place":["United States"]},{"name":"Department of Biochemistry and Physiology, University of Oklahoma Health Sciences Center , Oklahoma City, OK ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,8,14]]},"reference":[{"key":"2026011601315257700_ref1","first-page":"1","article-title":"Prevalence of obesity and severe obesity among adults: United States, 2017-2018","volume":"360","author":"Hales","year":"2020","journal-title":"NCHS Data Brief"},{"key":"2026011601315257700_ref2","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1093\/humrep\/deh277","article-title":"Obesity is associated with increased risk of first trimester and recurrent miscarriage: matched case-control study","volume":"19","author":"Lashen","year":"2004","journal-title":"Hum Reprod"},{"key":"2026011601315257700_ref3","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1001\/jama.2009.113","article-title":"Maternal overweight and obesity and the risk of congenital anomalies: a systematic review and meta-analysis","volume":"301","author":"Stothard","year":"2009","journal-title":"JAMA"},{"key":"2026011601315257700_ref4","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/j.ajog.2003.09.058","article-title":"Obstetric complications and cesarean delivery rate--a population-based screening study","volume":"190","author":"Weiss","year":"2004","journal-title":"Am J Obstet Gynecol"},{"key":"2026011601315257700_ref5","doi-asserted-by":"crossref","first-page":"e416e1-6","DOI":"10.1016\/j.ajog.2007.10.796","article-title":"Impact of maternal body mass index on neonate birthweight and body composition","volume":"198","author":"Hull","year":"2008","journal-title":"Am J Obstet Gynecol"},{"key":"2026011601315257700_ref6","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1001\/jama.2014.2269","article-title":"Maternal body mass index and the risk of fetal death, stillbirth, and infant death: a systematic review and meta-analysis","volume":"311","author":"Aune","year":"2014","journal-title":"JAMA."},{"key":"2026011601315257700_ref7","doi-asserted-by":"crossref","first-page":"e128","DOI":"10.1097\/AOG.0000000000004395","article-title":"Obesity in pregnancy. 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