{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T19:02:30Z","timestamp":1768590150996,"version":"3.49.0"},"reference-count":75,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T00:00:00Z","timestamp":1757635200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31772564"],"award-info":[{"award-number":["31772564"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32372834"],"award-info":[{"award-number":["32372834"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Collection, Utilization and Innovation of Germplasm Resources by Research Institutes and Enterprises of Chongqing, China"},{"name":"Chongqing Modern Agricultural Industry Technology System","award":["CQMAITS202413"],"award-info":[{"award-number":["CQMAITS202413"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Placental cotyledons play a crucial role in material exchange and gas transportation between the ruminant mother and fetus and their proper development is essential for the intrauterine growth and development of the fetus. This study aimed to investigate the relationships between cotyledon size, litter size, and birth weight, while also identifying the key candidate genes involved in cotyledon development. Based on 95 postpartum goat placentas, significant positive associations were observed between cotyledon area, litter size, and birth litter weight. Histological examination showed a significant increase in capillary density with increasing cotyledon area, accompanied by significant changes in the cotyledon villus structure. Through the RNA-seq analysis of large (diameter\u2009&amp;gt;\u200930\u00a0mm), medium (diameter between 10\u201330\u00a0mm), and small (diameter\u2009&amp;lt;\u200910\u00a0mm) placental cotyledons, a total of 1103 differentially expressed genes (DEGs) were identified while RT-qPCR experiments confirmed the reliability of the sequencing results. The KEGG analysis indicated that the identified DEGs were primarily enriched in pathways such as the PI3K-AKT signaling pathway, the ECM-receptor interaction, the JAK-STAT signaling pathway, and the Estrogen signaling pathway. In conjunction with Gene Ontology functional annotations and Gene Set Enrichment Analysis (GSEA), the Spp1, Efna3, Igta3, and Csf1r genes were identified as potential candidate genes affecting the development and angiogenesis of goat placental cotyledons. These findings provide important insights into the mechanisms underlying the development of goat cotyledons and their relationship with the reproductive performance of goats.<\/jats:p>","DOI":"10.1093\/biolre\/ioaf211","type":"journal-article","created":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T12:02:19Z","timestamp":1757592139000},"page":"259-272","source":"Crossref","is-referenced-by-count":0,"title":["PI3K-AKT signaling pathway mediates placental cotyledon development and angiogenesis in goats"],"prefix":"10.1093","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9163-2104","authenticated-orcid":false,"given":"Xingqiang","family":"Fang","sequence":"first","affiliation":[{"name":"College of Animal Science and Technology, Southwest University , Chongqing ,","place":["China"]},{"name":"Chongqing Key Laboratory of Herbivore Science , Chongqing ,","place":["China"]},{"name":"Chongqing Engineering Research Center for Herbivores Resource Protection and Utilization , Chongqing ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuqing","family":"Cheng","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Southwest University , Chongqing ,","place":["China"]},{"name":"Chongqing Key Laboratory of Herbivore Science , Chongqing ,","place":["China"]},{"name":"Chongqing Engineering Research Center for Herbivores Resource Protection and Utilization , Chongqing ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1428-0552","authenticated-orcid":false,"given":"Le","family":"Zhao","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Southwest University , Chongqing ,","place":["China"]},{"name":"Chongqing Key Laboratory of Herbivore Science , Chongqing ,","place":["China"]},{"name":"Chongqing Engineering Research Center for Herbivores Resource Protection and Utilization , Chongqing ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junyin","family":"Zhao","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Southwest University , Chongqing ,","place":["China"]},{"name":"Chongqing Key Laboratory of Herbivore Science , Chongqing ,","place":["China"]},{"name":"Chongqing Engineering Research Center for Herbivores Resource Protection and Utilization , Chongqing ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingming","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Southwest University , Chongqing ,","place":["China"]},{"name":"Chongqing Key Laboratory of Herbivore Science , Chongqing ,","place":["China"]},{"name":"Chongqing Engineering Research Center for Herbivores Resource Protection and Utilization , Chongqing ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhipeng","family":"Sun","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Southwest University , Chongqing ,","place":["China"]},{"name":"Chongqing Key Laboratory of Herbivore Science , Chongqing ,","place":["China"]},{"name":"Chongqing Engineering Research Center for Herbivores Resource Protection and Utilization , Chongqing ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3562-4118","authenticated-orcid":false,"given":"Jipan","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Southwest University , Chongqing ,","place":["China"]},{"name":"Chongqing Key Laboratory of Herbivore Science , Chongqing ,","place":["China"]},{"name":"Chongqing Engineering Research Center for Herbivores Resource Protection and Utilization , Chongqing ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9256-8856","authenticated-orcid":false,"given":"Yongju","family":"Zhao","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Southwest University , Chongqing ,","place":["China"]},{"name":"Chongqing Key Laboratory of Herbivore Science , Chongqing ,","place":["China"]},{"name":"Chongqing Engineering Research Center for Herbivores Resource Protection and Utilization , Chongqing ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,9,12]]},"reference":[{"key":"2026011601320930400_ref1","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1194\/jlr.P072355","article-title":"The influence of placental metabolism on fatty acid transfer to the fetus","volume":"58","author":"Perazzolo","year":"2017","journal-title":"J Lipid Res"},{"key":"2026011601320930400_ref2","doi-asserted-by":"crossref","first-page":"S98","DOI":"10.1016\/j.placenta.2005.12.008","article-title":"Regulation of placental efficiency for nutrient transport by imprinted genes","volume":"27","author":"Angiolini","year":"2006","journal-title":"Placenta"},{"key":"2026011601320930400_ref3","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.placenta.2011.05.001","article-title":"How does variability of immune system genes affect placentation?","volume":"32","author":"Colucci","year":"2011","journal-title":"Placenta"},{"key":"2026011601320930400_ref4","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1055\/s-0035-1570031","article-title":"Animal models to study placental development and function throughout Normal and dysfunctional human pregnancy","volume":"34","author":"Grigsby","year":"2016","journal-title":"Semin Reprod Med"},{"key":"2026011601320930400_ref5","doi-asserted-by":"publisher","first-page":"2467","DOI":"10.2527\/jas.2012-5929","article-title":"2011 AND 2012 EARLY CAREERS ACHIEVEMENT AWARDS: placental programming: how the maternal environment can impact placental function","volume":"91","author":"Vonnahme","year":"2013","journal-title":"J Anim Sci"},{"key":"2026011601320930400_ref6","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/j.theriogenology.2022.12.002","article-title":"Fetal and placental development in early gestation of hyper-prolific sows","volume":"197","author":"Lyderik","year":"2023","journal-title":"Theriogenology"},{"key":"2026011601320930400_ref7","doi-asserted-by":"crossref","first-page":"3224","DOI":"10.3168\/jds.2014-8283","article-title":"Effects of day of gestation and feeding regimen in Holstein x Gyr cows: III. Placental adaptations and placentome gene expression","volume":"98","author":"Rotta","year":"2015","journal-title":"J Dairy Sci"},{"key":"2026011601320930400_ref8","doi-asserted-by":"publisher","first-page":"705","DOI":"10.3109\/09513590.2010.492967","article-title":"Placental hormones and identification of pregnancy at risk","volume":"26","author":"Torricelli","year":"2010","journal-title":"Gynecol Endocrinol"},{"key":"2026011601320930400_ref9","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.aat6114","article-title":"Immune responses at the maternal-fetal interface","volume":"4","author":"Ander","year":"2019","journal-title":"Science Immunology"},{"key":"2026011601320930400_ref10","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0303-7207(98)00039-2","article-title":"Fetal growth and placental function","volume":"140","author":"Bauer","year":"1998","journal-title":"Mol Cell Endocrinol"},{"key":"2026011601320930400_ref11","doi-asserted-by":"crossref","first-page":"399","DOI":"10.17582\/journal.pjz\/2019.51.2.399.403","article-title":"Reproductive characteristics of Dazu black goats, a newly discovered Chinese indigenous breed resource with high litter sizes","volume":"51","author":"Zhao","year":"2019","journal-title":"Pak J Zool"},{"key":"2026011601320930400_ref12","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1530\/rep.1.00398","article-title":"Implantation mechanisms: insights from the sheep","volume":"128","author":"Spencer","year":"2004","journal-title":"Reproduction"},{"key":"2026011601320930400_ref13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.animal.2023.100796","article-title":"Review: implantation and placentation in ruminants","volume":"17","author":"Davenport","year":"2023","journal-title":"Animal"},{"key":"2026011601320930400_ref14","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/978-3-030-77360-1_7","volume-title":"Placentation in Mammals: Tribute to EC Amoroso's Lifetime Contributions to Viviparity","author":"Green","year":"2021"},{"key":"2026011601320930400_ref15","doi-asserted-by":"publisher","first-page":"554","DOI":"10.3906\/vet-1601-63","article-title":"Poor placental traits reduce kid birth weight in young Saanen dams in the first parity","volume":"40","author":"Sen","year":"2016","journal-title":"Turk J Vet Anim Sci"},{"key":"2026011601320930400_ref16","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1016\/j.livsci.2014.01.002","article-title":"Relationship between placental traits and birth related factors in Damascus goats","volume":"161","author":"Ocak","year":"2014","journal-title":"Livest Sci"},{"key":"2026011601320930400_ref17","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s12020-008-9052-3","article-title":"Placental vascularity and growth factor expression in singleton, twin, and triplet pregnancies in the sheep","volume":"33","author":"Vonnahme","year":"2008","journal-title":"Endocrine"},{"key":"2026011601320930400_ref18","doi-asserted-by":"publisher","first-page":"644","DOI":"10.2527\/jas.2012-5629","article-title":"Placental nutrient transport is affected by pregnancy rank in sheep","volume":"91","author":"Linden","year":"2013","journal-title":"J Anim Sci"},{"key":"2026011601320930400_ref19","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1017\/S1751731116000318","article-title":"Evidence for placental compensation in cattle","volume":"10","author":"Van Eetvelde","year":"2016","journal-title":"Animal"},{"key":"2026011601320930400_ref20","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.theriogenology.2023.03.009","article-title":"Effect of birth rank, and placentome subtype on expression of genes involved in placental nutrient transport in sheep","volume":"203","author":"McCoard","year":"2023","journal-title":"Theriogenology"},{"key":"2026011601320930400_ref21","doi-asserted-by":"crossref","DOI":"10.3390\/ani11072132","article-title":"Screening candidate genes regulating placental development from trophoblast transcriptome at early pregnancy in Dazu black goats (Capra hircus)","volume":"11","author":"Luo","year":"2021","journal-title":"Animals"},{"key":"2026011601320930400_ref22","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.theriogenology.2018.04.002","article-title":"Placental development during early pregnancy in sheep: progesterone and estrogen receptor protein expression","volume":"114","author":"Bairagi","year":"2018","journal-title":"Theriogenology"},{"key":"2026011601320930400_ref23","first-page":"1","article-title":"Gene expression profile of placentomes and clinical parameters in the cows with retained placenta. Bmc","volume":"23","author":"Moradi","year":"2022","journal-title":"Genomics"},{"key":"2026011601320930400_ref24","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222413579","article-title":"Maternal heat stress alters expression of genes associated with nutrient transport activity and metabolism in female placentae from mid-gestating pigs","volume":"22","author":"Zhao","year":"2021","journal-title":"Int J Mol Sci"},{"key":"2026011601320930400_ref25","first-page":"323","article-title":"RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome. Bmc","volume":"12","author":"Li","year":"2011","journal-title":"Bioinformatics"},{"key":"2026011601320930400_ref26","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(T)(-Delta Delta C) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"2026011601320930400_ref27","doi-asserted-by":"crossref","first-page":"39","DOI":"10.5194\/aab-63-39-2020","article-title":"Determination of relationships between placental characteristics and birth weight in Morkaraman sheep","volume":"63","author":"Ozyurek","year":"2020","journal-title":"Archives Animal Breeding"},{"key":"2026011601320930400_ref28","first-page":"269","article-title":"Effects of genotype, dams age, litter size, birth weight and ram on morphological parameters of the placenta in sheep","volume":"107","author":"Kaulfuss","year":"2000","journal-title":"Deutsche Tierarztliche Wochenschrift"},{"key":"2026011601320930400_ref29","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/2049-1891-5-55","article-title":"Placental accommodations for transport and metabolism during intra-uterine crowding in pigs","volume":"5","author":"Vallet","year":"2014","journal-title":"Journal of Animal Science and Biotechnology"},{"key":"2026011601320930400_ref30","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.bbcan.2014.09.008","article-title":"Portrait of the PI3K\/AKT pathway in colorectal cancer","volume":"1855","author":"Danielsen","year":"2015","journal-title":"Biochimica Et Biophysica Acta-Reviews on Cancer"},{"key":"2026011601320930400_ref31","first-page":"4529","article-title":"Research progress on the PI3K\/AKT signaling pathway in gynecological cancer (review)","volume":"19","author":"Shi","year":"2019","journal-title":"Mol Med Rep"},{"key":"2026011601320930400_ref32","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1007\/s10735-022-10073-x","article-title":"Echinacoside inhibits the proliferation, migration, invasion and angiogenesis of ovarian cancer cells through PI3K\/AKT pathway","volume":"53","author":"Liu","year":"2022","journal-title":"J Mol Histol"},{"key":"2026011601320930400_ref33","doi-asserted-by":"publisher","first-page":"2062","DOI":"10.1515\/med-2022-0617","article-title":"MGST1 alleviates the oxidative stress of trophoblast cells induced by hypoxia\/reoxygenation and promotes cell proliferation, migration, and invasion by activating the PI3K\/AKT\/mTOR pathway","volume":"17","author":"Dai","year":"2022","journal-title":"Open Medicine"},{"key":"2026011601320930400_ref34","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1111\/jog.15493","article-title":"Overexpressed LAMC2 promotes trophoblast over-invasion through the PI3K\/Akt\/MMP2\/9 pathway in placenta accreta spectrum","volume":"49","author":"Wang","year":"2023","journal-title":"J Obstet Gynaecol Res"},{"key":"2026011601320930400_ref35","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.freeradbiomed.2023.10.380","article-title":"FKBP5 regulates trophoblast-macrophage crosstalk in recurrent spontaneous abortion through PI3K\/AKT and NF-\u03baB signaling pathways","volume":"209","author":"Chen","year":"2023","journal-title":"Free Radic Biol Med"},{"key":"2026011601320930400_ref36","doi-asserted-by":"publisher","first-page":"936","DOI":"10.17179\/excli2019-1175","article-title":"CROCETIN promotes angiogenesis IN human endothelial cells through PI3K-AKT-ENOS SIGNALING pathway","volume":"18","author":"Nasirzadeh","year":"2019","journal-title":"EXCLI J"},{"key":"2026011601320930400_ref37","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.115455","article-title":"Molecular mechanisms of Thrombospondin-2 modulates tumor vasculogenic mimicry by PI3K\/AKT\/mTOR signaling pathway","volume":"167","author":"Huang","year":"2023","journal-title":"Biomed Pharmacother"},{"key":"2026011601320930400_ref38","doi-asserted-by":"crossref","first-page":"659260","DOI":"10.3389\/fcell.2021.659260","article-title":"BCAT1 activates PI3K\/AKT\/mTOR pathway and contributes to the angiogenesis and Tumorigenicity of gastric cancer","volume":"9","author":"Shu","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"2026011601320930400_ref39","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.13491","article-title":"Expression and correlation of the Pi3k\/Akt pathway and VEGF in oral submucous fibrosis","volume":"56","author":"Lin","year":"2023","journal-title":"Cell Prolif"},{"key":"2026011601320930400_ref40","doi-asserted-by":"crossref","DOI":"10.4149\/neo_2024_230907N476","article-title":"The role of HMGA2 in activating the IGFBP2 expression to promote angiogenesis and LUAD metastasis via the PI3K\/AKT\/VEGFA signaling pathway","volume":"71","author":"Qian","year":"2024","journal-title":"Neoplasma"},{"key":"2026011601320930400_ref41","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2024.119222","article-title":"Integrative multi-omics and network pharmacology reveal angiogenesis promotion by Quan-Du-Zhong capsule via VEGFA\/PI3K-Akt pathway","volume":"340","author":"Li","year":"2025","journal-title":"J Ethnopharmacol"},{"key":"2026011601320930400_ref42","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.niox.2024.12.002","article-title":"Hydrogen sulfide alleviates endothelial glycocalyx damage and promotes placental angiogenesis in rats exposed to cigarette smoke","volume":"154","author":"Zhang","year":"2025","journal-title":"Nitric Oxide-Biology and Chemistry"},{"key":"2026011601320930400_ref43","doi-asserted-by":"crossref","first-page":"596","DOI":"10.3390\/pathophysiology31040043","article-title":"Flavonoid-mediated suppression of tumor angiogenesis: roles of Ang-tie\/PI3K\/AKT","volume":"31","author":"Saini","year":"2024","journal-title":"Pathophysiology"},{"key":"2026011601320930400_ref44","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1042\/BST20110609","article-title":"Cross-talk between mitogenic Ras\/MAPK and survival PI3K\/Akt pathways: a fine balance","volume":"40","author":"Aksamitiene","year":"2012","journal-title":"Biochem Soc Trans"},{"key":"2026011601320930400_ref45","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1093\/cvr\/cvn325","article-title":"Phosphoinositide 3-kinase signalling in the vascular system","volume":"82","author":"Morello","year":"2009","journal-title":"Cardiovasc Res"},{"key":"2026011601320930400_ref46","doi-asserted-by":"publisher","first-page":"1458","DOI":"10.1095\/biolreprod.103.020651","article-title":"Osteopontin: roles in implantation and placentation","volume":"69","author":"Johnson","year":"2003","journal-title":"Biol Reprod"},{"key":"2026011601320930400_ref47","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1095\/biolreprod.108.071068","article-title":"Progesterone and placentation increase secreted phosphoprotein one (SPP1 or Osteopontin) in uterine glands and stroma for histotrophic and Hematotrophic support of ovine pregnancy","volume":"79","author":"Dunlap","year":"2008","journal-title":"Biol Reprod"},{"key":"2026011601320930400_ref48","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.placenta.2005.05.005","article-title":"Differential gene expression identified in complete hydatidiform mole by combining suppression subtractive hybridization and cDNA microarray","volume":"27","author":"Feng","year":"2006","journal-title":"Placenta"},{"key":"2026011601320930400_ref49","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1093\/biolre\/ioab125","article-title":"SPP1 expression in the mouse uterus and placenta: implications for implantation","volume":"105","author":"Kramer","year":"2021","journal-title":"Biol Reprod"},{"key":"2026011601320930400_ref50","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1093\/biolre\/ioaa212","article-title":"Loss of ITGB3 in ovine conceptuses decreases conceptus expression of NOS3 and SPP1: implications for the developing placental vasculature","volume":"104","author":"Frank","year":"2021","journal-title":"Biol Reprod"},{"key":"2026011601320930400_ref51","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1096\/fj.202200337R","article-title":"Single-cell sequencing reveals microglia induced angiogenesis by specific subsets of endothelial cells following spinal cord injury","volume":"36","author":"Yao","year":"2022","journal-title":"FASEB J"},{"key":"2026011601320930400_ref52","doi-asserted-by":"publisher","DOI":"10.1186\/s11658-024-00612-7","article-title":"LncRNA TRPM2-AS promotes endometrial carcinoma progression and angiogenesis via targeting miR-497-5p\/SPP1 axis","volume":"29","author":"Ma","year":"2024","journal-title":"Cell Mol Biol Lett"},{"key":"2026011601320930400_ref53","first-page":"417","article-title":"Secreted phosphoprotein 1 promotes angiogenesis of glioblastoma through upregulating PSMA expression via transcription factor HIF1\u03b1","volume":"55","author":"Tu","year":"2023","journal-title":"Acta Biochim Biophys Sin"},{"key":"2026011601320930400_ref54","first-page":"27","article-title":"Identification of potential crucial genes associated with early-onset preeclampsia via bioinformatic analysis","volume":"24","author":"Kang","year":"2021","journal-title":"Pregnancy Hypertension-an International Journal of Womens Cardiovascular Health"},{"key":"2026011601320930400_ref55","doi-asserted-by":"crossref","first-page":"4","DOI":"10.31083\/j.fbl2704117","article-title":"Osteopontin (OPN)\/secreted phosphoprotein 1 (SPP1) binds Integrins to activate transport of ions across the porcine placenta","volume":"27","author":"Wu","year":"2022","journal-title":"Frontiers in Bioscience-Landmark"},{"key":"2026011601320930400_ref56","doi-asserted-by":"crossref","first-page":"599","DOI":"10.2174\/156802609789007327","article-title":"Colony-stimulating Factor-1 receptor inhibitors for the treatment of cancer and inflammatory disease","volume":"9","author":"Patel","year":"2009","journal-title":"Curr Top Med Chem"},{"key":"2026011601320930400_ref57","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0143-4004(97)90087-4","article-title":"Effects of human trophoblast-induced interferons on the expression of proto-oncogenes c-fms\/CSF-1R, EGF-R and c-erbB2 in invasive and non-invasive trophoblast","volume":"18","author":"AboagyeMathiesen","year":"1997","journal-title":"Placenta"},{"key":"2026011601320930400_ref58","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1038\/s41594-023-00960-6","article-title":"Regulation of human trophoblast gene expression by endogenous retroviruses","volume":"30","author":"Frost","year":"2023","journal-title":"Nat Struct Mol Biol"},{"key":"2026011601320930400_ref59","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1210\/jcem-73-4-746","article-title":"Colony-stimulating factor-I and C-FMS expression IN human endometrial tissues and placenta during the menstrual-cycle and early-pregnancy","volume":"73","author":"Kauma","year":"1991","journal-title":"J Clin Endocrinol Metab"},{"key":"2026011601320930400_ref60","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1182\/blood-2009-08-237412","article-title":"Targeting distinct tumor-infiltrating myeloid cells by inhibiting CSF-1 receptor: combating tumor evasion of antiangiogenic therapy","volume":"115","author":"Priceman","year":"2010","journal-title":"Blood"},{"key":"2026011601320930400_ref61","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.isci.2024.109145","article-title":"Microglia-endothelial cross-talk regulates diabetesinduced retinal vascular dysfunction through remodeling inflammatory microenvironment","volume":"27","author":"Ben","year":"2024","journal-title":"Iscience"},{"key":"2026011601320930400_ref62","doi-asserted-by":"crossref","first-page":"796592","DOI":"10.3389\/fgene.2021.796592","article-title":"EFNA3 is a prognostic biomarker correlated with immune cell infiltration and immune checkpoints in gastric cancer","volume":"12","author":"Zheng","year":"2022","journal-title":"Front Genet"},{"key":"2026011601320930400_ref63","doi-asserted-by":"publisher","first-page":"2376","DOI":"10.1016\/j.devcel.2023.08.004","article-title":"Maternal and embryonic signals cause functional differentiation of luminal epithelial cells and receptivity establishment","volume":"58","author":"Wang","year":"2023","journal-title":"Dev Cell"},{"key":"2026011601320930400_ref64","doi-asserted-by":"publisher","first-page":"2085","DOI":"10.1016\/j.bbadis.2017.02.023","article-title":"Mesenchymal stem cells-derived extracellular vesicles, via miR-210, improve infarcted cardiac function by promotion of angiogenesis","volume":"1863","author":"Wang","year":"2017","journal-title":"BBA-Mol Basis Dis"},{"key":"2026011601320930400_ref65","first-page":"373","article-title":"Extracellular vesicles derived from human umbilical cord mesenchymal stem cells stimulate angiogenesis in myocardial infarction via the microRNA-423-5p\/EFNA3 axis","volume":"18","author":"Gao","year":"2022","journal-title":"Postepy W Kardiologii Interwencyjnej"},{"key":"2026011601320930400_ref66","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1016\/j.ymthe.2018.06.003","article-title":"miR-210 enhances the therapeutic potential of bone-marrow-derived circulating proangiogenic cells in the setting of limb ischemia","volume":"26","author":"Besnier","year":"2018","journal-title":"Mol Ther"},{"key":"2026011601320930400_ref67","article-title":"OSCC exosomes regulate miR-210-3p targeting EFNA3 to promote Oral cancer angiogenesis through the PI3K\/AKT pathway. Biomed research","volume":"2020","author":"Wang","year":"2020","journal-title":"International"},{"key":"2026011601320930400_ref68","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/7752277","article-title":"Hypoxia-induced miR-210 promotes endothelial cell permeability and angiogenesis via exosomes in pancreatic ductal adenocarcinoma","volume":"2022","author":"Wu","year":"2022","journal-title":"Biochem Res Int"},{"key":"2026011601320930400_ref69","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1016\/j.actbio.2022.07.015","article-title":"Small extracellular vesicles derived from hypoxic mesenchymal stem cells promote vascularized bone regeneration through the miR-210-3p\/EFNA3\/PI3K pathway","volume":"150","author":"Zhuang","year":"2022","journal-title":"Acta Biomater"},{"key":"2026011601320930400_ref70","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40104-023-00918-0","article-title":"Integrins and their potential roles in mammalian pregnancy","volume":"14","author":"Johnson","year":"2023","journal-title":"Journal of Animal Science and Biotechnology"},{"key":"2026011601320930400_ref71","first-page":"5","article-title":"Differential expression of extracellular matrix and adhesion molecules in Fetal-origin amniotic epithelial cells of Preeclamptic pregnancy","volume":"11","author":"Kim","year":"2016","journal-title":"PLoS One"},{"key":"2026011601320930400_ref72","doi-asserted-by":"crossref","first-page":"e17950","DOI":"10.7717\/peerj.17950","article-title":"Polycystic ovarian syndrome (PCOS) and recurrent spontaneous abortion (RSA) are associated with the PI3K-AKT pathway activation","volume":"12","author":"Lin","year":"2024","journal-title":"Peerj"},{"key":"2026011601320930400_ref73","article-title":"Combining Transcriptomics and proteomics to screen candidate genes related to bovine birth weight","volume":"14","author":"Wang","year":"2024","journal-title":"Animals"},{"key":"2026011601320930400_ref74","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1038\/nmat4954","article-title":"Hydrogels with precisely controlled integrin activation dictate vascular patterning and permeability","volume":"16","author":"Li","year":"2017","journal-title":"Nat Mater"},{"key":"2026011601320930400_ref75","doi-asserted-by":"crossref","first-page":"e2566","DOI":"10.1038\/cddis.2016.486","article-title":"MicroRNA-101 inhibits invasion and angiogenesis through targeting ITGA3 and its systemic delivery inhibits lung metastasis in nasopharyngeal carcinoma","volume":"8","author":"Tang","year":"2017","journal-title":"Cell Death Dis"}],"container-title":["Biology of Reproduction"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/biolreprod\/advance-article-pdf\/doi\/10.1093\/biolre\/ioaf211\/64257235\/ioaf211.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/biolreprod\/article-pdf\/114\/1\/259\/64257235\/ioaf211.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/biolreprod\/article-pdf\/114\/1\/259\/64257235\/ioaf211.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T06:32:18Z","timestamp":1768545138000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/biolreprod\/article\/114\/1\/259\/8252836"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,12]]},"references-count":75,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,9,12]]},"published-print":{"date-parts":[[2026,1,11]]}},"URL":"https:\/\/doi.org\/10.1093\/biolre\/ioaf211","relation":{},"ISSN":["0006-3363","1529-7268"],"issn-type":[{"value":"0006-3363","type":"print"},{"value":"1529-7268","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,1]]},"published":{"date-parts":[[2025,9,12]]}}}