{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T18:52:12Z","timestamp":1781981532018,"version":"3.54.5"},"reference-count":51,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T00:00:00Z","timestamp":1760659200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Anti-M\u00fcllerian hormone is a promising fertoprotective agent, demonstrating particularly strong efficacy against doxorubicin-induced ovarian toxicity. However, the impact of chemotherapy on the uterus, and the potential benefits of anti-M\u00fcllerian hormone in this context, remain poorly understood. In this study, we characterized doxorubicin-induced uterine damage and assessed the fertoprotective effect of anti-M\u00fcllerian hormone co-treatment in mice. Acutely, doxorubicin treatment caused the accumulation of DNA damage in multiple uterine cell-types, including the myometrium, as evidenced by both increased \u03b3-H2AX staining and upregulation of Cdkn1a, Trp53, and other downstream Trp53 pathway targets, both at the mRNA and protein levels. Anti-M\u00fcllerian hormone co-treatment counteracted these effects by reducing \u03b3-H2AX-positive DNA damage lesion accumulation and by suppressing Trp53 and its downstream pathway. Furthermore, anti-M\u00fcllerian hormone co-treatment significantly reduced the incidence of doxorubicin-induced labor dystocia, a complication of parturition, in pregnancies following chemotherapy treatment. These findings suggest that, in addition to ovarian protection, anti-M\u00fcllerian hormone may have benefits in preserving myometrial integrity and long-term uterine function following chemotherapy, further supporting its therapeutic potential for fertility preservation in cancer patients receiving chemotherapy.<\/jats:p>","DOI":"10.1093\/biolre\/ioaf233","type":"journal-article","created":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T12:16:35Z","timestamp":1760703395000},"page":"855-870","source":"Crossref","is-referenced-by-count":1,"title":["Anti-M\u00fcllerian hormone ameliorates uterine DNA damage response and prevents pregnancy complications in doxorubicin-treated mice"],"prefix":"10.1093","volume":"114","author":[{"given":"Ngoc Minh Phuong","family":"Nguyen","sequence":"first","affiliation":[{"name":"Pediatric Surgical Research Laboratories, Massachusetts General Hospital , Boston, MA ,","place":["USA"]},{"name":"Department of Surgery, Harvard Medical School , Boston, MA 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