{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T11:09:40Z","timestamp":1773745780467,"version":"3.50.1"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T00:00:00Z","timestamp":1773705600000},"content-version":"vor","delay-in-days":141,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22K07891"],"award-info":[{"award-number":["22K07891"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["19K08275"],"award-info":[{"award-number":["19K08275"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["15K09711"],"award-info":[{"award-number":["15K09711"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>For a successful pregnancy, decidualization is a crucial process involving the significant transformation of endometrial stromal cells surrounding the implanting blastocysts. Disruption of this process can lead to the breakdown of the fetomaternal interface and result in early pregnancy loss. However, the precise mechanisms governing this process remain incompletely understood. This study aimed to elucidate the impact of citrullination, a post-translational modification, on decidualization in mice and humans. Immunohistochemical analysis and immunoprecipitation followed by immunoblotting were performed on mouse and human uterine tissues. In this study, we showed that ezrin\/radixin\/moesin (ERM) proteins are expressed in decidual and endothelial cells within the decidua during pregnancy, with their expression patterns significantly influenced by two factors: citrullination mediated by peptidylarginine deiminase enzymes and sphingosine kinase activity. Notably, ERM proteins were found to undergo citrullination exclusively in the decidua during pregnancy, but not in interimplantation tissues during pregnancy or in nonpregnant uteri in mice. Similar findings were observed in human decidual tissues from cases of spontaneous abortion and elective termination. In conclusion, this study demonstrates that ERM proteins undergo citrullination in the decidua during early pregnancy in both mice and humans. Our findings provide important insights into the molecular changes involved in pregnancy, particularly decidualization.<\/jats:p>","DOI":"10.1093\/biolre\/ioaf241","type":"journal-article","created":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T11:59:16Z","timestamp":1761307156000},"page":"1018-1029","source":"Crossref","is-referenced-by-count":0,"title":["Ezrin, radixin, and moesin are novel citrullinated proteins in the decidua during pregnancy"],"prefix":"10.1093","volume":"114","author":[{"given":"Kouhei","family":"Yamashita","sequence":"first","affiliation":[{"name":"Department of Hematology, Kyoto University Hospital , Sakyo-ku, Kyoto 606-8507 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinji","family":"Ito","sequence":"additional","affiliation":[{"name":"Medical Research Support Center, Graduate School of Medicine, Kyoto University , Sakyo-ku, Kyoto 606-8501 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junko","family":"Satoh","sequence":"additional","affiliation":[{"name":"Medical Research Support Center, Graduate School of Medicine, Kyoto University , Sakyo-ku, Kyoto 606-8501 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akifumi","family":"Takaori-Kondo","sequence":"additional","affiliation":[{"name":"Department of Hematology, Kyoto University Hospital , Sakyo-ku, Kyoto 606-8507 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7558-4352","authenticated-orcid":false,"given":"Kiyomi","family":"Mizugishi","sequence":"additional","affiliation":[{"name":"Department of Hematology, Kyoto University Hospital , Sakyo-ku, Kyoto 606-8507 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,10,27]]},"reference":[{"key":"2026031706254478600_ref1","doi-asserted-by":"publisher","first-page":"1379","DOI":"10.1172\/JCI76369","article-title":"Emerging biology of sphingosine-1-phosphate: its role in pathogenesis and therapy","volume":"125","author":"Proia","year":"2015","journal-title":"J Clin Invest"},{"key":"2026031706254478600_ref2","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1111\/imr.13219","article-title":"Get me out of here: sphingosine 1-phosphate signaling and T cell exit from tissues during an immune response","volume":"317","author":"Hallisey","year":"2023","journal-title":"Immunol Rev"},{"key":"2026031706254478600_ref3","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1038\/nrc.2017.96","article-title":"Sphingolipid metabolism in cancer signalling and therapy","volume":"18","author":"Ogretmen","year":"2018","journal-title":"Nat Rev Cancer"},{"key":"2026031706254478600_ref4","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1038\/s41575-021-00574-7","article-title":"Alimentiv translational research consortium (ATRC). 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