{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T13:29:16Z","timestamp":1790947756612,"version":"4.1.0"},"reference-count":58,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T00:00:00Z","timestamp":1766448000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82402001"],"award-info":[{"award-number":["82402001"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82120108011"],"award-info":[{"award-number":["82120108011"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371699"],"award-info":[{"award-number":["82371699"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Key Research and Development Project","award":["2022YFC2704602"],"award-info":[{"award-number":["2022YFC2704602"]}]},{"name":"National Key Research and Development Project","award":["2022YFC2704502"],"award-info":[{"award-number":["2022YFC2704502"]}]},{"name":"Major Project of Shanghai Municipal Education Commission's Scientific Research and Innovation Plan","award":["2021-01-07-00-07-E00144"],"award-info":[{"award-number":["2021-01-07-00-07-E00144"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Maternal stress caused by the environmental factors varied in intrauterine and extrauterine during pregnancy may significantly affect placental and fetal development, as well as offspring health in adulthood. Epigenetic mechanisms are frequently invoked to elucidate these effects. RNA N6-methyladenosine (m6A) modification, one of the most prevalent and abundant post-transcriptional epigenetic modifications in eukaryotic mRNA, has recently garnered widespread attention in life sciences. RNA m6A modification plays critical roles in RNA splicing, translation, localization, stability, and has been implicated in various biological processes, including embryonic development, sex determination, and disease pathogenesis. In studies of placental developmental abnormalities induced by maternal stress during pregnancy, m6A modification has emerged as a key mechanism. This article initially introduces the impact of RNA m6A methylation modification on placental development, subsequently elaborates on recent advances in understanding how maternal stress induces placental abnormalities via m6A modification, and finally summarizes unresolved key questions in this field. This review aims to propose strategies for preventing and treating placental developmental abnormalities caused by maternal stress.<\/jats:p>","DOI":"10.1093\/biolre\/ioaf285","type":"journal-article","created":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T12:44:53Z","timestamp":1766493893000},"page":"700-707","source":"Crossref","is-referenced-by-count":2,"title":["Research progress on RNA m6A methylation modification mediating placental disorders induced by maternal stress"],"prefix":"10.1093","volume":"114","author":[{"given":"Lingtong","family":"Gao","sequence":"first","affiliation":[{"name":"Department of Physiology, College of Basic Medical Sciences, Naval Medical University , 800 Xiangyin Rd., Shanghai , 200433,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinan","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Physiology, College of Basic Medical Sciences, Naval Medical University , 800 Xiangyin Rd., Shanghai , 200433,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Physiology, College of Basic Medical Sciences, Naval Medical University , 800 Xiangyin Rd., Shanghai , 200433,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Physiology, College of Basic Medical Sciences, Naval Medical University , 800 Xiangyin Rd., Shanghai , 200433,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2170-2645","authenticated-orcid":false,"given":"Lu","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Physiology, College of Basic Medical Sciences, Naval Medical University , 800 Xiangyin Rd., Shanghai , 200433,","place":["China"]},{"name":"Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics , Shanghai Jiaotong University, Shanghai ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,12,23]]},"reference":[{"key":"2026031706260705000_ref1","doi-asserted-by":"publisher","first-page":"2516","DOI":"10.1001\/jama.2018.18200","article-title":"Unraveling the mysteries of the human placenta","volume":"320","author":"Rubin","year":"2018","journal-title":"JAMA"},{"key":"2026031706260705000_ref2","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.semcdb.2022.03.039","article-title":"Human placental development and function","volume":"131","author":"Cindrova-Davies","year":"2022","journal-title":"Semin Cell Dev Biol"},{"key":"2026031706260705000_ref3","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1038\/s41574-020-0372-6","article-title":"Tracking placental development in health and disease","volume":"16","author":"Aplin","year":"2020","journal-title":"Nat Rev Endocrinol"},{"key":"2026031706260705000_ref4","doi-asserted-by":"publisher","first-page":"956","DOI":"10.1161\/CIRCULATIONAHA.122.061934","article-title":"Placental inflammation leads to abnormal embryonic heart development","volume":"147","author":"Ward","year":"2023","journal-title":"Circulation"},{"key":"2026031706260705000_ref5","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1038\/s41581-019-0119-6","article-title":"Pre-eclampsia: pathogenesis, novel diagnostics and therapies","volume":"15","author":"Phipps","year":"2019","journal-title":"Nat Rev Nephrol"},{"key":"2026031706260705000_ref6","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1186\/s12916-021-02173-4","article-title":"P-gp expression inhibition mediates placental glucocorticoid barrier opening and fetal weight loss","volume":"19","author":"Ge","year":"2021","journal-title":"BMC Med"},{"key":"2026031706260705000_ref7","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1111\/j.1365-2796.2007.01809.x","article-title":"The origins of the developmental origins theory","volume":"261","author":"Barker","year":"2007","journal-title":"J Intern Med"},{"key":"2026031706260705000_ref8","doi-asserted-by":"publisher","first-page":"119316","DOI":"10.1016\/j.bbamcr.2022.119316","article-title":"Hypoxia induced ALKBH5 prevents spontaneous abortion by mediating m(6)A-demethylation of SMAD1\/5 mRNAs","volume":"1869","author":"Zheng","year":"2022","journal-title":"Biochim Biophys Acta, Mol Cell Res"},{"key":"2026031706260705000_ref9","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1038\/s41556-019-0315-4","article-title":"The RNA N(6)-methyladenosine modification landscape of human fetal tissues","volume":"21","author":"Xiao","year":"2019","journal-title":"Nat Cell Biol"},{"key":"2026031706260705000_ref10","doi-asserted-by":"publisher","first-page":"2236","DOI":"10.1016\/j.molcel.2022.05.029","article-title":"Hidden codes in mRNA: control of gene expression by m(6)a","volume":"82","author":"Murakami","year":"2022","journal-title":"Mol Cell"},{"key":"2026031706260705000_ref11","doi-asserted-by":"publisher","first-page":"167290","DOI":"10.1016\/j.bbadis.2024.167290","article-title":"N6-methyladenosine dynamics in placental development and trophoblast functions, and its potential role in placental diseases","volume":"1870","author":"Wu","year":"2024","journal-title":"Biochim Biophys Acta Mol basis Dis"},{"key":"2026031706260705000_ref12","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1096\/fj.201900619RR","article-title":"Epitranscriptomic profiling in human placenta: N6-methyladenosine modification at the 5\u2032-untranslated region is related to fetal growth and preeclampsia","volume":"34","author":"Taniguchi","year":"2020","journal-title":"FASEB J"},{"key":"2026031706260705000_ref13","doi-asserted-by":"publisher","first-page":"1365","DOI":"10.1038\/ijo.2010.62","article-title":"Placental FTO expression relates to fetal growth","volume":"34","author":"Bassols","year":"2010","journal-title":"Int J Obes"},{"key":"2026031706260705000_ref14","doi-asserted-by":"crossref","first-page":"97004","DOI":"10.1289\/EHP12207","article-title":"Effects of gestational arsenic exposures on placental and Fetal development in mice: the role of Cyr61 m6A","volume":"131","author":"Song","year":"2023","journal-title":"Environ Health Perspect"},{"key":"2026031706260705000_ref15","doi-asserted-by":"publisher","first-page":"3853","DOI":"10.7150\/thno.31868","article-title":"The m6A demethylase ALKBH5 controls trophoblast invasion at the maternal-fetal interface by regulating the stability of CYR61 mRNA","volume":"9","author":"Li","year":"2019","journal-title":"Theranostics"},{"key":"2026031706260705000_ref16","doi-asserted-by":"publisher","first-page":"176885","DOI":"10.1016\/j.scitotenv.2024.176885","article-title":"Arsenic induces ferroptosis in HTR-8\/SVneo cells and placental damage","volume":"955","author":"Dong","year":"2024","journal-title":"Sci Total Environ"},{"key":"2026031706260705000_ref17","doi-asserted-by":"publisher","first-page":"e18227","DOI":"10.7717\/peerj.18227","article-title":"ALKBH5 modulation of ferroptosis in recurrent miscarriage: implications in cytotrophoblast dysfunction","volume":"12","author":"Qin","year":"2024","journal-title":"PeerJ"},{"key":"2026031706260705000_ref18","doi-asserted-by":"publisher","first-page":"109879","DOI":"10.1016\/j.ecoenv.2019.109879","article-title":"Maternal cadmium exposure during late pregnancy causes fetal growth restriction via inhibiting placental progesterone synthesis","volume":"187","author":"Xiong","year":"2020","journal-title":"Ecotoxicol Environ Saf"},{"key":"2026031706260705000_ref19","doi-asserted-by":"publisher","first-page":"113807","DOI":"10.1016\/j.fct.2023.113807","article-title":"Gestational cadmium exposure disrupts fetal liver development via repressing estrogen biosynthesis in placental trophoblasts","volume":"176","author":"Fu","year":"2023","journal-title":"Food Chem Toxicol"},{"key":"2026031706260705000_ref20","doi-asserted-by":"publisher","first-page":"135668","DOI":"10.1016\/j.chemosphere.2022.135668","article-title":"Environmental cadmium exposure during gestation impairs fetal brain and cognitive function of adult offspring via reducing placenta-derived E2 level","volume":"307","author":"Liu","year":"2022","journal-title":"Chemosphere"},{"key":"2026031706260705000_ref21","doi-asserted-by":"publisher","first-page":"e2500924","DOI":"10.1002\/advs.202500924","article-title":"Placental RTN3L-dependent ER-Phagy contributes to Fetal testicular dysplasia upon environmental stress","volume":"12","author":"Luo","year":"2025","journal-title":"Adv Sci (Weinh)"},{"key":"2026031706260705000_ref22","doi-asserted-by":"publisher","first-page":"134741","DOI":"10.1016\/j.jhazmat.2024.134741","article-title":"BaP\/BPDE exposure causes human trophoblast cell dysfunctions and induces miscarriage by up-regulating lnc-HZ06-regulated IL1B","volume":"476","author":"Guo","year":"2024","journal-title":"J Hazard Mater"},{"key":"2026031706260705000_ref23","doi-asserted-by":"publisher","first-page":"131543","DOI":"10.1016\/j.jhazmat.2023.131543","article-title":"BPDE exposure promotes trophoblast cell pyroptosis and induces miscarriage by up-regulating lnc-HZ14\/ZBP1\/NLRP3 axis","volume":"455","author":"Wang","year":"2023","journal-title":"J Hazard Mater"},{"key":"2026031706260705000_ref24","doi-asserted-by":"publisher","first-page":"17009","DOI":"10.1289\/EHP10477","article-title":"BPDE, the migration and invasion of human trophoblast cells, and occurrence of miscarriage in humans: roles of a novel lncRNA-HZ09","volume":"131","author":"Dai","year":"2023","journal-title":"Environ Health Perspect"},{"key":"2026031706260705000_ref25","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/j.placenta.2020.09.067","article-title":"The role of maternal-foetal interface inflammation mediated by NLRP3 inflammasome in the pathogenesis of recurrent spontaneous abortion","volume":"101","author":"Gao","year":"2020","journal-title":"Placenta"},{"key":"2026031706260705000_ref26","doi-asserted-by":"publisher","first-page":"145950","DOI":"10.1016\/j.scitotenv.2021.145950","article-title":"Lnc-HZ01 with m6A RNA methylation inhibits human trophoblast cell proliferation and induces miscarriage by up-regulating BPDE-activated lnc-HZ01\/MXD1 positive feedback loop","volume":"776","author":"Xu","year":"2021","journal-title":"Sci Total Environ"},{"key":"2026031706260705000_ref27","doi-asserted-by":"publisher","first-page":"113564","DOI":"10.1016\/j.ecoenv.2022.113564","article-title":"Environmental BPDE induced human trophoblast cell apoptosis by up-regulating lnc-HZ01\/p53 positive feedback loop","volume":"237","author":"Huang","year":"2022","journal-title":"Ecotoxicol Environ Saf"},{"key":"2026031706260705000_ref28","doi-asserted-by":"publisher","first-page":"116409","DOI":"10.1016\/j.ecoenv.2024.116409","article-title":"Environmental BaP\/BPDE suppressed trophoblast cell invasion\/migration and induced miscarriage by down-regulating lnc-HZ01\/MEST\/VIM axis","volume":"278","author":"Chen","year":"2024","journal-title":"Ecotoxicol Environ Saf"},{"key":"2026031706260705000_ref29","doi-asserted-by":"publisher","DOI":"10.3390\/nu10101342","article-title":"Glycaemic index of maternal dietary carbohydrate differentially alters Fto and Lep expression in offspring in C57BL\/6 mice","volume":"10","author":"Sideratou","year":"2018","journal-title":"Nutrients"},{"key":"2026031706260705000_ref30","doi-asserted-by":"publisher","first-page":"109900","DOI":"10.1016\/j.isci.2024.109900","article-title":"Demethylase FTO-mediated m6A modification of SIK1 modulates placental cytotrophoblast syncytialization in type 2 diabetes mellitus","volume":"27","author":"Ning","year":"2024","journal-title":"iScience"},{"key":"2026031706260705000_ref31","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1016\/j.placenta.2012.05.006","article-title":"Placental weight and efficiency in relation to maternal body mass index and the risk of pregnancy complications in women delivering singleton babies","volume":"33","author":"Wallace","year":"2012","journal-title":"Placenta"},{"key":"2026031706260705000_ref32","doi-asserted-by":"crossref","first-page":"106","DOI":"10.3109\/14767058.2014.987749","article-title":"Birth weight is associated with placental fat mass- and obesity-associated gene expression and promoter methylation in a Chinese population","volume":"29","author":"Liu","year":"2016","journal-title":"J Matern Fetal Neonatal Med"},{"key":"2026031706260705000_ref33","doi-asserted-by":"publisher","first-page":"1563","DOI":"10.1097\/CM9.0000000000002840","article-title":"METTL3 regulates glucose transporter expression in placenta exposed to hyperglycemia through the mTOR signaling pathway","volume":"137","author":"Ning","year":"2024","journal-title":"Chin Med J"},{"key":"2026031706260705000_ref34","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1097\/CM9.0000000000000129","article-title":"Role of mammalian target of rapamycin signaling pathway in regulation of fatty acid oxidation in a preeclampsia-like mouse model treated with pravastatin","volume":"132","author":"Huai","year":"2019","journal-title":"Chin Med J"},{"key":"2026031706260705000_ref35","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2017092118","article-title":"Placental trophoblast syncytialization potentiates macropinocytosis via mTOR signaling to adapt to reduced amino acid supply","volume":"118","author":"Shao","year":"2021","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026031706260705000_ref36","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s10565-024-09855-8","article-title":"Fetal growth restriction exhibits various mTOR signaling in different regions of mouse placentas with altered lipid metabolism","volume":"40","author":"Dong","year":"2024","journal-title":"Cell Biol Toxicol"},{"key":"2026031706260705000_ref37","doi-asserted-by":"publisher","first-page":"1478","DOI":"10.7150\/ijbs.103428","article-title":"FTO-induced APOE promotes the malignant progression of pancreatic neuroendocrine neoplasms through FASN-mediated lipid metabolism","volume":"21","author":"Chen","year":"2025","journal-title":"Int J Biol Sci"},{"key":"2026031706260705000_ref38","doi-asserted-by":"publisher","first-page":"110072","DOI":"10.1016\/j.abb.2024.110072","article-title":"Fat mass and obesity-associated protein (FTO)-induced upregulation of flotillin-2 (FLOT2) contributes to cancer aggressiveness in diffuse large B-cell lymphoma (DLBCL) via activating the PI3K\/Akt\/mTOR signal pathway","volume":"758","author":"Zhang","year":"2024","journal-title":"Arch Biochem Biophys"},{"key":"2026031706260705000_ref39","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1186\/s40001-025-03217-8","article-title":"Epigenetic regulation by WTAPP1 promotes trophoblast dysfunction in gestational diabetes via CNR1\/NF-\u03baB activation","volume":"30","author":"Yang","year":"2025","journal-title":"Eur J Med Res"},{"key":"2026031706260705000_ref40","doi-asserted-by":"publisher","first-page":"e2100301","DOI":"10.1002\/mnfr.202100301","article-title":"Maternal exposure to oxidized soybean oil impairs placental development by modulating nutrient transporters in a rat model","volume":"65","author":"Wang","year":"2021","journal-title":"Mol Nutr Food Res"},{"key":"2026031706260705000_ref41","doi-asserted-by":"publisher","first-page":"6224","DOI":"10.1021\/acs.jafc.2c01100","article-title":"Maternal oxidized soybean oil Administration in Rats during pregnancy and lactation alters the intestinal DNA methylation in offspring","volume":"70","author":"Wang","year":"2022","journal-title":"J Agric Food Chem"},{"key":"2026031706260705000_ref42","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1093\/biolre\/ioy010","article-title":"Diet-induced obesity alters the maternal metabolome and early placenta transcriptome and decreases placenta vascularity in the mouse","volume":"98","author":"Stuart","year":"2018","journal-title":"Biol Reprod"},{"key":"2026031706260705000_ref43","doi-asserted-by":"publisher","first-page":"2279","DOI":"10.1007\/s00404-024-07462-w","article-title":"Maternal obesity and placental function: impaired maternal-fetal axis","volume":"309","author":"Louwen","year":"2024","journal-title":"Arch Gynecol Obstet"},{"key":"2026031706260705000_ref44","doi-asserted-by":"publisher","first-page":"1812","DOI":"10.1038\/s41366-018-0113-2","article-title":"Maternal obesity aggravates the abnormality of porcine placenta by increasing N(6)-methyladenosine","volume":"42","author":"Song","year":"2018","journal-title":"Int J Obes"},{"key":"2026031706260705000_ref45","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1007\/s00018-024-05494-8","article-title":"\u0392'-COP mediated loading of PPAR\u03b3 into trophoblast-derived extracellular vesicles","volume":"81","author":"Luo","year":"2024","journal-title":"Cell Mol Life Sci"},{"key":"2026031706260705000_ref46","doi-asserted-by":"publisher","first-page":"104103","DOI":"10.1016\/j.labinv.2025.104103","article-title":"Compromised peroxisome proliferator-activated receptor \u03b3-mediated impaired placental glucose transport via the phosphatidylinositol 3-kinase\/protein kinase B Signaling pathway is associated with Fetal growth restriction","volume":"105","author":"Huang","year":"2025","journal-title":"Lab Investig"},{"key":"2026031706260705000_ref47","doi-asserted-by":"publisher","first-page":"e2404983","DOI":"10.1002\/advs.202404983","article-title":"The placenta regulates intrauterine Fetal growth via Exosomal PPAR\u03b3","volume":"12","author":"Luo","year":"2025","journal-title":"Adv Sci (Weinh)"},{"key":"2026031706260705000_ref48","doi-asserted-by":"publisher","first-page":"1311","DOI":"10.1038\/s41401-021-00756-8","article-title":"The m(6)a demethylase FTO promotes the osteogenesis of mesenchymal stem cells by downregulating PPARG","volume":"43","author":"Chen","year":"2022","journal-title":"Acta Pharmacol Sin"},{"key":"2026031706260705000_ref49","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.reprotox.2021.12.002","article-title":"Maternal obesity increases DNA methylation and decreases RNA methylation in the human placenta","volume":"107","author":"Shen","year":"2022","journal-title":"Reprod Toxicol"},{"key":"2026031706260705000_ref50","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.jad.2023.05.098","article-title":"The role of m6A methylation in prenatal maternal psychological distress and birth outcome","volume":"338","author":"Li","year":"2023","journal-title":"J Affect Disord"},{"key":"2026031706260705000_ref51","doi-asserted-by":"crossref","first-page":"927615","DOI":"10.3389\/fgene.2022.927615","article-title":"Fear stress during pregnancy affects placental m6A-modifying enzyme expression and epigenetic modification levels","volume":"13","author":"Wang","year":"2022","journal-title":"Front Genet"},{"key":"2026031706260705000_ref52","doi-asserted-by":"publisher","first-page":"115305","DOI":"10.1016\/j.taap.2020.115305","article-title":"Inorganic arsenic and its methylated metabolites as endocrine disruptors in the placenta: mechanisms underpinning glucocorticoid receptor (GR) pathway perturbations","volume":"409","author":"Meakin","year":"2020","journal-title":"Toxicol Appl Pharmacol"},{"key":"2026031706260705000_ref53","doi-asserted-by":"publisher","first-page":"126785","DOI":"10.1016\/j.chemosphere.2020.126785","article-title":"Cadmium down-regulates 11\u03b2-HSD2 expression and elevates active glucocorticoid level via PERK\/p-eIF2\u03b1 pathway in placental trophoblasts","volume":"254","author":"Shi","year":"2020","journal-title":"Chemosphere"},{"key":"2026031706260705000_ref54","doi-asserted-by":"crossref","first-page":"e23056","DOI":"10.1002\/jbt.23056","article-title":"Selenium attenuates the cadmium-induced placenta glucocorticoid barrier damage by up-regulating the expression of specificity protein 1","volume":"36","author":"Wu","year":"2022","journal-title":"J Biochem Mol Toxicol"},{"key":"2026031706260705000_ref55","doi-asserted-by":"publisher","first-page":"2407","DOI":"10.1007\/s40618-024-02371-w","article-title":"Endocrine disruptors, aryl hydrocarbon receptor and cortisol secretion","volume":"47","author":"Pecori Giraldi","year":"2024","journal-title":"J Endocrinol Investig"},{"key":"2026031706260705000_ref56","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23116348","article-title":"Benzo[a]pyrene-environmental occurrence, human exposure, and mechanisms of toxicity","volume":"23","author":"Bukowska","year":"2022","journal-title":"Int J Mol Sci"},{"key":"2026031706260705000_ref57","doi-asserted-by":"publisher","first-page":"2538","DOI":"10.1080\/15548627.2023.2200625","article-title":"NR3C1\/glucocorticoid receptor activation promotes pancreatic \u03b2-cell autophagy overload in response to glucolipotoxicity","volume":"19","author":"Wu","year":"2023","journal-title":"Autophagy"},{"key":"2026031706260705000_ref58","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232415508","article-title":"Glucocorticoid regulates the synthesis of porcine muscle protein through m(6)a modified amino acid transporter SLC7A7","volume":"23","author":"Xu","year":"2022","journal-title":"Int J Mol Sci"}],"container-title":["Biology of Reproduction"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/biolreprod\/advance-article-pdf\/doi\/10.1093\/biolre\/ioaf285\/66114935\/ioaf285.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/biolreprod\/article\/114\/3\/700\/8402451","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/biolreprod\/article\/114\/3\/700\/8402451","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T10:26:14Z","timestamp":1773743174000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/biolreprod\/article\/114\/3\/700\/8402451"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,23]]},"references-count":58,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025,12,23]]},"published-print":{"date-parts":[[2026,3,16]]}},"URL":"https:\/\/doi.org\/10.1093\/biolre\/ioaf285","relation":{},"ISSN":["0006-3363","1529-7268"],"issn-type":[{"value":"0006-3363","type":"print"},{"value":"1529-7268","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,3]]},"published":{"date-parts":[[2025,12,23]]}}}