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Although the basement membrane is generally thought to be formed by surrounding somatic cells, whether SSCs also produce basement membrane proteins and, if so, whether SSC-produced laminin affects SSC behavior remains unknown. In this study, we found that mouse GFR\u03b11+ spermatogonia, which include SSCs, expressed several laminin subunit genes, including Lamc1, whose expression declined upon differentiation. To test whether GFR\u03b11+ spermatogonia-derived laminin regulates their behavior, we used two conditional knockout mouse models. In the Vasa-Cre model, which induces recombination in all germ cells, heterozygous deletion of Lamc1 increased both cell death and proliferation of GFR\u03b11+ spermatogonia, while maintaining an apparent steady state of GFR\u03b11+ cell density and spermatogenesis. In the tamoxifen-inducible GFR\u03b11-CreER model carrying Lamc1flox\/flox, tamoxifen-induced Lamc1 deletion in GFR\u03b11+ spermatogonia caused a rapid reduction in their cell density within a few days, followed by increased proliferation and an imbalance between proliferation and differentiation of GFR\u03b11+ spermatogonia that led to the restoration of GFR\u03b11+ spermatogonial density. Collectively, these genetic findings suggest that GFR\u03b11+ spermatogonia modulate their survival and behavior through laminin expression, likely by influencing the basement membrane around GFR\u03b11+ spermatogonia. Such cell-autonomous regulation allows GFR\u03b11+ spermatogonia, including SSCs, to form an appropriate local microenvironment wherever they reside within the testicular open niche, supporting stable behavior of spermatogonia during spermatogenesis.<\/jats:p>","DOI":"10.1093\/biolre\/ioag032","type":"journal-article","created":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T12:11:06Z","timestamp":1770120666000},"page":"1507-1519","source":"Crossref","is-referenced-by-count":1,"title":["Undifferentiated spermatogonia modulate their behavior via the expression of basement membrane protein laminin"],"prefix":"10.1093","volume":"114","author":[{"given":"Yusuke","family":"Kawabe","sequence":"first","affiliation":[{"name":"Laboratory of Animal Reproduction and Development, Graduate School of Agricultural Science, Tohoku University , 468-1 Aoba, Aramaki-aza, Aoba-ku, Sendai, Miyagi 980-8572 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