{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T06:09:43Z","timestamp":1778825383679,"version":"3.51.4"},"reference-count":74,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T00:00:00Z","timestamp":1770595200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100012553","name":"Chang Gung Memorial Hospital","doi-asserted-by":"publisher","award":["CMRPG8P0901"],"award-info":[{"award-number":["CMRPG8P0901"]}],"id":[{"id":"10.13039\/100012553","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Dynamin-related protein 1 (DRP1) is a central regulator of mitochondrial fission and plays a critical role in maintaining mitochondrial function, distribution, and turnover in reproductive cells. Mitochondrial integrity is essential for oocyte quality, folliculogenesis, fertilization, embryonic development, and ultimately, female reproductive longevity. In this review, we synthesize evidence from mammalian and invertebrate models to illustrate the essential roles of DRP1 in reproductive physiology and aging. Genetic deletion or pharmacologic inhibition of DRP1 results in mitochondrial clustering, energy failure, increased reactive oxygen species production, meiotic arrest, and embryo fragmentation. Furthermore, DRP1 dysfunction has been increasingly implicated in age-associated reproductive decline due to impaired mitophagy and defective organelle crosstalk. Model systems such as mice, pigs, and Caenorhabditis elegans have demonstrated that DRP1 activity is modulated by metabolic and epigenetic pathways, including NAD+\/sirtuin signaling and GTP metabolism. Therapeutic interventions aimed at restoring DRP1 function\u2014including nicotinamide mononucleotide, coenzyme Q10 (CoQ10), and dietary modulation\u2014have shown promising effects in delaying reproductive aging and improving oocyte or embryo competence in animal models. Despite the current absence of human interventional efficacy data, DRP1 is a plausible and testable target in reproductive biology, with preclinical findings indicating potential relevance to infertility treatment and reproductive aging. This review highlights DRP1 as a key target in reproductive biology, emphasizing its translational potential for treating infertility and mitigating age-related oocyte deterioration.<\/jats:p>","DOI":"10.1093\/biolre\/ioag035","type":"journal-article","created":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T12:47:40Z","timestamp":1770382060000},"page":"1559-1567","source":"Crossref","is-referenced-by-count":0,"title":["DRP1 in reproduction and reproductive aging"],"prefix":"10.1093","volume":"114","author":[{"given":"Cheng-Rung","family":"Huang","sequence":"first","affiliation":[{"name":"Center for Menopause and Reproductive Medicine Research, Kaohsiung Chang Gung Memorial Hospital , Kaohsiung ,","place":["Taiwan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yin-Hua","family":"Cheng","sequence":"additional","affiliation":[{"name":"Center for Menopause and Reproductive Medicine Research, Kaohsiung Chang Gung Memorial Hospital , Kaohsiung ,","place":["Taiwan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yung-Chiao","family":"Chang","sequence":"additional","affiliation":[{"name":"Center for Menopause and Reproductive Medicine Research, Kaohsiung Chang Gung Memorial Hospital , Kaohsiung ,","place":["Taiwan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pei-Ling","family":"Weng","sequence":"additional","affiliation":[{"name":"Center for Menopause and Reproductive Medicine Research, Kaohsiung Chang Gung Memorial Hospital , Kaohsiung ,","place":["Taiwan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3702-0091","authenticated-orcid":false,"given":"Kuo-Chung","family":"Lan","sequence":"additional","affiliation":[{"name":"Center for Menopause and Reproductive Medicine Research, Kaohsiung Chang Gung Memorial Hospital , Kaohsiung ,","place":["Taiwan"]},{"name":"Department of Obstetrics and Gynecology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine , Kaohsiung ,","place":["Taiwan"]},{"name":"School of Medicine, College of Medicine, National Sun Yat-sen University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2026,2,9]]},"reference":[{"key":"2026051501265732000_ref1","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/s41392-023-01547-9","article-title":"Mitochondrial dynamics in health and disease: mechanisms and potential targets","volume":"8","author":"Chen","year":"2023","journal-title":"Signal Transduct Target Ther"},{"key":"2026051501265732000_ref2","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1038\/s41580-020-0210-7","article-title":"The cell biology of mitochondrial membrane dynamics","volume":"21","author":"Giacomello","year":"2020","journal-title":"Nat Rev Mol Cell 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