{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T08:04:16Z","timestamp":1784102656313,"version":"3.55.0"},"reference-count":110,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:00:00Z","timestamp":1773014400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"UAMS: College of Medicine Barton Pilot Study Award"},{"name":"College of Medicine Sturgis Foundation Award"},{"name":"VCRI Medical Research Endowment Award"},{"name":"College of Medicine Development Enhancement Award for Proposals"},{"name":"NSF Dart Project","award":["OIA-1946391"],"award-info":[{"award-number":["OIA-1946391"]}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HD059056"],"award-info":[{"award-number":["R01 HD059056"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HD087057"],"award-info":[{"award-number":["R01 HD087057"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Institute of General Medical Sciences of the National Institutes of Health","award":["P20_GM109096"],"award-info":[{"award-number":["P20_GM109096"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Secretoneurin (SN) is a small, bioactive proteolytic product of secretogranin II (SCG2), a chromogranin protein involved in secretory vesicle packaging. Secretogranin II co-aggregates with luteinizing hormone (LH) in pituitary gonadotrope secretory granules and thus has long been associated with gonadotropin-releasing hormone\u2013regulated LH secretion. Previously, the SCG2-derived peptide SN has been identified as a regulator of LH production and secretion in fish and a murine gonadotrope-like cell line (L\u03b2T2). Though high levels of SCG2\/SN are present in the mammalian pituitary, the role of pituitary SN has not been identified in mammals. It is further unknown if pituitary SN function varies with age and sex. Here, we identify a decrease in levels of precursor SCG2, and a trend towards increased levels of SN throughout postnatal development, particularly in females, following the onset of puberty. Additionally, proteomic and bioinformatic analyses of adult male and female pituitaries revealed protein\u2013protein interactions between SCG2 and various peptides, many associated with prohormone processing and regulated secretion. Furthermore, we demonstrate for the first time that SN is capable of stimulating LH secretion from ex vivo mouse pituitaries, an effect previously documented only in non-mammalian vertebrate species and L\u03b2T2 cells. Exogenous SN stimulation significantly increased LH release from adult male (1.4\u00d7; P\u00a0&amp;lt;\u20090.01) and proestrous female (2.4\u00d7; P\u00a0&amp;lt;\u20090.0001) murine pituitaries. Notably, we found that SN treatment had no observed effect on LH secretion in prepubertal (PND14) male and female pituitaries, indicating that SN may function primarily in mature gonadotropes to promote fertility and estrous cycle progression.<\/jats:p>","DOI":"10.1093\/biolre\/ioag058","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T12:33:57Z","timestamp":1772973237000},"page":"161-177","source":"Crossref","is-referenced-by-count":0,"title":["Secretogranin II\u2013derived peptide secretoneurin differentially stimulates luteinizing hormone secretion by age and sex in ex vivo murine pituitaries"],"prefix":"10.1093","volume":"115","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-7108-4041","authenticated-orcid":false,"given":"Ashley K","family":"Herdman","sequence":"first","affiliation":[{"name":"Department of Neuroscience, University of Arkansas for Medical Sciences , Little Rock, AR ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Lagasse","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, University of Arkansas for Medical Sciences , Little Rock, AR ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cole R","family":"Bolen","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, University of Arkansas for Medical Sciences , Little Rock, AR ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milla M","family":"Reddick","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, University of Arkansas for Medical Sciences , Little Rock, AR ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anessa","family":"Haney","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, University of Arkansas for Medical Sciences , Little Rock, AR ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria G","family":"Ortega","sequence":"additional","affiliation":[{"name":"Arkansas Children\u2019s Nutrition Center, Arkansas Children\u2019s Hospital , Little Rock, AR ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2436-6907","authenticated-orcid":false,"given":"Ulrich","family":"Boehm","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Center for Molecular Signaling, Center for Gender-Specific Biology and Medicine, Saarland University School of Medicine , Homburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angus M","family":"MacNicol","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, University of Arkansas for Medical Sciences , Little Rock, AR ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie C","family":"MacNicol","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, University of Arkansas for Medical Sciences , Little Rock, AR ,","place":["USA"]},{"name":"Department of Biomedical Informatics, University of Arkansas for Medical Sciences , Little Rock, AR ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiffany K","family":"Miles","sequence":"additional","affiliation":[{"name":"Arkansas Children\u2019s Nutrition Center, Arkansas Children\u2019s Hospital , Little Rock, AR ,","place":["USA"]},{"name":"Department of Pediatrics, University of Arkansas for Medical Sciences , Little Rock, AR ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gwen V","family":"Childs","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, University of Arkansas for Medical Sciences , Little Rock, AR ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5017-9676","authenticated-orcid":false,"given":"Angela K","family":"Odle","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, University of Arkansas for Medical Sciences , Little Rock, AR ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,3,9]]},"reference":[{"key":"2026071503074172900_ref1","first-page":"94","article-title":"Purification of a sulfated secretory protein from the adenohypophysis. 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