{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:23:25Z","timestamp":1792034605727,"version":"4.4.0"},"reference-count":63,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T00:00:00Z","timestamp":1774051200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7amento de Pessoal de Nivel Superior"},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Global Consortium for Reproductive Longevity & Equality","award":["1023"],"award-info":[{"award-number":["1023"]}]},{"name":"Global Consortium for Reproductive Longevity & Equality","award":["0523"],"award-info":[{"award-number":["0523"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Senescent cells have been implicated in the pathogenesis of metabolic dysfunction\u2013associated liver disease (MASLD), which can negatively affect female fertility. Senolytic drugs are reported to eliminate senescent cells in various tissues, including the ovary. However, the efficacy of senolytic drugs in reducing liver damage and preserving fertility in female mice with MASLD remains unclear. Therefore, this study aimed to evaluate the protective effect of senolytic drugs on liver damage and fertility in reproductive-aged female mice with MASLD. Three-month-old female mice were fed a standard diet (SD) or Western diet (WD) to induce MASLD until 9\u00a0months of age. Starting at 6\u00a0months of age, mice were also randomized to receive senolytic treatment (dasatinib + quercetin, D\u2009+\u2009Q) or vehicle within each diet. We observed that mice fed the WD exhibited liver damage characteristic of MASLD, with increased liver size, triglyceride accumulation, and fibrosis. These mice also exhibited increased liver senescence and inflammation. Senolytic treatment slightly reduced liver mass and modulated some liver senescence and inflammation-related genes, suggesting limited efficacy in controlling WD-induced liver damage. Pregnancy rates were reduced in mice with MASLD and improved by senolytic treatment. Mice with MASLD had increased ovarian senescence, inflammation, and fibrosis, which was attenuated by senolytic treatment, despite having no effect on the ovarian follicle reserve. We conclude that senolytic treatment has potential for improving reproductive function in aged female mice with MASLD, despite limited impact in liver and systemic indicators.<\/jats:p>","DOI":"10.1093\/biolre\/ioag060","type":"journal-article","created":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T16:06:17Z","timestamp":1774109177000},"page":"194-206","source":"Crossref","is-referenced-by-count":4,"title":["Reduced fertility induced by MASLD in female mice is improved by senolytic treatment"],"prefix":"10.1093","volume":"115","author":[{"given":"J\u00e9ssica D","family":"Hense","sequence":"first","affiliation":[{"name":"Nutrition College, Department of Nutrition, Universidade Federal de Pelotas , Pelotas, RS ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 V V","family":"Isola","sequence":"additional","affiliation":[{"name":"Aging & Metabolism Research Program, Oklahoma Medical Research Foundation , Oklahoma City, OK 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Pelotas, RS ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel A","family":"Brie\u00f1o-Enriquez","sequence":"additional","affiliation":[{"name":"Magee-Womens Research Institute, University of Pittsburgh , Pittsburgh, PA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey B","family":"Mason","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Department of Veterinary Clinical and Life Sciences, Center for Integrated BioSystems, Utah State University , Logan, UT ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal M","family":"Masternak","sequence":"additional","affiliation":[{"name":"Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida , Orlando, FL ,","place":["USA"]},{"name":"Department of Head and Neck Surgery, Poznan University of Medical Sciences , Poznan 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