{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T08:04:07Z","timestamp":1784102647155,"version":"3.55.0"},"reference-count":64,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T00:00:00Z","timestamp":1777248000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Environmental arsenic exposure impairs spermatogenesis and testicular function, but the underlying mechanism remains unclear. In this study, 6-week-old male mice and rat primary Sertoli cells were utilized to explore the mechanism of arsenic-induced spermatogenic impairment. Serum testosterone levels were measured, testicular histology and ultrastructure were assessed, and the expression of tight junction (TJ) proteins, actin-related proteins (ARP3), cytokines, and key components of the mitogen-activated protein kinase (MAPK) pathway were further investigated. Our results indicated that arsenic exposure reduced sperm quality, altered histological structure of the testis, and impaired TJs and actin cytoskeleton in the spermatogenic epithelia. Further analysis demonstrated that arsenic suppressed the expression of TJ proteins (CLAUDIN-11, ZO-1) in both testis tissues and primary Sertoli cells. The mRNA level and localization of the ARP3 were also altered following arsenic exposure. Additionally, arsenic treatment markedly elevated testicular levels of the cytokines IFN-\u03b3 and transforming growth factor \u03b23 (TGF-\u03b23). The gene expression and phosphorylation level of p38 Mapk were significantly increased in arsenic-exposed mice. These findings demonstrate that interference with Sertoli cell junctions is an important factor in arsenic-induced spermatogenic dysfunction. TJ barrier permeability and F-actin realignment, which might be mediated by TGF-\u03b23\/p38 MAPK pathway, collectively contribute to the disruption of cell junction structure.<\/jats:p>","DOI":"10.1093\/biolre\/ioag085","type":"journal-article","created":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T11:35:10Z","timestamp":1777203310000},"page":"298-311","source":"Crossref","is-referenced-by-count":0,"title":["Arsenic disturbs spermatogenesis\n                    <i>via<\/i>\n                    disrupting Sertoli cell junctions in mice: potential involvement of the TGF-\u03b23\/p38 MAPK pathway"],"prefix":"10.1093","volume":"115","author":[{"given":"Xiujuan","family":"Li","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Shanxi Key Laboratory of Birth Defect and Cell Regeneration, Shanxi Medical University, Key Laboratory of Coal Environmental Pathogenicity and Prevention, Ministry of Education , Taiyuan 030001 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Zhao","sequence":"additional","affiliation":[{"name":"School of Chemistry and Materials Science, Shanxi Normal University , Taiyuan 030006 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyi","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Shanxi Key Laboratory of Birth Defect and Cell Regeneration, Shanxi Medical University, Key Laboratory of Coal Environmental Pathogenicity and Prevention, Ministry of Education , Taiyuan 030001 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liqun","family":"Huang","sequence":"additional","affiliation":[{"name":"Heping Hospital Affiliated to Changzhi Medical College , Changzhi 046000 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoli","family":"Chai","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Shanxi Key Laboratory of Birth Defect and Cell Regeneration, Shanxi Medical University, Key Laboratory of Coal Environmental Pathogenicity and Prevention, Ministry of Education , Taiyuan 030001 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenting","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Shanxi Key Laboratory of Birth Defect and Cell Regeneration, Shanxi Medical University, Key Laboratory of Coal Environmental Pathogenicity and Prevention, Ministry of Education , Taiyuan 030001 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanyan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shaoyang Institute for Food and Drug Control , Shaoyang 422000 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhizhen","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Shanxi Key Laboratory of Birth Defect and Cell Regeneration, Shanxi Medical University, Key Laboratory of Coal Environmental Pathogenicity and Prevention, Ministry of Education , Taiyuan 030001 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guiqin","family":"Yan","sequence":"additional","affiliation":[{"name":"School of Chemistry and Materials Science, Shanxi Normal University , Taiyuan 030006 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