{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T07:03:39Z","timestamp":1789542219773,"version":"build-2803163510"},"reference-count":70,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T00:00:00Z","timestamp":1781136000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100019553","name":"Minnesota Agricultural Experiment Station","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019553","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Rapid Agricultural Response Fund"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Turkey production faces significant challenges in maintaining breeder flock fertility, due in part to increased inflammation and accelerated reproductive aging in the distal reproductive tract. These conditions are associated with chronic oxidative stress and compromised cellular function. Activation of the antioxidant nuclear factor erythroid 2-related factor 2 (Nrf2), and inhibition of the pro-inflammatory nuclear factor kappa B (NF-\u03baB) may ameliorate these conditions. This approach remains unexplored in avian reproductive tissues, which possess distinct metabolic and physiological profiles from mammals. This study was designed to investigate the effects of Nrf2\/NF-\u03baB modulation in turkey reproductive cells using the Nrf2 activator, bardoxolone methyl (BM), in vitro and further evaluate the effects of this antioxidant in vivo. Turkey uterovaginal junction (UVJ) organoids were treated with BM and exposed to oxidant hydrogen peroxide. Treatment with 0.5\u00a0\u03bcM BM increased viability, reduced reactive oxygen species production, and inhibited nuclear translocation of NF-\ud835\udf05B. Furthermore, BM promoted Nrf2 nuclear accumulation and upregulated antioxidant markers, including heme oxygenase 1 and thioredoxin reductase 1. Short-term treatment with BM in breeder hens did not adversely affect body weight, egg production, or reproductive immune cell localization. Transcriptomic analysis of vaginal tissues revealed downregulation of oxidative phosphorylation and inflammatory markers, including secreted phosphoprotein 1. In the UVJ, reduced redox-sensitive transcripts suggested lowered baseline physiological stress. Direct exposure of turkey spermatozoa to BM did not impair viability, morphology, or motility. These findings suggest that targeting the turkey antioxidant response via the Nrf2\/NF-\u03baB axis may serve as a safe potential strategy for enhancing reproductive longevity.<\/jats:p>","DOI":"10.1093\/biolre\/ioag122","type":"journal-article","created":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T11:36:22Z","timestamp":1781004982000},"page":"724-738","source":"Crossref","is-referenced-by-count":0,"title":["Bardoxolone methyl modulates Nrf2\/NF-\ud835\udf05B signaling in turkey uterovaginal junction organoids with potential use for improving reproductive longevity in breeder hens"],"prefix":"10.1093","volume":"115","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9905-3019","authenticated-orcid":false,"given":"Pitchaya","family":"Coleman","sequence":"first","affiliation":[{"name":"Department of Animal Science, University of Minnesota , Saint Paul, MN 55108 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunantha","family":"Kosonsiriluk","sequence":"additional","affiliation":[{"name":"Department of Animal Science, University of Minnesota , Saint Paul, MN 55108 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Veterinary and Biomedical Sciences, University of Minnesota , Saint Paul, MN 55108 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"O\u2019Grady","sequence":"additional","affiliation":[{"name":"Department of Animal Science, University of Minnesota , Saint Paul, MN 55108 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marissa M","family":"Studniski","sequence":"additional","affiliation":[{"name":"Select Genetics , Willmar, MN 56201 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben W","family":"Wileman","sequence":"additional","affiliation":[{"name":"Select Genetics , Willmar, MN 56201 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2141-2656","authenticated-orcid":false,"given":"Kahina S","family":"Boukherroub","sequence":"additional","affiliation":[{"name":"Department of Animal Science, University of Minnesota , Saint Paul, MN 55108 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,6,11]]},"reference":[{"key":"2026091602214524900_ref1","article-title":"Turkey sector: background & statistics","author":"Grossen","journal-title":"USDA Economic Research Service"},{"key":"2026091602214524900_ref2","doi-asserted-by":"publisher","first-page":"104448","DOI":"10.1016\/j.psj.2024.104448","article-title":"Artificial insemination and laying cycle influence adaptive immune cell numbers and localization in the reproductive tract of Turkey breeder hens","volume":"103","author":"Chen","year":"2024","journal-title":"Poult Sci"},{"key":"2026091602214524900_ref3","doi-asserted-by":"crossref","first-page":"2150","DOI":"10.3382\/ps.0602150","article-title":"Effect of insemination intervals on oviducal sperm storage in turkeys","volume":"60","author":"Christensen","year":"1981","journal-title":"Poult Sci"},{"key":"2026091602214524900_ref4","first-page":"173","volume-title":"Avian Reproduction: From Behavior to Molecules","author":"Matsuzaki"},{"key":"2026091602214524900_ref5","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.3382\/ps.0482109","article-title":"Seasonal decline in fertility of Turkey eggs","volume":"48","author":"Harper","year":"1969","journal-title":"Poult Sci"},{"key":"2026091602214524900_ref6","doi-asserted-by":"publisher","first-page":"986","DOI":"10.3382\/ps.2009-00481","article-title":"Comparisons of sperm storage tubule distribution and number in 4 strains of mature broiler breeders and in Turkey hens before and after the onset of photostimulation","volume":"89","author":"Bakst","year":"2010","journal-title":"Poult Sci"},{"key":"2026091602214524900_ref7","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1262\/jrd.17027","article-title":"Changes in the localization of antigen presenting cells and T cells in the utero-vaginal junction after repeated artificial insemination in laying hens","volume":"51","author":"Das","year":"2005","journal-title":"J Reprod Dev"},{"key":"2026091602214524900_ref8","doi-asserted-by":"publisher","first-page":"1305168","DOI":"10.3389\/fphys.2023.1305168","article-title":"Turkey hen sperm storage tubule transcriptome response to artificial insemination and the presence of semen","volume":"14","author":"Brady","year":"2023","journal-title":"Front Physiol"},{"key":"2026091602214524900_ref9","doi-asserted-by":"publisher","first-page":"1275922","DOI":"10.3389\/fphys.2023.1275922","article-title":"Prolonged repeated inseminations trigger a local immune response and accelerate aging of the uterovaginal junction in Turkey hens","volume":"14","author":"Kosonsiriluk","year":"2023","journal-title":"Front Physiol"},{"key":"2026091602214524900_ref10","doi-asserted-by":"publisher","DOI":"10.21203\/rs.3.rs-5921097\/v1","article-title":"Gene expression changes in the Turkey hen vagina in response to artificial insemination across the lying cycle","author":"Boukherroub","year":"2025"},{"key":"2026091602214524900_ref11","doi-asserted-by":"publisher","first-page":"S4","DOI":"10.1038\/ki.2008.516","article-title":"Oxidative stress and inflammation, a link between chronic kidney disease and cardiovascular disease","volume":"74","author":"Cachofeiro","year":"2008","journal-title":"Kidney Int Suppl"},{"key":"2026091602214524900_ref12","doi-asserted-by":"publisher","first-page":"72","DOI":"10.7150\/ijbs.13188","article-title":"Isovitexin exerts anti-inflammatory and anti-oxidant activities on lipopolysaccharide-induced acute lung injury by inhibiting MAPK and NF-\u03baB and activating HO-1\/Nrf2 pathways","volume":"12","author":"Lv","year":"2016","journal-title":"Int J Biol Sci"},{"key":"2026091602214524900_ref13","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1042\/BST0351147","article-title":"Biochemistry of oxidative stress","volume":"35","author":"Halliwell","year":"2007","journal-title":"Biochem Soc Trans"},{"key":"2026091602214524900_ref14","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1038\/ki.2012.439","article-title":"Targeting the transcription factor Nrf2 to ameliorate oxidative stress and inflammation in chronic kidney disease","volume":"83","author":"Ruiz","year":"2013","journal-title":"Kidney Int"},{"key":"2026091602214524900_ref15","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/j.freeradbiomed.2014.01.028","article-title":"Rutin decreases lipopolysaccharide-induced acute lung injury via inhibition of oxidative stress and the MAPK\u2013NF-\u03baB pathway","volume":"69","author":"Yeh","year":"2014","journal-title":"Free Radic Biol Med"},{"key":"2026091602214524900_ref16","doi-asserted-by":"publisher","first-page":"115086","DOI":"10.1016\/j.jep.2022.115086","article-title":"Anti-inflammatory effect of flavonoids from chestnut flowers in lipopolysaccharide-stimulated RAW 264.7 macrophages and acute lung injury in mice","volume":"290","author":"Peng","year":"2022","journal-title":"J Ethnopharmacol"},{"key":"2026091602214524900_ref17","doi-asserted-by":"publisher","first-page":"3735","DOI":"10.2147\/DDDT.S314767","article-title":"Bardoxolone-methyl prevents oxidative stress-mediated apoptosis and extracellular matrix degradation in vitro and alleviates osteoarthritis in vivo","volume":"15","author":"Pang","year":"2021","journal-title":"Drug Des Devel Ther"},{"key":"2026091602214524900_ref18","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1124\/pr.117.014753","article-title":"Transcription factor NRF2 as a therapeutic target for chronic diseases: A systems medicine approach","volume":"70","author":"Cuadrado","year":"2018","journal-title":"Pharmacol Rev"},{"key":"2026091602214524900_ref19","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1124\/jpet.119.261792","article-title":"Therapeutic effects of Nrf2 activation by bardoxolone methyl in chronic heart failure","volume":"371","author":"Tian","year":"2019","journal-title":"J Pharmacol Exp Ther"},{"key":"2026091602214524900_ref20","doi-asserted-by":"publisher","first-page":"3616","DOI":"10.1007\/s12035-020-01989-0","article-title":"Bardoxolone methyl ameliorates Hyperglycemia induced mitochondrial dysfunction by activating the keap1-Nrf2-ARE pathway in experimental diabetic neuropathy","volume":"57","author":"Kalvala","year":"2020","journal-title":"Mol Neurobiol"},{"key":"2026091602214524900_ref21","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1007\/s10157-020-01917-5","article-title":"Bardoxolone methyl: drug development for diabetic kidney disease","volume":"24","author":"Kanda","year":"2020","journal-title":"Clin Exp Nephrol"},{"key":"2026091602214524900_ref22","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.bbrc.2019.06.006","article-title":"Bardoxolone treatment alleviates lipopolysaccharide (LPS)-induced acute lung injury through suppressing inflammation and oxidative stress regulated by Nrf2 signaling","volume":"516","author":"Pei","year":"2019","journal-title":"Biochem Biophys Res Commun"},{"key":"2026091602214524900_ref23","doi-asserted-by":"publisher","first-page":"35764","DOI":"10.1074\/jbc.M607160200","article-title":"Triterpenoid CDDO-me blocks the NF-kappaB pathway by direct inhibition of IKKbeta on Cys-179","volume":"281","author":"Ahmad","year":"2006","journal-title":"J Biol Chem"},{"key":"2026091602214524900_ref24","doi-asserted-by":"publisher","first-page":"4030","DOI":"10.3382\/ps\/pez072","article-title":"Nutritional modulation of the antioxidant capacities in poultry: the case of vitamin E","volume":"98","author":"Surai","year":"2019","journal-title":"Poult Sci"},{"key":"2026091602214524900_ref25","doi-asserted-by":"publisher","first-page":"103384","DOI":"10.1016\/j.xpro.2024.103384","article-title":"Protocol to establish Turkey oviductal organoids as an in vitro model","volume":"5","author":"Santativongchai","year":"2024","journal-title":"STAR Protoc"},{"key":"2026091602214524900_ref26","doi-asserted-by":"publisher","first-page":"1621","DOI":"10.1093\/biolre\/ioaf274","article-title":"Turkey oviduct epithelial organoids express region-associated markers and avian influenza virus receptor","volume":"114","author":"Santativongchai","year":"2025","journal-title":"Biol Reprod"},{"key":"2026091602214524900_ref27","doi-asserted-by":"publisher","first-page":"6822","DOI":"10.1073\/pnas.1806308115","article-title":"Differentiated human airway organoids to assess infectivity of emerging influenza virus","volume":"115","author":"Zhou","year":"2018","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026091602214524900_ref28","doi-asserted-by":"publisher","first-page":"e100300","DOI":"10.15252\/embj.2018100300","article-title":"Long-term expanding human airway organoids for disease modeling","volume":"38","author":"Sachs","year":"2019","journal-title":"EMBO J"},{"key":"2026091602214524900_ref29","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1186\/s12859-018-2190-6","article-title":"A computational approach to identify cellular heterogeneity and tissue-specific gene regulatory networks","volume":"19","author":"Jambusaria","year":"2018","journal-title":"BMC Bioinformatics"},{"key":"2026091602214524900_ref30","doi-asserted-by":"crossref","first-page":"D672","DOI":"10.1093\/nar\/gkae909","article-title":"KEGG: biological systems database as a model of the real world","volume":"53","author":"Kanehisa","year":"2025","journal-title":"Nucleic Acids Res"},{"key":"2026091602214524900_ref31","doi-asserted-by":"crossref","first-page":"iyad031","DOI":"10.1093\/genetics\/iyad031","article-title":"The gene ontology knowledgebase in 2023","volume":"224","author":"The Gene Ontology Consortium","year":"2023","journal-title":"Genetics"},{"key":"2026091602214524900_ref32","doi-asserted-by":"publisher","first-page":"16878","DOI":"10.1038\/s41598-017-17204-5","article-title":"QuPath: open source software for digital pathology image analysis","volume":"7","author":"Bankhead","year":"2017","journal-title":"Sci Rep"},{"key":"2026091602214524900_ref33","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1186\/s12859-018-2486-6","article-title":"iDEP: an integrated web application for differential expression and pathway analysis of RNA-Seq data","volume":"19","author":"Ge","year":"2018","journal-title":"BMC Bioinformatics"},{"key":"2026091602214524900_ref34","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol"},{"key":"2026091602214524900_ref35","volume-title":"2nd Edition: Techniques for Semen Evaluation, Semen Storage, and Fertility Determination","author":"Bakst","year":"2014"},{"key":"2026091602214524900_ref36","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.theriogenology.2016.11.001","article-title":"Impact of induced levels of specific free radicals and malondialdehyde on chicken semen quality and fertility","volume":"90","author":"Rui","year":"2017","journal-title":"Theriogenology"},{"key":"2026091602214524900_ref37","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1111\/rda.13734","article-title":"Cryopreservation of Ghagus chicken semen: effect of cryoprotectants, diluents and thawing temperature","volume":"55","author":"Murugesan","year":"2020","journal-title":"Reprod Domest Anim"},{"key":"2026091602214524900_ref38","doi-asserted-by":"crossref","first-page":"351","DOI":"10.4103\/tcmj.tcmj_127_25","article-title":"Ovulation: A consequence of acute inflammation cultivated by E2-induced reactive oxygen species and triggered by progesterone withdrawal","volume":"37","author":"Chen","year":"2025","journal-title":"Tzu Chi Med J"},{"key":"2026091602214524900_ref39","doi-asserted-by":"publisher","first-page":"206","DOI":"10.3109\/1547691X.2014.925995","article-title":"Characterization of the modes of action of deoxynivalenol (DON) in the human Jurkat T-cell line","volume":"12","author":"Katika","year":"2015","journal-title":"J Immunotoxicol"},{"key":"2026091602214524900_ref40","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.3390\/antiox9111151","article-title":"The NRF2, thioredoxin, and glutathione system in tumorigenesis and anticancer therapies","volume":"9","author":"Jaganjac","year":"2020","journal-title":"Antioxidants"},{"key":"2026091602214524900_ref41","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.freeradbiomed.2021.10.020","article-title":"Thioredoxin reductase-1 levels are associated with NRF2 pathway activation and tumor recurrence in non-small cell lung cancer","volume":"177","author":"Delgobo","year":"2021","journal-title":"Free Radic Biol Med"},{"key":"2026091602214524900_ref42","doi-asserted-by":"publisher","first-page":"42054","DOI":"10.1038\/srep42054","article-title":"The NRF2 transcriptional target, OSGIN1, contributes to monomethyl fumarate-mediated cytoprotection in human astrocytes","volume":"7","author":"Brennan","year":"2017","journal-title":"Sci Rep"},{"key":"2026091602214524900_ref43","doi-asserted-by":"publisher","first-page":"112318","DOI":"10.1016\/j.fct.2021.112318","article-title":"Docosahexaenoic acid promotes the formation of autophagosomes in MCF-7 breast cancer cells through oxidative stress-induced growth inhibitor 1 mediated activation of AMPK\/mTOR pathway","volume":"154","author":"Tsai","year":"2021","journal-title":"Food Chem Toxicol Int J Publ Br Ind Biol Res Assoc"},{"key":"2026091602214524900_ref44","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2020\/8861358","article-title":"Responsive expression of MafF to \u03b2-amyloid-induced oxidative stress","volume":"2020","author":"Wang","year":"2020","journal-title":"Dis Markers"},{"key":"2026091602214524900_ref45","doi-asserted-by":"publisher","first-page":"e2412850","DOI":"10.1002\/advs.202412850","article-title":"The multifaceted roles of BACH1 in disease: implications for biological functions and therapeutic applications","volume":"12","author":"Wei","year":"2025","journal-title":"Adv Sci Weinh Baden-Wurtt Ger"},{"key":"2026091602214524900_ref46","doi-asserted-by":"publisher","first-page":"e37191","DOI":"10.1016\/j.heliyon.2024.e37191","article-title":"The role of NF-\u03baB-SOX9 signalling pathway in osteoarthritis","volume":"10","author":"Tian","year":"2024","journal-title":"Heliyon"},{"key":"2026091602214524900_ref47","doi-asserted-by":"publisher","first-page":"1679","DOI":"10.1038\/s41418-025-01505-8","article-title":"GCLC desuccinylation regulated by oxidative stress protects human cancer cells from ferroptosis","volume":"32","author":"Chen","year":"2025","journal-title":"Cell Death Differ"},{"key":"2026091602214524900_ref48","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.freeradbiomed.2016.11.027","article-title":"Ptgr1 expression is regulated by NRF2 in rat hepatocarcinogenesis and promotes cell proliferation and resistance to oxidative stress","volume":"102","author":"S\u00e1nchez-Rodr\u00edguez","year":"2017","journal-title":"Free Radic Biol Med"},{"key":"2026091602214524900_ref49","doi-asserted-by":"publisher","first-page":"101417","DOI":"10.1016\/j.redox.2019.101417","article-title":"Peroxiredoxin-1 regulates lipid peroxidation in corneal endothelial cells","volume":"30","author":"Lovatt","year":"2020","journal-title":"Redox Biol"},{"key":"2026091602214524900_ref50","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1186\/s12935-021-02307-x","article-title":"Promotion of gastric tumor initiating cells in a 3D collagen gel culture model via YBX1\/SPP1\/NF-\u03baB signaling","volume":"21","author":"Deng","year":"2021","journal-title":"Cancer Cell Int"},{"key":"2026091602214524900_ref51","doi-asserted-by":"publisher","first-page":"106105","DOI":"10.1016\/j.isci.2023.106105","article-title":"ACKR4a induces autophagy to block NF-\u03baB signaling and apoptosis to facilitate Vibrio harveyi infection","volume":"26","author":"Chen","year":"2023","journal-title":"iScience"},{"key":"2026091602214524900_ref52","doi-asserted-by":"publisher","first-page":"6410","DOI":"10.1158\/0008-5472.CAN-16-0595","article-title":"TG2 and NF-kB signaling coordinates the survival of mantle cell lymphoma cells via IL-6-mediated autophagy","volume":"76","author":"Zhang","year":"2016","journal-title":"Cancer Res"},{"key":"2026091602214524900_ref53","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.bbrc.2008.05.058","article-title":"Human polynucleotide phosphorylase reduces oxidative RNA damage and protects HeLa cell against oxidative stress","volume":"372","author":"Wu","year":"2008","journal-title":"Biochem Biophys Res Commun"},{"key":"2026091602214524900_ref54","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21239149","article-title":"Use of H2O2 to cause oxidative stress, the catalase issue","volume":"21","author":"Ransy","year":"2020","journal-title":"Int J Mol Sci"},{"key":"2026091602214524900_ref55","doi-asserted-by":"publisher","first-page":"5055","DOI":"10.3390\/ijms26115055","article-title":"Lactoperoxidase: properties, functions, and potential applications","volume":"26","author":"\u00d6zhan","year":"2025","journal-title":"Int J Mol Sci"},{"key":"2026091602214524900_ref56","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1021\/acs.chemrestox.6b00319","article-title":"Aldo-keto reductase regulation by the Nrf2 system: implications for stress response, chemotherapy drug resistance, and carcinogenesis","volume":"30","author":"Penning","year":"2017","journal-title":"Chem Res Toxicol"},{"key":"2026091602214524900_ref57","doi-asserted-by":"publisher","first-page":"110367","DOI":"10.1016\/j.jbc.2025.110367","article-title":"Regulation of NRF2 by stably associated phosphoinositides and small heat shock proteins in response to stress","volume":"301","author":"Chen","year":"2025","journal-title":"J Biol Chem"},{"key":"2026091602214524900_ref58","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.addr.2009.02.003","article-title":"Induction of heat shock proteins for protection against oxidative stress","volume":"61","author":"Kalmar","year":"2009","journal-title":"Adv Drug Deliv Rev"},{"key":"2026091602214524900_ref59","doi-asserted-by":"publisher","first-page":"103081","DOI":"10.1016\/j.redox.2024.103081","article-title":"FBXL4 protects against HFpEF through Drp1-mediated regulation of mitochondrial dynamics and the downstream SERCA2a","volume":"70","author":"Abudureyimu","year":"2024","journal-title":"Redox Biol"},{"key":"2026091602214524900_ref60","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/j.freeradbiomed.2015.05.010","article-title":"Alteration of serum lipid profile, SRB1 loss, and impaired Nrf2 activation in CDKL5 disorder","volume":"86","author":"Pecorelli","year":"2015","journal-title":"Free Radic Biol Med"},{"key":"2026091602214524900_ref61","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1007\/s11684-023-1053-3","article-title":"Epigenetic silencing of BEND4, a novel DNA damage repair gene, is a synthetic lethal marker for ATM inhibitor in pancreatic cancer","volume":"18","author":"Yao","year":"2024","journal-title":"Front Med"},{"key":"2026091602214524900_ref62","doi-asserted-by":"publisher","first-page":"9376","DOI":"10.3390\/ijms23169376","article-title":"Expression of the calcium-binding protein CALB1 is induced and controls intracellular Ca2+ levels in senescent cells","volume":"23","author":"Raynard","year":"2022","journal-title":"Int J Mol Sci"},{"key":"2026091602214524900_ref63","doi-asserted-by":"publisher","DOI":"10.3390\/toxins16080361","article-title":"Importance of the cysteine-rich domain of snake venom prothrombin activators: insights gained from synthetic neutralizing antibodies","volume":"16","author":"Mindrebo","year":"2024","journal-title":"Toxins"},{"key":"2026091602214524900_ref64","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/0300-9629(81)90058-X","article-title":"Kinetics of avidin induction by tissue injury and inflammation in chicks and the dependence of induction on protein and RNA synthesis","volume":"68","author":"Elo","year":"1981","journal-title":"Comp Biochem Physiol A Physiol"},{"key":"2026091602214524900_ref65","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1186\/1750-1172-7-42","article-title":"Complement factor I deficiency: a not so rare immune defect. Characterization of new mutations and the first large gene deletion","volume":"7","author":"Alba-Dom\u00ednguez","year":"2012","journal-title":"Orphanet J Rare Dis"},{"key":"2026091602214524900_ref66","doi-asserted-by":"publisher","first-page":"269","DOI":"10.3934\/molsci.2016.2.269","article-title":"Oxidative stress and CCN1 protein in human skin connective tissue aging","volume":"3","author":"Qin","year":"2016","journal-title":"AIMS Mol Sci"},{"key":"2026091602214524900_ref67","doi-asserted-by":"publisher","first-page":"1405","DOI":"10.1053\/j.gastro.2017.12.016","article-title":"Villin-1 and gelsolin regulate changes in actin dynamics that affect cell survival Signaling pathways and intestinal inflammation","volume":"154","author":"Roy","year":"2018","journal-title":"Gastroenterology"},{"key":"2026091602214524900_ref68","doi-asserted-by":"publisher","first-page":"101086","DOI":"10.1016\/j.isci.2020.101086","article-title":"Molecular mechanisms of trophoblast dysfunction mediated by imbalance between STOX1 isoforms","volume":"23","author":"Ducat","year":"2020","journal-title":"iScience"},{"key":"2026091602214524900_ref69","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13071563","article-title":"ADAM and ADAMTS proteins, new players in the regulation of hepatocellular carcinoma microenvironment","volume":"13","author":"Th\u00e9ret","year":"2021","journal-title":"Cancers"},{"key":"2026091602214524900_ref70","doi-asserted-by":"publisher","first-page":"23743","DOI":"10.1074\/jbc.M109.036509","article-title":"Oxidative stress decreases phosphatidylinositol 4,5-bisphosphate levels by deactivating phosphatidylinositol- 4-phosphate 5-kinase \u03b2 in a Syk-dependent manner","volume":"284","author":"Chen","year":"2009","journal-title":"J Biol Chem"}],"container-title":["Biology of Reproduction"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/biolreprod\/advance-article-pdf\/doi\/10.1093\/biolre\/ioag122\/68513099\/ioag122.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/biolreprod\/article-pdf\/115\/3\/724\/68513099\/ioag122.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/biolreprod\/article-pdf\/115\/3\/724\/68513099\/ioag122.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T06:21:57Z","timestamp":1789539717000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/biolreprod\/article\/115\/3\/724\/8706328"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,11]]},"references-count":70,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,6,11]]},"published-print":{"date-parts":[[2026,9,14]]}},"URL":"https:\/\/doi.org\/10.1093\/biolre\/ioag122","relation":{},"ISSN":["0006-3363","1529-7268"],"issn-type":[{"value":"0006-3363","type":"print"},{"value":"1529-7268","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,9]]},"published":{"date-parts":[[2026,6,11]]}}}