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These ADM cellular targets are prominent constituents of the uterine-placental interface that undergo structural and functional transformation during pregnancy. To explore the biology of ADM at the uterine-placental interface, we examined ADM expression using in situ hybridization and generated and characterized an ADM mutant rat model using CRISPR-Cas9-mediated genome editing. At midgestation, Adm was prominently expressed in trophoblast giant cells. Adm expression shifted to the mesometrial uterus as gestation progressed. A germline Adm mutant model was generated. Adm heterozygous males and females were fertile; however, Adm heterozygous intercrosses did not generate live Adm null rats. Adm null fetal-placental sites were viable until gestation day (gd) 15.5. Fetal and placental growth restriction were evident on gd 13.5. On gd 15.5 some Adm null placentas exhibited prominent hemorrhagic regions, whereas both hemorrhage and edema were evident in gd 15.5 Adm null fetuses. Our results indicate that ADM serves as a regulator of placental and fetal development.<\/jats:p>","DOI":"10.1093\/biolre\/ioag125","type":"journal-article","created":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T12:21:38Z","timestamp":1781612498000},"page":"911-922","source":"Crossref","is-referenced-by-count":0,"title":["Placental and fetal responses to adrenomedullin deficiency in the rat"],"prefix":"10.1093","volume":"115","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5367-731X","authenticated-orcid":false,"given":"Marija","family":"Kuna","sequence":"first","affiliation":[{"name":"Institute for Reproductive and Developmental Sciences, University of Kansas Medical Center, Kansas City, KS 66160, United States"},{"name":"Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS 66160, United 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and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS 66160, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Parrish","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Kansas Medical Center , Kansas City, KS 66160 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen M","family":"Caron","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Physiology, University of North Carolina School of Medicine , Chapel Hill, NC 27599 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7158-1592","authenticated-orcid":false,"given":"Michael J","family":"Soares","sequence":"additional","affiliation":[{"name":"Institute for Reproductive and Developmental Sciences, University of Kansas Medical Center, Kansas City, KS 66160, United 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