{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T06:45:21Z","timestamp":1792046721751,"version":"4.4.0"},"reference-count":115,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006095","name":"South-Eastern Norway Regional Health Authority","doi-asserted-by":"publisher","award":["2023099"],"award-info":[{"award-number":["2023099"]}],"id":[{"id":"10.13039\/501100006095","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Preeclampsia is a serious pregnancy complication with unclear etiology, making early detection challenging but imperative to improve prognosis. We here examine the potential roles of protein-coding and long non-coding (lnc) RNA from peripheral blood mononuclear cells (PBMCs) in the development of preeclampsia by examining women during pregnancy and 5\u00a0years following pregnancy. We isolated PBMCs from women with preeclampsia (N\u2009=\u200937) and normal pregnant controls (N\u2009=\u2009215) at 22\u201324 and 36\u201338\u00a0weeks of gestation, and 5-year follow-up. We performed RNA sequencing at all time points for N\u2009=\u20097 normal pregnant controls and N\u2009=\u20099 women with preeclampsia and explored data manually and using bioinformatics analyses. Spearman correlation was used between lncRNA and preeclampsia-associated markers, while Notch-related RNAs were measured by qPCR. We found dysregulated RNAs at all time points, mostly at 36\u201338\u00a0weeks (491 upregulated, 155 downregulated). Most downregulated RNAs were lncRNA and these correlated positively with P-selectin and negatively with sFlt-1 and myeloperoxidase from the maternal circulation. Overrepresentation analyses and manual data exploration at 36\u201338\u00a0weeks revealed increased activation of adaptive immune functions and dampening of innate immune response, including Notch signaling. NOTCH2NLA\/B\/C was decreased at 22\u201324\u00a0weeks in the total cohort. In conclusion, circulating protein-coding and lncRNA from women developing preeclampsia broadly indicate enhanced adaptive immune cell activation but dampened innate immune responses. The association of downregulated lncRNAs with markers of endothelial dysfunction and platelet activation may support impaired immune regulation in these women. The function of circulating lncRNAs in women with preeclampsia warrants further study.<\/jats:p>","DOI":"10.1093\/biolre\/ioag143","type":"journal-article","created":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T11:42:59Z","timestamp":1783424579000},"page":"1212-1225","source":"Crossref","is-referenced-by-count":0,"title":["PBMC-derived RNA signatures show impaired ability to regulate immune responses in women developing preeclampsia"],"prefix":"10.1093","volume":"115","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-1806-6082","authenticated-orcid":false,"given":"Monica","family":"Fr\u00f8ystad","sequence":"first","affiliation":[{"name":"Research Institute of Internal Medicine, Oslo University Hospital , Oslo ,","place":["Norway"]},{"name":"Faculty of Medicine, University of Oslo , Oslo 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