{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T06:45:21Z","timestamp":1792046721744,"version":"4.4.0"},"reference-count":63,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T00:00:00Z","timestamp":1783987200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Purine nucleosides and nucleobases such as adenine (ADE) and adenosine (ADO) move through cellular transporters and play essential roles in various physiological processes, including proliferation, differentiation, immunity, and pregnancy. The cellular uptake of ADE, ADO, and other purine metabolites via these transporters regulates intracellular nucleotide pools and supports purine salvage pathways, thereby maintaining metabolic homeostasis and cellular function. Although the importance of nucleoside\/nucleobase transporters during pregnancy has been studied in some species, their expression and the role of ADE at the maternal\u2013conceptus interface have not been evaluated in pigs. Therefore, we investigated the expression and regulation of nucleoside\/nucleobase transporters SLC28As, SLC29As, and SLC43A2 and the function of ADE at the maternal\u2013conceptus interface in pigs. The expression of nucleoside\/nucleobase transporters in the endometrium varied dynamically during pregnancy, and the localization of these transporters was cell type-specific. During pregnancy, both conceptus and chorioallantoic tissues expressed nucleoside\/nucleobase transporters. Interleukin-1\u03b2 increased the expression of SLC29A2 and a calcium ionophore decreased the expression of SLC28A2 and SLC29A3 in endometrial explants. Increasing doses of ADE increased the expression of prostaglandin (PG) synthetic enzymes and transporters and cytokines in endometrial epithelial cells and the expression of PG synthetic enzymes and transporters as well as implantation-related genes, and migration of conceptus trophectoderm cells in vitro. These data suggest that the expression of nucleoside\/nucleobase transporters is dynamically regulated at the maternal-conceptus interface and ADE may play important roles in regulation of endometrial epithelial and conceptus trophectoderm cell function during the establishment and maintenance of pregnancy in pigs.<\/jats:p>","DOI":"10.1093\/biolre\/ioag150","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T11:27:43Z","timestamp":1783942063000},"page":"1091-1106","source":"Crossref","is-referenced-by-count":0,"title":["Expression and regulation of nucleoside\/nucleobase transporters and the role of adenine at the maternal-conceptus interface in pigs"],"prefix":"10.1093","volume":"115","author":[{"given":"Yugyeong","family":"Cheon","sequence":"first","affiliation":[{"name":"Division of Biological Science and Technology, Yonsei University , Wonju, Gangwon ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inkyu","family":"Yoo","sequence":"additional","affiliation":[{"name":"Division of Biological Science and Technology, Yonsei University , Wonju, Gangwon ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soohyung","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Biological Science and Technology, Yonsei University , Wonju, Gangwon ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eunhyeok","family":"Choi","sequence":"additional","affiliation":[{"name":"Division of Biological Science and Technology, Yonsei University , Wonju, Gangwon ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seonghyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Biological Science and Technology, Yonsei University , Wonju, Gangwon ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minsun","family":"Hong","sequence":"additional","affiliation":[{"name":"Division of Biological Science and Technology, Yonsei University , Wonju, Gangwon ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hakhyun","family":"Ka","sequence":"additional","affiliation":[{"name":"Division of Biological Science and Technology, Yonsei University , Wonju, Gangwon ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,7,14]]},"reference":[{"key":"2026101502071079800_ref1","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.diff.2013.11.005","article-title":"Pig blastocyst-uterine interactions","volume":"87","author":"Bazer","year":"2014","journal-title":"Differentiation"},{"key":"2026101502071079800_ref2","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/978-3-030-77360-1_5","article-title":"The early stages of implantation and placentation in the pig","volume":"234","author":"Johnson","year":"2021","journal-title":"Adv Anat Embryol Cell Biol"},{"key":"2026101502071079800_ref3","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s40104-018-0259-8","article-title":"Endometrial response to conceptus-derived estrogen and interleukin-1\u03b2 at the time of implantation in pigs","volume":"9","author":"Ka","year":"2018","journal-title":"J Anim Sci Biotechnol"},{"key":"2026101502071079800_ref4","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1002\/mrd.23567","article-title":"Novel insights into conceptus-maternal signaling during pregnancy establishment in pigs","volume":"90","author":"Kaczynski","year":"2023","journal-title":"Mol Reprod Dev"},{"key":"2026101502071079800_ref5","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1002\/mrd.22835","article-title":"Embryo-maternal dialogue during pregnancy establishment and implantation in the pig","volume":"84","author":"Waclawik","year":"2017","journal-title":"Mol Reprod Dev"},{"key":"2026101502071079800_ref6","doi-asserted-by":"crossref","first-page":"e240130","DOI":"10.1530\/REP-24-0130","article-title":"The history of interferon-stimulated genes in pregnant cattle, sheep, and pigs","volume":"168","author":"Johnson","year":"2024","journal-title":"Reproduction"},{"key":"2026101502071079800_ref7","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.theriogenology.2020.05.045","article-title":"Transcriptomic analysis of interferon-\u03b3-regulated genes in endometrial explants and their possible role in regulating maternal endometrial immunity during the implantation period in pigs, a true epitheliochorial placentation species","volume":"155","author":"Yoo","year":"2020","journal-title":"Theriogenology"},{"key":"2026101502071079800_ref8","doi-asserted-by":"crossref","first-page":"2398212818817494","DOI":"10.1177\/2398212818817494","article-title":"Purine and purinergic receptors","volume":"2","author":"Burnstock","year":"2018","journal-title":"Brain Neurosci Adv"},{"key":"2026101502071079800_ref9","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/978-3-540-89615-9_13","article-title":"Adenosine receptors in wound healing, fibrosis and angiogenesis","volume":"193","author":"Feoktistov","year":"2009","journal-title":"Handb Exp Pharmacol"},{"key":"2026101502071079800_ref10","doi-asserted-by":"crossref","first-page":"4580","DOI":"10.1111\/jcmm.15115","article-title":"Adenosine-5\u2032-triphosphate suppresses proliferation and migration capacity of human endometrial stem cells","volume":"24","author":"Semenova","year":"2020","journal-title":"J Cell Mol Med"},{"key":"2026101502071079800_ref11","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1124\/pharmrev.121.000528","article-title":"ATP and adenosine metabolism in cancer: exploitation for therapeutic gain","volume":"74","author":"Yegutkin","year":"2022","journal-title":"Pharmacol Rev"},{"key":"2026101502071079800_ref12","doi-asserted-by":"crossref","first-page":"509027","DOI":"10.1155\/2014\/509027","article-title":"High expression of ecto-nucleotidases CD39 and CD73 in human endometrial tumors","volume":"2014","author":"Aliagas","year":"2014","journal-title":"Mediators Inflamm"},{"key":"2026101502071079800_ref13","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1161\/HYPERTENSIONAHA.114.03240","article-title":"Danger signals from ATP and adenosine in pregnancy and preeclampsia","volume":"63","author":"Spaans","year":"2014","journal-title":"Hypertension"},{"key":"2026101502071079800_ref14","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1023\/A:1004017714702","article-title":"Distributional changes of purinergic receptor subtypes (P2X 1-7) in uterine epithelial cells during early pregnancy","volume":"32","author":"Slater","year":"2000","journal-title":"Histochem J"},{"key":"2026101502071079800_ref15","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1002\/jcp.30594","article-title":"The implications of the purinergic signaling throughout pregnancy","volume":"237","author":"Sagrillo-Fagundes","year":"2022","journal-title":"J Cell Physiol"},{"key":"2026101502071079800_ref16","doi-asserted-by":"crossref","first-page":"5532","DOI":"10.3390\/ijms20225532","article-title":"Impaired expression of Ectonucleotidases in ectopic and Eutopic endometrial tissue is in favor of ATP accumulation in the tissue microenvironment in endometriosis","volume":"20","author":"Trapero","year":"2019","journal-title":"Int J Mol Sci"},{"key":"2026101502071079800_ref17","doi-asserted-by":"crossref","first-page":"1328398","DOI":"10.3389\/fphar.2023.1328398","article-title":"Impairment of adenosine signaling disrupts early embryo development: unveiling the underlying mechanisms","volume":"14","author":"Glaser","year":"2023","journal-title":"Front Pharmacol"},{"key":"2026101502071079800_ref18","doi-asserted-by":"crossref","first-page":"e12737","DOI":"10.1111\/cpr.12737","article-title":"ATP mediates the interaction between human blastocyst and endometrium","volume":"53","author":"Gu","year":"2020","journal-title":"Cell Prolif"},{"key":"2026101502071079800_ref19","doi-asserted-by":"crossref","first-page":"eaba3396","DOI":"10.1126\/scisignal.aba3396","article-title":"Blastocyst-induced ATP release from luminal epithelial cells initiates decidualization through the P2Y2 receptor in mice","volume":"13","author":"Gu","year":"2020","journal-title":"Sci Signal"},{"key":"2026101502071079800_ref20","doi-asserted-by":"crossref","first-page":"e190","DOI":"10.1161\/ATVBAHA.122.318948","article-title":"Adenosine-ADORA2A promotes ang-induced angiogenesis in intrauterine growth restriction placenta via the Stat3\/Akt pathway","volume":"43","author":"Wu","year":"2023","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2026101502071079800_ref21","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1093\/biolre\/ioaf028","article-title":"Purinergic system molecules: expression and regulation of enzymes, transporters, and ATP receptors and the role of ATP at the maternal-conceptus Interface in pigs","volume":"112","author":"Cheon","year":"2025","journal-title":"Biol Reprod"},{"key":"2026101502071079800_ref22","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1093\/biolre\/ioaf171","article-title":"Spatiotemporal expression and regulation of adenosine receptors and the role of adenosine Signaling at the maternal-conceptus Interface in pigs","volume":"114","author":"Cheon","year":"2025","journal-title":"Biol Reprod"},{"key":"2026101502071079800_ref23","doi-asserted-by":"crossref","first-page":"426","DOI":"10.2174\/157016109789043892","article-title":"Nucleoside transporter proteins","volume":"7","author":"Molina-Arcas","year":"2009","journal-title":"Curr Vasc Pharmacol"},{"key":"2026101502071079800_ref24","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.mam.2012.05.007","article-title":"The human concentrative and equilibrative nucleoside transporter families, SLC28 and SLC29","volume":"34","author":"Young","year":"2013","journal-title":"Mol Aspects Med"},{"key":"2026101502071079800_ref25","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1007\/s00424-003-1107-y","article-title":"The concentrative nucleoside transporter family, SLC28","volume":"447","author":"Gray","year":"2004","journal-title":"Pflugers Arch"},{"key":"2026101502071079800_ref26","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1007\/s00424-003-1103-2","article-title":"The equilibrative nucleoside transporter family, SLC29","volume":"447","author":"Baldwin","year":"2004","journal-title":"Pflugers Arch"},{"key":"2026101502071079800_ref27","doi-asserted-by":"crossref","first-page":"15880","DOI":"10.1074\/jbc.M414337200","article-title":"Functional characterization of novel human and mouse equilibrative nucleoside transporters (hENT3 and mENT3) located in intracellular membranes","volume":"280","author":"Baldwin","year":"2005","journal-title":"J Biol Chem"},{"key":"2026101502071079800_ref28","doi-asserted-by":"crossref","first-page":"13","DOI":"10.3389\/fphar.2015.00013","article-title":"Nucleoside transporter proteins as biomarkers of drug responsiveness and drug targets","volume":"6","author":"Pastor-Anglada","year":"2015","journal-title":"Front Pharmacol"},{"key":"2026101502071079800_ref29","doi-asserted-by":"crossref","first-page":"809","DOI":"10.2217\/pgs.10.70","article-title":"Drug transporter pharmacogenetics in nucleoside-based therapies","volume":"11","author":"Errasti-Murugarren","year":"2010","journal-title":"Pharmacogenomics"},{"key":"2026101502071079800_ref30","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1124\/dmd.118.083329","article-title":"Equilibrative nucleoside transporter 1 (ENT1, SLC29A1) facilitates transfer of the antiretroviral drug abacavir across the placenta","volume":"46","author":"Cerveny","year":"2018","journal-title":"Drug Metab Dispos"},{"key":"2026101502071079800_ref31","doi-asserted-by":"crossref","first-page":"2732","DOI":"10.1021\/acs.molpharmaceut.8b00238","article-title":"Expression of concentrative nucleoside transporters ( SLC28A) in the human placenta: effects of gestation age and prototype differentiation-affecting agents","volume":"15","author":"Jiraskova","year":"2018","journal-title":"Mol Pharm"},{"key":"2026101502071079800_ref32","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.3390\/pharmaceutics14071376","article-title":"Transporter regulation in critical protective barriers: focus on brain and placenta","volume":"14","author":"Taggi","year":"2022","journal-title":"Pharmaceutics"},{"key":"2026101502071079800_ref33","doi-asserted-by":"crossref","first-page":"3602","DOI":"10.1016\/j.cell.2024.05.011","article-title":"De novo and salvage purine synthesis pathways across tissues and tumors","volume":"187","author":"Tran","year":"2024","journal-title":"Cell"},{"key":"2026101502071079800_ref34","doi-asserted-by":"crossref","first-page":"a040592","DOI":"10.1101\/cshperspect.a040592","article-title":"Nucleotide metabolism","volume":"13","author":"Chandel","year":"2021","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"2026101502071079800_ref35","doi-asserted-by":"crossref","first-page":"15057","DOI":"10.1038\/srep15057","article-title":"Functional identification of SLC43A3 as an equilibrative nucleobase transporter involved in purine salvage in mammals","volume":"5","author":"Furukawa","year":"2015","journal-title":"Sci Rep"},{"key":"2026101502071079800_ref36","doi-asserted-by":"crossref","first-page":"6166","DOI":"10.1210\/en.2008-0354","article-title":"Analysis of lysophosphatidic acid (LPA) receptor and LPA-induced endometrial prostaglandin-endoperoxide synthase 2 expression in the porcine uterus","volume":"149","author":"Seo","year":"2008","journal-title":"Endocrinology"},{"key":"2026101502071079800_ref37","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.5713\/ab.22.0415","article-title":"Spatiotemporal expression and regulation of peptidase inhibitor 3 and secretory leukocyte protease inhibitor at the maternal-fetal interface in pigs","volume":"36","author":"Lee","year":"2023","journal-title":"Anim Biosci"},{"key":"2026101502071079800_ref38","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1093\/biolre\/ioz233","article-title":"Uterine epithelial expression of the tumor necrosis factor superfamily: a strategy for immune privilege during pregnancy in a true epitheliochorial placentation species","volume":"102","author":"Yoo","year":"2020","journal-title":"Biol Reprod"},{"key":"2026101502071079800_ref39","doi-asserted-by":"crossref","first-page":"2303","DOI":"10.1210\/endo.142.6.8194","article-title":"Keratinocyte growth factor is up-regulated by estrogen in the porcine uterine endometrium and functions in trophectoderm cell proliferation and differentiation","volume":"142","author":"Ka","year":"2001","journal-title":"Endocrinology"},{"key":"2026101502071079800_ref40","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1095\/biolreprod.103.015842","article-title":"Characterization of the interleukin-1beta system during porcine trophoblastic elongation and early placental attachment","volume":"69","author":"Ross","year":"2003","journal-title":"Biol Reprod"},{"key":"2026101502071079800_ref41","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1095\/biolreprod55.3.613","article-title":"Characterization of a polarized porcine uterine epithelial model system","volume":"55","author":"Bowen","year":"1996","journal-title":"Biol Reprod"},{"key":"2026101502071079800_ref42","doi-asserted-by":"crossref","first-page":"3933","DOI":"10.1210\/en.2005-0090","article-title":"Functional effects of transforming growth factor beta on adhesive properties of porcine trophectoderm","volume":"146","author":"Jaeger","year":"2005","journal-title":"Endocrinology"},{"key":"2026101502071079800_ref43","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1095\/biolreprod.115.137174","article-title":"Lysophosphatidic acid (LPA) receptor 3-mediated LPA signal transduction pathways: a possible relationship with early development of peri-implantation porcine conceptus","volume":"94","author":"Jeong","year":"2016","journal-title":"Biol Reprod"},{"key":"2026101502071079800_ref44","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.jff.2016.11.013","article-title":"Adenine has an anti-inflammatory effect through the activation of adenine receptor signaling in mouse macrophage","volume":"28","author":"Fukuda","year":"2017","journal-title":"J Funct Foods"},{"key":"2026101502071079800_ref45","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.imlet.2023.12.003","article-title":"Adenine is an anti-inflammatory metabolite found to be more abundant in M-CSF over GM-CSF-differentiated human macrophages","volume":"265","author":"Harber","year":"2024","journal-title":"Immunol Lett"},{"key":"2026101502071079800_ref46","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1093\/biolre\/ioy147","article-title":"Cysteine-X-cysteine motif chemokine ligand 12 and its receptor CXCR4: expression, regulation, and possible function at the maternal-conceptus interface during early pregnancy in pigs","volume":"99","author":"Han","year":"2018","journal-title":"Biol Reprod"},{"key":"2026101502071079800_ref47","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"2026101502071079800_ref48","doi-asserted-by":"crossref","first-page":"2748","DOI":"10.1210\/endo.139.6.6049","article-title":"Differential expression of peroxisome proliferator-activated receptor-alpha, \u2212beta, and -gamma during rat embryonic development","volume":"139","author":"Braissant","year":"1998","journal-title":"Endocrinology"},{"key":"2026101502071079800_ref49","doi-asserted-by":"crossref","first-page":"643","DOI":"10.5713\/ajas.16.0637","article-title":"Expression and regulation of prostaglandin transporters, ATP-binding cassette, subfamily C, member 1 and 9, and solute carrier organic anion transporter family, member 2A1 and 5A1 in the uterine endometrium during the estrous cycle and pregnancy in pigs","volume":"30","author":"Jang","year":"2017","journal-title":"Asian Australas J Anim Sci"},{"key":"2026101502071079800_ref50","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1038\/sj.bjp.0703848","article-title":"The effects of P2Y receptor agonists and adenosine on prostaglandin production by the Guinea-pig uterus","volume":"132","author":"Aitken","year":"2001","journal-title":"Br J Pharmacol"},{"key":"2026101502071079800_ref51","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1161\/HYPERTENSIONAHA.109.130880","article-title":"Adenosine contributes to blood flow regulation in the exercising human leg by increasing prostaglandin and nitric oxide formation","volume":"53","author":"Mortensen","year":"2009","journal-title":"Hypertension"},{"key":"2026101502071079800_ref52","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1113\/jphysiol.2002.023440","article-title":"Interactions of adenosine, prostaglandins and nitric oxide in hypoxia-induced vasodilatation: in vivo and in vitro studies","volume":"544","author":"Ray","year":"2002","journal-title":"J Physiol"},{"key":"2026101502071079800_ref53","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/nri2938","article-title":"Immune cell regulation by autocrine purinergic signalling","volume":"11","author":"Junger","year":"2011","journal-title":"Nat Rev Immunol"},{"key":"2026101502071079800_ref54","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.bbamcr.2008.01.024","article-title":"Nucleotide- and nucleoside-converting ectoenzymes: important modulators of purinergic signalling cascade","volume":"1783","author":"Yegutkin","year":"2008","journal-title":"Biochim Biophys Acta"},{"key":"2026101502071079800_ref55","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1124\/dmd.104.001123","article-title":"Tissue distribution of concentrative and equilibrative nucleoside transporters in male and female rats and mice","volume":"32","author":"Lu","year":"2004","journal-title":"Drug Metab Dispos"},{"key":"2026101502071079800_ref56","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1093\/biolre\/ioaf192","article-title":"Uterine histotroph and conceptus development. IV. Metabolomic analyses of uterine luminal fluid reveals regulatory landscapes during the peri-implantation period of pregnancy in pigs","volume":"113","author":"Liu","year":"2025","journal-title":"Biol Reprod"},{"key":"2026101502071079800_ref57","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.placenta.2025.11.005","article-title":"Adenosine promotes trophoblast proliferation without inducing differentiation or apoptosis","volume":"172","author":"Ali","year":"2025","journal-title":"Placenta"},{"key":"2026101502071079800_ref58","doi-asserted-by":"crossref","first-page":"30275","DOI":"10.1038\/s41598-025-16183-2","article-title":"Dynamic shifts in trophoblast nucleos(t)ide metabolism, transport, and adenosine signaling during gestation and preterm birth","volume":"15","author":"Ali","year":"2025","journal-title":"Sci Rep"},{"key":"2026101502071079800_ref59","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1471-2393-14-2","article-title":"Adenosine A2B receptors induce proliferation, invasion and activation of cAMP response element binding protein (CREB) in trophoblast cells","volume":"14","author":"Darashchonak","year":"2014","journal-title":"BMC Pregnancy Childbirth"},{"key":"2026101502071079800_ref60","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1002\/jlb.67.3.345","article-title":"Nitric oxide regulates nucleoside transport in activated B lymphocytes","volume":"67","author":"Soler","year":"2000","journal-title":"J Leukoc Biol"},{"key":"2026101502071079800_ref61","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.5713\/ab.22.0478","article-title":"Matrix metalloproteinases: expression and regulation in the endometrium during the estrous cycle and at the maternal-conceptus interface during pregnancy in pigs","volume":"36","author":"Yoo","year":"2023","journal-title":"Anim Biosci"},{"key":"2026101502071079800_ref62","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1093\/biolre\/ioac058","article-title":"Interleukin-10 and its receptors at the maternal-conceptus interface: expression, regulation, and implication for T helper 2 cytokine predominance and maternal immune tolerance in the pig, a true epitheliochorial placentation species\u2020","volume":"106","author":"Han","year":"2022","journal-title":"Biol Reprod"},{"key":"2026101502071079800_ref63","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF00928361","article-title":"Physiological concentrations of purines and pyrimidines","volume":"140","author":"Traut","year":"1994","journal-title":"Mol Cell Biochem"}],"container-title":["Biology of Reproduction"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/biolreprod\/advance-article-pdf\/doi\/10.1093\/biolre\/ioag150\/68771841\/ioag150.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/biolreprod\/article-pdf\/115\/4\/1091\/68771841\/ioag150.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/biolreprod\/article-pdf\/115\/4\/1091\/68771841\/ioag150.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T06:07:28Z","timestamp":1792044448000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/biolreprod\/article\/115\/4\/1091\/8734036"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,14]]},"references-count":63,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2026,7,14]]},"published-print":{"date-parts":[[2026,10,15]]}},"URL":"https:\/\/doi.org\/10.1093\/biolre\/ioag150","relation":{},"ISSN":["0006-3363","1529-7268"],"issn-type":[{"value":"0006-3363","type":"print"},{"value":"1529-7268","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,10]]},"published":{"date-parts":[[2026,7,14]]}}}