{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:29:06Z","timestamp":1787772546890,"version":"build-2784847793"},"reference-count":80,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Jining Key Research and Development Program","award":["2024YXNS175"],"award-info":[{"award-number":["2024YXNS175"]}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2026MS1230"],"award-info":[{"award-number":["ZR2026MS1230"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"name":"China Agriculture Research System","award":["CARS-36"],"award-info":[{"award-number":["CARS-36"]}]},{"name":"Shandong Provincial Medical and Health Science and Technology Development Program","award":["2018WSB33011"],"award-info":[{"award-number":["2018WSB33011"]}]},{"name":"Shandong Province Medical and Health Science and Technology Development Plan","award":["202201010591"],"award-info":[{"award-number":["202201010591"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Stress adversely affects various aspects of the female reproductive process, including follicle development, maturation, ovulation, luteal activity, and embryo implantation. Restraint stress reduces the number of implanted embryos. The precise mechanisms by which stress affects embryo implantation are not fully understood. In this study, a mouse model of restraint stress was used to investigate the effects of stress on uterine receptivity and the underlying mechanisms. Mice were randomly divided into three groups. The groups were the Control group, Stress group, and Ab-IL-6 treatment group. Mice in the Stress and Ab-IL-6 treatment groups underwent restraint stress in perforated 50\u00a0ml centrifuge tubes for 4\u00a0h daily over seven consecutive days. Results indicated that the number of implanted blastocysts and total litter size in the stress group were significantly lower than those in the control group. These findings indicate that restraint stress leads to high IL-6 expression in the endometrium. This increased expression may affect the endometrium\u2019s receptivity, resulting in a decreased number of implanted blastocysts. Furthermore, we demonstrated that IL-6 regulated autophagy through the IL-6\/JAK2\/BECN1 pathway in Ishikawa cells and mouse endometrial epithelial cells, and treatment with an IL-6 antibody significantly mitigated the adverse effects of stress-induced blastocyst implantation. Our findings demonstrated that restraint stress had a negative influence on endometrial receptivity via the IL-6\/JAK2\/BECN1 pathway. This effect led to a reduction in the number of implanted embryos. Consequently, inhibiting IL-6 expression may represent a potential therapeutic strategy for preventing stress-induced implantation failure.<\/jats:p>","DOI":"10.1093\/biolre\/ioag173","type":"journal-article","created":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T11:37:11Z","timestamp":1786448231000},"source":"Crossref","is-referenced-by-count":0,"title":["Chronic stress regulates endometrial autophagy through IL-6\/JAK2\/BECN1 signaling pathway"],"prefix":"10.1093","author":[{"given":"Xinxin","family":"Cao","sequence":"first","affiliation":[{"name":"Key Laboratory of Agricultural Animal Genetics, Breeding, and Reproduction of the Ministry of Education and Key Laboratory of Swine Genetics and Breeding of the Ministry of Agriculture, College of Animal Science and Technology, Huazhong Agricultural University , Wuhan ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueying","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine, Jining No.1 People\u2019s Hospital , Jining ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dengying","family":"Gao","sequence":"additional","affiliation":[{"name":"Institute of Pediatrics, Children\u2019s Hospital of Fudan University , Shanghai ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahao","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory of Agricultural Animal Genetics, Breeding, and Reproduction of the Ministry of Education and Key Laboratory of Swine Genetics and Breeding of the Ministry of Agriculture, College of Animal Science and Technology, Huazhong Agricultural University , Wuhan ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuesong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine, Jining No.1 People\u2019s Hospital , Jining ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoran","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Precision Medicine, Jining Medical University , Jining ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7515-6497","authenticated-orcid":false,"given":"Minggang","family":"Lei","sequence":"additional","affiliation":[{"name":"Key Laboratory of Agricultural Animal Genetics, Breeding, and Reproduction of the Ministry of Education and Key Laboratory of Swine Genetics and Breeding of the Ministry of Agriculture, College of Animal Science and Technology, Huazhong Agricultural University , Wuhan 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