{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T20:09:09Z","timestamp":1789416549638,"version":"build-2803163510"},"reference-count":62,"publisher":"Oxford University Press (OUP)","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Maternal effects on offspring development do not end at birth. Bioactive factors are transmitted from mothers to nursing offspring through colostrum, by a process known as lactocrine signaling. In pigs, naturally occurring lactocrine insufficiency, indicated by reduced serum immunoglobulin immunocrit (iCrit) ratios within 24-h of postnatal life, impaired uterine development, and reduced adult fecundity. This effect was evaluated at postnatal day (PND) 14 with histology and transcriptomics on six pairs of littermates with high- vs. low-iCrit measured at PND 1. RNA-seq analysis identified 148 differentially expressed genes (DEGs) between groups (P\u2009&amp;lt;\u20090.05), and eight DEGs were validated by qRT-PCR (P\u2009&amp;lt;\u20090.05), including FOXA2, a gene with well-established expression in the uterine glandular epithelium (GE) across multiple mammalian species. Immunohistochemistry confirmed FOXA2 localization in the PND 14 pig uterus, and lactocrine deficiency reduced endometrial glandularity, supported by fewer GE cells\/mm2 in low versus high iCrit gilts (P\u2009&amp;lt;\u20090.05). Downregulated genes in uteri from low-iCrit gilts were associated with growth, differentiation, and secretion, whereas upregulated genes were enriched for immune processes, including complement activation and cytokine signaling. These findings suggest that inadequate colostrum-derived antibodies trigger uterine immune activation at PND 14, potentially impairing development and reducing adult uterine capacity. Highly expressed genes in PND 14 pig uterus were enriched for structural, developmental, and growth functions and included a subset of tissue-specific genes shared between pigs and humans. Integration of pig and human GTEx datasets identified conserved and species-specific uterine-biased genes, including DEG between high- and low-iCrit gilts, highlighting potential uterine biomarkers of early uterine development.<\/jats:p>","DOI":"10.1093\/biolre\/ioag181","type":"journal-article","created":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T11:41:07Z","timestamp":1787398867000},"source":"Crossref","is-referenced-by-count":0,"title":["Lactocrine insufficiency at birth impacts uterine gene expression and development in postnatal day 14 pigs"],"prefix":"10.1093","author":[{"given":"Xiaolei","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Pathobiology, College of Veterinary Medicine, Auburn University , Auburn, AL 36849 ,","place":["USA"]},{"name":"Center for Advanced Science, Innovation, and Commerce, Alabama Agricultural Experiment Station, Auburn University , Auburn, AL 36849 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiruni R","family":"Wijesena","sequence":"additional","affiliation":[{"name":"USDA-ARS, US Meat Animal Research Center, Clay Center , NE 68933 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, College of Veterinary Medicine, Auburn University , Auburn, AL 36849 ,","place":["USA"]},{"name":"Center for Advanced Science, Innovation, and Commerce, Alabama Agricultural Experiment Station, Auburn University , Auburn, AL 36849 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy R","family":"Miles","sequence":"additional","affiliation":[{"name":"USDA-ARS, US Meat Animal Research Center, Clay Center , NE 68933 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William T","family":"Oliver","sequence":"additional","affiliation":[{"name":"USDA-ARS, US Meat Animal Research Center, Clay Center , NE 68933 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenqi","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, College of Veterinary Medicine, Auburn University , Auburn, AL 36849 ,","place":["USA"]},{"name":"Center for Advanced Science, Innovation, and Commerce, Alabama Agricultural Experiment Station, Auburn University , Auburn, AL 36849 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Paranjpe","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences, Rutgers University , New Brunswick, NJ 08901 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank F","family":"Bartol","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Physiology and Pharmacology, College of Veterinary Medicine, Auburn University , Auburn, AL 36849 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2512-7764","authenticated-orcid":false,"given":"Clay A","family":"Lents","sequence":"additional","affiliation":[{"name":"USDA-ARS, US Meat Animal Research Center, Clay Center , NE 68933 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0058-8233","authenticated-orcid":false,"given":"Carol A","family":"Bagnell","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences, Rutgers University , New Brunswick, NJ 08901 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7594-5004","authenticated-orcid":false,"given":"Xu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, College of Veterinary Medicine, Auburn University , Auburn, AL 36849 ,","place":["USA"]},{"name":"Center for Advanced Science, Innovation, and Commerce, Alabama Agricultural Experiment Station, Auburn University , Auburn, AL 36849 ,","place":["USA"]},{"name":"The HudsonAlpha Institute for Biotechnology , Huntsville, AL 35806 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,8,22]]},"reference":[{"key":"2026091415465645600_ref1","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.zool.2007.06.007","article-title":"The phases of maternal investment in eutherian mammals","volume":"111","author":"Langer","year":"2008","journal-title":"Zoology"},{"key":"2026091415465645600_ref2","doi-asserted-by":"publisher","first-page":"696","DOI":"10.2527\/jas.2012-5764","article-title":"Lactation biology symposium: lactocrine signaling and developmental programming","volume":"91","author":"Bartol","year":"2013","journal-title":"J Anim Sci"},{"key":"2026091415465645600_ref3","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1111\/j.1439-0531.2008.01174.x","article-title":"Epigenetic programming of porcine endometrial function and the lactocrine hypothesis","volume":"43","author":"Bartol","year":"2008","journal-title":"Reprod Domest Anim"},{"key":"2026091415465645600_ref4","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1016\/S0022-3476(82)80753-1","article-title":"Immunologic factors in human milk during the first year of lactation","volume":"100","author":"Goldman","year":"1982","journal-title":"J Pediatr"},{"key":"2026091415465645600_ref5","doi-asserted-by":"publisher","first-page":"7945","DOI":"10.1080\/10408398.2022.2053058","article-title":"Human milk: from complex tailored nutrition to bioactive impact on child cognition and behavior","volume":"63","author":"Weerth","year":"2023","journal-title":"Crit Rev Food Sci Nutr"},{"key":"2026091415465645600_ref6","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1093\/nutrit\/nuab099","article-title":"Bioactives in bovine milk: chemistry, technology, and applications","volume":"79","author":"Lin","year":"2021","journal-title":"Nutr Rev"},{"key":"2026091415465645600_ref7","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1095\/biolreprod.115.136150","article-title":"Age and nursing affect the neonatal porcine uterine transcriptome","volume":"94","author":"Rahman","year":"2016","journal-title":"Biol Reprod"},{"key":"2026091415465645600_ref8","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1093\/biolre\/iox001","article-title":"Defining age- and lactocrine-sensitive elements of the neonatal porcine uterine microRNA-mRNA interactome","volume":"96","author":"George","year":"2017","journal-title":"Biol Reprod"},{"key":"2026091415465645600_ref9","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1095\/biolreprod.112.105056","article-title":"Nursing for 48 hours from birth supports porcine uterine gland development and endometrial cell compartment-specific gene expression","volume":"88","author":"Miller","year":"2013","journal-title":"Biol Reprod"},{"key":"2026091415465645600_ref10","doi-asserted-by":"publisher","first-page":"2657","DOI":"10.2527\/jas.2010-2972","article-title":"Differential composition of proteomes in sow colostrum and milk from anterior and posterior mammary glands","volume":"88","author":"Wu","year":"2010","journal-title":"J Anim Sci"},{"key":"2026091415465645600_ref11","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/2049-1891-6-3","article-title":"Current strategies for reproductive management of gilts and sows in North America","volume":"6","author":"Kraeling","year":"2015","journal-title":"J Anim Sci Biotechnol"},{"key":"2026091415465645600_ref12","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.tvjl.2012.06.009","article-title":"A simple novel measure of passive transfer of maternal immunoglobulin is predictive of preweaning mortality in piglets","volume":"195","author":"Vallet","year":"2013","journal-title":"Vet J"},{"key":"2026091415465645600_ref13","doi-asserted-by":"publisher","first-page":"2722","DOI":"10.2527\/jas.2014-8535","article-title":"Relationships between day one piglet serum immunoglobulin immunocrit and subsequent growth, puberty attainment, litter size, and lactation performance","volume":"93","author":"Vallet","year":"2015","journal-title":"J Anim Sci"},{"key":"2026091415465645600_ref14","doi-asserted-by":"publisher","first-page":"E1018","DOI":"10.1073\/pnas.1618433114","article-title":"Forkhead box a2 (FOXA2) is essential for uterine function and fertility","volume":"114","author":"Kelleher","year":"2017","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026091415465645600_ref15","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1262\/jrd.2014-086","article-title":"Expression and regulation of Foxa2 in the rat uterus during early pregnancy","volume":"60","author":"Yamagami","year":"2014","journal-title":"J Reprod Dev"},{"key":"2026091415465645600_ref16","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1146\/annurev-animal-020518-115321","article-title":"Development and function of uterine glands in domestic animals","volume":"7","author":"Spencer","year":"2019","journal-title":"Annu Rev Anim Biosci"},{"key":"2026091415465645600_ref17","doi-asserted-by":"publisher","first-page":"8543","DOI":"10.1096\/fj.201900013R","article-title":"Integrative analysis of the forkhead box A2 (FOXA2) cistrome for the human endometrium","volume":"33","author":"Kelleher","year":"2019","journal-title":"FASEB J"},{"key":"2026091415465645600_ref18","doi-asserted-by":"publisher","first-page":"2227","DOI":"10.1101\/gad.176826.111","article-title":"Pioneer transcription factors: establishing competence for gene expression","volume":"25","author":"Zaret","year":"2011","journal-title":"Genes Dev"},{"key":"2026091415465645600_ref19","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1095\/biolreprod.113.107631","article-title":"Endometrial glands are essential for blastocyst implantation and decidualization in the mouse uterus","volume":"88","author":"Filant","year":"2013","journal-title":"Biol Reprod"},{"key":"2026091415465645600_ref20","author":"National Pork Producers C","year":"2024"},{"key":"2026091415465645600_ref21","volume-title":"Guide for the Care and Use of Agricultural Animals in Research and Teaching","author":"Federation of Animal Science S","year":"2020"},{"key":"2026091415465645600_ref22","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1093\/biolre\/ioy180","article-title":"Neonatal lactocrine deficiency affects the adult porcine endometrial transcriptome at pregnancy day 13","volume":"100","author":"George","year":"2019","journal-title":"Biol Reprod"},{"key":"2026091415465645600_ref23","doi-asserted-by":"publisher","first-page":"E113","DOI":"10.2527\/2006.8413_supplE113x","article-title":"Consequences of birth weight for postnatal growth performance and carcass quality in pigs as related to myogenesis","volume":"84 Suppl","author":"Rehfeldt","year":"2006","journal-title":"J Anim Sci"},{"key":"2026091415465645600_ref24","author":"American Veterinary Medical A","year":"2020"},{"key":"2026091415465645600_ref25","author":"Andrews","year":"2010"},{"key":"2026091415465645600_ref26","doi-asserted-by":"publisher","first-page":"2114","DOI":"10.1093\/bioinformatics\/btu170","article-title":"Trimmomatic: a flexible trimmer for Illumina sequence data","volume":"30","author":"Bolger","year":"2014","journal-title":"Bioinformatics"},{"key":"2026091415465645600_ref27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/gb-2013-14-4-r36","article-title":"TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions","volume":"14","author":"Kim","year":"2013","journal-title":"Genome Biol"},{"key":"2026091415465645600_ref28","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1038\/nbt.1621","article-title":"Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation","volume":"28","author":"Trapnell","year":"2010","journal-title":"Nat Biotechnol"},{"key":"2026091415465645600_ref29","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1093\/bioinformatics\/btq033","article-title":"BEDTools: a flexible suite of utilities for comparing genomic features","volume":"26","author":"Quinlan","year":"2010","journal-title":"Bioinformatics"},{"key":"2026091415465645600_ref30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/gb-2010-11-3-r25","article-title":"A scaling normalization method for differential expression analysis of RNA-seq data","volume":"11","author":"Robinson","year":"2010","journal-title":"Genome Biol"},{"key":"2026091415465645600_ref31","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","article-title":"edgeR: a Bioconductor package for differential expression analysis of digital gene expression data","volume":"26","author":"Robinson","year":"2010","journal-title":"Bioinformatics"},{"key":"2026091415465645600_ref32","author":"Team RC","year":"2013"},{"key":"2026091415465645600_ref33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41467-019-09234-6","article-title":"Metascape provides a biologist-oriented resource for the analysis of systems-level datasets","volume":"10","author":"Zhou","year":"2019","journal-title":"Nat Commun"},{"key":"2026091415465645600_ref34","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1093\/bioinformatics\/bti042","article-title":"Genome-wide midrange transcription profiles reveal expression level relationships in human tissue specification","volume":"21","author":"Yanai","year":"2005","journal-title":"Bioinformatics"},{"key":"2026091415465645600_ref35","author":"Carithers","year":"2015"},{"key":"2026091415465645600_ref36","doi-asserted-by":"publisher","first-page":"22","DOI":"10.3390\/jpm5010022","article-title":"The genotype-tissue expression (GTEx) project: linking clinical data with molecular analysis to advance personalized medicine","volume":"5","author":"Keen","year":"2015","journal-title":"J Pers Med"},{"key":"2026091415465645600_ref37","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.mce.2011.10.008","article-title":"Lactocrine programming of female reproductive tract development: environmental connections to the reproductive continuum","volume":"354","author":"Bartol","year":"2012","journal-title":"Mol Cell Endocrinol"},{"key":"2026091415465645600_ref38","doi-asserted-by":"publisher","first-page":"2200","DOI":"10.2527\/jas.2016.1144","article-title":"PHYSIOLOGY AND ENDOCRINOLOGY SYMPOSIUM: postnatal reproductive development and the lactocrine hypothesis","volume":"95","author":"Bartol","year":"2017","journal-title":"J Anim Sci"},{"key":"2026091415465645600_ref39","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1016\/j.domaniend.2006.07.002","article-title":"Neonatal porcine endometrial development and epithelial proliferation affected by age and exposure to estrogen and relaxin","volume":"33","author":"Masters","year":"2007","journal-title":"Domest Anim Endocrinol"},{"key":"2026091415465645600_ref40","doi-asserted-by":"publisher","first-page":"4511","DOI":"10.1210\/en.2012-1329","article-title":"Nursing during the first two days of life is essential for the expression of proteins important for growth and remodeling of the neonatal porcine cervix","volume":"153","author":"Frankshun","year":"2012","journal-title":"Endocrinology"},{"key":"2026091415465645600_ref41","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1530\/REP-14-0257","article-title":"Effects of age, nursing, and oral IGF1 supplementation on neonatal porcine cervical development","volume":"148","author":"Camp","year":"2014","journal-title":"Reproduction"},{"key":"2026091415465645600_ref42","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.1002\/art.39030","article-title":"Identification of a Prg4-expressing articular cartilage progenitor cell population in mice","volume":"67","author":"Kozhemyakina","year":"2015","journal-title":"Arthritis Rheumatol"},{"key":"2026091415465645600_ref43","doi-asserted-by":"publisher","first-page":"1186","DOI":"10.1016\/j.ajpath.2017.01.006","article-title":"Complement component C3 and complement factor B promote growth of cutaneous squamous cell carcinoma","volume":"187","author":"Riihil\u00e4","year":"2017","journal-title":"Am J Pathol"},{"key":"2026091415465645600_ref44","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1089\/gtmb.2018.0110","article-title":"Association between complement factor C2\/C3\/CFB\/CFH polymorphisms and age-related macular degeneration: a meta-analysis","volume":"22","author":"Lu","year":"2018","journal-title":"Genet Test Mol Biomarkers"},{"key":"2026091415465645600_ref45","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1093\/ndt\/gfv054","article-title":"Familial C3 glomerulonephritis associated with mutations in the gene for complement factor B","volume":"30","author":"Imamura","year":"2015","journal-title":"Nephrol Dial Transplant"},{"key":"2026091415465645600_ref46","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1093\/biolre\/iox074","article-title":"Analysis of cysteine-X-cysteine motif chemokine ligands 9, 10, and 11, their receptor CXCR3, and their possible role on the recruitment of immune cells at the maternal-conceptus interface in pigs","volume":"97","author":"Han","year":"2017","journal-title":"Biol Reprod"},{"key":"2026091415465645600_ref47","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1093\/biolre\/ioae044","article-title":"Pig conceptuses utilize extracellular vesicles for interferon-gamma-mediated paracrine communication with the endometriumdagger","volume":"111","author":"Cain","year":"2024","journal-title":"Biol Reprod"},{"key":"2026091415465645600_ref48","doi-asserted-by":"publisher","first-page":"3195","DOI":"10.4049\/jimmunol.168.7.3195","article-title":"IFN-gamma-inducible protein 10 (IP-10; CXCL10)-deficient mice reveal a role for IP-10 in effector T cell generation and trafficking","volume":"168","author":"Dufour","year":"2002","journal-title":"J Immunol"},{"key":"2026091415465645600_ref49","doi-asserted-by":"publisher","first-page":"1809","DOI":"10.1084\/jem.177.6.1809","article-title":"Recombinant human interferon-inducible protein 10 is a chemoattractant for human monocytes and T lymphocytes and promotes T cell adhesion to endothelial cells","volume":"177","author":"Taub","year":"1993","journal-title":"J Exp Med"},{"key":"2026091415465645600_ref50","doi-asserted-by":"publisher","first-page":"1018","DOI":"10.1093\/biolre\/ioaa132","article-title":"Pig conceptuses secrete interferon gamma to recruit T cells to the endometrium during the peri-implantation period","volume":"103","author":"McLendon","year":"2020","journal-title":"Biol Reprod"},{"key":"2026091415465645600_ref51","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1095\/biolreprod.103.020412","article-title":"Porcine endometrial expression of kininogen, factor XII, and plasma kallikrein in cyclic and pregnant gilts","volume":"70","author":"Vonnahme","year":"2004","journal-title":"Biol Reprod"},{"key":"2026091415465645600_ref52","doi-asserted-by":"publisher","first-page":"15262","DOI":"10.3390\/ijms242015262","article-title":"CWH43 is a novel tumor suppressor gene with negative regulation of TTK in colorectal cancer","volume":"24","author":"Lee","year":"2023","journal-title":"Int J Mol Sci"},{"key":"2026091415465645600_ref53","doi-asserted-by":"publisher","first-page":"1419","DOI":"10.1007\/s10815-018-1231-4","article-title":"Oviductal glycoprotein 1 (OVGP1) is expressed by endometrial epithelium that regulates receptivity and trophoblast adhesion","volume":"35","author":"Laheri","year":"2018","journal-title":"J Assist Reprod Genet"},{"key":"2026091415465645600_ref54","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1093\/biolre\/ioad159","article-title":"The fluid factor OVGP1 provides a significant oviductal microenvironment for the reproductive process in golden hamsterdagger","volume":"110","author":"Yamatoya","year":"2024","journal-title":"Biol Reprod"},{"key":"2026091415465645600_ref55","doi-asserted-by":"publisher","first-page":"795","DOI":"10.5713\/ajas.2012.12529","article-title":"Regulation of interferon-stimulated gene (ISG)12, ISG15, and MX1 and MX2 by conceptus interferons (IFNTs) in bovine uterine epithelial cells","volume":"26","author":"Kim","year":"2013","journal-title":"Asian Australas J Anim Sci"},{"key":"2026091415465645600_ref56","doi-asserted-by":"publisher","first-page":"110780","DOI":"10.1016\/j.ygeno.2023.110780","article-title":"Cell specification and functional interactions in the pig blastocyst inferred from single-cell transcriptomics and uterine fluids proteomics","volume":"116","author":"Dufour","year":"2024","journal-title":"Genomics"},{"key":"2026091415465645600_ref57","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/0303-7207(96)03837-3","article-title":"The unique endometrial expression and genomic organization of the porcine IGFBP-2 gene","volume":"120","author":"Song","year":"1996","journal-title":"Mol Cell Endocrinol"},{"key":"2026091415465645600_ref58","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1530\/rep.0.1210719","article-title":"Possible role of kallikrein in proteolysis of insulin-like growth factor binding proteins during the oestrous cycle and early pregnancy in pigs","volume":"121","author":"Geisert","year":"2001","journal-title":"Reproduction"},{"key":"2026091415465645600_ref59","doi-asserted-by":"publisher","first-page":"e70395","DOI":"10.1096\/fj.202402212RR","article-title":"Insights into the single-cell transcriptome characteristics of porcine endometrium with embryo loss","volume":"39","author":"Chu","year":"2025","journal-title":"FASEB J"},{"key":"2026091415465645600_ref60","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1016\/j.fertnstert.2014.11.030","article-title":"Nonsense mutation of EMX2 is potential causative for uterus didelphysis: first molecular explanation for isolated incomplete mullerian fusion","volume":"103","author":"Liu","year":"2015","journal-title":"Fertil Steril"},{"key":"2026091415465645600_ref61","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.ejogrb.2025.02.028","article-title":"HOXD10: a novel gene implicated in human Mullerian duct anomalies","volume":"308","author":"Chen","year":"2025","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"2026091415465645600_ref62","doi-asserted-by":"publisher","DOI":"10.17912\/micropub.biology.001942","article-title":"Deletion of Rspo1 or Rspo3 in the mesenchyme does not affect Wolffian duct maintenance or morphogenesis","volume":"2026","author":"Jia","year":"2026","journal-title":"MicroPubl Biol"}],"container-title":["Biology of Reproduction"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/biolreprod\/advance-article-pdf\/doi\/10.1093\/biolre\/ioag181\/70764088\/ioag181.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/biolreprod\/advance-article-pdf\/doi\/10.1093\/biolre\/ioag181\/70764088\/ioag181.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T19:47:02Z","timestamp":1789415222000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/biolreprod\/advance-article\/doi\/10.1093\/biolre\/ioag181\/8768721"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,22]]},"references-count":62,"URL":"https:\/\/doi.org\/10.1093\/biolre\/ioag181","relation":{},"ISSN":["0006-3363","1529-7268"],"issn-type":[{"value":"0006-3363","type":"print"},{"value":"1529-7268","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,22]]},"article-number":"ioag181"}}