{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T06:53:17Z","timestamp":1791183197498,"version":"4.1.0"},"reference-count":138,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"CAPES","doi-asserted-by":"publisher","award":["# 312742\/2022-3"],"award-info":[{"award-number":["# 312742\/2022-3"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"publisher","award":["406866\/2022-8"],"award-info":[{"award-number":["406866\/2022-8"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Obesity and metabolic syndrome are major contributors to male infertility. These conditions disrupt the hypothalamic\u2013pituitary\u2013gonadal (HPG) axis and compromise testicular steroidogenesis and spermatogenesis through mechanisms that include altered aromatase activity, insulin resistance, chronic inflammation, and oxidative stress. Irisin, an exercise-induced myokine, has emerged as a metabolic signal with potential effects on male reproductive function. This review summarizes irisin biology, proposed mechanisms of action, and putative functions of irisin in male reproduction, with emphasis on obesity-associated fertility impairment. Studies in high-fat diet\u2013induced obese rodent models indicate that exogenous irisin can improve metabolic homeostasis, restore testosterone production, increase expression of key steroidogenic enzymes, and mitigate obesity-associated reductions in spermatogenesis and sperm quality. These effects are commonly attributed to anti-inflammatory, antioxidant, and cytoprotective actions, as well as modulation of cellular energy metabolism through AMP-activated protein kinase and mitogen-activated protein kinase signaling. Irisin has also been reported to influence central neuroendocrine pathways involved in gonadotropin regulation and to improve sexual behavior in rodent models of metabolic- and antidepressant-induced sexual dysfunction. However, the physiological relevance of irisin in men\u2019s reproductive physiology remains incompletely defined. Clinical evidence is largely associative, and data on irisin receptor expression and downstream signaling in the male reproductive tract are limited. Key gaps also include the regulation of irisin secretion and potential tissue-specific actions across stages of male reproductive development. Translational studies are needed to clarify irisin\u2019s actions within the HPG axis and gonads, and to evaluate its potential to mitigate obesity-related male reproductive dysfunction.<\/jats:p>","DOI":"10.1093\/biolre\/ioag183","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:45:07Z","timestamp":1790682307000},"source":"Crossref","is-referenced-by-count":0,"title":["Irisin as a metabolic regulator of male reproduction"],"prefix":"10.1093","author":[{"given":"Iqra","family":"Batool","sequence":"first","affiliation":[{"name":"Graduate Program in Veterinary Medicine, Federal University of Santa Maria , Santa Maria , RS,","place":["Brazil"]},{"name":"Graduate Program in Animal Science, Department of Animal Science, Federal University of Cear\u00e1 , Fortaleza , CE,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4686-6067","authenticated-orcid":false,"given":"Eduardo Rodrigues","family":"Pessoa","sequence":"additional","affiliation":[{"name":"Graduate Program in Animal Science, Department of Animal Science, Federal University of Cear\u00e1 , Fortaleza , CE,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elzania Sales","family":"Pereira","sequence":"additional","affiliation":[{"name":"Graduate Program in Animal Science, Department of Animal Science, Federal University of Cear\u00e1 , Fortaleza , CE,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise Damasceno","family":"Guerreiro","sequence":"additional","affiliation":[{"name":"Graduate Program in Animal Science, Department of Animal Science, Federal University of Cear\u00e1 , Fortaleza , CE,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8271-5733","authenticated-orcid":false,"given":"Arlindo Alencar","family":"Moura","sequence":"additional","affiliation":[{"name":"Graduate Program in Animal Science, Department of Animal Science, Federal University of Cear\u00e1 , Fortaleza , CE,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,10,1]]},"reference":[{"key":"2026100502415659900_ref1","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.clinbiochem.2018.03.012","article-title":"Fertility and infertility: definition and epidemiology","volume":"62","author":"Vander Borght","year":"2018","journal-title":"Clin Biochem"},{"key":"2026100502415659900_ref2","volume-title":"Infertility prevalence estimates, 1990\u20132021","author":"Organization WH","year":"2023"},{"key":"2026100502415659900_ref3","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1186\/s12889-023-16793-3","article-title":"Global, regional and national burden of male infertility in 204 countries and territories between 1990 and 2019: an analysis of global burden of disease study","volume":"23","author":"Huang","year":"2023","journal-title":"BMC Public Health"},{"key":"2026100502415659900_ref4","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1016\/S0140-6736(05)67402-8","article-title":"The metabolic syndrome--a new worldwide definition","volume":"366","author":"Alberti","year":"2005","journal-title":"Lancet."},{"key":"2026100502415659900_ref5","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.tcm.2015.10.004","article-title":"Metabolic syndrome update","volume":"26","author":"Grundy","year":"2016","journal-title":"Trends Cardiovasc Med"},{"key":"2026100502415659900_ref6","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1177\/1753944717711379","article-title":"Metabolic syndrome: pathophysiology, management, and modulation by natural compounds","volume":"11","author":"Rochlani","year":"2017","journal-title":"Ther Adv Cardiovasc 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thermogenesis","volume":"481","author":"Bostr\u00f6m","year":"2012","journal-title":"Nature."},{"key":"2026100502415659900_ref13","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/j.cmet.2015.08.001","article-title":"Detection and quantitation of circulating human irisin by tandem mass spectrometry","volume":"22","author":"Jedrychowski","year":"2015","journal-title":"Cell Metab"},{"key":"2026100502415659900_ref14","doi-asserted-by":"crossref","first-page":"e291896","DOI":"10.1590\/1519-6984.291896","article-title":"Irisin and its role in the reproductive physiology: a review","volume":"85","author":"Alves","year":"2025","journal-title":"Braz J Biol"},{"key":"2026100502415659900_ref15","doi-asserted-by":"crossref","first-page":"4647","DOI":"10.21608\/mjcu.2018.65747","article-title":"Role of irisin administration in modulating testicular function in adult obese albino rats","volume":"86","author":"Nanees","year":"2018","journal-title":"The Medical Journal of Cairo 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a myth rather than an exercise-inducible myokine","volume":"5","author":"Albrecht","year":"2015","journal-title":"Sci Rep"},{"key":"2026100502415659900_ref39","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1016\/j.metabol.2015.09.001","article-title":"Irisin: a true, circulating hormone","volume":"64","author":"Polyzos","year":"2015","journal-title":"Metabolism."},{"key":"2026100502415659900_ref40","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1016\/j.metabol.2013.04.007","article-title":"Pharmacological concentrations of irisin increase cell proliferation without influencing markers of neurite outgrowth and synaptogenesis in mouse H19-7 hippocampal cell lines","volume":"62","author":"Moon","year":"2013","journal-title":"Metabolism."},{"key":"2026100502415659900_ref41","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.cell.2020.06.021","article-title":"CD81 controls beige fat progenitor cell growth and energy balance via FAK Signaling","volume":"182","author":"Oguri","year":"2020","journal-title":"Cell."},{"key":"2026100502415659900_ref42","doi-asserted-by":"crossref","first-page":"514","DOI":"10.2337\/db13-1106","article-title":"Irisin stimulates browning of white adipocytes through mitogen-activated protein kinase p38 MAP kinase and ERK MAP kinase signaling","volume":"63","author":"Zhang","year":"2014","journal-title":"Diabetes."},{"key":"2026100502415659900_ref43","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1096\/fj.12-225755","article-title":"Myostatin knockout drives browning of white adipose tissue through activating the AMPK-PGC1\u03b1-Fndc5 pathway in muscle","volume":"27","author":"Shan","year":"2013","journal-title":"FASEB J"},{"key":"2026100502415659900_ref44","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1016\/j.metabol.2012.09.002","article-title":"FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise","volume":"61","author":"Huh","year":"2012","journal-title":"Metabolism."},{"key":"2026100502415659900_ref45","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.neuroscience.2013.02.050","article-title":"Irisin-immunoreactivity in neural and non-neural cells of the rodent","volume":"240","author":"Dun","year":"2013","journal-title":"Neuroscience."},{"key":"2026100502415659900_ref46","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.peptides.2014.03.021","article-title":"Three new players in energy regulation: preptin, adropin and irisin","volume":"56","author":"Aydin","year":"2014","journal-title":"Peptides."},{"key":"2026100502415659900_ref47","doi-asserted-by":"crossref","first-page":"389","DOI":"10.5830\/CVJA-2017-025","article-title":"The effect of iloprost and sildenafil, alone and in combination, on myocardial ischaemia and nitric oxide and irisin levels","volume":"28","author":"Aydin","year":"2017","journal-title":"Cardiovasc J Afr"},{"key":"2026100502415659900_ref48","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.peptides.2013.09.011","article-title":"Alterations of irisin concentrations in saliva and serum of obese and normal-weight subjects, before and after 45 min of a Turkish bath or running","volume":"50","author":"Aydin","year":"2013","journal-title":"Peptides."},{"key":"2026100502415659900_ref49","doi-asserted-by":"crossref","first-page":"746049","DOI":"10.3389\/fphys.2021.746049","article-title":"Irisin, energy homeostasis and male reproduction","volume":"12","author":"Sengupta","year":"2021","journal-title":"Front Physiol"},{"key":"2026100502415659900_ref50","doi-asserted-by":"crossref","first-page":"110670","DOI":"10.1016\/j.mce.2019.110670","article-title":"Irisin is expressed by undifferentiated spermatogonia and modulates gene expression in organotypic primate testis cultures","volume":"504","author":"Wahab","year":"2020","journal-title":"Mol Cell Endocrinol"},{"key":"2026100502415659900_ref51","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1111\/andr.12459","article-title":"Leydig cell insufficiency in hypospermatogenesis: a paracrine effect of activin-inhibin signaling?","volume":"6","author":"Winters","year":"2018","journal-title":"Andrology."},{"key":"2026100502415659900_ref52","doi-asserted-by":"crossref","DOI":"10.3390\/molecules27031118","article-title":"FNDC5\/irisin: physiology and pathophysiology","volume":"27","author":"Waseem","year":"2022","journal-title":"Molecules."},{"key":"2026100502415659900_ref53","doi-asserted-by":"crossref","first-page":"D607","DOI":"10.1093\/nar\/gky1131","article-title":"STRING v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental 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activation","volume":"18","author":"Mazur-Bialy","year":"2017","journal-title":"Int J Mol Sci"},{"key":"2026100502415659900_ref57","doi-asserted-by":"crossref","first-page":"4899","DOI":"10.1210\/jc.2013-2373","article-title":"Circulating irisin in relation to insulin resistance and the metabolic syndrome","volume":"98","author":"Park","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"key":"2026100502415659900_ref58","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1210\/er.2002-0012","article-title":"Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulator","volume":"24","author":"Puigserver","year":"2003","journal-title":"Endocr Rev"},{"key":"2026100502415659900_ref59","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1038\/nn1073","article-title":"Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor","volume":"6","author":"Xu","year":"2003","journal-title":"Nat Neurosci"},{"key":"2026100502415659900_ref60","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1152\/physrev.00015.2003","article-title":"Brown adipose tissue: function and physiological significance","volume":"84","author":"Cannon","year":"2004","journal-title":"Physiol Rev"},{"key":"2026100502415659900_ref61","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1172\/JCI23606","article-title":"FGF-21 as a novel metabolic regulator","volume":"115","author":"Kharitonenkov","year":"2005","journal-title":"J Clin Invest"},{"key":"2026100502415659900_ref62","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s13578-020-00413-3","article-title":"New insights into the cellular activities of Fndc5\/irisin and its signaling pathways","volume":"10","author":"Rabiee","year":"2020","journal-title":"Cell 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