{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T08:00:32Z","timestamp":1793865632690,"version":"4.6.1"},"reference-count":60,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We hypothesized that high-frequency stimulation with kisspeptin or gonadotropin-releasing hormone (GnRH), mimicking increased GnRH pulsatility, would amplify the GnRH-induced luteinizing hormone (LH) surge in heifers. Additionally, LH pulse and surge parameters were compared between Bos taurus and B. indicus heifers. Ovariectomized estradiol-replaced Hereford (n\u2009=\u20096) and Brahman (n\u2009=\u20098) heifers received two intravaginal progesterone devices on d\u2009\u2212\u20095. On d\u2009\u2212\u20090.5, jugular catheters were placed and on d 0 blood samples were collected every 15\u00a0min for 12\u00a0h. In a crossover design, each heifer received all three treatments in separate replicates, administered hourly during the first 8\u00a0h: Control\u2009=\u2009saline; Kisspeptin\u2009=\u20090.4\u00a0\u03bcg\/kg of kisspeptin; or GnRH\u2009=\u20090.005\u00a0\u03bcg\/kg of gonadorelin acetate. At 8\u00a0h, 100\u00a0\u03bcg of gonadorelin acetate was administered to induce an LH surge. Both kisspeptin and GnRH treatments effectively induced high-frequency LH pulses. Regardless of the genetic group, 75% of kisspeptin and 87.5% of GnRH injections resulted in detectable LH pulses. LH pulsatility was greater (P\u2009&amp;lt;\u20090.01) in kisspeptin- and GnRH-treated heifers compared to controls (6.1\u2009\u00b1\u20090.6, 7.0\u2009\u00b1\u20090.4, 2.3\u2009\u00b1\u20090.5 pulses\/8\u00a0h, respectively). Nevertheless, neither endogenous nor treatment-induced LH pulse parameters differed between breeds. The GnRH-induced LH surge was not enhanced by the high-frequency stimulation; however, it was markedly reduced in Brahman compared to Hereford heifers (P\u2009&amp;lt;\u20090.01). In conclusion, the high-frequency GnRH stimulation did not enhance LH surge response to a GnRH challenge. Although LH pulsatile secretion was similar, differential pituitary responsiveness to a GnRH ovulatory stimulus may contribute to differences in reproductive function between B. taurus and B. indicus heifers.<\/jats:p>","DOI":"10.1093\/biolre\/ioag198","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T11:51:37Z","timestamp":1788954697000},"source":"Crossref","is-referenced-by-count":1,"title":["Effects of high-frequency administration of GnRH or kisspeptin on LH pulse and surge profiles in ovariectomized\n                    <i>Bos taurus<\/i>\n                    and\n                    <i>Bos indicus<\/i>\n                    heifers"],"prefix":"10.1093","author":[{"given":"Lucas O e","family":"Silva","sequence":"first","affiliation":[{"name":"Department of Animal Reproduction, Faculty of Veterinary Medicine and Animal Science, University of S\u00e3o Paulo , Pirassununga, SP ,","place":["Brazil"]},{"name":"Department of Animal Science, Texas A&M University , College Station, TX ,","place":["USA"]},{"name":"Department of Animal Science, Luiz de Queiroz College of Agriculture, University of S\u00e3o Paulo , Piracicaba, SP ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"West","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Texas A&M University , College Station, TX ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viviana","family":"Garza","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Texas A&M University , College Station, TX ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Sustaita-Monroe","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Texas A&M University , College Station, TX ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie","family":"King","sequence":"additional","affiliation":[{"name":"Department of Animal Reproduction, Faculty of Veterinary Medicine and Animal Science, University of S\u00e3o Paulo , Pirassununga, SP ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haley","family":"Sellers","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Texas A&M University , College Station, TX ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morgan","family":"Weynand","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Texas A&M University , College Station, TX ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayden","family":"Feist","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Texas A&M University , College Station, TX ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0102-9046","authenticated-orcid":false,"given":"George","family":"Perry","sequence":"additional","affiliation":[{"name":"Texas A&M AgriLife Research and Extension Center , Overton, TX ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6917-0057","authenticated-orcid":false,"given":"Roberto","family":"Sartori","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Luiz de Queiroz College of Agriculture, University of S\u00e3o Paulo , Piracicaba, SP ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2466-5205","authenticated-orcid":false,"given":"Rodolfo C","family":"Cardoso","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Texas A&M University , College Station, TX 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