{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:03:21Z","timestamp":1792785801720,"version":"4.5.0"},"reference-count":69,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Hagler Institute of Advanced Study of Texas A&M University","id":[{"id":"https:\/\/ror.org\/01f5ytq51","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Blastocyst implantation is associated with quasi-inflammatory reactions in the endometrium, which are resolved during the establishment of the definitive placenta. Quasi-inflammatory processes have also been documented in pregnant pigs, even though the blastocyst only attaches to, rather than implants into the endometrium. We asked what processes lead to the resolution of attachment-associated inflammation. In wound healing the transition toward an anti-inflammatory state includes the transition from M1 to M2 polarized macrophages. In order to determine whether this scenario applies also to the peri-attachment porcine uterus, we produced a series of bulk transcriptomes spanning days 13\u201325 of gestation. We found slower changes in the transcriptome between D20 and D25 than prior to D20, suggesting a turning point in pregnancy-related endometrial reprogramming. This period corresponds to the firm attachment of trophectoderm to the uterine epithelium and the cessation of interferon gamma, IFNG, signaling from the blastocyst. We found increased expression of genes implicated in resolution of inflammation and M2 polarization such as ARG1, MRC1, CD86, TGFb1, and IL10, and an increase in expression of HGPD, the enzyme metabolizing prostaglandins. While immunoreactivity for ARG1 was found in putative macrophages, other M2 markers were localized to non-immune cells: MRC1 in fibroblast-like stromal cells, CD86 on trophoblast cells, and IL10 in endometrial epithelia. CD86 undergoes trogocytosis into the luminal epithelium by D25. These results suggest that intrauterine immune regulation is decoupled from that of the rest of the body by engaging non-immune cells as anti-inflammatory mediators during the peri-attachment period of porcine pregnancy.<\/jats:p>","DOI":"10.1093\/biolre\/ioag208","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T12:01:03Z","timestamp":1790164863000},"source":"Crossref","is-referenced-by-count":0,"title":["Conceptus attachment coincides with initiation of an anti-inflammatory cytokine profile in the pig endometrium"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3097-002X","authenticated-orcid":false,"given":"G\u00fcnter P","family":"Wagner","sequence":"first","affiliation":[{"name":"Department of Ecology and Evolutionary Biology, Yale University , New Haven, CT 06511 ,","place":["USA"]},{"name":"Department of Evolutionary Biology, University of Vienna , A-1030 Vienna ,","place":["Austria"]},{"name":"Department of Animal Science, Texas A&M University , College Station, TX 77843 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thaina","family":"Minela","sequence":"additional","affiliation":[{"name":"Department of Veterinary Integrative Biosciences, Texas A&M University , College Station, TX 77843 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-0763-9727","authenticated-orcid":false,"given":"Alexandria","family":"Ross","sequence":"additional","affiliation":[{"name":"Department of Veterinary Integrative Biosciences, Texas A&M University , College Station, TX 77843 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Engelhardt","sequence":"additional","affiliation":[{"name":"Department of Evolutionary Biology, University of Vienna , A-1030 Vienna ,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5823-5086","authenticated-orcid":false,"given":"Fuller W","family":"Bazer","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Texas A&M University , College Station, TX 77843 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1949-1797","authenticated-orcid":false,"given":"Gregory A","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Veterinary Integrative Biosciences, Texas A&M University , College Station, TX 77843 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,9,23]]},"reference":[{"key":"2026101511513040900_ref1","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.diff.2013.11.005","article-title":"Pig blastocyst-uterine 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