{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T18:49:09Z","timestamp":1792349349609,"version":"4.4.0"},"reference-count":58,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The transient receptor potential cation channel subfamily V member 1 (Trpv1) is a polymodal sensor of noxious stimuli, including heat and pain. However, its contribution to mammalian reproductive physiology remains incompletely understood. Here, we evaluated reproductive phenotypes and transcriptomic responses in a Trpv1-knockout mouse model under normal and heat-stress (HS) conditions. Vaginal-smear profiling showed altered estrous cyclicity in Trpv1-deficient females. Bulk RNA-seq and Smart-seq2 analyses identified tissue- and condition-dependent gene-expression changes associated with Trpv1 deficiency, including extracellular-matrix-related transcriptional signatures in heat-stressed oocytes. In males, Trpv1 deficiency was associated with altered sperm-motility measurements under heat stress, changes in steroidogenesis-related transcripts, and testicular stress-response signatures. These findings identify candidate molecular pathways associated with Trpv1 deficiency and thermal challenge. Further studies, including mating, fertilization, embryo-development, protein-level, and cellular functional assays, are required to determine the consequences for gamete competence and fertility.<\/jats:p>","DOI":"10.1093\/biolre\/ioag217","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T12:00:37Z","timestamp":1790769637000},"source":"Crossref","is-referenced-by-count":0,"title":["Reproductive phenotypes and transcriptomic responses associated with\n                    <i>Trpv1<\/i>\n                    deficiency in mice"],"prefix":"10.1093","author":[{"given":"Penghao","family":"Li","sequence":"first","affiliation":[{"name":"Jinxin Research Institute for Reproductive Medicine and Genetics, Sichuan Jinxin Xinan Women's and Children's Hospital , Chengdu, Sichuan ,","place":["People's Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingyu","family":"Luo","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Sichuan Agricultural University , Chengdu, Sichuan ,","place":["People's Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Chengdu University , Chengdu, Sichuan ,","place":["People's Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7490-3550","authenticated-orcid":false,"given":"Diyan","family":"Li","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Chengdu University , Chengdu, Sichuan ,","place":["People's Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,10,1]]},"reference":[{"key":"2026101814013438300_ref1","doi-asserted-by":"publisher","first-page":"184","DOI":"10.2174\/1567202614666170313105337","article-title":"Warming up to new possibilities with the capsaicin 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