{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T13:30:18Z","timestamp":1793539818196,"version":"4.5.0"},"reference-count":77,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T00:00:00Z","timestamp":1791590400000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004281","name":"National Science Centre","doi-asserted-by":"publisher","award":["2020\/39\/D\/NZ9\/01742"],"award-info":[{"award-number":["2020\/39\/D\/NZ9\/01742"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Placenta insufficiency, arising from impaired trophoblast (Tr) function, contributes to early embryo loss and fetal growth restriction. Sirtuin (SIRT) 1 and SIRT6 are redox modulators in early embryonic development, yet their roles in porcine Tr remain unclear. This study examined the expression and roles of SIRT1\/6 in porcine Tr during early pregnancy. Conceptus and Tr tissues from days 12 to 30 pregnant gilts were analyzed for SIRT1\/6 expression. Then, day-15 Tr cells were treated with SIRT1\/6 modulators to assess gene expression, cell viability, cell-cycle proteins, cell adhesion, cytokine synthesis, and reactive oxygen species (ROS) generation under control and hydrogen peroxide (H2O2)-induced oxidative stress. SIRT1 mRNA expression increased with placenta development (days 15\u201330 of gestation), while its protein levels remained unchanged. SIRT6 protein abundance was greater during implantation (day-15 conceptuses) and at placentation onset (day-20 Tr) compared with day-30 Tr. SIRT1 activation stimulated mRNA expression of mitochondrial biogenesis regulators (NFE2L2, TFAM) and respiratory chain components (MT-ND1-2, MT-ATP6\/8). The SIRT6 activator induced NRF1, TFAM, and all 13 mitochondrial respiratory subunit genes (MT-ND1-6, MT-CYB, MT-CO1-3, MT-ATP6\/8). Both activators stimulated cell proliferation, possibly by shortening mitosis as evidenced by reduced phospho-H3-S10 levels. IL6 synthesis was upregulated, while IFN\u03b3 production was decreased in these cells. SIRT6 activation counteracted H2O2-induced oxidative stress, reducing ROS and supporting cell viability, while amplifying stress-induced mitochondrial pathways. In conclusion, SIRT1\/6 may support porcine Tr development and function. SIRT6 appears to modulate the response of peri-implantation conceptuses to oxidative stress, suggesting its potential as a target for improving prenatal survival.<\/jats:p>","DOI":"10.1093\/biolre\/ioag227","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T11:47:26Z","timestamp":1791546446000},"source":"Crossref","is-referenced-by-count":0,"title":["Expression and role of SIRT1 and SIRT6 in porcine conceptus and trophoblasts: relevance to early placenta development"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7159-2256","authenticated-orcid":false,"given":"Magdalena","family":"Szymanska","sequence":"first","affiliation":[{"name":"InLife Institute of Animal Reproduction and Food Research, Polish Academy of Sciences , Olsztyn,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9852-0079","authenticated-orcid":false,"given":"Agnieszka","family":"Blitek","sequence":"additional","affiliation":[{"name":"InLife Institute of Animal Reproduction and Food Research, Polish Academy of Sciences , Olsztyn,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,10,10]]},"reference":[{"key":"2026110107414792200_ref1","doi-asserted-by":"publisher","first-page":"48","DOI":"10.2527\/af.2013-0033","article-title":"Early pregnancy: concepts, challenges, and potential solutions","volume":"3","author":"Spencer","year":"2013","journal-title":"Anim Front"},{"key":"2026110107414792200_ref2","doi-asserted-by":"publisher","first-page":"E195","DOI":"10.2527\/jas.2009-2446","article-title":"Impacts of amino acid nutrition on pregnancy outcome in pigs: mechanisms and implications for swine 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