{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T15:10:21Z","timestamp":1789312221258,"version":"build-2803163510"},"reference-count":72,"publisher":"Oxford University Press (OUP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1093\/biolre\/iox021","type":"journal-article","created":{"date-parts":[[2017,4,5]],"date-time":"2017-04-05T15:26:24Z","timestamp":1491405984000},"page":"921-935","source":"Crossref","is-referenced-by-count":18,"title":["Epididymal CYP2E1 plays a critical role in acrylamide-induced DNA damage in spermatozoa and paternally mediated embryonic resorptions\u2020"],"prefix":"10.1093","volume":"96","author":[{"given":"Aimee Lee","family":"Katen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Sipil\u00e4","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa A.","family":"Mitchell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone J.","family":"Stanger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brett","family":"Nixon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaun D.","family":"Roman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,3,31]]},"reference":[{"key":"key\n\t\t\t\t20170519010025_bib1","volume-title":"Risk Assessment of Acrylamide (In Swedish) Report PM 7\/98","year":"1998"},{"key":"key\n\t\t\t\t20170519010025_bib2","doi-asserted-by":"crossref","first-page":"125","DOI":"10.5271\/sjweh.1878","article-title":"Neurological and electroneuromyographic assessment of the adverse effects of acrylamide on occupationally exposed workers","volume":"15","year":"1989","journal-title":"Scand J Work Environ Health"},{"key":"key\n\t\t\t\t20170519010025_bib3","first-page":"389","article-title":"Some industrial chemicals","volume-title":"IARC Monographs on the evaluation of carcinogenic risks to human","author":"IARC. International Agency for Research on Cancer","year":"1994"},{"key":"key\n\t\t\t\t20170519010025_bib4","doi-asserted-by":"crossref","first-page":"4504","DOI":"10.1021\/jf030204+","article-title":"Chemistry, biochemistry, and safety of acrylamide, a review","volume":"51","year":"2003","journal-title":"J Agr Food Chem"},{"key":"key\n\t\t\t\t20170519010025_bib5","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.mrfmmm.2015.04.008","article-title":"The genetic consequences of paternal acrylamide exposure and potential for amelioration","volume":"777","year":"2015","journal-title":"Mutat Res"},{"key":"key\n\t\t\t\t20170519010025_bib6","doi-asserted-by":"crossref","first-page":"219","DOI":"10.5271\/sjweh.608","article-title":"Health effects of occupational exposure to acrylamide using hemoglobin adducts as biomarkers of internal dose","volume":"27","year":"2001","journal-title":"Scand J Work Environ Health"},{"key":"key\n\t\t\t\t20170519010025_bib7","first-page":"45","article-title":"A study on patients treated with polyacrylamide hydrogel injection for facial corrections","volume":"28","year":"2004","journal-title":"Aesthet Plast Surg"},{"key":"key\n\t\t\t\t20170519010025_bib8","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1021\/tx960113p","article-title":"Hemoglobin adducts of acrylamide and acrylonitrile in laboratory workers, smokers and nonsmokers","volume":"10","year":"1997","journal-title":"Chem Res Toxicol"},{"key":"key\n\t\t\t\t20170519010025_bib9","doi-asserted-by":"crossref","first-page":"4998","DOI":"10.1021\/jf020302f","article-title":"Analysis of acrylamide, a carcinogen formed in heated foodstuffs","volume":"50","year":"2002","journal-title":"J Agric Food Chem"},{"key":"key\n\t\t\t\t20170519010025_bib10","doi-asserted-by":"crossref","first-page":"4782","DOI":"10.1021\/jf034180i","article-title":"Acrylamide formation mechanism in heated foods","volume":"51","year":"2003","journal-title":"J Agric Food Chem"},{"key":"key\n\t\t\t\t20170519010025_bib11","article-title":"Summary Report of the Seventy-Second Meeting, Expert Committee on Food Additives, Rome, 16\u201325 February 2010","volume-title":"Rome: Joint FAO\/WHO Expert Committee on Food Additives","author":"JECFA. Joint FAO\/WHO Expert Committee on Food Additives","year":"2010"},{"key":"key\n\t\t\t\t20170519010025_bib12","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1093\/carcin\/16.5.1161","article-title":"Formation of N-7-(2-carbamoyl-2-hydroxyethyl)guanine in DNA of the mouse and the rat following intraperitoneal administration of [14C]acrylamide","volume":"16","year":"1995","journal-title":"Carcinogenesis"},{"key":"key\n\t\t\t\t20170519010025_bib13","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1093\/mutage\/2.3.215","article-title":"Comparison of the dominant lethal effects of acrylonitrile and acrylamide in male Fischer 344 rats","volume":"2","year":"1987","journal-title":"Mutagenesis"},{"key":"key\n\t\t\t\t20170519010025_bib14","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1093\/mutage\/15.2.133","article-title":"1-Aminobenzotriazole inhibits acrylamide-induced dominant lethal effects in spermatids of male mice","volume":"15","year":"2000","journal-title":"Mutagenesis"},{"key":"key\n\t\t\t\t20170519010025_bib15","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/0165-7992(92)90106-R","article-title":"Reevaluation of the induction of specific-locus mutations in spermatogonia of the mouse by acrylamide","volume":"283","year":"1992","journal-title":"Mutat Res Lett"},{"key":"key\n\t\t\t\t20170519010025_bib16","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/0165-7992(86)90008-4","article-title":"Dominant lethal effects of acrylamide in male mice","volume":"173","year":"1986","journal-title":"Mutat Res"},{"key":"key\n\t\t\t\t20170519010025_bib17","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1093\/toxsci\/kfi307","article-title":"Role of CYP2E1 in the epoxidation of acrylamide to glycidamide and formation of DNA and hemoglobin adducts","volume":"88","year":"2005","journal-title":"Toxicol Sci"},{"key":"key\n\t\t\t\t20170519010025_bib18","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1095\/biolreprod.104.033308","article-title":"Comparison of germ cell mutagenicity in male CYP2E1-null and wild-type mice treated with acrylamide: evidence supporting a glycidamide-mediated effect","volume":"72","year":"2005","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170519010025_bib19","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0165-1218(96)90106-8","article-title":"Dominant lethal mutations, heritable translocations, and unscheduled DNA synthesis induced in male mouse germ cells by glycidamide, a metabolite of acrylamide","volume":"371","year":"1996","journal-title":"Mutat Res"},{"key":"key\n\t\t\t\t20170519010025_bib20","first-page":"1","article-title":"Mouse spermatocytes express CYP2E1 and respond to acrylamide exposure","volume":"9","year":"2014","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20170519010025_bib21","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1093\/toxsci\/kfs178","article-title":"Chronic exposure to acrylamide induces DNA damage in male germ cells of mice","volume":"129","year":"2012","journal-title":"Toxicol Sci"},{"key":"key\n\t\t\t\t20170519010025_bib22","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.gdata.2015.09.012","article-title":"Assessment of microRNA expression in mouse epididymal epithelial cells and spermatozoa by next generation sequencing","volume":"6","year":"2015","journal-title":"Genom Data"},{"key":"key\n\t\t\t\t20170519010025_bib23","doi-asserted-by":"crossref","first-page":"2597","DOI":"10.1093\/humrep\/dev214","article-title":"The impact of oxidative stress on chaperone-mediated human sperm\u2013egg interaction","volume":"30","year":"2015","journal-title":"Human Reprod"},{"key":"key\n\t\t\t\t20170519010025_bib24","first-page":"86","article-title":"The culture of mouse embryos in vitro","volume-title":"Methods in Mammalian Embryology","year":"1971"},{"key":"key\n\t\t\t\t20170519010025_bib25","article-title":"Estimating the maximum safe starting dose in initial clinical trials for therapeutics in adult healthy volunteers","author":"Food and Drug Administration","year":"2005"},{"key":"key\n\t\t\t\t20170519010025_bib26","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1096\/fj.07-9574LSF","article-title":"Dose translation from animal to human studies revisited","volume":"22","year":"2008","journal-title":"FASEB J"},{"key":"key\n\t\t\t\t20170519010025_bib27","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0027-5107(00)00075-0","article-title":"Microgels for estimation of DNA strand breaks, DNA protein crosslinks and apoptosis","volume":"455","year":"2000","journal-title":"Mutat Res"},{"key":"key\n\t\t\t\t20170519010025_bib28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.reprotox.2016.05.004","article-title":"Chronic acrylamide exposure in male mice induces DNA damage to spermatozoa; Potential for amelioration by resveratrol","volume":"63","year":"2016","journal-title":"Reprod Toxicol"},{"key":"key\n\t\t\t\t20170519010025_bib29","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/0041-008X(91)90036-E","article-title":"Formation of hemoglobin adducts of acrylamide and its epoxide metabolite glycidamide in the rat","volume":"111","year":"1991","journal-title":"Toxicol Appl Pharmacol"},{"key":"key\n\t\t\t\t20170519010025_bib30","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1210\/en.2003-0831","article-title":"Immortalization of epididymal epithelium in transgenic mice expressing simian virus 40 T antigen: characterization of cell lines and regulation of the polyoma enhancer activator 3","volume":"145","year":"2004","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170519010025_bib31","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.bcp.2016.09.015","article-title":"Analysis of the effects of polyphenols on human spermatozoa reveals unexpected impacts on mitochondrial membrane potential, oxidative stress and DNA integrity; implications for assisted reproductive technology","volume":"121","year":"2016","journal-title":"Biochem Pharmacol"},{"key":"key\n\t\t\t\t20170519010025_bib32","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1095\/biolreprod.109.076836","article-title":"DNA damage in human spermatozoa is highly correlated with the efficiency of chromatin remodeling and the formation of 8-hydroxy-2\u0384-deoxyguanosine, a marker of oxidative stress","volume":"81","year":"2009","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170519010025_bib33","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1093\/mutage\/gel019","article-title":"hOGG1 recognizes oxidative damage using the comet assay with greater specificity than FPG or ENDOIII","volume":"21","year":"2006","journal-title":"Mutagenesis"},{"key":"key\n\t\t\t\t20170519010025_bib34","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1002\/ajim.4700190406","article-title":"Acrylamide neuropathy in a South African factory: an epidemiologic investigation","volume":"19","year":"1991","journal-title":"Am J Ind Med"},{"key":"key\n\t\t\t\t20170519010025_bib35","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1136\/pgmj.53.615.16","article-title":"Acrylamide poisoning","volume":"53","year":"1977","journal-title":"Postgraduate Med J"},{"key":"key\n\t\t\t\t20170519010025_bib36","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1136\/bmj.4.5572.134","article-title":"Six cases of acrylamide poisoning","volume":"4","year":"1967","journal-title":"BMJ"},{"key":"key\n\t\t\t\t20170519010025_bib37","doi-asserted-by":"crossref","first-page":"21","DOI":"10.5271\/sjweh.761","article-title":"Effects on the peripheral nervous system of tunnel workers exposed to acrylamide and N-methylolacrylamide","volume":"30","year":"2004","journal-title":"Scand J Work Environ Health"},{"key":"key\n\t\t\t\t20170519010025_bib38","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1517\/17425255.2.6.875","article-title":"Species differences between mouse, rat, dog, monkey and human CYP-mediated drug metabolism, inhibition and induction","volume":"2","year":"2006","journal-title":"Expert Opin Drug Metab Toxicol"},{"key":"key\n\t\t\t\t20170519010025_bib39","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1038\/clpt.2008.50","article-title":"Mice as clinically relevant models for the study of cytochrome P450\u2010dependent metabolism","volume":"83","year":"2008","journal-title":"Clin Pharmacol Ther"},{"key":"key\n\t\t\t\t20170519010025_bib40","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0009-2797(97)00068-9","article-title":"Comparisons of catalytic selectivity of cytochrome P450 subfamily enzymes from different species","volume":"106","year":"1997","journal-title":"Chem Biol Interact"},{"key":"key\n\t\t\t\t20170519010025_bib41","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.mrfmmm.2005.05.004","article-title":"Absence of acrylamide-induced genotoxicity in CYP2E1-null mice: evidence consistent with a glycidamide-mediated effect","volume":"578","year":"2005","journal-title":"Mutat Res"},{"key":"key\n\t\t\t\t20170519010025_bib42","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.taap.2005.01.060","article-title":"How do male germ cells handle DNA damage? Toxicol","volume":"207","year":"2005","journal-title":"Appl Pharmacol"},{"key":"key\n\t\t\t\t20170519010025_bib43","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1093\/nar\/29.8.1791","article-title":"Nucleotide excision repair in rat male germ cells: low level of repair in intact cells contrasts with high dual incision activity in vitro","volume":"29","year":"2001","journal-title":"Nucleic Acids Res"},{"key":"key\n\t\t\t\t20170519010025_bib44","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1002\/(SICI)1098-2280(1997)30:4<410::AID-EM6>3.0.CO;2-M","article-title":"Induction of chromosomal aberrations in mouse zygotes by acrylamide treatment of male germ cells and their correlation with dominant lethality and heritable translocations","volume":"30","year":"1997","journal-title":"Environ Mol Mutagen"},{"key":"key\n\t\t\t\t20170519010025_bib45","first-page":"1","article-title":"Chronic acrylamide exposure in male mice results in elevated DNA damage in the germline and heritable induction of CYP2E1 in the testes","volume":"95","year":"2016","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170519010025_bib46","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1002\/em.2860090403","article-title":"Acrylamide: induction of heritable translocations in male mice","volume":"9","year":"1987","journal-title":"Environ Mutagen"},{"key":"key\n\t\t\t\t20170519010025_bib47","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1071\/RD9930361","article-title":"The epididymis and sperm maturation: a perspective","volume":"5","year":"1993","journal-title":"Reprod Fertil Dev"},{"key":"key\n\t\t\t\t20170519010025_bib48","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1095\/biolreprod.102.014845","article-title":"Evidence for trichloroethylene bioactivation and adduct formation in the rat epididymis and efferent ducts","volume":"69","year":"2003","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170519010025_bib49","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1007\/BF00157898","article-title":"Cellular localization of the class I alcohol dehydrogenase transcript in adult rat tissues","volume":"26","year":"1994","journal-title":"Histochem J"},{"key":"key\n\t\t\t\t20170519010025_bib50","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1002\/j.1939-4640.1994.tb00476.x","article-title":"Immunocytochemical Localization of glutathione S\u2010Transferase Yo subunit in the rat testis and epididymis","volume":"15","year":"1994","journal-title":"J Androl"},{"key":"key\n\t\t\t\t20170519010025_bib51","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1093\/toxsci\/kfh066","article-title":"Epoxide hydrolases in the rat epididymis: possible roles in xenobiotic and endogenous fatty acid metabolism","volume":"78","year":"2004","journal-title":"Toxicol Sci"},{"key":"key\n\t\t\t\t20170519010025_bib52","first-page":"2074","article-title":"Epididymis seleno-independent glutathione peroxidase 5 maintains sperm DNA integrity in mice","volume":"119","year":"2009","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t20170519010025_bib53","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/0003-9861(80)90185-X","article-title":"Regulation of indoleamine 2, 3-dioxygenase activity in the small intestine and the epididymis of mice","volume":"203","year":"1980","journal-title":"Arch Biochem Biophys"},{"key":"key\n\t\t\t\t20170519010025_bib54","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1002\/(SICI)1098-2795(199812)51:4<362::AID-MRD2>3.0.CO;2-L","article-title":"GPx3: the plasma\u2010type glutathione peroxidase is expressed under androgenic control in the mouse epididymis and vas deferens","volume":"51","year":"1998","journal-title":"Mol Reprod Dev"},{"key":"key\n\t\t\t\t20170519010025_bib55","first-page":"559","article-title":"Structural organization, chromosomal localization, expression and phylogenetic evaluation of mouse glutathione peroxidase encoding genes","volume":"319","year":"1996","journal-title":"C R Acad Sci III"},{"key":"key\n\t\t\t\t20170519010025_bib56","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1071\/RD9950731","article-title":"The epididymis as protector of maturing spermatozoa","volume":"7","year":"1995","journal-title":"Reprod Fertil Dev"},{"key":"key\n\t\t\t\t20170519010025_bib57","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1046\/j.1439-0272.2000.00393.x","article-title":"Xenobiotic metabolism, genetic polymorphisms and male infertility","volume":"32","year":"2000","journal-title":"Andrologia"},{"key":"key\n\t\t\t\t20170519010025_bib58","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0165-1110(96)90040-8","article-title":"DNA adducts in human carcinogenesis: etiological relevance and structure-activity relationship","volume":"340","year":"1996","journal-title":"Mutat Res"},{"key":"key\n\t\t\t\t20170519010025_bib59","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/taap.1996.8074","article-title":"Selective protein covalent binding and target organ toxicity","volume":"143","year":"1997","journal-title":"Toxicol Appl Pharmacol"},{"key":"key\n\t\t\t\t20170519010025_bib60","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.mrgentox.2004.10.013","article-title":"DNA adducts derived from administration of acrylamide and glycidamide to mice and rats","volume":"580","year":"2005","journal-title":"Mutat Res"},{"key":"key\n\t\t\t\t20170519010025_bib61","first-page":"81","article-title":"Epididymal cell types and their functions","volume-title":"The Epididymis: From Molecules to Clinical Practice","year":"2002"},{"key":"key\n\t\t\t\t20170519010025_bib62","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/0041-008X(86)90373-X","article-title":"The distribution of [14C] acrylamide in male and pregnant Swiss-Webster mice studied by whole-body autoradiography","volume":"86","year":"1986","journal-title":"Toxicol Appl Pharm"},{"key":"key\n\t\t\t\t20170519010025_bib63","first-page":"103","article-title":"Cellular interactions and the blood-epididymal barrier","volume-title":"The Epididymis: from Molecules to Clinical Practice","year":"2002"},{"key":"key\n\t\t\t\t20170519010025_bib64","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/0012-1606(78)90137-9","article-title":"Development of tight junctions in the caput epididymal epithelium of the mouse","volume":"63","year":"1978","journal-title":"Dev Biol"},{"key":"key\n\t\t\t\t20170519010025_bib65","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1095\/biolreprod20.3.511","article-title":"Urea in the seminiferous tubule: evidence for active transport","volume":"20","year":"1979","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170519010025_bib66","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/S0015-0282(16)47368-1","article-title":"The transepithelial movement of 3H-3-O-methyl-D-glucose in the hamster seminiferous and cauda epididymidal tubules","volume":"40","year":"1983","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20170519010025_bib67","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1530\/jrf.0.0630095","article-title":"Permeability characteristics of the epithelium in the rat caput epididymidis","volume":"63","year":"1981","journal-title":"J Reprod Fertil"},{"key":"key\n\t\t\t\t20170519010025_bib68","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/S0022-5347(17)40116-9","article-title":"Transepithelial movement of non-polar and polar compounds in male rat reproductive tubule examined by in vivo microperifusion and in vivo micropuncture","volume":"143","year":"1990","journal-title":"J Urol"},{"key":"key\n\t\t\t\t20170519010025_bib69","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1006\/scdb.1998.0226","article-title":"Post-transcriptional control of gene expression during spermatogenesis","volume":"9","year":"1998","journal-title":"Semin Cell Dev Biol"},{"key":"key\n\t\t\t\t20170519010025_bib70","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1002\/mrd.20039","article-title":"Phospholipid hydroperoxide glutathione peroxidase: expression pattern during testicular development in mouse and evolutionary conservation in spermatozoa","volume":"67","year":"2004","journal-title":"Mol Reprod Dev"},{"key":"key\n\t\t\t\t20170519010025_bib71","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.tox.2015.10.001","article-title":"Subcellular localization of rat CYP2E1 impacts metabolic efficiency toward common substrates","volume":"338","year":"2015","journal-title":"Toxicology"},{"key":"key\n\t\t\t\t20170519010025_bib72","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1517\/17425255.2010.503955","article-title":"Bimodal targeting of microsomal cytochrome P450s to mitochondria: implications in drug metabolism and toxicity","volume":"6","year":"2010","journal-title":"Expert Opin Drug Metab Toxicol"}],"container-title":["Biology of Reproduction"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/biolreprod\/article-pdf\/96\/4\/921\/17232426\/iox021.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,23]],"date-time":"2024-06-23T12:35:16Z","timestamp":1719146116000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/biolreprod\/article-lookup\/doi\/10.1093\/biolre\/iox021"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,31]]},"references-count":72,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2017,3,31]]},"published-print":{"date-parts":[[2017,4]]}},"URL":"https:\/\/doi.org\/10.1093\/biolre\/iox021","relation":{},"ISSN":["0006-3363","1529-7268"],"issn-type":[{"value":"0006-3363","type":"print"},{"value":"1529-7268","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,31]]}}}