{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T14:15:36Z","timestamp":1790950536767,"version":"4.1.0"},"reference-count":53,"publisher":"Oxford University Press (OUP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,8,1]]},"DOI":"10.1093\/biolre\/iox085","type":"journal-article","created":{"date-parts":[[2017,7,29]],"date-time":"2017-07-29T06:57:07Z","timestamp":1501311427000},"page":"324-333","source":"Crossref","is-referenced-by-count":50,"title":["Molecular regulation of sex change induced by methyltestosterone -feeding and methyltestosterone -feeding withdrawal in the protogynous orange-spotted grouper\u2020"],"prefix":"10.1093","volume":"97","author":[{"given":"Qing","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dengdong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haifa","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huihong","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuisheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoran","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,7,29]]},"reference":[{"key":"key\n\t\t\t\t20171009001711_bib1","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1146\/annurev.physiol.60.1.497","article-title":"Sex in the 90s: SRY and the switch to the male pathway","volume":"60","year":"1998","journal-title":"Annu Rev Physiol"},{"key":"key\n\t\t\t\t20171009001711_bib2","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1002\/dvg.1020150310","article-title":"Temperature-dependent sex determination in reptiles: proximate mechanisms, ultimate outcomes, and practical applications","volume":"15","year":"1994","journal-title":"Dev Genet"},{"key":"key\n\t\t\t\t20171009001711_bib3","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.semcdb.2008.10.003","article-title":"Sex determination in amphibians","volume":"20","year":"2009","journal-title":"Semin Cell Dev Biol"},{"key":"key\n\t\t\t\t20171009001711_bib4","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0044-8486(02)00057-1","article-title":"Sex determination and sex differentiation in fish: an overview of genetic, physiological, and environmental influences","volume":"208","year":"2002","journal-title":"Aquaculture"},{"key":"key\n\t\t\t\t20171009001711_bib5","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.2108\/zsj.22.1163","article-title":"Sex reversal in the medaka Oryzias latipes by brief exposure of early embryos to estradiol-17\u03b2","volume":"22","year":"2005","journal-title":"Zoolog Sci"},{"key":"key\n\t\t\t\t20171009001711_bib6","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1159\/000074351","article-title":"Induction of XY sex reversal by estrogen involves altered gene expression in a teleost, tilapia","volume":"101","year":"2003","journal-title":"Cytogenet Genome Res"},{"key":"key\n\t\t\t\t20171009001711_bib7","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0044-8486(01)00589-0","article-title":"Endocrine sex control strategies for the feminization of teleost fish","volume":"197","year":"2001","journal-title":"Aquaculture"},{"key":"key\n\t\t\t\t20171009001711_bib8","first-page":"288","article-title":"Transient sex change in the immature Malabar grouper, Epinephelus malabaricus, androgen treatment","volume":"91","year":"2014","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20171009001711_bib9","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1210\/en.2013-1959","article-title":"Transdifferentiation of differentiated ovary into functional testis by long-term treatment of aromatase inhibitor in Nile tilapia","volume":"155","year":"2014","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20171009001711_bib10","first-page":"3738","article-title":"Estrogen oversees the maintenance of the female genetic program in terminally differentiated gonochorists","volume":"3","year":"2013","journal-title":"Sci Rep"},{"key":"key\n\t\t\t\t20171009001711_bib11","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.ygcen.2008.02.003","article-title":"Sex change of adult initial-phase male wrasse, Halichoeres trimaculatus by estradiol-17\u03b2 treatment","volume":"156","year":"2008","journal-title":"Gen Comp Endocrinol"},{"key":"key\n\t\t\t\t20171009001711_bib12","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1002\/mrd.20027","article-title":"Aromatase inhibitor induces complete sex change in the protogynous honeycomb grouper (Epinephelus merra)","volume":"67","year":"2004","journal-title":"Mol Reprod Dev"},{"key":"key\n\t\t\t\t20171009001711_bib13","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.cbpb.2012.04.011","article-title":"Molecular identification of an androgen receptor and its changes in mRNA levels during 17\u03b1-methyltestosterone-induced sex reversal in the orange-spotted grouper Epinephelus coioides","volume":"163","year":"2012","journal-title":"Comp Biochem Phys B"},{"key":"key\n\t\t\t\t20171009001711_bib14","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.mce.2004.03.007","article-title":"Differential expression of thyroid-stimulating hormone beta subunit in gonads during sex reversal of orange-spotted and red-spotted groupers","volume":"220","year":"2004","journal-title":"Mol Cell Endocrinol"},{"key":"key\n\t\t\t\t20171009001711_bib15","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.ygcen.2005.06.014","article-title":"Suppression of steroidogenic enzyme expression during androgen-induced sex reversal in Nile tilapia (Oreochromis niloticus)","volume":"145","year":"2006","journal-title":"Gen Comp Endocrinol"},{"key":"key\n\t\t\t\t20171009001711_bib16","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1095\/biolreprod.109.080044","article-title":"Molecular identification of the kiss2\/kiss1ra system and its potential function during 17alpha-methyltestosterone-induced sex reversal in the orange-spotted grouper, Epinephelus coioides1","volume":"83","year":"2010","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20171009001711_bib17","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ygcen.2015.04.016","article-title":"Molecular identification of GnIH\/GnIHR signal and its reproductive function in protogynous hermaphroditic orange-spotted grouper (Epinephelus coioides)","volume":"216","year":"2015","journal-title":"Gen Comp Endocrinol"},{"key":"key\n\t\t\t\t20171009001711_bib18","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1002\/mrd.21319","article-title":"Expression profiles of gonadotropins and their receptors during 17\u03b1-methyltestosterone implantation-induced sex change in the orange-spotted grouper","volume":"78","year":"2011","journal-title":"Mol Reprod Dev"},{"key":"key\n\t\t\t\t20171009001711_bib19","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1002\/mrd.20642","article-title":"The mRNA expression of p450 aromatase, gonadotropin beta-subunits and ftz-f1 in the orange-spotted grouper (epinephelus coioides) during 17alpha-methyltestosterone-induced precocious sex change","volume":"74","year":"2007","journal-title":"Mol Reprod Dev"},{"key":"key\n\t\t\t\t20171009001711_bib20","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1111\/j.1365-2109.2005.01453.x","article-title":"Gonadal development, aromatase activity and p450 aromatase gene expression during sex inversion of protogynous red-spotted grouper epinephelus akaara, (temminck and schlegel) after implantation of the aromatase inhibitor, fadrozole","volume":"37","year":"2006","journal-title":"Aquac Res"},{"key":"key\n\t\t\t\t20171009001711_bib21","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.jsbmb.2004.05.010","article-title":"Two distinct cytochrome p450 aromatases in the orange-spotted grouper (epinephelus coioides): cDNA cloning and differential mRNA expression","volume":"92","year":"2004","journal-title":"J Steroid Biochem"},{"key":"key\n\t\t\t\t20171009001711_bib22","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1002\/bies.201600045","article-title":"Germline stem cells are critical for sexual fate decision of germ cells","volume":"38","year":"2016","journal-title":"Bioessays"},{"key":"key\n\t\t\t\t20171009001711_bib23","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1159\/000447313","article-title":"A structurally and functionally common unit in testes and ovaries of medaka (Oryzias latipes), a teleost fish","volume":"10","year":"2016","journal-title":"Sex Dev"},{"key":"key\n\t\t\t\t20171009001711_bib24","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/BF00001282","article-title":"Histological and ultrastructural evidence for the role of gonadal steroid hormones in sex change in the protogynous wrasse Thalassoma duperrey","volume":"24","year":"1989","journal-title":"Environ Biol Fish"},{"key":"key\n\t\t\t\t20171009001711_bib25","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1006\/gcen.1995.1166","article-title":"Stimulation of spermatogenesis or of sex reversal according to the dose of exogenous estradiol-17\u03b2 in juvenile males of protandrous black porgy, Acanthopagrus schlegeli","volume":"100","year":"1995","journal-title":"Gen Comp Endocrinol"},{"key":"key\n\t\t\t\t20171009001711_bib26","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.ygcen.2009.11.003","article-title":"Sex differentiation and sex change in the protandrous black porgy, Acanthopagrus schlegeli","volume":"167","year":"2010","journal-title":"Gen Comp Endocrinol"},{"key":"key\n\t\t\t\t20171009001711_bib27","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/S0167-4781(00)00186-X","article-title":"DMRT1 expression during gonadal differentiation and spermatogenesis in the rainbow trout, Oncorhynchus mykiss","volume":"1493","year":"2000","journal-title":"Biochim Biophys Acta"},{"key":"key\n\t\t\t\t20171009001711_bib28","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1095\/biolreprod.105.041830","article-title":"Large-scale temporal gene expression profiling during gonadal differentiation and early gametogenesis in rainbow trout","volume":"73","year":"2005","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20171009001711_bib29","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1002\/mrd.10145","article-title":"Molecular cloning and expression during spermatogenesis of a cDNA encoding testicular 11\u03b2-hydroxylase (P45011\u03b2) in rainbow trout (Oncorhynchus mykiss)","volume":"62","year":"2002","journal-title":"Mol Reprod Dev"},{"key":"key\n\t\t\t\t20171009001711_bib30","doi-asserted-by":"crossref","first-page":"2198","DOI":"10.1002\/dvdy.21212","article-title":"Characterization of early molecular sex differentiation in rainbow trout, Oncorhynchus mykiss","volume":"236","year":"2007","journal-title":"Dev Dyn"},{"key":"key\n\t\t\t\t20171009001711_bib31","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1080\/10641260802324644","article-title":"Fish gonadogenesis. Part II: molecular biology and genomics of sex differentiation","volume":"16","year":"2008","journal-title":"Rev Fish Sci"},{"key":"key\n\t\t\t\t20171009001711_bib32","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.ygcen.2009.03.002","article-title":"Ovarian aromatase and estrogens: a pivotal role for gonadal sex differentiation and sex change in fish","volume":"165","year":"2010","journal-title":"Gen Comp Endocrinol"},{"key":"key\n\t\t\t\t20171009001711_bib33","first-page":"221","article-title":"Testicular dmrt1 is involved in the sexual fate of the ovotestis in the protandrous black porgy","volume":"86","year":"2012","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20171009001711_bib34","first-page":"19","article-title":"Identification of the molecular sex-differentiation period in the siberian sturgeon","volume":"83","year":"2015","journal-title":"Mol Reprod Dev"},{"key":"key\n\t\t\t\t20171009001711_bib35","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.aquaculture.2008.10.027","article-title":"Gonad development during sexual differentiation in hatchery-produced orange-spotted grouper (Epinephelus coioides) and humpback grouper (Cromileptes altivelis) (pisces: Serranidae, Epinephelinae)","volume":"287","year":"2009","journal-title":"Aquaculture"},{"key":"key\n\t\t\t\t20171009001711_bib36","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.mce.2006.09.014","article-title":"Differential and spermatogenic cell-specific expression of DMRT1 during sex reversal in protogynous hermaphroditic groupers","volume":"263","year":"2007","journal-title":"Mol Cell Endocrinol"},{"key":"key\n\t\t\t\t20171009001711_bib37","doi-asserted-by":"crossref","first-page":"909","DOI":"10.2108\/zsj.13.909","article-title":"Antibodies against trout 3b-hydroxysteroid dehydrogenase: their preparation and immunocytochemical use for fish steroidogenic tissue","volume":"13","year":"1996","journal-title":"Zool Sci"},{"key":"key\n\t\t\t\t20171009001711_bib38","first-page":"693","article-title":"Development of gonadal tissue and aromatase function in the protogynous orange-spotted grouper Epinephelus coioides","volume":"50","year":"2011","journal-title":"Zool Stud"},{"key":"key\n\t\t\t\t20171009001711_bib39","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1111\/j.1095-8649.2001.tb00544.x","article-title":"Reproduction in the dusky grouper from the southern Mediterranean","volume":"58","year":"2001","journal-title":"J Fish Biol"},{"key":"key\n\t\t\t\t20171009001711_bib40","doi-asserted-by":"crossref","first-page":"e0145438","DOI":"10.1371\/journal.pone.0145438","article-title":"Sexual fate reprogramming in the steroid-induced bi-directional sex change in the protogynous orange-spotted grouper, Epinephelus coioides","volume":"10","year":"2015","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20171009001711_bib41","first-page":"357","article-title":"Androgens stimulate sex change in protogynous grouper, Epinephelus coioides: spawning performance in sex-changed males","volume":"135","year":"2003","journal-title":"Comp Biochem Physiol C"},{"key":"key\n\t\t\t\t20171009001711_bib42","first-page":"171","article-title":"Effects of 17a-methyltestosterone on sex reversal in Epinephelus akaara","volume":"16","year":"1992","journal-title":"J Fish China"},{"key":"key\n\t\t\t\t20171009001711_bib43","doi-asserted-by":"crossref","first-page":"65","DOI":"10.2108\/zsj.23.65","article-title":"Induction of female-to-male sex change in the honeycomb grouper (Epinephelus merra) by 11-ketotestosterone treatments","volume":"23","year":"2006","journal-title":"Zool Sci"},{"key":"key\n\t\t\t\t20171009001711_bib44","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.aquaculture.2006.01.034","article-title":"Permanent sex inversion in 1-year-old juveniles of the protogynous dusky grouper (Epinephelus marginatus) using controlled-release 17a-methyltestosterone implants","volume":"256","year":"2006","journal-title":"Aquaculture"},{"key":"key\n\t\t\t\t20171009001711_bib45","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1002\/dvdy.20335","article-title":"Novel steroidogenic factor-1 homolog (ff1d) is coexpressed with anti-Mullerian hormone (AMH) in zebrafish","volume":"233","year":"2005","journal-title":"Dev Dyn"},{"key":"key\n\t\t\t\t20171009001711_bib46","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.2108\/zsj.20.1399","article-title":"Gonadal restricting and correlative steroid hormone profiles during natural sex change in protogynous honeycomb grouper (Epinephelus merra)","volume":"20","year":"2003","journal-title":"Zool Sci"},{"key":"key\n\t\t\t\t20171009001711_bib47","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1095\/biolreprod.107.064246","article-title":"Sexual dimorphic expression of genes in gonads during early differentiation of a teleost fish, the Nile tilapia Oreochromis niloticus","volume":"78","year":"2008","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20171009001711_bib48","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1002\/dvdy.21129","article-title":"Anti-M\u00fcllerian hormone and 11 \u03b2-hydroxylase show reciprocal expression to that of aromatase in the transforming gonad of zebrafish males","volume":"236","year":"2007","journal-title":"Dev Dynam"},{"key":"key\n\t\t\t\t20171009001711_bib49","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1002\/mrd.20393","article-title":"Changes in androgen producing cell size and circulating 11-ketotestosterone level during female-male sex change of honeycomb grouper Epinephelus merra","volume":"73","year":"2006","journal-title":"Mol Reprod Dev"},{"key":"key\n\t\t\t\t20171009001711_bib50","doi-asserted-by":"crossref","first-page":"3352","DOI":"10.1021\/cr020456u","article-title":"Chemistry and structural biology of androgen receptor","volume":"105","year":"2005","journal-title":"Chem Rev"},{"key":"key\n\t\t\t\t20171009001711_bib51","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1210\/er.2007-0019","article-title":"Androgen receptor (AR) coregulators: a diversity of functions converging on and regulating the AR transcriptional complex","volume":"28","year":"2007","journal-title":"Endocr Rev"},{"key":"key\n\t\t\t\t20171009001711_bib52","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1210\/me.2006-0248","article-title":"Foxl2 up-regulates aromatase gene transcription in a female-specific manner by binding to the promoter as well as interacting with ad4 binding protein\/steroidogenic factor 1","volume":"21","year":"2007","journal-title":"Mol Endocr"},{"key":"key\n\t\t\t\t20171009001711_bib53","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1126\/science.1185473","article-title":"Identification of germline stem cells in the ovary of the teleost medaka","volume":"328","year":"2010","journal-title":"Science"}],"container-title":["Biology of Reproduction"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/biolreprod\/article-pdf\/97\/2\/324\/20710472\/iox085.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,10,9]],"date-time":"2017-10-09T04:17:22Z","timestamp":1507522642000},"score":1,"resource":{"primary":{"URL":"http:\/\/academic.oup.com\/biolreprod\/article\/97\/2\/324\/4055956\/Molecular-regulation-of-sex-change-induced-by"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,29]]},"references-count":53,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2017,7,29]]},"published-print":{"date-parts":[[2017,8,1]]}},"URL":"https:\/\/doi.org\/10.1093\/biolre\/iox085","relation":{},"ISSN":["0006-3363","1529-7268"],"issn-type":[{"value":"0006-3363","type":"print"},{"value":"1529-7268","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2017,8]]},"published":{"date-parts":[[2017,7,29]]}}}