{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T11:25:54Z","timestamp":1790767554008,"version":"4.1.0"},"reference-count":66,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2018,4,4]],"date-time":"2018-04-04T00:00:00Z","timestamp":1522800000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Homer and Martha Gudelsky Family Foundation, Inc."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,9,1]]},"DOI":"10.1093\/biolre\/ioy078","type":"journal-article","created":{"date-parts":[[2018,4,4]],"date-time":"2018-04-04T11:10:24Z","timestamp":1522840224000},"page":"565-577","source":"Crossref","is-referenced-by-count":90,"title":["Knockout of the Gnrh genes in zebrafish: effects on reproduction and potential compensation by reproductive and feeding-related neuropeptides\u2020"],"prefix":"10.1093","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4043-1887","authenticated-orcid":false,"given":"Miranda","family":"Marvel","sequence":"first","affiliation":[{"name":"Department of Marine Biotechnology, Institute of Marine and Environmental Technology, University of Maryland Baltimore County, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia Smith","family":"Spicer","sequence":"additional","affiliation":[{"name":"Department of Marine Biotechnology, Institute of Marine and Environmental Technology, University of Maryland Baltimore County, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5573-9767","authenticated-orcid":false,"given":"Ten-Tsao","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Marine Biotechnology, Institute of Marine and Environmental Technology, University of Maryland Baltimore County, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nilli","family":"Zmora","sequence":"additional","affiliation":[{"name":"Department of Marine Biotechnology, Institute of Marine and Environmental Technology, University of Maryland Baltimore County, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonathan","family":"Zohar","sequence":"additional","affiliation":[{"name":"Department of Marine Biotechnology, Institute of Marine and Environmental Technology, University of Maryland Baltimore County, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,4,4]]},"reference":[{"issue":"4001","key":"key\n\t\t\t\t20180912023331_bib1","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1126\/science.173.4001.1036","article-title":"Gonadotropin-releasing hormone: one polypeptide regulates secretion of luteinizing and follicle-stimulating hormones","volume":"173","author":"Schally","year":"1971","journal-title":"Science"},{"issue":"3","key":"key\n\t\t\t\t20180912023331_bib2","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.ygcen.2009.04.017","article-title":"Neuroendocrinology of reproduction in teleost fish","volume":"165","author":"Zohar","year":"2010","journal-title":"Gen Comp Endocrinol"},{"issue":"3","key":"key\n\t\t\t\t20180912023331_bib3","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1006\/frne.1999.0181","article-title":"Gonadotropin-releasing hormone genes: phylogeny, structure, and functions","volume":"20","author":"Fernald","year":"1999","journal-title":"Front Neuroendocrinol"},{"issue":"26","key":"key\n\t\t\t\t20180912023331_bib4","doi-asserted-by":"crossref","first-page":"2742","DOI":"10.1056\/NEJMoa0900136","article-title":"Isolated familial hypogonadotropic hypogonadism and a GNRH1 mutation","volume":"360","author":"Bouligand","year":"2009","journal-title":"N Engl J Med"},{"issue":"4","key":"key\n\t\t\t\t20180912023331_bib5","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/0169-328X(89)90076-4","article-title":"Luteinizing hormone-releasing hormone (LHRH)-expressing cells do not migrate normally in an inherited hypogonadal (Kallmann) syndrome","volume":"6","author":"Schwanzel-Fukuda","year":"1989","journal-title":"Mol Brain Res"},{"issue":"4782","key":"key\n\t\t\t\t20180912023331_bib6","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1126\/science.3024317","article-title":"A deletion truncating the gonadotropin-releasing hormone gene is responsible for hypogonadism in the hpg mouse","volume":"234","author":"Mason","year":"1986","journal-title":"Science"},{"issue":"12","key":"key\n\t\t\t\t20180912023331_bib7","doi-asserted-by":"crossref","first-page":"3874","DOI":"10.1073\/pnas.81.12.3874","article-title":"Identification of the second gonadotropin-releasing hormone in chicken hypothalamus: evidence that gonadotropin secretion is probably controlled by two distinct gonadotropin-releasing hormones in avian species.","volume":"81","author":"Miyamoto","year":"1984","journal-title":"Proc Natl Acad Sci USA"},{"issue":"3-4","key":"key\n\t\t\t\t20180912023331_bib8","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S0361-9230(01)00676-1","article-title":"Evolutionary development of three gonadotropin-releasing hormone (GnRH) systems in vertebrates","volume":"57","author":"Dubois","year":"2002","journal-title":"Brain Res Bull"},{"issue":"1","key":"key\n\t\t\t\t20180912023331_bib9","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/0016-6480(90)90155-F","article-title":"Differences in salmon GnRH and chicken GnRH-II contents in discrete brain areas of male and female rainbow trout according to age and stage of maturity","volume":"80","author":"Okuzawa","year":"1990","journal-title":"Gen Comp Endocrinol"},{"issue":"1","key":"key\n\t\t\t\t20180912023331_bib10","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0016-6480(03)00144-8","article-title":"Molecular characterization of the GnRH system in zebrafish (Danio rerio): cloning of chicken GnRH-II, adult brain expression patterns and pituitary content of salmon GnRH and chicken GnRH-II","volume":"133","author":"Steven","year":"2003","journal-title":"Gen Comp Endocrinol"},{"issue":"3","key":"key\n\t\t\t\t20180912023331_bib11","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1006\/gcen.1998.7163","article-title":"Gonadotropin-releasing hormone (GnRH) in ancient teleosts, the bonytongue fishes: putative origin of salmon GnRH","volume":"112","author":"O\u2019Neill","year":"1998","journal-title":"Gen Comp Endocrinol"},{"key":"key\n\t\t\t\t20180912023331_bib12","doi-asserted-by":"crossref","first-page":"122","DOI":"10.3389\/fendo.2012.00122","article-title":"Gonadotropin-releasing hormone 2 suppresses food intake in the zebrafish, Danio rerio","volume":"3","author":"Nishiguchi","year":"2012","journal-title":"Front Endocrin"},{"issue":"3","key":"key\n\t\t\t\t20180912023331_bib13","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1006\/gcen.1999.7377","article-title":"Actions of two forms of gonadotropin releasing hormone and a GnRH antagonist on spawning behavior of the goldfish Carassius auratus","volume":"116","author":"Volkoff","year":"1999","journal-title":"Gen Comp Endocrinol"},{"issue":"5","key":"key\n\t\t\t\t20180912023331_bib14","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.1210\/en.2009-1207","article-title":"The highly conserved gonadotropin-releasing hormone-2 form acts as a melatonin-releasing factor in the pineal of a teleost fish, the European sea bass dicentrarchus labrax","volume":"151","author":"Servili","year":"2010","journal-title":"Endocrinology"},{"issue":"3","key":"key\n\t\t\t\t20180912023331_bib15","doi-asserted-by":"crossref","first-page":"e0174143","DOI":"10.1371\/journal.pone.0174143","article-title":"GnRH-mediated olfactory and visual inputs promote mating-like behaviors in male zebrafish","volume":"12","author":"Li","year":"2017","journal-title":"PLoS One"},{"issue":"6","key":"key\n\t\t\t\t20180912023331_bib16","doi-asserted-by":"crossref","first-page":"e0158141","DOI":"10.1371\/journal.pone.0158141","article-title":"Targeted mutagenesis of the hypophysiotropic Gnrh3 in zebrafish (Danio rerio) reveals no effects on reproductive performance","volume":"11","author":"Spicer","year":"2016","journal-title":"PLoS One"},{"issue":"1-2","key":"key\n\t\t\t\t20180912023331_bib17","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.mce.2011.05.041","article-title":"Genetic counseling for isolated GnRH deficiency","volume":"346","author":"Au","year":"2011","journal-title":"Mol Cell Endocrinol"},{"issue":"1","key":"key\n\t\t\t\t20180912023331_bib18","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1210\/en.2009-0548","article-title":"Targeted gonadotropin-releasing hormone-3 neuron ablation in zebrafish: effects on neurogenesis, neuronal migration, and reproduction","volume":"151","author":"Abraham","year":"2010","journal-title":"Endocrinology"},{"issue":"2","key":"key\n\t\t\t\t20180912023331_bib19","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1210\/en.2014-1204","article-title":"The kiss\/kissr systems are dispensable for zebrafish reproduction: evidence from gene knockout studies","volume":"156","author":"Tang","year":"2015","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20180912023331_bib20","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1210\/en.2016-1540","article-title":"Genetic evidence for multifactorial control of the reproductive axis in zebrafish","volume":"158","author":"Liu","year":"2017","journal-title":"Endocrinology"},{"issue":"35","key":"key\n\t\t\t\t20180912023331_bib21","doi-asserted-by":"crossref","first-page":"8691","DOI":"10.1523\/JNEUROSCI.1775-08.2008","article-title":"Kisspeptin-GPR54 signaling is essential for preovulatory gonadotropin-releasing hormone neuron activation and the luteinizing hormone surge","volume":"28","author":"Clarkson","year":"2008","journal-title":"J Neurosci"},{"issue":"1","key":"key\n\t\t\t\t20180912023331_bib22","doi-asserted-by":"crossref","first-page":"3676","DOI":"10.1038\/srep03676","article-title":"Comprehensive analysis of GnRH2 neuronal projections in zebrafish","volume":"4","author":"Xia","year":"2015","journal-title":"Sci Rep"},{"issue":"5","key":"key\n\t\t\t\t20180912023331_bib23","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1093\/icb\/icn070","article-title":"Four functional GnRH receptors in zebrafish: analysis of structure, signaling, synteny and phylogeny","volume":"48","author":"Tello","year":"2008","journal-title":"Integr Comp Biol"},{"issue":"3","key":"key\n\t\t\t\t20180912023331_bib24","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.yhbeh.2008.04.011","article-title":"Interactions between gonadotropin-releasing hormone (GnRH) and orexin in the regulation of feeding and reproduction in goldfish (Carassius auratus)","volume":"54","author":"Hoskins","year":"2008","journal-title":"Horm Behav"},{"issue":"1","key":"key\n\t\t\t\t20180912023331_bib25","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.peptides.2010.10.013","article-title":"Gonadotropin-releasing hormone II (GnRH II) mediates the anorexigenic actions of \u03b1-melanocyte-stimulating hormone (\u03b1-MSH) and corticotropin-releasing hormone (CRH) in goldfish","volume":"32","author":"Kang","year":"2011","journal-title":"Peptides"},{"key":"key\n\t\t\t\t20180912023331_bib26","volume-title":"The Zebrafish Book, A Guide For The Laboratory Use Of Zebrafish (Danio rerio)","author":"Westerfield","year":"2007","edition":"5th edn"},{"issue":"2","key":"key\n\t\t\t\t20180912023331_bib27","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1002\/jmor.1052180209","article-title":"Stages of oocyte development in the zebrafish,Brachydanio rerio","volume":"218","author":"Selman","year":"1993","journal-title":"J Morphol"},{"issue":"1","key":"key\n\t\t\t\t20180912023331_bib28","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1095\/biolreprod.109.076299","article-title":"Histological and stereological evaluation of zebrafish (Danio rerio) spermatogenesis with an emphasis on spermatogonial generations","volume":"81","author":"Leal","year":"2009","journal-title":"Biol Reprod"},{"issue":"6","key":"key\n\t\t\t\t20180912023331_bib29","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1111\/jfb.12915","article-title":"Genome-wide identification of suitable zebrafish Danio rerio reference genes for normalization of gene expression data by RT-qPCR","volume":"88","author":"Xu","year":"2016","journal-title":"J Fish Biol"},{"key":"key\n\t\t\t\t20180912023331_bib30","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-0348-8979-7","volume-title":"Neuroanatomy of The Zebrafish Brain: A Topological Atlas","author":"Wullimann","year":"1996"},{"issue":"10","key":"key\n\t\t\t\t20180912023331_bib31","doi-asserted-by":"crossref","first-page":"3994","DOI":"10.1210\/en.2016-1356","article-title":"Evolution of the hypothalamic-pituitary-gonadal axis regulation in vertebrates revealed by knockout medaka","volume":"157","author":"Takahashi","year":"2016","journal-title":"Endocrinology"},{"issue":"1-2","key":"key\n\t\t\t\t20180912023331_bib32","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.mce.2009.04.009","article-title":"Endocrine\/paracrine control of zebrafish ovarian development","volume":"312","author":"Clelland","year":"2009","journal-title":"Mol Cell Endocrinol"},{"issue":"1-2","key":"key\n\t\t\t\t20180912023331_bib33","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.mce.2013.12.009","article-title":"Luteinizing hormone and human chorionic gonadotropin: origins of difference","volume":"383","author":"Choi","year":"2014","journal-title":"Mol Cell Endocrinol"},{"issue":"5","key":"key\n\t\t\t\t20180912023331_bib34","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.beem.2017.09.002","article-title":"The hypothalamic\u2013pituitary\u2013thyroid axis and biological rhythms: the discovery of TSH's unexpected role using animal models","volume":"31","author":"Ikegami","year":"2017","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"issue":"4","key":"key\n\t\t\t\t20180912023331_bib35","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1210\/endo.137.4.8625908","article-title":"Glycoprotein hormone alpha-subunit functions synergistically with progesterone to stimulate differentiation of cultured human endometrial stromal cells to decidualized cells: a novel role for free alpha-subunit in reproduction.","volume":"137","author":"Moy","year":"1996","journal-title":"Endocrinology"},{"issue":"4","key":"key\n\t\t\t\t20180912023331_bib36","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1210\/endo-129-4-2257","article-title":"Free alpha molecules from pregnancy stimulate secretion of prolactin from human decidual cells: a novel function for free alpha in pregnancy.","volume":"129","author":"Blithe","year":"1991","journal-title":"Endocrinology"},{"issue":"5","key":"key\n\t\t\t\t20180912023331_bib37","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1093\/biolre\/iox032","article-title":"The gonadotropin-inhibitory hormone (Lpxrfa) system's regulation of reproduction in the brain\u2013pituitary axis of the zebrafish (Danio rerio)","volume":"96","author":"Spicer","year":"2017","journal-title":"Biol Reprod"},{"issue":"1-2","key":"key\n\t\t\t\t20180912023331_bib38","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.mce.2012.04.007","article-title":"The evolution of tachykinin\/tachykinin receptor (TAC\/TACR) in vertebrates and molecular identification of the TAC3\/TACR3 system in zebrafish (Danio rerio)","volume":"361","author":"Zhou","year":"2012","journal-title":"Mol Cell Endocrinol"},{"issue":"26","key":"key\n\t\t\t\t20180912023331_bib39","doi-asserted-by":"crossref","first-page":"10269","DOI":"10.1073\/pnas.1119165109","article-title":"Neurokinin Bs and neurokinin B receptors in zebrafish-potential role in controlling fish reproduction","volume":"109","author":"Biran","year":"2012","journal-title":"Proc Natl Acad Sci USA"},{"issue":"12","key":"key\n\t\t\t\t20180912023331_bib40","doi-asserted-by":"crossref","first-page":"4831","DOI":"10.1210\/en.2013-2114","article-title":"Direct regulation of gonadotropin release by neurokinin b in tilapia ( Oreochromis niloticus)","volume":"155","author":"Biran","year":"2014","journal-title":"Endocrinology"},{"issue":"4","key":"key\n\t\t\t\t20180912023331_bib41","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.npep.2006.05.002","article-title":"Secretoneurin stimulates goldfish pituitary luteinizing hormone production","volume":"40","author":"Zhao","year":"2006","journal-title":"Neuropeptides"},{"issue":"2","key":"key\n\t\t\t\t20180912023331_bib42","doi-asserted-by":"crossref","first-page":"E288","DOI":"10.1152\/ajpendo.00070.2011","article-title":"Secretoneurin stimulates the production and release of luteinizing hormone in mouse L\u03b2T2 gonadotropin cells","volume":"301","author":"Zhao","year":"2011","journal-title":"Am J Physiol-Endocrinol Metab"},{"issue":"6","key":"key\n\t\t\t\t20180912023331_bib43","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1046\/j.1365-2826.2001.00667.x","article-title":"PACAP stimulation of gonadotropin-II secretion in goldfish pituitary cells: mechanisms of action and interaction with gonadotropin releasing hormone signalling","volume":"13","author":"Chang","year":"2001","journal-title":"J Neuroendocrinol"},{"issue":"5","key":"key\n\t\t\t\t20180912023331_bib44","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1111\/jne.12024","article-title":"Seasonal effect of gonadotrophin inhibitory hormone on gonadotrophin-releasing hormone-induced gonadotroph functions in the goldfish pituitary","volume":"25","author":"Moussavi","year":"2013","journal-title":"J Neuroendocrinol"},{"issue":"11","key":"key\n\t\t\t\t20180912023331_bib45","doi-asserted-by":"crossref","first-page":"4391","DOI":"10.1210\/en.2013-2047","article-title":"LPXRFa, the piscine ortholog of GnIH, and LPXRF receptor positively regulate gonadotropin secretion in tilapia (Oreochromis niloticus)","volume":"155","author":"Biran","year":"2014","journal-title":"Endocrinology"},{"issue":"9","key":"key\n\t\t\t\t20180912023331_bib46","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1016\/j.peptides.2007.05.011","article-title":"What is the role of PACAP in gonadotrope function?","volume":"28","author":"Counis","year":"2007","journal-title":"Peptides"},{"issue":"2","key":"key\n\t\t\t\t20180912023331_bib47","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1210\/en.2012-1759","article-title":"Dopamine inhibits reproduction in female zebrafish (Danio rerio) via three pituitary D2 receptor subtypes","volume":"154","author":"Fontaine","year":"2013","journal-title":"Endocrinology"},{"issue":"7564","key":"key\n\t\t\t\t20180912023331_bib48","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/nature14580","article-title":"Genetic compensation induced by deleterious mutations but not gene knockdowns","volume":"524","author":"Rossi","year":"2015","journal-title":"Nature"},{"issue":"1","key":"key\n\t\t\t\t20180912023331_bib49","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1210\/me.2014-1256","article-title":"Genetic analysis of zebrafish gonadotropin (FSH and LH) functions by TALEN-mediated gene disruption","volume":"29","author":"Zhang","year":"2015","journal-title":"Mol Endocrinol"},{"issue":"12","key":"key\n\t\t\t\t20180912023331_bib50","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1210\/me.2015-1126","article-title":"Gonadotropin signaling in zebrafish ovary and testis development: insights from gene knockout study","volume":"29","author":"Chu","year":"2015","journal-title":"Mol Endocrinol"},{"issue":"18","key":"key\n\t\t\t\t20180912023331_bib51","doi-asserted-by":"crossref","first-page":"3748","DOI":"10.1002\/cne.22688","article-title":"Forebrain mapping of secretoneurin-like immunoreactivity and its colocalization with isotocin in the preoptic nucleus and pituitary gland of goldfish","volume":"519","author":"Canosa","year":"2011","journal-title":"J Comp Neurol"},{"issue":"1","key":"key\n\t\t\t\t20180912023331_bib52","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.ygcen.2011.10.008","article-title":"Is secretoneurin a new hormone?","volume":"175","author":"Trudeau","year":"2012","journal-title":"Gen Comp Endocrinol"},{"issue":"1","key":"key\n\t\t\t\t20180912023331_bib53","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.regpep.2009.11.019","article-title":"Secretoneurin as a hormone regulator in the pituitary","volume":"165","author":"Zhao","year":"2010","journal-title":"Regul Pept"},{"key":"key\n\t\t\t\t20180912023331_bib54","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.ygcen.2017.04.014","article-title":"Secretoneurin-A inhibits aromatase B (cyp19a1b) expression in female goldfish (Carassius auratus) radial glial cells","volume":"257","author":"Da Fonte","year":"2017","journal-title":"Gen Comp Endocrinol"},{"key":"key\n\t\t\t\t20180912023331_bib55","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.ygcen.2014.03.010","article-title":"Radial glial cell: critical functions and new perspective as a steroid synthetic cell","volume":"203","author":"Xing","year":"2014","journal-title":"Gen Comp Endocrinol"},{"issue":"3","key":"key\n\t\t\t\t20180912023331_bib56","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/jne.12459","article-title":"A potential role for the secretogranin II-derived peptide EM66 in the hypothalamic regulation of feeding behaviour","volume":"29","author":"Trebak","year":"2017","journal-title":"J Neuroendocrinol"},{"issue":"121","key":"key\n\t\t\t\t20180912023331_bib57","first-page":"121","article-title":"Gonadotropin inhibitory hormone down-regulates the brain-pituitary reproductive axis of male European Sea Bass (Dicentrarchus labrax)","volume":"94","author":"Paullada-Salmer\u00f3n","year":"2016","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20180912023331_bib58","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1126\/science.278.5335.135","article-title":"Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein","volume":"278","author":"Ollmann","year":"1997","journal-title":"Science"},{"key":"key\n\t\t\t\t20180912023331_bib59","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1038\/35078085","article-title":"Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus","volume":"411","author":"Cowley","year":"2001","journal-title":"Nature"},{"key":"key\n\t\t\t\t20180912023331_bib60","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/S0896-6273(04)00074-1","article-title":"Neuropeptide Y-mediated inhibition of proopiomelanocortin neurons in the arcuate nucleus shows enhanced desensitization in ob\/ob mice","volume":"41","author":"Roseberry","year":"2004","journal-title":"Neuron"},{"key":"key\n\t\t\t\t20180912023331_bib61","doi-asserted-by":"crossref","first-page":"3155","DOI":"10.1073\/pnas.1120501109","article-title":"Ablation of neurons expressing agouti-related protein, but not melanin concentrating hormone, in leptin-deficient mice restores metabolic functions and fertility","volume":"109","author":"Wu","year":"2012","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20180912023331_bib62","doi-asserted-by":"crossref","first-page":"2413","DOI":"10.1073\/pnas.1621065114","article-title":"AgRP to Kiss1 neuron signaling links nutritional state and fertility","volume":"114","author":"Padilla","year":"2017","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20180912023331_bib63","doi-asserted-by":"crossref","first-page":"2408","DOI":"10.1210\/en.2011-1822","article-title":"Effects of leptin and melanocortin signaling interactions on pubertal development and reproduction","volume":"153","author":"Israel","year":"2012","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20180912023331_bib64","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1210\/en.2008-0962","article-title":"Suppression of basal spontaneous gonadotropin-releasing hormone neuronal activity during lactation: role of inhibitory effects of Neuropeptide Y","volume":"150","author":"Xu","year":"2009","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20180912023331_bib65","doi-asserted-by":"crossref","first-page":"2736","DOI":"10.1210\/en.2009-1198","article-title":"Neuropeptide Y directly inhibits neuronal activity in a subpopulation of gonadotropin-releasing hormone-1 neurons via Y1 receptors","volume":"151","author":"Klenke","year":"2010","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20180912023331_bib66","doi-asserted-by":"crossref","first-page":"10205","DOI":"10.1523\/JNEUROSCI.2098-10.2010","article-title":"Kisspeptin directly excites anorexigenic proopiomelanocortin neurons but inhibits orexigenic neuropeptide Y cells by an indirect synaptic mechanism","volume":"30","author":"Fu","year":"2010","journal-title":"J Neurosci"}],"container-title":["Biology of Reproduction"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/biolreprod\/article-pdf\/99\/3\/565\/25716844\/ioy078.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,13]],"date-time":"2019-10-13T23:28:06Z","timestamp":1571009286000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/biolreprod\/article\/99\/3\/565\/4961130"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,4]]},"references-count":66,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2018,4,4]]},"published-print":{"date-parts":[[2018,9,1]]}},"URL":"https:\/\/doi.org\/10.1093\/biolre\/ioy078","relation":{},"ISSN":["0006-3363","1529-7268"],"issn-type":[{"value":"0006-3363","type":"print"},{"value":"1529-7268","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,9]]},"published":{"date-parts":[[2018,4,4]]}}}