{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T14:08:15Z","timestamp":1790777295703,"version":"4.1.0"},"reference-count":113,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"DOI":"10.1093\/biolre\/ioy208","type":"journal-article","created":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T17:22:40Z","timestamp":1538414560000},"source":"Crossref","is-referenced-by-count":30,"title":["Telomere length: lights and shadows on their role in human reproduction"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4794-9745","authenticated-orcid":false,"given":"Maria Santa","family":"Rocca","sequence":"first","affiliation":[{"name":"Department of Medicine, Unit of Andrology and Reproductive Medicine, University of Padova, Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Foresta","sequence":"additional","affiliation":[{"name":"Department of Medicine, Unit of Andrology and Reproductive Medicine, University of Padova, Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5817-8141","authenticated-orcid":false,"given":"Alberto","family":"Ferlin","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Sciences, Unit of Endocrinology, University of Brescia, Brescia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,10,1]]},"reference":[{"issue":"14","key":"key\n\t\t\t\t2018121704241405400_bib1","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1200\/JCO.2006.10.3101","article-title":"Senescence as an anticancer mechanism","volume":"25","author":"Hornsby","year":"2007","journal-title":"J Clin Oncol"},{"issue":"4","key":"key\n\t\t\t\t2018121704241405400_bib2","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1083\/jcb.201610111","article-title":"Telomere-driven diseases and telomere-targeting therapies","volume":"216","author":"Mart\u00ednez","year":"2017","journal-title":"J Cell Biol"},{"issue":"7","key":"key\n\t\t\t\t2018121704241405400_bib3","doi-asserted-by":"crossref","first-page":"E39","DOI":"10.3390\/genes7070039","article-title":"Therapeutic targeting of telomerase","volume":"7","author":"J\u00e4ger","year":"2016","journal-title":"Genes"},{"issue":"18","key":"key\n\t\t\t\t2018121704241405400_bib4","doi-asserted-by":"crossref","first-page":"6622","DOI":"10.1073\/pnas.85.18.6622","article-title":"A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes","volume":"85","author":"Moyzis","year":"1988","journal-title":"Proc Natl Acad Sci USA"},{"issue":"4-5","key":"key\n\t\t\t\t2018121704241405400_bib5","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1046\/j.1432-0436.2002.690412.x","article-title":"Telomerase and differentiation in multicellular organisms: turn it off, turn it on, and turn it off again","volume":"69","author":"Forsyth","year":"2002","journal-title":"Differentiation"},{"issue":"9","key":"key\n\t\t\t\t2018121704241405400_bib6","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1186\/gb-2008-9-9-232","article-title":"The telosome\/shelterin complex and its functions","volume":"9","author":"Xin","year":"2008","journal-title":"Genome Biol"},{"issue":"1","key":"key\n\t\t\t\t2018121704241405400_bib7","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0165-1110(96)90006-8","article-title":"The roles of telomeres and telomerase in cell life span","volume":"366","author":"Counter","year":"1996","journal-title":"Mutat Res"},{"issue":"5","key":"key\n\t\t\t\t2018121704241405400_bib8","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1007\/s10577-007-1149-7","article-title":"Telomere regulation and function during meiosis","volume":"15","author":"Siderakis","year":"2007","journal-title":"Chromosome Res"},{"issue":"4","key":"key\n\t\t\t\t2018121704241405400_bib9","doi-asserted-by":"crossref","first-page":"pii: E12","DOI":"10.3390\/biology6010012","article-title":"The consequences of chromosome segregation errors in mitosis and meiosis","volume":"6","author":"Potapova","year":"2017","journal-title":"Biology"},{"issue":"1","key":"key\n\t\t\t\t2018121704241405400_bib10","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0092-8674(01)00504-9","article-title":"The shortest telomere, not average telomere length, is critical for cell viability and chromosome stability","volume":"107","author":"Hemann","year":"2001","journal-title":"Cell"},{"issue":"7","key":"key\n\t\t\t\t2018121704241405400_bib11","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1038\/sj.bjc.6603671","article-title":"Telomere and telomerase in stem cells","volume":"96","author":"Hiyama","year":"2007","journal-title":"Br J Cancer"},{"issue":"5230","key":"key\n\t\t\t\t2018121704241405400_bib12","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1126\/science.7545310","article-title":"Telomerase and DNA end replication: no longer a lagging strand problem?","volume":"269","author":"Lingner","year":"1995","journal-title":"Science"},{"issue":"3","key":"key\n\t\t\t\t2018121704241405400_bib13","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1128\/MMBR.66.3.407-425.2002","article-title":"Human telomerase and its regulation","volume":"66","author":"Cong","year":"2002","journal-title":"Microbiol Mol Biol Rev"},{"issue":"5193","key":"key\n\t\t\t\t2018121704241405400_bib14","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1126\/science.7605428","article-title":"Specific association of human telomerase activity with immortal cells and cancer","volume":"266","author":"Kim","year":"1994","journal-title":"Science"},{"issue":"1","key":"key\n\t\t\t\t2018121704241405400_bib15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev.genom.8.021506.172017","article-title":"Human telomere structure and biology","volume":"9","author":"Riethman","year":"2008","journal-title":"Annu Rev Genom Hum Genet"},{"issue":"1","key":"key\n\t\t\t\t2018121704241405400_bib16","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1071\/RD08229","article-title":"Telomeres and reproductive aging","volume":"21","author":"Keefe","year":"2009","journal-title":"Reprod Fertil Dev"},{"issue":"2","key":"key\n\t\t\t\t2018121704241405400_bib17","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1093\/humrep\/des363","article-title":"Telomeric repeat-containing RNA and telomerase in human fetal oocytes","volume":"28","author":"Reig-Viader","year":"2013","journal-title":"Hum Reprod"},{"issue":"5","key":"key\n\t\t\t\t2018121704241405400_bib18","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1095\/biolreprod.113.116954","article-title":"Telomeric repeat-containing RNA (TERRA) and telomerase are components of telomeres during mammalian gametogenesis","volume":"90","author":"Reig-Viader","year":"2014","journal-title":"Biol Reprod"},{"issue":"2","key":"key\n\t\t\t\t2018121704241405400_bib19","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1095\/biolreprod63.2.591","article-title":"Telomere length in male germ cells is inversely correlated with telomerase activity","volume":"63","author":"Achi","year":"2000","journal-title":"Biol Reprod"},{"issue":"12","key":"key\n\t\t\t\t2018121704241405400_bib20","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1038\/ncb1664","article-title":"Telomere lengthening early in development","volume":"9","author":"Liu","year":"2007","journal-title":"Nat Cell Biol"},{"issue":"2","key":"key\n\t\t\t\t2018121704241405400_bib21","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1002\/(SICI)1520-6408(1996)18:2<173::AID-DVG10>3.0.CO;2-3","article-title":"Telomerase activity in human germline and embryonic tissues and cells","volume":"18","author":"Wright","year":"1996","journal-title":"Dev Genet"},{"issue":"4","key":"key\n\t\t\t\t2018121704241405400_bib22","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1095\/biolreprod.110.087205","article-title":"Species-specific telomere length differences between blastocyst cell compartments and ectopic telomere extension in early bovine embryos by human telomerase reverse transcriptase","volume":"84","author":"Iqbal","year":"2011","journal-title":"Biol Reprod"},{"issue":"8","key":"key\n\t\t\t\t2018121704241405400_bib23","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1093\/molehr\/gat021","article-title":"Telomere lengths in human pronuclei, oocytes and spermatozoa","volume":"19","author":"Turner","year":"2013","journal-title":"Mol Hum Reprod"},{"issue":"5","key":"key\n\t\t\t\t2018121704241405400_bib24","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1038\/nrg2763","article-title":"Alternative lengthening of telomeres: models, mechanisms and implications","volume":"11","author":"Cesare","year":"2010","journal-title":"Nat Rev Genet"},{"issue":"17","key":"key\n\t\t\t\t2018121704241405400_bib25","doi-asserted-by":"crossref","first-page":"3800","DOI":"10.1016\/j.febslet.2010.06.009","article-title":"Assaying and investigating alternative lengthening of telomeres activity in human cells and cancers","volume":"584","author":"Henson","year":"2010","journal-title":"FEBS Lett"},{"issue":"18","key":"key\n\t\t\t\t2018121704241405400_bib26","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1093\/hmg\/10.18.1953","article-title":"Effects of reconstitution of telomerase activity on telomere maintenance by the alternative lengthening of telomeres (ALT) pathway","volume":"110","author":"Grobelny","year":"2001","journal-title":"Hum Mol Genet"},{"issue":"3","key":"key\n\t\t\t\t2018121704241405400_bib27","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1038\/ng834","article-title":"Molecular characterization of inter-telomere and intra-telomere mutations in human ALT cells","volume":"30","author":"Varley","year":"2002","journal-title":"Nat Genet"},{"issue":"7","key":"key\n\t\t\t\t2018121704241405400_bib28","doi-asserted-by":"crossref","first-page":"2324","DOI":"10.1158\/0008-5472.CAN-03-4035","article-title":"Alternative lengthening of telomeres is characterized by high rates of telomeric exchange","volume":"64","author":"Londono-Vallejo","year":"2004","journal-title":"Cancer Res"},{"issue":"1","key":"key\n\t\t\t\t2018121704241405400_bib29","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s13039-016-0224-1","article-title":"The paradox of longer sperm telomeres in older men's testes: a birth-cohort effect caused by transgenerational telomere erosion in the female germline","volume":"9","author":"Stindl","year":"2016","journal-title":"Mol Cytogenet"},{"issue":"5851","key":"key\n\t\t\t\t2018121704241405400_bib30","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1126\/science.1147182","article-title":"Telomeric repeat containing RNA and RNA surveillance factors at mammalian chromosome ends","volume":"318","author":"Azzalin","year":"2007","journal-title":"Science"},{"issue":"2","key":"key\n\t\t\t\t2018121704241405400_bib31","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1053\/j.seminhematol.2013.03.030","article-title":"Telomere dynamics in mice and humans","volume":"50","author":"Calado","year":"2013","journal-title":"Semin Hematol"},{"issue":"10","key":"key\n\t\t\t\t2018121704241405400_bib32","doi-asserted-by":"crossref","first-page":"e110963","DOI":"10.1371\/journal.pone.0110963","article-title":"Oxidative stress induces persistent telomeric DNA damage responsible for nuclear morphology change in mammalian cells","volume":"9","author":"Coluzzi","year":"2014","journal-title":"PLoS One"},{"issue":"5","key":"key\n\t\t\t\t2018121704241405400_bib33","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1093\/nar\/gkg208","article-title":"Ageing and telomeres: a study into organ- and gender-specific telomere shortening","volume":"31","author":"Cherif","year":"2003","journal-title":"Nucleic Acids Res"},{"key":"key\n\t\t\t\t2018121704241405400_bib34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.freeradbiomed.2013.02.011","article-title":"Reactive oxygen species and the free radical theory of aging","volume":"60","author":"Liochev","year":"2013","journal-title":"Free Radic Biol Med"},{"issue":"5","key":"key\n\t\t\t\t2018121704241405400_bib35","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1093\/ije\/dyv165","article-title":"Leukocyte telomere length dynamics in women and men: menopause vs age effects","volume":"44","author":"Dalg\u00e5rd","year":"2015","journal-title":"Int J Epidemiol"},{"key":"key\n\t\t\t\t2018121704241405400_bib36","first-page":"5917","article-title":"Estrogen activates telomerase","volume":"59","author":"Kyo","year":"1999","journal-title":"Cancer Res"},{"issue":"4","key":"key\n\t\t\t\t2018121704241405400_bib37","doi-asserted-by":"crossref","first-page":"471","DOI":"10.3349\/ymj.2005.46.4.471","article-title":"Effect of long-term hormone therapy on telomere length in postmenopausal women","volume":"46","author":"Lee","year":"2005","journal-title":"Yonsei Med J"},{"key":"key\n\t\t\t\t2018121704241405400_bib38","doi-asserted-by":"crossref","first-page":"8","DOI":"10.3410\/M4-8","article-title":"Telomeres in disease","volume":"4","author":"Calado","year":"2012","journal-title":"F1000 Med Rep"},{"issue":"35","key":"key\n\t\t\t\t2018121704241405400_bib39","doi-asserted-by":"crossref","first-page":"13051","DOI":"10.1073\/pnas.0804280105","article-title":"Short telomeres are a risk factor for idiopathic pulmonary fibrosis","volume":"105","author":"Alder","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t2018121704241405400_bib40","first-page":"317","article-title":"Telomerase mutations in families with idiopathic pulmonary fibrosis","volume":"3561","author":"Armanios","year":"2007","journal-title":"N Engl J Med"},{"issue":"7","key":"key\n\t\t\t\t2018121704241405400_bib41","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1164\/rccm.200804-550OC","article-title":"Telomere shortening in familial and sporadic pulmonary fibrosis","volume":"178","author":"Cronkhite","year":"2008","journal-title":"Am J Respir Crit Care Med"},{"issue":"1-2","key":"key\n\t\t\t\t2018121704241405400_bib42","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.mrfmmm.2011.06.008","article-title":"Dyskeratosis congenita as a disorder of telomere maintenance","volume":"730","author":"Nelson","year":"2012","journal-title":"Mutat Res"},{"issue":"1","key":"key\n\t\t\t\t2018121704241405400_bib43","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1001\/jama.2010.897","article-title":"Telomere length and risk of incident cancer and cancer mortality","volume":"304","author":"Willeit","year":"2010","journal-title":"JAMA"},{"issue":"6","key":"key\n\t\t\t\t2018121704241405400_bib44","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1177\/0300060516667132","article-title":"Association between telomere length and diabetes mellitus: A meta-analysis","volume":"44","author":"Wang","year":"2016","journal-title":"J Int Med Res"},{"issue":"47","key":"key\n\t\t\t\t2018121704241405400_bib45","doi-asserted-by":"crossref","first-page":"17119","DOI":"10.1073\/pnas.0505318102","article-title":"The effect of TERC haploinsufficiency on the inheritance of telomere length","volume":"102","author":"Goldman","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"issue":"3","key":"key\n\t\t\t\t2018121704241405400_bib46","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1182\/blood-2003-01-0335","article-title":"Mutations of the human telomerase RNA gene (TERC) in aplastic anemia and myelodysplastic syndrome","volume":"102","author":"Yamaguchi","year":"2003","journal-title":"Blood"},{"issue":"14","key":"key\n\t\t\t\t2018121704241405400_bib47","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1056\/NEJMoa042980","article-title":"Mutations in TERT, the gene for telomerase reverse transcriptase, in aplastic anemia","volume":"352","author":"Yamaguchi","year":"2005","journal-title":"N Engl J Med"},{"issue":"9486","key":"key\n\t\t\t\t2018121704241405400_bib48","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/S0140-6736(05)66630-5","article-title":"Obesity, cigarette smoking, and telomere length in women","volume":"366","author":"Valdes","year":"2005","journal-title":"Lancet North Am Ed"},{"issue":"5","key":"key\n\t\t\t\t2018121704241405400_bib49","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.3945\/ajcn.2009.28947","article-title":"Associations between diet, lifestyle factors, and telomere length in women","volume":"91","author":"Cassidy","year":"2010","journal-title":"Am J Clin Nutr"},{"issue":"4","key":"key\n\t\t\t\t2018121704241405400_bib50","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1111\/j.1472-8206.2010.00866.x","article-title":"Smoking and health: association between telomere length and factors impacting on human disease, quality of life and life span in a large population-based cohort under the effect of smoking duration","volume":"25","author":"Babizhayev","year":"2011","journal-title":"Fundam Clin Pharmacol"},{"issue":"1","key":"key\n\t\t\t\t2018121704241405400_bib51","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/1476-069X-8-41","article-title":"Association between leukocyte telomere shortening and exposure to traffic pollution: a cross-sectional study on traffic officers and indoor office workers","volume":"8","author":"Hoxha","year":"2009","journal-title":"Environ Health"},{"issue":"2","key":"key\n\t\t\t\t2018121704241405400_bib52","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1093\/carcin\/bgp278","article-title":"Shorter telomere length in peripheral blood lymphocytes of workers exposed to polycyclic aromatic hydrocarbons","volume":"31","author":"Pavanello","year":"2010","journal-title":"Carcinogenesis"},{"key":"key\n\t\t\t\t2018121704241405400_bib53","first-page":"44","article-title":"Systematic correlation of environmental exposure and physiological and self-reported behaviour factors with leukocyte telomere length","volume":"46","author":"Patel","year":"2017","journal-title":"Int J Epidemiol"},{"issue":"1","key":"key\n\t\t\t\t2018121704241405400_bib54","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1097\/MCO.0b013e32834121b1","article-title":"Telomeres, lifestyle, cancer, and aging","volume":"14","author":"Shammas","year":"2011","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"key\n\t\t\t\t2018121704241405400_bib55","first-page":"876","article-title":"Genetic determination of telomere size in humans: a twin study of three age groups","volume":"5","author":"Slagboom","year":"1994","journal-title":"Am J Hum Genet"},{"issue":"9408","key":"key\n\t\t\t\t2018121704241405400_bib56","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/S0140-6736(04)15535-9","article-title":"Telomere length and possible link to X chromosome","volume":"363","author":"Nawrot","year":"2004","journal-title":"Lancet North Am Ed"},{"issue":"2","key":"key\n\t\t\t\t2018121704241405400_bib57","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1111\/j.1474-9728.2005.00144.x","article-title":"Paternal age is positively linked to telomere length of children","volume":"4","author":"Unryn","year":"2005","journal-title":"Aging Cell"},{"issue":"45","key":"key\n\t\t\t\t2018121704241405400_bib58","doi-asserted-by":"crossref","first-page":"16374","DOI":"10.1073\/pnas.0501724102","article-title":"Telomere length and heredity: Indications of paternal inheritance","volume":"102","author":"Nordfj\u00e4ll","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"issue":"29","key":"key\n\t\t\t\t2018121704241405400_bib59","doi-asserted-by":"crossref","first-page":"12135","DOI":"10.1073\/pnas.0702703104","article-title":"Telomere length is paternally inherited and is associated with parental lifespan","volume":"104","author":"Njajou","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"issue":"1","key":"key\n\t\t\t\t2018121704241405400_bib60","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/ejhg.2013.202","article-title":"Inconsistent inheritance of telomere length (TL): is offspring TL more strongly correlated with maternal or paternal TL?","volume":"22","author":"Eisenberg","year":"2014","journal-title":"Eur J Hum Genet"},{"issue":"2","key":"key\n\t\t\t\t2018121704241405400_bib61","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1002\/ajhb.21127","article-title":"An evolutionary review of human telomere biology: the thrifty telomere hypothesis and notes on potential adaptive paternal effects","volume":"23","author":"Eisenberg","year":"2011","journal-title":"Am J Hum Biol"},{"issue":"1","key":"key\n\t\t\t\t2018121704241405400_bib62","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1530\/REP-15-0375","article-title":"Spermatozoa telomeres determine telomere length in early embryos and offspring","volume":"151","author":"de Frutos","year":"2016","journal-title":"Reproduction"},{"issue":"12","key":"key\n\t\t\t\t2018121704241405400_bib63","doi-asserted-by":"crossref","first-page":"3622","DOI":"10.1093\/humrep\/des314","article-title":"Paternal age at birth is associated with offspring leukocyte telomere length in the nurses' health study","volume":"12","author":"Prescott","year":"2012","journal-title":"Hum Reprod"},{"issue":"2","key":"key\n\t\t\t\t2018121704241405400_bib64","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1093\/ije\/dys236","article-title":"Leukocyte telomere length and the Father's age enigma: implications for population health and for life course","volume":"42","author":"Aviv","year":"2013","journal-title":"Int J Epidemiol"},{"issue":"26","key":"key\n\t\t\t\t2018121704241405400_bib65","doi-asserted-by":"crossref","first-page":"10251","DOI":"10.1073\/pnas.1202092109","article-title":"Delayed paternal age of reproduction in humans is associated with longer telomeres across two generations of descendants","volume":"109","author":"Eisenberg","year":"2012","journal-title":"Proc Natl Acad Sci USA"},{"issue":"12","key":"key\n\t\t\t\t2018121704241405400_bib66","doi-asserted-by":"crossref","first-page":"3370","DOI":"10.1093\/humrep\/det392","article-title":"In young men sperm telomere length is related to sperm number and parental age","volume":"28","author":"Ferlin","year":"2013","journal-title":"Hum Reprod"},{"issue":"9","key":"key\n\t\t\t\t2018121704241405400_bib67","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1038\/nprot.2010.124","article-title":"Measurement of telomere length by the Southern blot analysis of terminal restriction fragment lengths","volume":"5","author":"Kimura","year":"2010","journal-title":"Nat Protoc"},{"issue":"2","key":"key\n\t\t\t\t2018121704241405400_bib68","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/ng1084","article-title":"Extensive allelic variation and ultrashort telomeres in senescent human cells","volume":"33","author":"Baird","year":"2003","journal-title":"Nat Genet"},{"issue":"8","key":"key\n\t\t\t\t2018121704241405400_bib69","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1093\/humrep\/dev144","article-title":"Sperm telomere length is positively associated with the quality of early embryonic development","volume":"30","author":"Yang","year":"2015","journal-title":"Hum Reprod"},{"issue":"1","key":"key\n\t\t\t\t2018121704241405400_bib70","doi-asserted-by":"crossref","first-page":"39051","DOI":"10.1038\/srep39051","article-title":"Semen preparation methods and sperm telomere length: density gradient centrifugation versus the swim up procedure","volume":"6","author":"Zhao","year":"2016","journal-title":"Sci Rep"},{"issue":"2","key":"key\n\t\t\t\t2018121704241405400_bib71","doi-asserted-by":"crossref","first-page":"e12867","DOI":"10.1111\/and.12840","article-title":"Sperm telomere length in motile sperm selection techniques: A qFISH approach","volume":"50","author":"Lafuente","year":"2018","journal-title":"Andrologia"},{"issue":"13","key":"key\n\t\t\t\t2018121704241405400_bib72","doi-asserted-by":"crossref","first-page":"2626","DOI":"10.1200\/JCO.2000.18.13.2626","article-title":"Role of telomerase in normal and cancer cells","volume":"18","author":"Meyerson","year":"2000","journal-title":"JCO"},{"issue":"3","key":"key\n\t\t\t\t2018121704241405400_bib73","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1183\/09031936.06.00087005","article-title":"Telomere shortening in smokers with and without COPD","volume":"27","author":"Morla","year":"2006","journal-title":"Eur Respir J"},{"issue":"5","key":"key\n\t\t\t\t2018121704241405400_bib74","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.aanat.2010.07.005","article-title":"Sizing the ends: normal length of human telomeres","volume":"192","author":"Samassekou","year":"2010","journal-title":"Ann Anat"},{"issue":"1","key":"key\n\t\t\t\t2018121704241405400_bib75","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/aja.2011.69","article-title":"Advanced paternal age and reproductive outcome","volume":"14","author":"Wiener-Megnazi","year":"2012","journal-title":"Asian J Androl"},{"issue":"1","key":"key\n\t\t\t\t2018121704241405400_bib76","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s12958-015-0028-x","article-title":"Effects of increased paternal age on sperm quality, reproductive outcome and associated epigenetic risks to offspring","volume":"13","author":"Sharma","year":"2015","journal-title":"Reprod Biol Endocrinol"},{"issue":"6","key":"key\n\t\t\t\t2018121704241405400_bib77","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1093\/humrep\/dew061","article-title":"Sperm telomere length as a parameter of sperm quality in normozoospermic men","volume":"31","author":"Rocca","year":"2016","journal-title":"Hum Reprod"},{"issue":"3","key":"key\n\t\t\t\t2018121704241405400_bib78","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.rbmo.2016.06.006","article-title":"Investigation of sperm telomere length as a potential marker of paternal genome integrity and semen quality","volume":"33","author":"Cariati","year":"2016","journal-title":"Reprod Biomed Online"},{"issue":"4","key":"key\n\t\t\t\t2018121704241405400_bib79","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1091\/mbc.e05-07-0672","article-title":"PARP1 Is a TRF2-associated poly(ADP-ribose)polymerase and protects eroded telomeres","volume":"17","author":"Gomez","year":"2006","journal-title":"Mol Biol Cell"},{"issue":"1","key":"key\n\t\t\t\t2018121704241405400_bib80","doi-asserted-by":"crossref","first-page":"29787","DOI":"10.1038\/srep29787","article-title":"Effect of paternal overweight or obesity on IVF treatment outcomes and the possible mechanisms involved","volume":"6","author":"Yang","year":"2016","journal-title":"Sci Rep"},{"issue":"1","key":"key\n\t\t\t\t2018121704241405400_bib81","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/1471-2407-2-32","article-title":"The differentiation status of primary gonadal germ cell tumors correlates inversely with telomerase activity and the expression level of the gene encoding the catalytic subunit of telomerase","volume":"2","author":"Schrader","year":"2002","journal-title":"BMC Cancer"},{"issue":"7","key":"key\n\t\t\t\t2018121704241405400_bib82","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1038\/ng.607","article-title":"Variants near DMRT1, TERT and ATF7IP are associated with testicular germ cell cancer","volume":"42","author":"Turnbull","year":"2010","journal-title":"Nat Genet"},{"issue":"11","key":"key\n\t\t\t\t2018121704241405400_bib83","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1093\/jnci\/djs222","article-title":"Telomerase reverse transcriptase locus polymorphisms and cancer risk: a field synopsis and meta-analysis","volume":"104","author":"Mocellin","year":"2012","journal-title":"J Natl Cancer Inst"},{"issue":"10","key":"key\n\t\t\t\t2018121704241405400_bib84","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1038\/nrurol.2017.104","article-title":"Telomeres and telomerase in prostate cancer development and therapy","volume":"14","author":"Graham","year":"2017","journal-title":"Nat Rev Urol"},{"key":"key\n\t\t\t\t2018121704241405400_bib85","first-page":"1","article-title":"Telomeres as a molecular marker of male infertility","author":"Boniewska-Bernacka","year":"2018","journal-title":"Hum Fertil"},{"issue":"4","key":"key\n\t\t\t\t2018121704241405400_bib86","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1016\/j.ajog.2005.01.036","article-title":"Telomere length predicts embryo fragmentation after in vitro fertilization in women\u2014Toward a telomere theory of reproductive aging in women","volume":"192","author":"Keefe","year":"2005","journal-title":"Am J Obstet Gynecol"},{"issue":"1","key":"key\n\t\t\t\t2018121704241405400_bib87","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/molehr\/gat055","article-title":"Telomere length and telomerase activity during oocyte maturation and early embryo development in mammalian species","volume":"20","author":"Ozturk","year":"2014","journal-title":"Mol Hum Reprod"},{"issue":"2","key":"key\n\t\t\t\t2018121704241405400_bib88","doi-asserted-by":"crossref","first-page":"E234","DOI":"10.1210\/jc.2013-3685","article-title":"A possible new mechanism in the pathophysiology of polycystic ovary syndrome (PCOS): the discovery that leukocyte telomere length is strongly associated with PCOS","volume":"99","author":"Li","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"key\n\t\t\t\t2018121704241405400_bib89","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.fertnstert.2014.10.035","article-title":"Inflammatory biomarkers and telomere length in women with polycystic ovary syndrome","volume":"103","author":"Pedroso","year":"2015","journal-title":"Fertil Steril"},{"issue":"7","key":"key\n\t\t\t\t2018121704241405400_bib90","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1007\/s10815-017-0945-z","article-title":"Significantly lengthened telomere in granulosa cells from women with polycystic ovarian syndrome (PCOS)","volume":"34","author":"Wei","year":"2017","journal-title":"J Assist Reprod Genet"},{"issue":"3","key":"key\n\t\t\t\t2018121704241405400_bib91","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1158\/1055-9965.EPI-08-0935","article-title":"Obesity and weight gain in adulthood and telomere length","volume":"18","author":"Kim","year":"2009","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"key\n\t\t\t\t2018121704241405400_bib92","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.placenta.2008.08.007","article-title":"Infertility as a cancer risk factor - a review","volume":"29","author":"Cetin","year":"2008","journal-title":"Placenta"},{"key":"key\n\t\t\t\t2018121704241405400_bib93","doi-asserted-by":"crossref","first-page":"3410","DOI":"10.1128\/JVI.68.5.3410-3414.1994","article-title":"Stabilization of short telomeres and telomerase activity accompany immortalization of Epstein-Barr virus-transformed human B lymphocytes","volume":"68","author":"Counter","year":"1994","journal-title":"J Virol"},{"issue":"6","key":"key\n\t\t\t\t2018121704241405400_bib94","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1002\/(SICI)1097-0215(19990315)80:6<804::AID-IJC2>3.0.CO;2-B","article-title":"Expression of human telomerase subunits in ovarian malignant, borderline and benign tumors","volume":"80","author":"Kyo","year":"1999","journal-title":"Int J Cancer"},{"issue":"2","key":"key\n\t\t\t\t2018121704241405400_bib95","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1530\/REP-10-0008","article-title":"Telomerase in the ovary","volume":"140","author":"Liu","year":"2010","journal-title":"Reproduction"},{"issue":"8","key":"key\n\t\t\t\t2018121704241405400_bib96","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1038\/modpathol.2011.67","article-title":"Telomere length in different histologic types of ovarian carcinoma with emphasis on clear cell carcinoma","volume":"24","author":"Kuhn","year":"2011","journal-title":"Mod Pathol"},{"issue":"9","key":"key\n\t\t\t\t2018121704241405400_bib97","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1093\/molehr\/gaq048","article-title":"Telomere lengths in human oocytes, cleavage stage embryos and blastocysts","volume":"16","author":"Turner","year":"2010","journal-title":"Mol Hum Reprod"},{"issue":"11","key":"key\n\t\t\t\t2018121704241405400_bib98","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1007\/s10815-015-0574-3","article-title":"A single-cell assay for telomere DNA content shows increasing telomere length heterogeneity, as well as increasing mean telomere length in human spermatozoa with advancing age","volume":"32","author":"Antunes","year":"2015","journal-title":"J Assist Reprod Genet"},{"issue":"6","key":"key\n\t\t\t\t2018121704241405400_bib99","doi-asserted-by":"crossref","first-page":"e1002161","DOI":"10.1371\/journal.pgen.1002161","article-title":"Telomere DNA deficiency is associated with development of human embryonic aneuploidy","volume":"7","author":"Treff","year":"2011","journal-title":"PLoS Genet"},{"issue":"11","key":"key\n\t\t\t\t2018121704241405400_bib100","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1007\/s10815-015-0581-4","article-title":"Cell-free DNA and telomere length among women undergoing in vitro fertilization treatment","volume":"32","author":"Czamanski-Cohen","year":"2015","journal-title":"J Assist Reprod Genet"},{"issue":"1","key":"key\n\t\t\t\t2018121704241405400_bib101","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.rbmo.2015.02.016","article-title":"Processing of semen by density gradient centrifugation selects spermatozoa with longer telomeres for assisted reproduction techniques","volume":"31","author":"Yang","year":"2015","journal-title":"Reprod Biomed Online"},{"issue":"4","key":"key\n\t\t\t\t2018121704241405400_bib102","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1007\/s00404-012-2632-8","article-title":"Analysis of sperm telomere length in men with idiopathic infertility","volume":"287","author":"Thilagavathi","year":"2013","journal-title":"Arch Gynecol Obstet"},{"issue":"4","key":"key\n\t\t\t\t2018121704241405400_bib103","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.maturitas.2013.05.001","article-title":"Age-dependence of relative telomere length profiles during spermatogenesis in man","volume":"75","author":"J\u00f8rgensen","year":"2013","journal-title":"Maturitas"},{"key":"key\n\t\t\t\t2018121704241405400_bib104","doi-asserted-by":"crossref","first-page":"163","DOI":"10.5662\/wjm.v6.i2.163","article-title":"Mild oxidative stress is beneficial for sperm telomere length maintenance","volume":"6","author":"Mishra","year":"2016","journal-title":"World J Methodol"},{"key":"key\n\t\t\t\t2018121704241405400_bib105","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1093\/humrep\/den172","article-title":"Endometriosis is associated with aberrant endometrial expression of telomerase and increased telomere length","volume":"23","author":"Hapangama","year":"2008","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t2018121704241405400_bib106","doi-asserted-by":"crossref","first-page":"4835","DOI":"10.1210\/jc.2008-2269","article-title":"Correlation of telomere length and telomerase activity with occult ovarian insufficiency","volume":"94","author":"Butts","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2018121704241405400_bib107","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1093\/humrep\/dep007","article-title":"Telomere length and reproductive aging","volume":"24","author":"Hanna","year":"2009","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t2018121704241405400_bib108","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1093\/humrep\/den416","article-title":"Sustained replication in endometrium of women with endometriosis occurs without evoking a DNA damage response","volume":"24","author":"Hapangama","year":"2009","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t2018121704241405400_bib109","first-page":"2816","article-title":"Human endometrial epithelial telomerase is important for epithelial proliferation and glandular formation with potential implications in endometriosis","volume":"30","author":"Valentijn","year":"2015","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t2018121704241405400_bib110","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1111\/cen.13283","article-title":"Telomeric repeat-containing RNA (TERRA) related to polycystic ovary syndrome (PCOS)","volume":"86","author":"Wang","year":"2017","journal-title":"Clin Endocrinol"},{"key":"key\n\t\t\t\t2018121704241405400_bib111","doi-asserted-by":"crossref","first-page":"3432","DOI":"10.1038\/s41598-017-03685-x","article-title":"Competing factors link to bone health in polycystic ovary syndrome: chronic low-grade inflammation takes a toll","volume":"7","author":"Kalyan","year":"2017","journal-title":"Sci Rep"},{"key":"key\n\t\t\t\t2018121704241405400_bib112","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1007\/s10815-017-0929-z","article-title":"Telomere length is short in PCOS and oral contraceptive does not affect the telomerase activity in granulosa cells of patients with PCOS","volume":"34","author":"Li","year":"2017","journal-title":"J Assist Reprod Genet"},{"key":"key\n\t\t\t\t2018121704241405400_bib113","first-page":"201","article-title":"Impaired telomere length and telomerase activity in peripheral blood leukocytes and granulosa cells in patients with biochemical primary ovarian insufficiency","volume":"32","author":"Xu","year":"2017","journal-title":"Hum Reprod"}],"container-title":["Biology of Reproduction"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/biolreprod\/advance-article-pdf\/doi\/10.1093\/biolre\/ioy208\/27170505\/ioy208.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,11]],"date-time":"2020-11-11T19:49:26Z","timestamp":1605124166000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/biolreprod\/advance-article\/doi\/10.1093\/biolre\/ioy208\/5113454"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,1]]},"references-count":113,"URL":"https:\/\/doi.org\/10.1093\/biolre\/ioy208","relation":{},"ISSN":["0006-3363","1529-7268"],"issn-type":[{"value":"0006-3363","type":"print"},{"value":"1529-7268","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,1]]}}}