{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T05:41:45Z","timestamp":1790487705305,"version":"4.1.0"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2018,10,4]],"date-time":"2018-10-04T00:00:00Z","timestamp":1538611200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002241","name":"Japanese Science and Technology Agency","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003382","name":"CREST","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003382","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Japanese Agency for Medical Research and Development"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The fertility of sex-reversed XY female mice is severely impaired by a massive loss of oocytes and failure of meiotic progression. This phenomenon remains an outstanding mystery. We sought to determine the molecular etiology of XY oocyte dysfunction by generating sex-reversed females that bear genetic ablation of Sry, a vital sex determination gene, on an inbred C57BL\/6 background. These mutant mice, termed XYsry\u2212 mutants, showed severe attrition of germ cells during fetal development, resulting in the depletion of ovarian germ cells prior to sexual maturation. Comprehensive transcriptome analyses of primordial germ cells (PGCs) and postnatal oocytes demonstrated that XYsry\u2212 females had deviated significantly from normal developmental processes during the stages of mitotic proliferation. The impaired proliferation of XYsry\u2212 PGCs was associated with aberrant \u03b2-catenin signaling and the excessive expression of transposable elements. Upon entry to the meiotic stage, XYsry\u2212 oocytes demonstrated extensive defects, including the impairment of crossover formation, the failure of primordial follicle maintenance, and no capacity for embryo development. Together, these results suggest potential molecular causes for germ cell disruption in sex-reversed female mice, thereby providing insights into disorders of sex differentiation in humans, such as \u201cSwyer syndrome,\u201d in which patients with an XY karyotype present as typical females and are infertile.<\/jats:p>","DOI":"10.1093\/biolre\/ioy214","type":"journal-article","created":{"date-parts":[[2018,10,4]],"date-time":"2018-10-04T16:31:34Z","timestamp":1538670694000},"page":"697-710","source":"Crossref","is-referenced-by-count":9,"title":["XY oocytes of sex-reversed females with a Sry mutation deviate from the normal developmental process beyond the mitotic stage\u2020"],"prefix":"10.1093","volume":"100","author":[{"given":"Akihiko","family":"Sakashita","sequence":"first","affiliation":[{"name":"Department of Bioscience, Tokyo University of Agriculture, Setagaya, Tokyo, Japan"},{"name":"Division of Reproductive Sciences, Division of Developmental Biology, Perinatal Institute, 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