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There is still no consensus on what physiological microbiota exists in the upper reproductive tract of the vast majority of women who are not in periods of infection or pregnancy, and the role of bacteria that colonize the upper reproductive tract in uterine diseases or pregnancy outcomes is not well established. Despite published studies and advances in uterine microbiome sequencing, some study aspects\u2014such as study design, sampling method, DNA extraction, sequencing methods, downstream analysis, and assignment of taxa\u2014have not yet been improved and standardized. It is time to further investigate the uterine microbiome to increase our understanding of the female reproductive tract and to develop more personalized reproductive therapies, highlighting the potential importance of using microbiological assessment in infertile patients.<\/jats:p>","DOI":"10.1093\/biolre\/ioy257","type":"journal-article","created":{"date-parts":[[2018,12,13]],"date-time":"2018-12-13T15:24:52Z","timestamp":1544714692000},"page":"1102-1114","source":"Crossref","is-referenced-by-count":34,"title":["Uterine microbiome\u2014low biomass and high expectations\u2020"],"prefix":"10.1093","volume":"101","author":[{"given":"Iolanda","family":"Garcia-Grau","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Obstetrics and Gynecology, School of Medicine, University of Valencia, Valencia, Spain"},{"name":"Igenomix Foundation, Instituto de Investigaci\u00f3n Sanitaria Hospital Cl\u00ednico (INCLIVA), Valencia, 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