{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T03:06:33Z","timestamp":1793156793831,"version":"4.5.0"},"reference-count":143,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2018,12,28]],"date-time":"2018-12-28T00:00:00Z","timestamp":1545955200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000016","name":"U.S. Department of Health and Human Services","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000016","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,5,1]]},"DOI":"10.1093\/biolre\/ioy264","type":"journal-article","created":{"date-parts":[[2018,12,28]],"date-time":"2018-12-28T14:03:17Z","timestamp":1546005797000},"page":"1306-1318","source":"Crossref","is-referenced-by-count":100,"title":["Inhibition of the NLRP3 inflammasome can prevent sterile intra-amniotic inflammation, preterm labor\/birth, and adverse neonatal outcomes\u2020"],"prefix":"10.1093","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3406-5262","authenticated-orcid":false,"given":"Nardhy","family":"Gomez-Lopez","sequence":"first","affiliation":[{"name":"Perinatology Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, U.S. Department of Health and Human Services, Bethesda, Maryland, and Detroit, Michigan, USA"},{"name":"Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, Michigan, USA"},{"name":"Department of Immunology, Microbiology and Biochemistry, Wayne State University School of Medicine, Detroit, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Romero","sequence":"additional","affiliation":[{"name":"Perinatology Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, U.S. Department of Health and Human Services, Bethesda, Maryland, and Detroit, Michigan, USA"},{"name":"Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, Michigan, USA"},{"name":"Department of Epidemiology and Biostatistics, Michigan State University, East Lansing, Michigan, USA"},{"name":"Center for Molecular Medicine and Genetics, Wayne State University, Detroit, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Garcia-Flores","sequence":"additional","affiliation":[{"name":"Perinatology Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, U.S. Department of Health and Human Services, Bethesda, Maryland, and Detroit, Michigan, USA"},{"name":"Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaozhu","family":"Leng","sequence":"additional","affiliation":[{"name":"Perinatology Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, U.S. Department of Health and Human Services, Bethesda, Maryland, and Detroit, Michigan, USA"},{"name":"Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5812-7771","authenticated-orcid":false,"given":"Derek","family":"Miller","sequence":"additional","affiliation":[{"name":"Perinatology Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, U.S. Department of Health and Human Services, Bethesda, Maryland, and Detroit, Michigan, USA"},{"name":"Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia S","family":"Hassan","sequence":"additional","affiliation":[{"name":"Perinatology Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, U.S. Department of Health and Human Services, Bethesda, Maryland, and Detroit, Michigan, USA"},{"name":"Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, Michigan, USA"},{"name":"Department of Physiology, Wayne State University School of Medicine, Detroit, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaur-Dong","family":"Hsu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, Michigan, USA"},{"name":"Department of Physiology, Wayne State University School of Medicine, Detroit, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bogdan","family":"Panaitescu","sequence":"additional","affiliation":[{"name":"Perinatology Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, U.S. Department of Health and Human Services, Bethesda, Maryland, and Detroit, Michigan, USA"},{"name":"Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,12,28]]},"reference":[{"key":"2019050220123945600_bib1","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/S0140-6736(14)61698-6","article-title":"Global, regional, and national causes of child mortality in 2000\u201313, with projections to inform post-2015 priorities: an updated systematic analysis","volume":"385","author":"Liu","year":"2015","journal-title":"Lancet North Am Ed"},{"key":"2019050220123945600_bib2","doi-asserted-by":"crossref","first-page":"e20163239","DOI":"10.1542\/peds.2016-3239","article-title":"Annual summary of vital statistics: 2013\u20132014","volume":"139","author":"Murphy","year":"2017","journal-title":"Pediatrics"},{"key":"2019050220123945600_bib3","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0140-6736(08)60074-4","article-title":"Epidemiology and causes of preterm birth","volume":"371","author":"Goldenberg","year":"2008","journal-title":"Lancet North Am Ed"},{"key":"2019050220123945600_bib4","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1126\/science.1251816","article-title":"Preterm labor: one syndrome, many causes","volume":"345","author":"Romero","year":"2014","journal-title":"Science"},{"key":"2019050220123945600_bib5","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1111\/aji.12189","article-title":"A novel molecular microbiologic technique for the rapid diagnosis of microbial invasion of the amniotic cavity and intra-amniotic infection in preterm labor with intact membranes","volume":"71","author":"Romero","year":"2014","journal-title":"Am J Reprod Immunol"},{"key":"2019050220123945600_bib6","doi-asserted-by":"crossref","first-page":"125.e1","DOI":"10.1016\/j.ajog.2013.11.032","article-title":"Amniotic fluid infection, inflammation, and colonization in preterm labor with intact membranes","volume":"210","author":"Combs","year":"2014","journal-title":"Am J Obstet Gynecol"},{"key":"2019050220123945600_bib7","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1111\/aji.12296","article-title":"Prevalence and clinical significance of sterile intra-amniotic inflammation in patients with preterm labor and intact membranes","volume":"72","author":"Romero","year":"2014","journal-title":"Am J Reprod Immunol"},{"key":"2019050220123945600_bib8","doi-asserted-by":"crossref","first-page":"592.e1","DOI":"10.1016\/j.ajog.2017.08.008","article-title":"Preterm labor in the absence of acute histologic chorioamnionitis is characterized by cellular senescence of the chorioamniotic membranes","volume":"217","author":"Gomez-Lopez","year":"2017","journal-title":"Am J Obstet Gynecol"},{"key":"2019050220123945600_bib9","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.jri.2017.12.004","article-title":"Intrauterine inflammatory activation, functional progesterone withdrawal, and the timing of term and preterm birth","volume":"125","author":"Keelan","year":"2018","journal-title":"J Reprod Immunol"},{"key":"2019050220123945600_bib10","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.3109\/14767058.2014.954243","article-title":"Sterile intra-amniotic inflammation in asymptomatic patients with a sonographic short cervix: prevalence and clinical significance","volume":"28","author":"Romero","year":"2015","journal-title":"J Matern Fetal Neonatal Med"},{"key":"2019050220123945600_bib11","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.3109\/14767058.2014.958463","article-title":"Sterile and microbial-associated intra-amniotic inflammation in preterm prelabor rupture of membranes","volume":"28","author":"Romero","year":"2015","journal-title":"J Matern Fetal Neonatal Med"},{"key":"2019050220123945600_bib12","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1515\/jpm-2014-0249","article-title":"Clinical chorioamnionitis at term I: microbiology of the amniotic cavity using cultivation and molecular techniques","volume":"43","author":"Romero","year":"2015","journal-title":"J Perinat Med"},{"key":"2019050220123945600_bib13","doi-asserted-by":"crossref","first-page":"3296","DOI":"10.1096\/fj.201600583R","article-title":"Lipidomic analysis of patients with microbial invasion of the amniotic cavity reveals up-regulation of leukotriene B4","volume":"30","author":"Maddipati","year":"2016","journal-title":"FASEB J"},{"key":"2019050220123945600_bib14","first-page":"5","article-title":"Clinical chorioamnionitis at term II: the intra-amniotic inflammatory response","volume":"44","author":"Romero","year":"2016","journal-title":"J Perinat Med"},{"key":"2019050220123945600_bib15","first-page":"23","article-title":"Clinical chorioamnionitis at term III: how well do clinical criteria perform in the identification of proven intra-amniotic infection?","volume":"44","author":"Romero","year":"2016","journal-title":"J Perinat Med"},{"key":"2019050220123945600_bib16","first-page":"77","article-title":"Clinical chorioamnionitis at term IV: the maternal plasma cytokine profile","volume":"44","author":"Romero","year":"2016","journal-title":"J Perinat Med"},{"key":"2019050220123945600_bib17","first-page":"53","article-title":"Clinical chorioamnionitis at term V: umbilical cord plasma cytokine profile in the context of a systemic maternal inflammatory response","volume":"44","author":"Romero","year":"2016","journal-title":"J Perinat Med"},{"key":"2019050220123945600_bib18","first-page":"33","article-title":"Clinical chorioamnionitis at term VI: acute chorioamnionitis and funisitis according to the presence or absence of microorganisms and inflammation in the amniotic cavity","volume":"44","author":"Romero","year":"2016","journal-title":"J Perinat Med"},{"key":"2019050220123945600_bib19","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1515\/jpm-2016-0344","article-title":"Clinical chorioamnionitis at term VIII: a rapid MMP-8 test for the identification of intra-amniotic inflammation","volume":"45","author":"Chaiyasit","year":"2017","journal-title":"J Perinat Med"},{"key":"2019050220123945600_bib20","article-title":"The diagnostic performance of the beta-glucan assay in the detection of intra-amniotic infection with Candida species","author":"Pacora","year":"2017","journal-title":"J Matern Fetal Neonatal Med"},{"key":"2019050220123945600_bib21","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1097\/00003081-195902030-00010","article-title":"Amniotic infection syndrome; pathogenesis, morphology, and significance in circumnatal mortality","volume":"2","author":"Blanc","year":"1959","journal-title":"Clin Obstet Gynecol"},{"key":"2019050220123945600_bib22","first-page":"127","article-title":"Inflammatory lesions of the human placenta: clinical significance of acute chorioamnionitis","volume":"2","author":"Russell","year":"1979","journal-title":"Am J Diagn Gynecol Obstet"},{"key":"2019050220123945600_bib23","first-page":"17","article-title":"Pathology of the placenta and cord in ascending and in haematogenous infection","volume":"77","author":"Blanc","year":"1979","journal-title":"Ciba Found Symp"},{"key":"2019050220123945600_bib24","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1056\/NEJM198810133191503","article-title":"A case\u2013control study of chorioamnionic infection and histologic chorioamnionitis in prematurity","volume":"319","author":"Hillier","year":"1988","journal-title":"N Engl J Med"},{"key":"2019050220123945600_bib25","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/0002-9378(91)90447-Y","article-title":"Microbiologic causes and neonatal outcomes associated with chorioamnion infection","volume":"165","author":"Hillier","year":"1991","journal-title":"Am J Obstet Gynecol"},{"key":"2019050220123945600_bib26","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1016\/0002-9378(92)91609-E","article-title":"The relationship between acute inflammatory lesions of the preterm placenta and amniotic fluid microbiology","volume":"166","author":"Romero","year":"1992","journal-title":"Am J Obstet Gynecol"},{"key":"2019050220123945600_bib27","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1007\/s10024-003-7070-y","article-title":"Amniotic infection syndrome: nosology and reproducibility of placental reaction patterns","volume":"6","author":"Redline","year":"2003","journal-title":"Pediatr Dev Pathol"},{"key":"2019050220123945600_bib28","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.siny.2003.09.005","article-title":"Placental inflammation","volume":"9","author":"Redline","year":"2004","journal-title":"Semin Neonatol"},{"key":"2019050220123945600_bib29","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/B978-1-4160-2592-4.50016-3","article-title":"Infections and inflammatory lesions of the placenta","volume-title":"Pathology of the Placenta","author":"Fox","year":"2007","edition":"3rd ed."},{"key":"2019050220123945600_bib30","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1007\/978-3-642-23941-0_20","article-title":"Infectious diseases","volume-title":"Pathology of the Human Placenta","author":"Benirschke","year":"2012"},{"key":"2019050220123945600_bib31","doi-asserted-by":"crossref","first-page":"S29","DOI":"10.1016\/j.ajog.2015.08.040","article-title":"Acute chorioamnionitis and funisitis: definition, pathologic features, and clinical significance","volume":"213","author":"Kim","year":"2015","journal-title":"Am J Obstet Gynecol"},{"key":"2019050220123945600_bib32","doi-asserted-by":"crossref","first-page":"S21","DOI":"10.1016\/j.ajog.2015.05.056","article-title":"Classification of placental lesions","volume":"213","author":"Redline","year":"2015","journal-title":"Am J Obstet Gynecol"},{"key":"2019050220123945600_bib33","doi-asserted-by":"crossref","first-page":"e12623","DOI":"10.1111\/aji.12623","article-title":"Current concepts in maternal-fetal immunology: recognition and response to microbial pathogens by decidual stromal cells","volume":"77","author":"Anders","year":"2017","journal-title":"Am J Reprod Immunol"},{"key":"2019050220123945600_bib34","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1006\/smim.1998.0143","article-title":"An innate sense of danger","volume":"10","author":"Matzinger","year":"1998","journal-title":"Semin Immunol"},{"key":"2019050220123945600_bib35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.clim.2007.02.006","article-title":"Damage associated molecular pattern molecules","volume":"124","author":"Lotze","year":"2007","journal-title":"Clin Immunol"},{"key":"2019050220123945600_bib36","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.coi.2005.06.002","article-title":"Alarmins: chemotactic activators of immune responses","volume":"17","author":"Oppenheim","year":"2005","journal-title":"Curr Opin Immunol"},{"key":"2019050220123945600_bib37","doi-asserted-by":"crossref","first-page":"836.e1","DOI":"10.1016\/j.ajog.2015.07.037","article-title":"Evidence of perturbations of the cytokine network in preterm labor","volume":"213","author":"Romero","year":"2015","journal-title":"Am J Obstet Gynecol"},{"key":"2019050220123945600_bib38","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/cmi.2016.34","article-title":"HMGB1, IL-1alpha, IL-33 and S100 proteins: dual-function alarmins","volume":"14","author":"Bertheloot","year":"2017","journal-title":"Cell Mol Immunol"},{"key":"2019050220123945600_bib39","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/0002-9378(91)90450-6","article-title":"Systemic administration of interleukin-1 induces preterm parturition in mice","volume":"165","author":"Romero","year":"1991","journal-title":"Am J Obstet Gynecol"},{"key":"2019050220123945600_bib40","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/S0002-9378(12)80035-4","article-title":"The natural interleukin-1 receptor antagonist prevents interleukin-l-induced preterm delivery in mice","volume":"167","author":"Romero","year":"1992","journal-title":"Am J Obstet Gynecol"},{"key":"2019050220123945600_bib41","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/aji.12443","article-title":"Intra-Amniotic administration of HMGB1 induces spontaneous preterm labor and birth","volume":"75","author":"Gomez-Lopez","year":"2016","journal-title":"Am J Reprod Immunol"},{"key":"2019050220123945600_bib42","first-page":"922","article-title":"Mouse models of preterm birth: suggested assessment and reporting guidelines","volume":"99","author":"McCarthy","year":"2018","journal-title":"Biol Reprod"},{"key":"2019050220123945600_bib43","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1189\/jlb.0306170","article-title":"S100 proteins expressed in phagocytes: a novel group of damage-associated molecular pattern molecules","volume":"81","author":"Foell","year":"2007","journal-title":"J Leukoc Biol"},{"key":"2019050220123945600_bib44","first-page":"960","article-title":"S100A4 promotes the development of lipopolysaccharide-induced mouse endometritis","volume":"99","author":"Wu","year":"2018","journal-title":"Biol Reprod"},{"key":"2019050220123945600_bib45","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1515\/JPM.2007.101","article-title":"The calcium binding protein, S100B, is increased in the amniotic fluid of women with intra-amniotic infection\/inflammation and preterm labor with intact or ruptured membranes","volume":"35","author":"Friel","year":"2007","journal-title":"J Perinat Med"},{"key":"2019050220123945600_bib46","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1080\/14767050802212109","article-title":"Evidence of the involvement of caspase-1 under physiologic and pathologic cellular stress during human pregnancy: a link between the inflammasome and parturition","volume":"21","author":"Gotsch","year":"2008","journal-title":"J Matern Fetal Neonatal Med"},{"key":"2019050220123945600_bib47","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1177\/1933719116687656","article-title":"A role for the inflammasome in spontaneous preterm labor with acute histologic chorioamnionitis","volume":"24","author":"Gomez-Lopez","year":"2017","journal-title":"Reprod Sci"},{"key":"2019050220123945600_bib48","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.ajog.2017.12.009","article-title":"Spontaneous preterm birth: advances toward the discovery of genetic predisposition","volume":"218","author":"Strauss","year":"2018","journal-title":"Am J Obstet Gynecol"},{"key":"2019050220123945600_bib49","doi-asserted-by":"crossref","first-page":"e13049","DOI":"10.1111\/aji.13049","article-title":"Inflammasome activation during spontaneous preterm labor with intra-amniotic infection or sterile intra-amniotic inflammation","volume":"80","author":"Gomez-Lopez","year":"2018","journal-title":"Am J Reprod Immunol"},{"key":"2019050220123945600_bib50","doi-asserted-by":"crossref","DOI":"10.1093\/biolre\/ioy261","article-title":"Intra-Amniotic inflammation induces preterm birth by activating the NLRP3 inflammasome","author":"Faro","year":"2018","journal-title":"Biol Reprod"},{"key":"2019050220123945600_bib51","doi-asserted-by":"crossref","first-page":"e12440","DOI":"10.1111\/aji.12440","article-title":"A role for the inflammasome in spontaneous labor at term","volume":"79","author":"Romero","year":"2016","journal-title":"Am J Reprod Immunol"},{"key":"2019050220123945600_bib52","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1177\/1933719116675058","article-title":"A role for the inflammasome in spontaneous labor at term with acute histologic chorioamnionitis","volume":"24","author":"Gomez-Lopez","year":"2017","journal-title":"Reprod Sci"},{"key":"2019050220123945600_bib53","doi-asserted-by":"crossref","first-page":"e12648","DOI":"10.1111\/aji.12648","article-title":"Inflammasome assembly in the chorioamniotic membranes during spontaneous labor at term","volume":"77","author":"Gomez-Lopez","year":"2017","journal-title":"Am J Reprod Immunol"},{"key":"2019050220123945600_bib54","article-title":"In vivo evidence of inflammasome activation during spontaneous labor at term","author":"Panaitescu","year":"2018","journal-title":"J Matern Fetal Neonatal Med"},{"key":"2019050220123945600_bib55","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S1097-2765(02)00599-3","article-title":"The Inflammasome","volume":"10","author":"Martinon","year":"2002","journal-title":"Mol Cell"},{"key":"2019050220123945600_bib56","doi-asserted-by":"crossref","first-page":"R581","DOI":"10.1016\/j.cub.2005.07.049","article-title":"The inflammasome","volume":"15","author":"Petrilli","year":"2005","journal-title":"Curr Biol"},{"key":"2019050220123945600_bib57","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.cell.2006.08.002","article-title":"The inflammasome: first line of the immune response to cell stress","volume":"126","author":"Ogura","year":"2006","journal-title":"Cell"},{"key":"2019050220123945600_bib58","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/nri1997","article-title":"Inflammasome adaptors and sensors: intracellular regulators of infection and inflammation","volume":"7","author":"Mariathasan","year":"2007","journal-title":"Nat Rev Immunol"},{"key":"2019050220123945600_bib59","doi-asserted-by":"crossref","first-page":"3502","DOI":"10.1172\/JCI40599","article-title":"Inflammasomes: too big to miss","volume":"119","author":"Stutz","year":"2009","journal-title":"J Clin Invest"},{"key":"2019050220123945600_bib60","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/ni.1703","article-title":"The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis","volume":"10","author":"Franchi","year":"2009","journal-title":"Nat Immunol"},{"key":"2019050220123945600_bib61","doi-asserted-by":"crossref","first-page":"7623","DOI":"10.4049\/jimmunol.0902425","article-title":"Inflammasome-associated nucleotide-binding domain, leucine-rich repeat proteins and inflammatory diseases","volume":"183","author":"Jha","year":"2009","journal-title":"J Immunol"},{"key":"2019050220123945600_bib62","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.cell.2010.01.040","article-title":"The inflammasomes","volume":"140","author":"Schroder","year":"2010","journal-title":"Cell"},{"key":"2019050220123945600_bib63","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1002\/eji.200940180","article-title":"Inflammasomes as microbial sensors","volume":"40","author":"Franchi","year":"2010","journal-title":"Eur J Immunol"},{"key":"2019050220123945600_bib64","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1111\/j.1600-065X.2011.01046.x","article-title":"The inflammasome: an integrated view","volume":"243","author":"Gross","year":"2011","journal-title":"Immunol Rev"},{"key":"2019050220123945600_bib65","doi-asserted-by":"crossref","first-page":"597","DOI":"10.4049\/jimmunol.1100229","article-title":"Modulation of inflammasome pathways by bacterial and viral pathogens","volume":"187","author":"Lamkanfi","year":"2011","journal-title":"J Immunol"},{"key":"2019050220123945600_bib66","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1111\/j.1600-065X.2011.01050.x","article-title":"Intracellular sensing of microbes and danger signals by the inflammasomes","volume":"243","author":"Horvath","year":"2011","journal-title":"Immunol Rev"},{"key":"2019050220123945600_bib67","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.it.2011.01.003","article-title":"Inflammasome activation and IL-1beta and IL-18 processing during infection","volume":"32","author":"van de Veerdonk","year":"2011","journal-title":"Trends Immunol"},{"key":"2019050220123945600_bib68","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/ni.2231","article-title":"Sensing and reacting to microbes through the inflammasomes","volume":"13","author":"Franchi","year":"2012","journal-title":"Nat Immunol"},{"key":"2019050220123945600_bib69","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1126\/science.1229010","article-title":"Orchestrating Inflammasomes","volume":"337","author":"Franchi","year":"2012","journal-title":"Science"},{"key":"2019050220123945600_bib70","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/ni.2257","article-title":"Inflammasomes: far beyond inflammation","volume":"13","author":"Henao-Mejia","year":"2012","journal-title":"Nat Immunol"},{"key":"2019050220123945600_bib71","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/nri3452","article-title":"Activation and regulation of the inflammasomes","volume":"13","author":"Latz","year":"2013","journal-title":"Nat Rev Immunol"},{"key":"2019050220123945600_bib72","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/j.cell.2014.04.007","article-title":"Mechanisms and functions of inflammasomes","volume":"157","author":"Lamkanfi","year":"2014","journal-title":"Cell"},{"key":"2019050220123945600_bib73","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1038\/nm.3893","article-title":"Inflammasomes: mechanism of action, role in disease and therapeutics","volume":"21","author":"Guo","year":"2015","journal-title":"Nat Med"},{"key":"2019050220123945600_bib74","doi-asserted-by":"crossref","first-page":"5323","DOI":"10.1016\/S0021-9258(18)83546-3","article-title":"A pre-aspartate-specific protease from human leukocytes that cleaves pro-interleukin-1 beta","volume":"264","author":"Black","year":"1989","journal-title":"J Biol Chem"},{"key":"2019050220123945600_bib75","doi-asserted-by":"crossref","first-page":"5227","DOI":"10.1073\/pnas.86.14.5227","article-title":"Identification of a monocyte specific pre-interleukin 1 beta convertase activity.","volume":"86","author":"Kostura","year":"1989","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019050220123945600_bib76","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1038\/356768a0","article-title":"A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes","volume":"356","author":"Thornberry","year":"1992","journal-title":"Nature"},{"key":"2019050220123945600_bib77","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1126\/science.1373520","article-title":"Molecular cloning of the interleukin-1 beta converting enzyme","volume":"256","author":"Cerretti","year":"1992","journal-title":"Science"},{"key":"2019050220123945600_bib78","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1126\/science.275.5297.206","article-title":"Activation of interferon-gamma inducing factor mediated by interleukin-1beta converting enzyme","volume":"275","author":"Gu","year":"1997","journal-title":"Science"},{"key":"2019050220123945600_bib79","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1038\/386619a0","article-title":"Caspase-1 processes IFN-gamma-inducing factor and regulates LPS-induced IFN- gamma production","volume":"386","author":"Ghayur","year":"1997","journal-title":"Nature"},{"key":"2019050220123945600_bib80","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1749-6632.1998.tb08307.x","article-title":"Interleukin-1beta, interleukin-18, and the interleukin-1beta converting enzyme","volume":"856","author":"Dinarello","year":"1998","journal-title":"Ann NY Acad Sci"},{"key":"2019050220123945600_bib81","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1023\/A:1020506300324","article-title":"Interleukin-18 and interleukin-1 beta: two cytokine substrates for ICE (caspase-1)","volume":"19","author":"Fantuzzi","year":"1999","journal-title":"J Clin Immunol"},{"key":"2019050220123945600_bib82","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1146\/annurev-immunol-032414-112306","article-title":"Inflammasome-independent regulation of IL-1-family cytokines","volume":"33","author":"Netea","year":"2015","journal-title":"Annu Rev Immunol"},{"key":"2019050220123945600_bib83","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1095\/biolreprod.116.144139","article-title":"HMGB1 induces an inflammatory response in the chorioamniotic membranes that is partially mediated by the inflammasome","volume":"95","author":"Plazyo","year":"2016","journal-title":"Biol Reprod"},{"key":"2019050220123945600_bib84","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/nm.3806","article-title":"A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases","volume":"21","author":"Coll","year":"2015","journal-title":"Nat Med"},{"key":"2019050220123945600_bib85","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1016\/0002-9378(88)90216-5","article-title":"Labor and infection. II. Bacterial endotoxin in amniotic fluid and its relationship to the onset of preterm labor","volume":"158","author":"Romero","year":"1988","journal-title":"Am J Obstet Gynecol"},{"key":"2019050220123945600_bib86","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1080\/14767058.2017.1287894","article-title":"Intra-amniotic administration of lipopolysaccharide induces spontaneous preterm labor and birth in the absence of a body temperature change","volume":"31","author":"Gomez-Lopez","year":"2018","journal-title":"J Matern Fetal Neonatal Med"},{"key":"2019050220123945600_bib87","doi-asserted-by":"crossref","first-page":"9021","DOI":"10.1073\/pnas.0812690106","article-title":"The IL-1-like cytokine IL-33 is inactivated after maturation by caspase-1","volume":"106","author":"Cayrol","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019050220123945600_bib88","doi-asserted-by":"crossref","first-page":"327","DOI":"10.3109\/14767058.2012.735724","article-title":"Interleukin-33 in the human placenta","volume":"26","author":"Topping","year":"2013","journal-title":"J Matern Fetal Neonatal Med"},{"key":"2019050220123945600_bib89","first-page":"120","article-title":"Modeling sepsis in the laboratory: merging sound science with animal well-being","volume":"58","author":"Nemzek","year":"2008","journal-title":"Comp Med"},{"key":"2019050220123945600_bib90","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.4049\/jimmunol.1601342","article-title":"Alarmins: feel the stress","volume":"198","author":"Rider","year":"2017","journal-title":"J Immunol"},{"key":"2019050220123945600_bib91","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/1471-213X-7-15","article-title":"Developmental expression of the receptor for advanced glycation end-products (RAGE) and its response to hyperoxia in the neonatal rat lung","volume":"7","author":"Lizotte","year":"2007","journal-title":"BMC Dev Biol"},{"key":"2019050220123945600_bib92","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1038\/pr.2014.113","article-title":"Intra-amniotic LPS modulates expression of antimicrobial peptides in the fetal sheep lung","volume":"76","author":"Schmidt","year":"2014","journal-title":"Pediatr Res"},{"key":"2019050220123945600_bib93","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1542\/peds.93.5.712","article-title":"Association of pulmonary inflammation and increased microvascular permeability during the development of bronchopulmonary dysplasia: a sequential analysis of inflammatory mediators in respiratory fluids of high-risk preterm neonates","volume":"93","author":"Groneck","year":"1994","journal-title":"Pediatrics"},{"key":"2019050220123945600_bib94","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1016\/S0002-9378(96)70585-9","article-title":"Interleukin-6 concentrations in umbilical cord plasma are elevated in neonates with white matter lesions associated with periventricular leukomalacia","volume":"174","author":"Yoon","year":"1996","journal-title":"Am J Obstet Gynecol"},{"key":"2019050220123945600_bib95","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0002-9378(97)70432-0","article-title":"Amniotic fluid inflammatory cytokines (interleukin-6, interleukin-1beta, and tumor necrosis factor-alpha), neonatal brain white matter lesions, and cerebral palsy","volume":"177","author":"Yoon","year":"1997","journal-title":"Am J Obstet Gynecol"},{"key":"2019050220123945600_bib96","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1203\/00006450-199707000-00001","article-title":"Maternal intrauterine infection, cytokines, and brain damage in the preterm newborn","volume":"42","author":"Dammann","year":"1997","journal-title":"Pediatr Res"},{"key":"2019050220123945600_bib97","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/S0002-9378(97)70271-0","article-title":"Experimentally induced intrauterine infection causes fetal brain white matter lesions in rabbits","volume":"177","author":"Yoon","year":"1997","journal-title":"Am J Obstet Gynecol"},{"key":"2019050220123945600_bib98","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1067\/mob.2000.104207","article-title":"Fetal exposure to an intra-amniotic inflammation and the development of cerebral palsy at the age of three years","volume":"182","author":"Yoon","year":"2000","journal-title":"Am J Obstet Gynecol"},{"key":"2019050220123945600_bib99","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1203\/00006450-200006000-00009","article-title":"Intrauterine infection induces programmed cell death in rabbit periventricular white matter","volume":"47","author":"Debillon","year":"2000","journal-title":"Pediatr Res"},{"key":"2019050220123945600_bib100","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1016\/S0140-6736(01)06723-X","article-title":"Intrauterine T-cell activation and increased proinflammatory cytokine concentrations in preterm infants with cerebral lesions","volume":"358","author":"Duggan","year":"2001","journal-title":"Lancet North Am Ed"},{"key":"2019050220123945600_bib101","doi-asserted-by":"crossref","first-page":"F455","DOI":"10.1136\/adc.2007.121327","article-title":"Bronchopulmonary dysplasia and inflammatory biomarkers in the premature neonate","volume":"93","author":"Bose","year":"2008","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"2019050220123945600_bib102","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1177\/0883073809338066","article-title":"Fetal inflammatory response and brain injury in the preterm newborn","volume":"24","author":"Malaeb","year":"2009","journal-title":"J Child Neurol"},{"key":"2019050220123945600_bib103","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.cca.2015.02.028","article-title":"The clinical and diagnostic utility of S100B in preterm newborns","volume":"444","author":"Serpero","year":"2015","journal-title":"Clin Chim Acta"},{"key":"2019050220123945600_bib104","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.3389\/fimmu.2018.01291","article-title":"Inflammation-induced adverse pregnancy and neonatal outcomes can be improved by the immunomodulatory peptide exendin-4","volume":"9","author":"Garcia-Flores","year":"2018","journal-title":"Front Immunol"},{"key":"2019050220123945600_bib105","first-page":"223 e221\u2013227","article-title":"Prevention of preterm birth by progestational agents: what are the molecular mechanisms?","volume":"208","author":"Nold","year":"2013","journal-title":"Am J Obstet Gynecol"},{"key":"2019050220123945600_bib106","doi-asserted-by":"crossref","first-page":"846.e1","DOI":"10.1016\/j.ajog.2015.08.010","article-title":"Vaginal progesterone, but not 17alpha-hydroxyprogesterone caproate, has antiinflammatory effects at the murine maternal-fetal interface","volume":"213","author":"Furcron","year":"2015","journal-title":"Am J Obstet Gynecol"},{"key":"2019050220123945600_bib107","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.ajog.2015.09.102","article-title":"Vaginal progesterone to prevent preterm birth in pregnant women with a sonographic short cervix: clinical and public health implications","volume":"214","author":"Conde-Agudelo","year":"2016","journal-title":"Am J Obstet Gynecol"},{"key":"2019050220123945600_bib108","doi-asserted-by":"crossref","first-page":"371.e1","DOI":"10.1016\/j.ajog.2017.05.022","article-title":"Gestational age at initiation of 17-alpha hydroxyprogesterone caproate and recurrent preterm birth","volume":"217","author":"Ning","year":"2017","journal-title":"Am J Obstet Gynecol"},{"key":"2019050220123945600_bib109","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1210\/en.2016-1930","article-title":"Steroid hormones are key modulators of tissue mechanical function via regulation of collagen and elastic fibers","volume":"158","author":"Nallasamy","year":"2017","journal-title":"Endocrinology"},{"key":"2019050220123945600_bib110","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1095\/biolreprod.116.142844","article-title":"Contributions to the dynamics of cervix remodeling prior to term and preterm birth","volume":"96","author":"Yellon","year":"2017","journal-title":"Biol Reprod"},{"key":"2019050220123945600_bib111","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.3389\/fimmu.2018.01293","article-title":"Progesterone modulation of pregnancy-related immune responses","volume":"9","author":"Shah","year":"2018","journal-title":"Front Immunol"},{"key":"2019050220123945600_bib112","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.ajog.2017.11.576","article-title":"Vaginal progesterone for preventing preterm birth and adverse perinatal outcomes in singleton gestations with a short cervix: a meta-analysis of individual patient data","volume":"218","author":"Romero","year":"2018","journal-title":"Am J Obstet Gynecol"},{"key":"2019050220123945600_bib113","first-page":"486","article-title":"Antenatal betamethasone for women at risk for late preterm delivery","volume":"375","author":"Gyamfi-Bannerman","year":"2016","journal-title":"N Engl J Med"},{"key":"2019050220123945600_bib114","doi-asserted-by":"crossref","first-page":"B13","DOI":"10.1016\/j.ajog.2016.03.013","article-title":"Implementation of the use of antenatal corticosteroids in the late preterm birth period in\u00a0women at risk for preterm delivery","volume":"215","author":"Committee. SfM-FMSP","year":"2016","journal-title":"Am J Obstet Gynecol"},{"key":"2019050220123945600_bib115","doi-asserted-by":"crossref","first-page":"461.e1","DOI":"10.1016\/j.ajog.2017.04.029","article-title":"Assessing the potential impact of extending antenatal steroids to the late preterm period","volume":"217","author":"Souter","year":"2017","journal-title":"Am J Obstet Gynecol"},{"key":"2019050220123945600_bib116","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1095\/biolreprod.116.139345","article-title":"Human chorionic gonadotropin has anti-inflammatory effects at the maternal-fetal interface and prevents endotoxin-induced preterm birth, but causes dystocia and fetal compromise in mice","volume":"94","author":"Furcron","year":"2016","journal-title":"Biol Reprod"},{"key":"2019050220123945600_bib117","doi-asserted-by":"crossref","first-page":"e72138","DOI":"10.1371\/journal.pone.0072138","article-title":"S100A8 and S100A9 induce cytokine expression and regulate the NLRP3 inflammasome via ROS-dependent activation of NF-kappa B1","volume":"8","author":"Simard","year":"2013","journal-title":"PLoS One"},{"key":"2019050220123945600_bib118","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1159\/000480340","article-title":"Involvement of S100A8\/A9-TLR4-NLRP3 inflammasome pathway in contrast-induced acute kidney injury","volume":"43","author":"Tan","year":"2017","journal-title":"Cell Physiol Biochem"},{"key":"2019050220123945600_bib119","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.bbrc.2018.06.057","article-title":"Inflammatory mediators ATP and S100A12 activate the NLRP3 inflammasome to induce MUC5AC production in airway epithelial cells","volume":"503","author":"Kim","year":"2018","journal-title":"Biochem Biophys Res Commun"},{"key":"2019050220123945600_bib120","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1038\/ni.2919","article-title":"The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response","volume":"15","author":"Baroja-Mazo","year":"2014","journal-title":"Nat Immunol"},{"key":"2019050220123945600_bib121","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1038\/ni.2913","article-title":"The adaptor ASC has extracellular and \u2018prionoid\u2019 activities that propagate inflammation","volume":"15","author":"Franklin","year":"2014","journal-title":"Nat Immunol"},{"key":"2019050220123945600_bib122","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1111\/aji.12462","article-title":"Differential receptor for advanced glycation end products expression in preeclamptic, intrauterine growth restricted, and gestational diabetic placentas","volume":"75","author":"Alexander","year":"2016","journal-title":"Am J Reprod Immunol"},{"key":"2019050220123945600_bib123","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1111\/j.1365-2567.2007.02662.x","article-title":"The novel inflammatory cytokine high mobility group box protein 1 (HMGB1) is expressed by human term placenta","volume":"122","author":"Holmlund","year":"2007","journal-title":"Immunology"},{"key":"2019050220123945600_bib124","doi-asserted-by":"crossref","first-page":"2421","DOI":"10.4049\/jimmunol.1600035","article-title":"Efficacy and pharmacology of the NLRP3 inflammasome inhibitor CP-456,773 (CRID3) in murine models of dermal and pulmonary inflammation","volume":"197","author":"Primiano","year":"2016","journal-title":"J Immunol"},{"key":"2019050220123945600_bib125","first-page":"3212","article-title":"Resveratrol pretreatment attenuates traumatic brain injury in rats by suppressing NLRP3 inflammasome activation via SIRT1","volume":"17","author":"Zou","year":"2018","journal-title":"Mol Med Rep"},{"key":"2019050220123945600_bib126","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1038\/nrd.2018.97","article-title":"Targeting the NLRP3 inflammasome in inflammatory diseases","volume":"17","author":"Mangan","year":"2018","journal-title":"Nat Rev Drug Discov"},{"key":"2019050220123945600_bib127","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1038\/nature16959","article-title":"NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux","volume":"530","author":"He","year":"2016","journal-title":"Nature"},{"key":"2019050220123945600_bib128","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1038\/ni.3333","article-title":"NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component","volume":"17","author":"Shi","year":"2016","journal-title":"Nat Immunol"},{"key":"2019050220123945600_bib129","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/ni.3391","article-title":"The NEK-sus of the NLRP3 inflammasome","volume":"17","author":"Van Hauwermeiren","year":"2016","journal-title":"Nat Immunol"},{"key":"2019050220123945600_bib130","doi-asserted-by":"crossref","first-page":"8618","DOI":"10.1038\/s41598-018-26775-w","article-title":"MCC950, a specific small molecule inhibitor of NLRP3 inflammasome attenuates colonic inflammation in spontaneous colitis mice","volume":"8","author":"Perera","year":"2018","journal-title":"Sci Rep"},{"key":"2019050220123945600_bib131","doi-asserted-by":"crossref","first-page":"522","DOI":"10.3390\/molecules23030522","article-title":"Inhibiting the NLRP3 inflammasome activation with MCC950 ameliorates diabetic encephalopathy in db\/db mice","volume":"23","author":"Zhai","year":"2018","journal-title":"Molecules"},{"key":"2019050220123945600_bib132","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1089\/neu.2017.5344","article-title":"MCC950, the selective inhibitor of nucleotide oligomerization domain-like receptor protein-3 inflammasome, protects mice against traumatic brain injury","volume":"35","author":"Ismael","year":"2018","journal-title":"J Neurotrauma"},{"key":"2019050220123945600_bib133","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.nbd.2018.05.016","article-title":"Selective NLRP3 inflammasome inhibitor reduces neuroinflammation and improves long-term neurological outcomes in a murine model of traumatic brain injury","volume":"117","author":"Xu","year":"2018","journal-title":"Neurobiol Dis"},{"key":"2019050220123945600_bib134","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1161\/ATVBAHA.117.309575","article-title":"NLRP3 inflammasome inhibition by MCC950 reduces atherosclerotic lesion development in apolipoprotein E\u2013deficient mice\u2014brief report","volume":"37","author":"van der Heijden","year":"2017","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2019050220123945600_bib135","doi-asserted-by":"crossref","first-page":"5971","DOI":"10.1038\/s41598-018-24350-x","article-title":"Inhibition of the NLRP3-inflammasome as a potential approach for neuroprotection after stroke","volume":"8","author":"Ismael","year":"2018","journal-title":"Sci Rep"},{"key":"2019050220123945600_bib136","doi-asserted-by":"crossref","first-page":"E1530","DOI":"10.1073\/pnas.1716095115","article-title":"OLT1177, a beta-sulfonyl nitrile compound, safe in humans, inhibits the NLRP3 inflammasome and reverses the metabolic cost of inflammation","volume":"115","author":"Marchetti","year":"2018","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019050220123945600_bib137","doi-asserted-by":"crossref","first-page":"3219","DOI":"10.1084\/jem.20171419","article-title":"Identification of a selective and direct NLRP3 inhibitor to treat inflammatory disorders","volume":"214","author":"Jiang","year":"2017","journal-title":"J Exp Med"},{"key":"2019050220123945600_bib138","doi-asserted-by":"crossref","first-page":"782","DOI":"10.3389\/fimmu.2017.00782","article-title":"Inhibition of the NOD-like receptor protein 3 inflammasome is protective in juvenile influenza a virus infection","volume":"8","author":"Coates","year":"2017","journal-title":"Front Immunol"},{"key":"2019050220123945600_bib139","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/0002-9378(89)90172-5","article-title":"Infection and labor. III. Interleukin-1: a signal for the onset of parturition","volume":"160","author":"Romero","year":"1989","journal-title":"Am J Obstet Gynecol"},{"key":"2019050220123945600_bib140","first-page":"235","article-title":"Amniotic fluid interleukin-1 in spontaneous labor at term","volume":"35","author":"Romero","year":"1990","journal-title":"J Reprod Med"},{"key":"2019050220123945600_bib141","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1111\/j.1600-0897.1992.tb00737.x","article-title":"Interleukin-1 alpha and Interleukin-1 beta in preterm and term human parturition","volume":"27","author":"Romero","year":"1992","journal-title":"Am J Reprod Immunol"},{"key":"2019050220123945600_bib142","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1016\/S0002-9378(99)70400-X","article-title":"Cytokine abundance in placental tissues: evidence of inflammatory activation in gestational membranes with term and preterm parturition","volume":"181","author":"Keelan","year":"1999","journal-title":"Am J Obstet Gynecol"},{"key":"2019050220123945600_bib143","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1111\/aji.12174","article-title":"Caspase-1 activation is increased with human labour in foetal membranes and myometrium and mediates infection-induced interleukin-1beta secretion","volume":"71","author":"Lappas","year":"2014","journal-title":"Am J Reprod Immunol"}],"container-title":["Biology of Reproduction"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/biolreprod\/article-pdf\/100\/5\/1306\/28554352\/ioy264.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,9]],"date-time":"2022-09-09T05:57:50Z","timestamp":1662703070000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/biolreprod\/article\/100\/5\/1306\/5266296"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,28]]},"references-count":143,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2018,12,28]]},"published-print":{"date-parts":[[2019,5,1]]}},"URL":"https:\/\/doi.org\/10.1093\/biolre\/ioy264","relation":{},"ISSN":["0006-3363","1529-7268"],"issn-type":[{"value":"0006-3363","type":"print"},{"value":"1529-7268","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,5]]},"published":{"date-parts":[[2018,12,28]]}}}