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On day 15 postbreeding, macrophages (F4\/80+) were depleted in cervix and kidney, but not in liver, ovary, or other non-reproductive tissues in DT\u2014compared to saline\u2014treated dtr mice or wild-type controls given DT or saline. Within 24 h of DT-treatment, the density of cell nuclei and macrophages declined in cervix stroma in dtr mice versus controls, but birefringence of collagen, as an indication of extracellular cross-linked structure, remained unchanged. Only in the cervix of DT-treated dtr mice was an apoptotic morphology evident in macrophages. DT-treatment did not alter the sparse presence or morphology of neutrophils. By day 18 postbreeding, macrophages repopulated the cervix in DT-treated dtr mice so that the numbers were comparable to that in controls. However, at term, evidence of fetal mortality without cervix ripening occurred in most dtr mice given DT\u2014a possible consequence of treatment effects on placental function. These findings suggest that CD11b+ F4\/80+ macrophages are important to sustain pregnancy and are required for processes that remodel the cervix in preparation for parturition.<\/jats:p>","DOI":"10.1093\/biolre\/ioz002","type":"journal-article","created":{"date-parts":[[2019,1,9]],"date-time":"2019-01-09T15:38:44Z","timestamp":1547048324000},"page":"1386-1394","source":"Crossref","is-referenced-by-count":36,"title":["Effects of macrophage depletion on characteristics of cervix remodeling and pregnancy in CD11b-dtr mice"],"prefix":"10.1093","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4850-3590","authenticated-orcid":false,"given":"S M","family":"Yellon","sequence":"first","affiliation":[{"name":"Longo Center for Perinatal Biology"},{"name":"Division of Physiology, Departments of Basic Sciences, and Pediatrics, Loma Linda University School of Medicine, Loma Linda, CA 92350, 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