{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T08:51:01Z","timestamp":1788511861065,"version":"build-2803163510"},"reference-count":53,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2019,7,27]],"date-time":"2019-07-27T00:00:00Z","timestamp":1564185600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Graduate Innovation Fund of PUMC","award":["2017-0710-10"],"award-info":[{"award-number":["2017-0710-10"]}]},{"name":"Major State Basic Research Project of China","award":["2016YFA0101001"],"award-info":[{"award-number":["2016YFA0101001"]}]},{"name":"Major State Basic Research Project of China","award":["2018YFC1003902"],"award-info":[{"award-number":["2018YFC1003902"]}]},{"name":"CAMS Initiative for Innovative Medicine","award":["2017-I2M-B&R-06"],"award-info":[{"award-number":["2017-I2M-B&R-06"]}]},{"name":"CAMS Initiative for Innovative Medicine","award":["2017-I2M-3-007"],"award-info":[{"award-number":["2017-I2M-3-007"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,10,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The seminal vesicles can be infected by microorganisms, thereby resulting in vesiculitis and impairment in male fertility. Innate immune responses in seminal vesicles cells to microbial infections, which facilitate vesiculitis, have yet to be investigated. The present study aims to elucidate pattern recognition receptor\u2013mediated innate immune responses in seminal vesicles epithelial cells. Various pattern recognition receptors, including Toll-like receptor 3, Toll-like receptor 4, cytosolic ribonucleic acid, and deoxyribonucleic acid sensors, are abundantly expressed in seminal vesicles epithelial cells. These pattern recognition receptors can recognize their respective ligands, thus activating nuclear factor kappa B and interferon regulatory factor 3. The pattern recognition receptor signaling induces expression of pro-inflammatory cytokines, such as tumor necrosis factor alpha (Tnfa) and interleukin 6 (Il6), chemokines monocyte chemoattractant protein-1 (Mcp1) and C\u2013X\u2013C motif chemokine 10 (Cxcl10), and type 1 interferons Ifna and Ifnb. Moreover, pattern recognition receptor-mediated innate immune responses up-regulated the expression of microsomal prostaglandin E synthase and cyclooxygenase 2, but they down-regulated semenogelin-1 expression. These results provide novel insights into the mechanism underlying vesiculitis and its impact on the functions of the seminal vesicles.<\/jats:p>","DOI":"10.1093\/biolre\/ioz136","type":"journal-article","created":{"date-parts":[[2019,7,27]],"date-time":"2019-07-27T06:40:16Z","timestamp":1564209616000},"page":"733-747","source":"Crossref","is-referenced-by-count":14,"title":["Pattern recognition receptor-mediated innate immune responses in seminal vesicle epithelial cell and their impacts on cellular function\u2020"],"prefix":"10.1093","volume":"101","author":[{"given":"Maolei","family":"Gong","sequence":"first","affiliation":[{"name":"Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, 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