{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T22:56:53Z","timestamp":1784674613092,"version":"3.55.0"},"reference-count":78,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2019,8,2]],"date-time":"2019-08-02T00:00:00Z","timestamp":1564704000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,11,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Endometriosis is a major health issue among women of reproductive age. However, its etiology has not yet been completely understood. We investigated 10 single nucleotide polymorphisms from six novel nucleotide excision repair genes and the susceptibility to endometriosis. A total of 153 patients with endometriosis were recruited during 2000\u20132010 from central Taiwan. Pathological confirmation was necessary for all patients, and exclusion criteria included the presence of leiomyoma, adenomyosis, or cancer of the uterine, cervix, or ovary and a prescription of hormone therapy. Furthermore, a total of 636 age-matched individuals without endometriosis were recruited during the same time period from central Taiwan. The polymerase chain reaction coupled with restriction fragment length polymorphism methodology was applied for genotyping. The multivariate logistic regression analysis showed that subjects carrying the ERCC1 rs11615 TT (OR\u00a0=\u00a02.04, 95% CI\u00a0=\u00a01.36\u20133.41), ERCC2 rs1799793 AA (OR\u00a0=\u00a01.86, 95% CI\u00a0=\u00a01.14\u20133.11), and ERCC6 rs2228528 AA genotypes (OR\u00a0=\u00a01.79, 95% CI\u00a0=\u00a01.13\u20132.83) exhibited significantly increased risks of developing endometriosis compared with their counterparts carrying the wild-type genotypes. This study suggests that certain single nucleotide polymorphisms of nucleotide excision repair genes excision repair cross-complementation group 1 (ERCC1, ERCC2, and ERCC6) predispose women to the development of endometriosis.<\/jats:p>","DOI":"10.1093\/biolre\/ioz150","type":"journal-article","created":{"date-parts":[[2019,10,11]],"date-time":"2019-10-11T07:19:53Z","timestamp":1570778393000},"page":"928-937","source":"Crossref","is-referenced-by-count":7,"title":["Genetic variants in the nucleotide excision repair genes are associated with the risk of developing endometriosis"],"prefix":"10.1093","volume":"101","author":[{"given":"Te-Chun","family":"Shen","sequence":"first","affiliation":[{"name":"Terry Fox Cancer Research Laboratory, Translational Medicine Research Center, China Medical University Hospital, Taichung, Taiwan"},{"name":"Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan"},{"name":"Intensive Care Unit, Chu Shang Show Chwan Hospital, Nantou, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Wen","family":"Tsai","sequence":"additional","affiliation":[{"name":"Terry Fox Cancer Research Laboratory, Translational Medicine Research Center, China Medical University Hospital, Taichung, Taiwan"},{"name":"Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Shin","family":"Chang","sequence":"additional","affiliation":[{"name":"Terry Fox Cancer Research Laboratory, Translational Medicine Research Center, China Medical University Hospital, Taichung, Taiwan"},{"name":"Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-Chi","family":"Wang","sequence":"additional","affiliation":[{"name":"Terry Fox Cancer Research Laboratory, Translational Medicine Research Center, China Medical University Hospital, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huai-Mei","family":"Hsu","sequence":"additional","affiliation":[{"name":"Terry Fox Cancer Research Laboratory, Translational Medicine Research Center, China Medical University Hospital, Taichung, Taiwan"},{"name":"Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsin-Ting","family":"Li","sequence":"additional","affiliation":[{"name":"Terry Fox Cancer Research Laboratory, Translational Medicine Research Center, China Medical University Hospital, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Da-Tian","family":"Bau","sequence":"additional","affiliation":[{"name":"Terry Fox Cancer Research Laboratory, Translational Medicine Research Center, China Medical University Hospital, Taichung, Taiwan"},{"name":"Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan"},{"name":"Department of Bioinformatics and Medical Engineering, Asia University, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,8,2]]},"reference":[{"key":"2019112601003137900_ref1","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1016\/S0140-6736(04)17403-5","article-title":"Endometriosis","volume":"364","author":"Giudice","year":"2004","journal-title":"Lancet"},{"key":"2019112601003137900_ref2","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.1001\/jama.1986.03370140102032","article-title":"The relation of endometriosis to menstrual characteristics, smoking, and exercise","volume":"255","author":"Cramer","year":"1986","journal-title":"JAMA"},{"key":"2019112601003137900_ref3","doi-asserted-by":"crossref","first-page":"2389","DOI":"10.1056\/NEJMcp1000274","article-title":"Clinical practice. Endometriosis","volume":"362","author":"Giudice","year":"2010","journal-title":"N Engl J Med"},{"key":"2019112601003137900_ref4","doi-asserted-by":"crossref","first-page":"e33941","DOI":"10.1371\/journal.pone.0033941","article-title":"Women with endometriosis are more likely to suffer from migraines: a population-based study","volume":"7","author":"Yang","year":"2012","journal-title":"PLoS One"},{"key":"2019112601003137900_ref5","doi-asserted-by":"crossref","first-page":"e1633","DOI":"10.1097\/MD.0000000000001633","article-title":"The risk of epithelial ovarian cancer of women with endometriosis may be varied greatly if diagnostic criteria are different: a nationwide population-based cohort study","volume":"94","author":"Lee","year":"2015","journal-title":"Medicine"},{"key":"2019112601003137900_ref6","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.tjog.2014.04.025","article-title":"Endometriosis and the subsequent risk of epithelial ovarian cancer","volume":"53","author":"Chang","year":"2014","journal-title":"Taiwan J Obstet Gynecol"},{"key":"2019112601003137900_ref7","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1186\/1471-2407-14-831","article-title":"An increased risk of epithelial ovarian cancer in Taiwanese women with a new surgico-pathological diagnosis of endometriosis","volume":"14","author":"Wang","year":"2014","journal-title":"BMC Cancer"},{"key":"2019112601003137900_ref8","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1097\/IGC.0000000000000454","article-title":"The risks for ovarian, endometrial, breast, colorectal, and other cancers in women with newly diagnosed endometriosis or adenomyosis: a population-based study","volume":"25","author":"Kok","year":"2015","journal-title":"Int J Gynecol Cancer"},{"key":"2019112601003137900_ref9","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1056\/NEJMra0804690","article-title":"Endometriosis","volume":"360","author":"Bulun","year":"2009","journal-title":"N Engl J Med"},{"key":"2019112601003137900_ref10","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1097\/01.ogx.0000279293.60436.60","article-title":"Endometriosis and genetic polymorphisms","volume":"62","author":"Falconer","year":"2007","journal-title":"Obstet Gynecol Surv"},{"key":"2019112601003137900_ref11","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1056\/NEJM199306173282407","article-title":"Endometriosis","volume":"328","author":"Olive","year":"1993","journal-title":"N Engl J Med"},{"key":"2019112601003137900_ref12","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.mce.2009.03.022","article-title":"Estrogen metabolism and action in endometriosis","volume":"307","author":"Rizner","year":"2009","journal-title":"Mol Cell Endocrinol"},{"key":"2019112601003137900_ref13","doi-asserted-by":"crossref","first-page":"e1002732","DOI":"10.1080\/2162402X.2014.1002732","article-title":"Chronic inflammation in endometriosis and endometriosis-associated ovarian cancer: new roles for the \"old\" complement pathway","volume":"4","author":"Edwards","year":"2015","journal-title":"Oncoimmunology"},{"key":"2019112601003137900_ref14","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.ejogrb.2016.04.021","article-title":"Epidemiology of endometriosis and its comorbidities","volume":"209","author":"Parazzini","year":"2017","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"2019112601003137900_ref15","first-page":"7052","article-title":"Loss of heterozygosity on 10q23.3 and mutation of the tumor suppressor gene PTEN in benign endometrial cyst of the ovary: possible sequence progression from benign endometrial cyst to endometrioid carcinoma and clear cell carcinoma of the ovary","volume":"60","author":"Sato","year":"2000","journal-title":"Cancer Res"},{"key":"2019112601003137900_ref16","doi-asserted-by":"crossref","first-page":"3187","DOI":"10.1093\/humrep\/des282","article-title":"Common chromosomal imbalances and stemness-related protein expression markers in endometriotic lesions from different anatomical sites: the potential role of stem cells","volume":"27","author":"Silveira","year":"2012","journal-title":"Hum Reprod"},{"key":"2019112601003137900_ref17","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0165-0378(01)00131-0","article-title":"Somatic DNA alterations in endometriosis: high frequency of chromosome 17 and p53 loss in late-stage endometriosis","volume":"55","author":"Bischoff","year":"2002","journal-title":"J Reprod Immunol"},{"key":"2019112601003137900_ref18","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0301-2115(03)00367-1","article-title":"Increased prevalence of p53 overexpression from typical endometriosis to atypical endometriosis and ovarian cancer associated with endometriosis","volume":"113","author":"Sainz de la Cuesta","year":"2004","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"2019112601003137900_ref19","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1093\/molehr\/gar049","article-title":"Oncogenic events associated with endometrial and ovarian cancers are rare in endometriosis","volume":"17","author":"Vestergaard","year":"2011","journal-title":"Mol Hum Reprod"},{"key":"2019112601003137900_ref20","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1056\/NEJMoa1614814","article-title":"Cancer-associated mutations in endometriosis without cancer","volume":"376","author":"Anglesio","year":"2017","journal-title":"N Engl J Med"},{"key":"2019112601003137900_ref21","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.1093\/humrep\/dep175","article-title":"Expression of selected tumor suppressor and oncogenes in endometrium of women with endometriosis","volume":"24","author":"Laudanski","year":"2009","journal-title":"Hum Reprod"},{"key":"2019112601003137900_ref22","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1002\/path.2940","article-title":"PIK3CA mutation is an early event in the development of endometriosis-associated ovarian clear cell adenocarcinoma","volume":"225","author":"Yamamoto","year":"2011","journal-title":"J Pathol"},{"key":"2019112601003137900_ref23","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1002\/path.4516","article-title":"Multifocal endometriotic lesions associated with cancer are clonal and carry a high mutation burden","volume":"236","author":"Anglesio","year":"2015","journal-title":"J Pathol"},{"key":"2019112601003137900_ref24","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1056\/NEJMoa1008433","article-title":"ARID1A mutations in endometriosis-associated ovarian carcinomas","volume":"363","author":"Wiegand","year":"2010","journal-title":"N Engl J Med"},{"key":"2019112601003137900_ref25","doi-asserted-by":"crossref","first-page":"1964","DOI":"10.1016\/j.humpath.2012.02.005","article-title":"Involvement of pelvic inflammation-related mismatch repair abnormalities and microsatellite instability in the malignant transformation of ovarian endometriosis","volume":"43","author":"Fuseya","year":"2012","journal-title":"Hum Pathol"},{"key":"2019112601003137900_ref26","doi-asserted-by":"crossref","first-page":"603","DOI":"10.3109\/09513590.2013.788632","article-title":"High-resolution array-comparative genomic hybridization profiling reveals 20q13.33 alterations associated with ovarian endometriosis","volume":"29","author":"Yang","year":"2013","journal-title":"Gynecol Endocrinol"},{"key":"2019112601003137900_ref27","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s10815-016-0822-1","article-title":"Copy number variation analysis reveals additional variants contributing to endometriosis development","volume":"34","author":"Mafra","year":"2017","journal-title":"J Assist Reprod Genet"},{"key":"2019112601003137900_ref28","first-page":"1867","article-title":"Mismatch repair system in endometriotic tissue and eutopic endometrium of unaffected women","volume":"8","author":"Grassi","year":"2015","journal-title":"Int J Clin Exp Pathol"},{"key":"2019112601003137900_ref29","doi-asserted-by":"crossref","first-page":"560","DOI":"10.3109\/00016349309058164","article-title":"The familial risk of endometriosis","volume":"72","author":"Moen","year":"1993","journal-title":"Acta Obstet Gynecol Scand"},{"key":"2019112601003137900_ref30","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1177\/1933719112466301","article-title":"Oxidative cell injury as a predictor of endometriosis progression","volume":"20","author":"Carvalho","year":"2013","journal-title":"Reprod Sci"},{"key":"2019112601003137900_ref31","doi-asserted-by":"crossref","first-page":"772","DOI":"10.3389\/fendo.2018.00772","article-title":"Association between impairment of DNA double strand break repair and decreased ovarian reserve in patients with endometriosis","volume":"9","author":"Choi","year":"2018","journal-title":"Front Endocrinol (Lausanne)"},{"key":"2019112601003137900_ref32","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1002\/mrd.20829","article-title":"XRCC4 codon 247*A and XRCC4 promoter \u22121394*T related genotypes but not XRCC4 intron 3 gene polymorphism are associated with higher susceptibility for endometriosis","volume":"75","author":"Hsieh","year":"2008","journal-title":"Mol Reprod Dev"},{"key":"2019112601003137900_ref33","first-page":"326","article-title":"Polymorphism of XRCC1 codon arg 399 Gln is associated with higher susceptibility to endometriosis","volume":"50","author":"Bau","year":"2007","journal-title":"Chin J Physiol"},{"key":"2019112601003137900_ref34","doi-asserted-by":"crossref","first-page":"629","DOI":"10.4238\/vol9-2gmr779","article-title":"DNA repair genes in endometriosis","volume":"9","author":"Attar","year":"2010","journal-title":"Genet Mol Res"},{"key":"2019112601003137900_ref35","doi-asserted-by":"crossref","first-page":"305","DOI":"10.3109\/09513590.2011.631624","article-title":"XRCC1 399 Arg-related genotype and allele, but not XRCC1 His107Arg, XRCC1 Trp194Arg, KCNQ2, AT1R, and hOGG1 polymorphisms, are associated with higher susceptibility of endometriosis","volume":"28","author":"Hsieh","year":"2012","journal-title":"Gynecol Endocrinol"},{"key":"2019112601003137900_ref36","doi-asserted-by":"crossref","first-page":"636","DOI":"10.4238\/2014.January.28.9","article-title":"Association among XRCC1, XRCC3, and BLHX gene polymorphisms and chromosome instability in lymphocytes from patients with endometriosis and ovarian cancer","volume":"13","author":"Monteiro","year":"2014","journal-title":"Genet Mol Res"},{"key":"2019112601003137900_ref37","first-page":"295","article-title":"The role of apurinic\/apyrimidinic endonuclease DNA repair gene in endometriosis","volume":"11","author":"Hsu","year":"2014","journal-title":"Cancer Genomics Proteomics"},{"key":"2019112601003137900_ref38","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1159\/000366444","article-title":"DNA repair gene XRCC1 and XRCC4 variations and risk of endometriosis: an association study","volume":"80","author":"Saliminejad","year":"2015","journal-title":"Gynecol Obstet Invest"},{"key":"2019112601003137900_ref39","first-page":"1513","article-title":"Polymorphisms in DNA repair genes and associations with cancer risk","volume":"11","author":"Goode","year":"2002","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"2019112601003137900_ref40","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1126\/science.286.5446.1897","article-title":"Quality control by DNA repair","volume":"286","author":"Lindahl","year":"1999","journal-title":"Science"},{"issue":"Suppl 1","key":"2019112601003137900_ref41","doi-asserted-by":"crossref","first-page":"S130","DOI":"10.1093\/toxsci\/kfq371","article-title":"Endogenous versus exogenous DNA adducts: their role in carcinogenesis, epidemiology, and risk assessment","volume":"120","author":"Swenberg","year":"2011","journal-title":"Toxicol Sci"},{"key":"2019112601003137900_ref42","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1007\/s00018-009-8737-y","article-title":"DNA repair in mammalian cells: nucleotide excision repair: variations on versatility","volume":"66","author":"Nouspikel","year":"2009","journal-title":"Cell Mol Life Sci"},{"key":"2019112601003137900_ref43","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1007\/s10930-007-9095-y","article-title":"Conformational effects of a common codon 399 polymorphism on the BRCT1 domain of the XRCC1 protein","volume":"26","author":"Monaco","year":"2007","journal-title":"Protein J"},{"key":"2019112601003137900_ref44","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1093\/carcin\/21.4.551","article-title":"XPD polymorphisms: effects on DNA repair proficiency","volume":"21","author":"Lunn","year":"2000","journal-title":"Carcinogenesis"},{"key":"2019112601003137900_ref45","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1093\/carcin\/bgp058","article-title":"Genetic susceptibility to esophageal cancer: the role of the nucleotide excision repair pathway","volume":"30","author":"Pan","year":"2009","journal-title":"Carcinogenesis"},{"key":"2019112601003137900_ref46","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1093\/carcin\/24.3.505","article-title":"XPA polymorphism associated with reduced lung cancer risk and a modulating effect on nucleotide excision repair capacity","volume":"24","author":"Wu","year":"2003","journal-title":"Carcinogenesis"},{"key":"2019112601003137900_ref47","doi-asserted-by":"crossref","first-page":"130","DOI":"10.4077\/CJP.2010.AMK005","article-title":"Significant association of XPD Asp312Asn polymorphism with breast cancer in Taiwanese patients","volume":"53","author":"Wang","year":"2010","journal-title":"Chin J Physiol"},{"key":"2019112601003137900_ref48","first-page":"4975","article-title":"Contribution of DNA repair xeroderma pigmentosum group D genotype to gastric cancer risk in Taiwan","volume":"35","author":"Ji","year":"2015","journal-title":"Anticancer Res"},{"key":"2019112601003137900_ref49","first-page":"1657","article-title":"Contribution of DNA repair xeroderma pigmentosum group D genotypes to colorectal cancer risk in Taiwan","volume":"36","author":"Chang","year":"2016","journal-title":"Anticancer Res"},{"key":"2019112601003137900_ref50","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.21873\/anticanres.11568","article-title":"The contribution of excision repair cross-complementing group 1 genotypes to colorectal cancer susceptibility in Taiwan","volume":"37","author":"Yueh","year":"2017","journal-title":"Anticancer Res"},{"key":"2019112601003137900_ref51","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.oraloncology.2007.07.006","article-title":"A novel single nucleotide polymorphism in ERCC6 gene is associated with oral cancer susceptibility in Taiwanese patients","volume":"44","author":"Chiu","year":"2008","journal-title":"Oral Oncol"},{"key":"2019112601003137900_ref52","first-page":"555","article-title":"Comparison of two human ovarian carcinoma cell lines (A2780\/CP70 and MCAS) that are equally resistant to platinum, but differ at codon 118 of the ERCC1 gene","volume":"16","author":"Yu","year":"2000","journal-title":"Int J Oncol"},{"key":"2019112601003137900_ref53","first-page":"604","article-title":"Nonconservative amino acid substitution variants exist at polymorphic frequency in DNA repair genes in healthy humans","volume":"58","author":"Shen","year":"1998","journal-title":"Cancer Res"},{"key":"2019112601003137900_ref54","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1093\/mutage\/17.6.463","article-title":"ERCC2\/XPD gene polymorphisms and cancer risk","volume":"17","author":"Benhamou","year":"2002","journal-title":"Mutagenesis"},{"key":"2019112601003137900_ref55","first-page":"5121","article-title":"Significant association of ERCC6 single nucleotide polymorphisms with bladder cancer susceptibility in Taiwan","volume":"29","author":"Chang","year":"2009","journal-title":"Anticancer Res"},{"key":"2019112601003137900_ref56","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.dnarep.2007.08.006","article-title":"Modulation of DNA damage\/DNA repair capacity by XPC polymorphisms","volume":"7","author":"Zhu","year":"2008","journal-title":"DNA Repair"},{"key":"2019112601003137900_ref57","doi-asserted-by":"crossref","first-page":"425","DOI":"10.7150\/jca.8594","article-title":"ERCC1, XRCC1 and GSTP1 single nucleotide polymorphisms and survival of patients with colon cancer receiving oxaliplatin-based adjuvant chemotherapy","volume":"5","author":"Zaanan","year":"2014","journal-title":"J Cancer"},{"key":"2019112601003137900_ref58","doi-asserted-by":"crossref","first-page":"17228","DOI":"10.4238\/2015.December.16.22","article-title":"Genetic variability of DNA repair mechanisms in chemotherapy treatment outcome of gastric cancer patients","volume":"14","author":"Zhong","year":"2015","journal-title":"Genet Mol Res"},{"key":"2019112601003137900_ref59","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1007\/s11605-011-1700-x","article-title":"Neoadjuvant radiochemotherapy in adenocarcinoma of the esophagus: ERCC1 gene polymorphisms for prediction of response and prognosis","volume":"16","author":"Metzger","year":"2012","journal-title":"J Gastrointest Surg"},{"key":"2019112601003137900_ref60","doi-asserted-by":"crossref","first-page":"4782","DOI":"10.1002\/jcb.26147","article-title":"Evaluation of prediction of polymorphisms of DNA repair genes on the efficacy of platinum-based chemotherapy in patients with non-small cell lung cancer: a network meta-analysis","volume":"118","author":"Yu","year":"2017","journal-title":"J Cell Biochem"},{"key":"2019112601003137900_ref61","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1093\/carcin\/bgn067","article-title":"A distinct ERCC1 haplotype is associated with mRNA expression levels in prostate cancer patients","volume":"29","author":"Woelfelschneider","year":"2008","journal-title":"Carcinogenesis"},{"key":"2019112601003137900_ref62","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.lungcan.2015.05.001","article-title":"Polymorphisms in ERCC1 and ERCC2\/XPD genes and carcinogen DNA adducts in human lung","volume":"89","author":"Lee","year":"2015","journal-title":"Lung Cancer"},{"key":"2019112601003137900_ref63","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.4238\/2014.February.27.5","article-title":"Investigation of the effects of single-nucleotide polymorphisms in DNA repair genes on the risk of glioma","volume":"13","author":"Gao","year":"2014","journal-title":"Genet Mol Res"},{"key":"2019112601003137900_ref64","doi-asserted-by":"crossref","first-page":"22863","DOI":"10.18632\/oncotarget.15282","article-title":"Impact of DNA repair gene polymorphisms on the risk of biochemical recurrence after radiotherapy and overall survival in prostate cancer","volume":"8","author":"Zanusso","year":"2017","journal-title":"Oncotarget"},{"key":"2019112601003137900_ref65","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.gene.2014.06.026","article-title":"Common variants of xeroderma pigmentosum genes and prostate cancer risk","volume":"546","author":"Mirecka","year":"2014","journal-title":"Gene"},{"key":"2019112601003137900_ref66","doi-asserted-by":"crossref","first-page":"77","DOI":"10.3233\/BLC-150027","article-title":"Independent replication of published germline polymorphisms associated with urinary bladder cancer prognosis and treatment response","volume":"2","author":"Grotenhuis","year":"2016","journal-title":"Bladder Cancer"},{"key":"2019112601003137900_ref67","first-page":"3903","article-title":"Significant association of XPD codon 312 single nucleotide polymorphism with bladder cancer susceptibility in Taiwan","volume":"29","author":"Chang","year":"2009","journal-title":"Anticancer Res"},{"key":"2019112601003137900_ref68","doi-asserted-by":"crossref","first-page":"17529","DOI":"10.4238\/2015.December.21.25","article-title":"Genetic variability of ERCC1 and ERCC2 influences treatment outcomes in gastric cancer","volume":"14","author":"Yu","year":"2015","journal-title":"Genet Mol Res"},{"key":"2019112601003137900_ref69","first-page":"4106","article-title":"Genetic variability of DNA repair mechanisms influences chemotherapy outcome of gastric cancer","volume":"8","author":"Yu","year":"2015","journal-title":"Int J Clin Exp Pathol"},{"key":"2019112601003137900_ref70","doi-asserted-by":"crossref","first-page":"e71994","DOI":"10.1371\/journal.pone.0071994","article-title":"ERCC1 and ERCC2 variants predict survival in gastric cancer patients","volume":"8","author":"Li","year":"2013","journal-title":"PLoS One"},{"key":"2019112601003137900_ref71","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1007\/s11033-014-3824-z","article-title":"Polymorphisms in nucleotide excision repair genes and susceptibility to colorectal cancer in the Polish population","volume":"42","author":"Paszkowska-Szczur","year":"2015","journal-title":"Mol Biol Rep"},{"key":"2019112601003137900_ref72","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s10238-014-0329-y","article-title":"Polymorphisms in DNA repair genes and breast cancer risk in Russian population: a case-control study","volume":"16","author":"Shadrina","year":"2016","journal-title":"Clin Exp Med"},{"key":"2019112601003137900_ref73","first-page":"2934","article-title":"Correlation of rs1799793 polymorphism in ERCC2 and the clinical response to platinum-based chemotherapy in patients with triple negative breast cancer","volume":"8","author":"Lu","year":"2015","journal-title":"Int J Clin Exp Med"},{"key":"2019112601003137900_ref74","doi-asserted-by":"crossref","first-page":"5082","DOI":"10.1038\/s41598-017-05246-8","article-title":"Gene-gene and gene-environment interactions influence platinum-based chemotherapy response and toxicity in non-small cell lung cancer patients","volume":"7","author":"Cui","year":"2017","journal-title":"Sci Rep"},{"key":"2019112601003137900_ref75","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.3892\/ol.2015.3510","article-title":"Genetic variability of DNA repair mechanisms influences treatment outcome of gastric cancer","volume":"10","author":"Ding","year":"2015","journal-title":"Oncol Lett"},{"key":"2019112601003137900_ref76","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1186\/s12885-015-1776-x","article-title":"CYP39A1 polymorphism is associated with toxicity during intensive induction chemotherapy in patients with advanced head and neck cancer","volume":"15","author":"Melchardt","year":"2015","journal-title":"BMC Cancer"},{"key":"2019112601003137900_ref77","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.yexmp.2011.03.004","article-title":"DNA repair gene ERCC2 polymorphisms and risk of squamous cell carcinoma of the head and neck","volume":"91","author":"Gugatschka","year":"2011","journal-title":"Exp Mol Pathol"},{"key":"2019112601003137900_ref78","first-page":"698","article-title":"Pterygium and genetic polymorphisms of the DNA repair enzymes XRCC1, XPA, and XPD","volume":"16","author":"Chiang","year":"2010","journal-title":"Mol Vis"}],"container-title":["Biology of Reproduction"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/biolreprod\/advance-article-pdf\/doi\/10.1093\/biolre\/ioz150\/30126620\/ioz150.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/biolreprod\/article-pdf\/101\/5\/928\/31137852\/ioz150.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/biolreprod\/article-pdf\/101\/5\/928\/31137852\/ioz150.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,11,26]],"date-time":"2019-11-26T06:01:01Z","timestamp":1574748061000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/biolreprod\/article\/101\/5\/928\/5542929"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,2]]},"references-count":78,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2019,8,2]]},"published-print":{"date-parts":[[2019,11,21]]}},"URL":"https:\/\/doi.org\/10.1093\/biolre\/ioz150","relation":{},"ISSN":["0006-3363","1529-7268"],"issn-type":[{"value":"0006-3363","type":"print"},{"value":"1529-7268","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,11]]},"published":{"date-parts":[[2019,8,2]]}}}