{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T05:39:35Z","timestamp":1783489175056,"version":"3.55.0"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2019,8,12]],"date-time":"2019-08-12T00:00:00Z","timestamp":1565568000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RO1HD040793"],"award-info":[{"award-number":["RO1HD040793"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RO1DK097124"],"award-info":[{"award-number":["RO1DK097124"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012489","name":"Boston Area Diabetes Endocrinology Research Center","doi-asserted-by":"publisher","award":["DK57521"],"award-info":[{"award-number":["DK57521"]}],"id":[{"id":"10.13039\/100012489","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002883","name":"Foundation for Clinical Research in Inflammatory Bowel Disease","doi-asserted-by":"publisher","award":["DK43351"],"award-info":[{"award-number":["DK43351"]}],"id":[{"id":"10.13039\/100002883","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,2,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Efferent duct ligation (EDL) induces epithelial cell degeneration followed by regeneration in the epididymal initial segment. We tested here the role of androgens in the recovery phase. EDL was performed at post-natal weeks (PNW) 3, 4, 5, 6, and 7, and apoptotic and proliferating epithelial cells were quantified 24\u00a0h, and at days 2 and 2.5 post-EDL, respectively. A progressive increase in the number of apoptotic basal cells (BCs) and principal cells (PCs) was detected from PNW3 to 6, 24\u00a0h after EDL. Two\u00a0days after EDL, no increase in proliferating BCs and PCs was observed at PNW3 and 4, despite the induction of apoptosis by EDL. A progressive increase in the number of proliferating BCs was then observed from PNW5 to 6, while the number of proliferating PCs remained low. 2.5\u00a0days after EDL, the number of proliferating BCs and PCs remained low at PNW3, 4, and 5, but a marked increase in the number of proliferating PCs was observed at PNW6. Flutamide pretreatment for 3\u00a0weeks followed by EDL at PNW7 dramatically decreased the number of proliferating BCs on EDL day 2, and the number of proliferating PCs on EDL day 2.5, compared to controls. We conclude that (1) BCs are the first to show recovery after EDL, followed by PCs; (2) androgens are essential for BC and PC repair after injury in the postpubertal epididymis; and (3) the prepubertal epididymis lacks repair ability following injury.<\/jats:p>","DOI":"10.1093\/biolre\/ioz152","type":"journal-article","created":{"date-parts":[[2019,8,12]],"date-time":"2019-08-12T12:24:59Z","timestamp":1565612699000},"page":"76-83","source":"Crossref","is-referenced-by-count":13,"title":["Androgens are essential for epithelial cell recovery after efferent duct ligation in the initial segment of the mouse epididymis\u2020"],"prefix":"10.1093","volume":"102","author":[{"given":"Bongki","family":"Kim","sequence":"first","affiliation":[{"name":"Center for Systems Biology, Program in Membrane Biology and Division of Nephrology, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 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