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Although a number of research efforts have been conducted, therapeutic advances for treating RSA have not lived up to their expectations. Hence, other treatments should be explored. The important role of natural killer (NK) cells in immunotherapy is attracting increasing attention, both as a pharmaceutical target and for cell therapies. NK cells are abundant in the endometrium and play a role in implantation and placentation in normal pregnancy. As research progresses, NK cells are increasingly regarded as playing essential roles in the emergence and development of RSA. In this article, I review recent findings on the role of uterine NK cells in the pathophysiology of RSA. These cells may become therapeutic NK cell-related targets. In conclusion, although several issues regarding NK cells in RSA remain unresolved and require further investigation, extensive evidence is available for the treatment of RSA.<\/jats:p>","DOI":"10.1093\/biolre\/ioz203","type":"journal-article","created":{"date-parts":[[2019,11,19]],"date-time":"2019-11-19T12:50:58Z","timestamp":1574167858000},"page":"524-531","source":"Crossref","is-referenced-by-count":16,"title":["Natural killer cells: functional differences in recurrent spontaneous abortion\u2020"],"prefix":"10.1093","volume":"102","author":[{"given":"Fan","family":"Hao","sequence":"first","affiliation":[{"name":"Clinical and Translational Research Center, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangyu","family":"Zhou","sequence":"first","affiliation":[{"name":"Clinical and Translational Research Center, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Jin","sequence":"first","affiliation":[{"name":"Clinical and Translational Research Center, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,11,19]]},"reference":[{"key":"2020031302272902000_ref1","doi-asserted-by":"crossref","first-page":"467","DOI":"10.3389\/fimmu.2017.00467","article-title":"Uterine natural killer cells: functional distinctions and influence on pregnancy in humans and mice","volume":"8","author":"Gaynor","year":"2017","journal-title":"Front Immunol"},{"key":"2020031302272902000_ref2","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1177\/0192623313482205","article-title":"The placenta in toxicology. 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