{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T01:12:10Z","timestamp":1776215530574,"version":"3.50.1"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2019,11,11]],"date-time":"2019-11-11T00:00:00Z","timestamp":1573430400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["CHD R01 HD088590"],"award-info":[{"award-number":["CHD R01 HD088590"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NIH R01 HL138181"],"award-info":[{"award-number":["NIH R01 HL138181"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association, Inc.","doi-asserted-by":"publisher","award":["7PRE33410652"],"award-info":[{"award-number":["7PRE33410652"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association, Inc.","doi-asserted-by":"publisher","award":["1S10OD018156-01"],"award-info":[{"award-number":["1S10OD018156-01"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Small Animal Ultrasound Imager"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,3,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Incomplete maternal vascular responses to pregnancy contribute to pregnancy complications including intrauterine growth restriction (IUGR) and preeclampsia. We aimed to characterize maternal vascular dysfunction in a murine model of fetal growth restriction as an approach toward identifying targetable pathways for improving pregnancy outcomes. We utilized a murine model of late-gestation hypoxia-induced IUGR that reduced E18.5 fetal weight by 34%. Contrary to our hypothesis, uterine artery blood flow as measured in vivo by Doppler ultrasound was increased in mice housed under hypobaric hypoxia (385\u00a0mmHg; 5500\u00a0m) vs normoxia (760\u00a0mmHg; 0\u00a0m). Using wire myography, uterine arteries isolated from hypoxic mice had similar vasodilator responses to the two activators A769662 and acetylcholine as those from normoxic mice, although the contribution of an increase in nitric oxide production to uterine artery vasodilation was reduced in the hypoxic vs normoxic groups. Vasoconstrictor responses to phenylephrine and potassium chloride were unaltered by hypoxia. The levels of activated adenosine monophosphate-activated protein kinase (AMPK) were reduced with hypoxia in both the uterine artery and placenta as measured by western blot and immunohistochemistry. We concluded that the rise in uterine artery blood flow may be compensatory to hypoxia but was not sufficient to prevent fetal growth restriction. Although AMPK signaling was reduced by hypoxia, AMPK was still receptive to pharmacologic activation in the uterine arteries in which it was a potent vasodilator. Thus, AMPK activation may represent a new therapy for pregnancy complications involving reduced uteroplacental perfusion.<\/jats:p>","DOI":"10.1093\/biolre\/ioz208","type":"journal-article","created":{"date-parts":[[2019,11,11]],"date-time":"2019-11-11T17:16:13Z","timestamp":1573492573000},"page":"660-670","source":"Crossref","is-referenced-by-count":21,"title":["Increased uterine artery blood flow in hypoxic murine pregnancy is not sufficient to prevent fetal growth restriction"],"prefix":"10.1093","volume":"102","author":[{"given":"Sydney L","family":"Lane","sequence":"first","affiliation":[{"name":"Integrated Physiology PhD Program , University of Colorado Denver Graduate School, Aurora, CO, USA"},{"name":"Division of Reproductive Sciences , Department of Obstetrics and Gynecology, University of Colorado-Denver Anschutz Medical Campus, Aurora, CO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandrea S","family":"Doyle","sequence":"additional","affiliation":[{"name":"Division of Bioinformatics and Personalized Medicine , Department of Medicine, University of Colorado-Denver Anschutz Medical Campus, Aurora, CO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elise S","family":"Bales","sequence":"additional","affiliation":[{"name":"Division of Reproductive Sciences , Department of Obstetrics and Gynecology, University of Colorado-Denver Anschutz Medical Campus, Aurora, CO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ram\u00f3n A","family":"Lorca","sequence":"additional","affiliation":[{"name":"Division of Reproductive Sciences , Department of Obstetrics and Gynecology, University of Colorado-Denver Anschutz Medical Campus, Aurora, CO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Colleen G","family":"Julian","sequence":"additional","affiliation":[{"name":"Division of Bioinformatics and Personalized Medicine , Department of Medicine, University of Colorado-Denver Anschutz Medical Campus, Aurora, CO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorna G","family":"Moore","sequence":"additional","affiliation":[{"name":"Division of Reproductive Sciences , Department of Obstetrics and Gynecology, University of Colorado-Denver Anschutz Medical Campus, Aurora, CO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,11,11]]},"reference":[{"key":"2026041420171505700_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67349-7","article-title":"Pre-eclampsia and cardiovascular disease in later life","volume":"366","author":"Roberts","year":"2005","journal-title":"The Lancet"},{"key":"2026041420171505700_ref2","first-page":"73","article-title":"Epigenetics and preeclampsia: programming of future outcomes","volume":"2018","author":"Peixoto","year":"1710","journal-title":"Methods Mol Biol"},{"key":"2026041420171505700_ref3","doi-asserted-by":"crossref","first-page":"20140068","DOI":"10.1098\/rstb.2014.0068","article-title":"Uterine artery blood flow, fetal hypoxia and fetal growth","volume":"370","author":"Browne","year":"2015","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"2026041420171505700_ref4","first-page":"R52","article-title":"O2 delivery to the pregnant uterus: its relationship to O2 consumption","volume":"237","author":"Caton","year":"1979","journal-title":"Am J Physiol"},{"key":"2026041420171505700_ref5","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1080\/14767050902784171","article-title":"Prenatal medicine: The child is the father of the man","volume":"22","author":"Romero","year":"2009","journal-title":"J Matern Fetal Neonatal Med"},{"key":"2026041420171505700_ref6","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1001\/archpedi.1957.02060040668009","article-title":"Studies of babies born at high altitude. 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