{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T02:01:45Z","timestamp":1791597705644,"version":"4.3.4"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2020,4,15]],"date-time":"2020-04-15T00:00:00Z","timestamp":1586908800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,9,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Meta-analysis has become a powerful tool for improving inference by gathering evidence from multiple sources. It pools summary-level data from different studies to improve estimation efficiency with the assumption that all participating studies are analysed under the same statistical model. It is challenging to integrate external summary data calculated from different models with a newly conducted internal study in which individual-level data are collected. We develop a novel statistical inference framework that can effectively synthesize internal and external data for the integrative analysis. The new framework is versatile enough to assimilate various types of summary data from multiple sources. We establish asymptotic properties for the proposed procedure and prove that the new estimate is theoretically more efficient than the internal data based maximum likelihood estimate, as well as a recently developed constrained maximum likelihood approach that incorporates the external information. We illustrate an application of our method by evaluating cervical cancer risk using data from a large cervical screening program.<\/jats:p>","DOI":"10.1093\/biomet\/asaa014","type":"journal-article","created":{"date-parts":[[2020,2,14]],"date-time":"2020-02-14T20:12:05Z","timestamp":1581711125000},"page":"689-703","source":"Crossref","is-referenced-by-count":60,"title":["Generalized integration model for improved statistical inference by leveraging external summary data"],"prefix":"10.1093","volume":"107","author":[{"given":"Han","family":"Zhang","sequence":"first","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute, 9609 Medical Center Drive, Bethesda, Maryland 20892, U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Deng","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute, 9609 Medical Center Drive, Bethesda, Maryland 20892, U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Schiffman","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute, 9609 Medical Center Drive, Bethesda, Maryland 20892, U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Qin","sequence":"additional","affiliation":[{"name":"National Institute of Allergy and Infectious Diseases, National Institute of Health, 6700B Rockledge Drive, Bethesda, Maryland 20892, U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Yu","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute, 9609 Medical Center Drive, Bethesda, Maryland 20892, U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,4,15]]},"reference":[{"key":"2020081714265175300_B1","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1080\/01621459.2015.1123157","article-title":"Constrained maximum likelihood estimation for model calibration using summary-level information from external big data sources","volume":"111","author":"Chatterjee,","year":"2016","journal-title":"J. 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