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Our study aims to comprehensively review all studies conducted in this area and thus generate informed conclusions on the potential for adopting the UCP-LF assay for diagnosing this important yet neglected tropical disease. Using the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guidelines, we generated search criteria to capture all studies in English journals available in the Scopus and PubMed databases on 20 December 2022. A total of 219 articles were identified, and 84 that met the inclusion criteria were retrieved and eventually included in the study. Twelve different assay methods were identified with a noteworthy transition from enzyme-linked immunosorbent assay (ELISA) to the UCP-LF assay, a laboratory-based assay that may be applicable as a point-of-care (POC) diagnostic test for schistosomiasis. Reducing the time, cost, and dependence on specialized laboratory skills and equipment, especially relating to the trichloroacetic acid extraction step and centrifugation in the UCP-LF CAA assay may go a long way to aid its potential as a POC tool. We also propose the development of a CAA-specific aptamer (short protein\/antigen-binding oligonucleotide) as a possible alternative to monoclonal antibodies in the assay. UCP-LF has great potential for POC application.<\/jats:p>","DOI":"10.1093\/biomethods\/bpad006","type":"journal-article","created":{"date-parts":[[2023,4,3]],"date-time":"2023-04-03T14:41:16Z","timestamp":1680532876000},"source":"Crossref","is-referenced-by-count":25,"title":["UCP-LF and other assay methods for schistosome circulating anodic antigen between 1978 and 2022"],"prefix":"10.1093","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4362-9004","authenticated-orcid":false,"given":"Ilemobayo Victor","family":"Fasogbon","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Kampala International University-Western Campus , Kampala, Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick Maduabuchi","family":"Aja","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Kampala International University-Western Campus , Kampala, Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erick Nyakundi","family":"Ondari","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Kampala International University-Western Campus , Kampala, Uganda"},{"name":"Department of Biological Sciences, School of Pure & Applied Sciences, Kisii University , Kisii, Kenya"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ismail","family":"Adebayo","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Kampala International University-Western Campus , Kampala, Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olukayode Adebola","family":"Ibitoye","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Kampala International University-Western Campus , Kampala, Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moses","family":"Egesa","sequence":"additional","affiliation":[{"name":"MRC\/UVRI & LSHTM Uganda Research Unit , Entebbe, 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