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Motivated by an open problem in cancer genomics, we develop a novel model that flexibly clusters patients with similar predictive characteristics and similar treatment responses; this approach identifies, via predictive inference, which one among a set of treatments is better suited for a new patient. The proposed method is fully model based, avoiding uncertainty underestimation attained when treatment assignment is performed by adopting heuristic clustering procedures, and belongs to the class of product partition models with covariates, here extended to include the cohesion induced by the normalized generalized gamma process. The method performs particularly well in scenarios characterized by considerable heterogeneity of the predictive covariates in simulation studies. A cancer genomics case study illustrates the potential benefits in terms of treatment response yielded by the proposed approach. Finally, being model based, the approach allows estimating clusters\u2019 specific response probabilities and then identifying patients more likely to benefit from personalized treatment.<\/jats:p>","DOI":"10.1093\/biomtc\/ujad003","type":"journal-article","created":{"date-parts":[[2024,2,16]],"date-time":"2024-02-16T22:52:42Z","timestamp":1708123962000},"source":"Crossref","is-referenced-by-count":3,"title":["Personalized treatment selection via product partition models with covariates"],"prefix":"10.1093","volume":"80","author":[{"given":"Matteo","family":"Pedone","sequence":"first","affiliation":[{"name":"Department of Statistics, Computer Science and Applications, University of Florence , Florence , Italy , 50134"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raffaele","family":"Argiento","sequence":"additional","affiliation":[{"name":"Department of Economics, University of Bergamo , Bergamo , Italy , 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