{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T06:45:43Z","timestamp":1763016343569},"reference-count":24,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2001,11,1]],"date-time":"2001-11-01T00:00:00Z","timestamp":1004572800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,12,4]],"date-time":"2017-12-04T00:00:00Z","timestamp":1512345600000},"content-version":"vor","delay-in-days":5877,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["British Journal of Anaesthesia"],"published-print":{"date-parts":[[2001,11]]},"DOI":"10.1093\/bja\/87.5.794","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T18:42:52Z","timestamp":1027708972000},"page":"794-798","source":"Crossref","is-referenced-by-count":36,"title":["Pathophysiological role of the serotonin system in malignant hyperthermia"],"prefix":"10.1016","volume":"87","author":[{"given":"F.","family":"Wappler","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Fiege","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Schulte am Esch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1093\/bja\/87.5.794_bib1","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1016\/S0006-3223(98)00132-2","article-title":"The molecular biology of serotonin receptors: therapeutic implications for the interface of mood and psychosis","volume":"44","author":"Kroeze","year":"1998","journal-title":"Biol Psychiatr"},{"key":"10.1093\/bja\/87.5.794_bib2","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1615\/CritRevNeurobiol.v12.i4.30","article-title":"Serotonin 5-HT2A receptors: molecular biology and mechanisms of regulation","volume":"12","author":"Roth","year":"1998","journal-title":"Crit Rev Neurobiol"},{"key":"10.1093\/bja\/87.5.794_bib3","first-page":"640","article-title":"Inhibition by serotonin of amino acid release and protein degradation in skeletal muscle","volume":"13","author":"Garber","year":"1977","journal-title":"Mol Pharmacol"},{"key":"10.1093\/bja\/87.5.794_bib4","doi-asserted-by":"crossref","first-page":"14825","DOI":"10.1074\/jbc.272.23.14825","article-title":"Identification and localization of a skeletal muscle serotonin 5-HT2A receptor coupled to the Jak\/STAT pathway","volume":"272","author":"Guilliett-Deniau","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1093\/bja\/87.5.794_bib5","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1006\/bbrc.1999.0471","article-title":"Biochemical localisation of the 5-HT2A (serotonin) receptor in rat skeletal muscle","volume":"257","author":"Hajduch","year":"1999","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1093\/bja\/87.5.794_bib6","doi-asserted-by":"crossref","first-page":"13563","DOI":"10.1074\/jbc.274.19.13563","article-title":"Serotonin (5-hydroxytryptamine), a novel regulator of glucose transport in rat skeletal muscle","volume":"274","author":"Hajduch","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1093\/bja\/87.5.794_bib7","series-title":"Veterinary Pharmacology and Toxicology","first-page":"263","article-title":"Serotonin and S2 antagonists in veterinary medicine","author":"Ooms","year":"1983"},{"key":"10.1093\/bja\/87.5.794_bib8","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1111\/j.1532-950X.1986.tb00208.x","article-title":"Treatment of stress hyperthermia in elk with ketanserin, a serotonin receptor blocker","volume":"15","author":"Stanley","year":"1986","journal-title":"Vet Surg"},{"key":"10.1093\/bja\/87.5.794_bib9","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1007\/BF00171727","article-title":"Pharmacodynamic effects of serotonin (5-HT) receptor ligands in pigs: stimulation of 5-HT2 receptors induces malignant hyperthermia","volume":"341","author":"Lo\u00a8scher","year":"1990","journal-title":"Naunyn-Schmiedebergs Arch Pharmacol"},{"key":"10.1093\/bja\/87.5.794_bib10","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/0014-2999(92)90016-W","article-title":"Increase of serotonin in plasma during onset of halothane-induced malignant hyperthermia in pigs","volume":"220","author":"Gerdes","year":"1992","journal-title":"Eur J Pharmacol"},{"key":"10.1093\/bja\/87.5.794_bib11","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/j.1399-6576.1986.tb02356.x","article-title":"Ketanserin and malignant hyperthermia in pigs","volume":"30","author":"\u00d8rding","year":"1986","journal-title":"Acta Anaesthesiol Scand"},{"key":"10.1093\/bja\/87.5.794_bib12","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/BF00178953","article-title":"Lack of prophylactic or therapeutic efficacy of 5-HT2A receptor antagonists in halothane-induced porcine malignant hyperthermia","volume":"350","author":"Lo\u00a8scher","year":"1994","journal-title":"Naunyn-Schmiedebergs Arch Pharmacol"},{"key":"10.1093\/bja\/87.5.794_bib13","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1007\/BF00170833","article-title":"Effects of the 5-HT2 receptor antagonist ritanserin on halothane-induced increase of inositol phosphates in porcine malignant hyperthermia","volume":"354","author":"Richter","year":"1996","journal-title":"Naunyn-Schmiedebergs Arch Pharmacol"},{"key":"10.1093\/bja\/87.5.794_bib14","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1097\/00000542-199606000-00002","article-title":"Effects of the serotonin2 receptor agonist DOI on skeletal muscle specimens from malignant hyperthermia susceptible patients","volume":"84","author":"Wappler","year":"1996","journal-title":"Anesthesiology"},{"key":"10.1093\/bja\/87.5.794_bib15","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1111\/j.1399-6576.1997.tb04650.x","article-title":"Attenuation of serotonin-induced contractures in skeletal muscles from malignant hyperthermia susceptible patients with dantrolene","volume":"41","author":"Wappler","year":"1997","journal-title":"Acta Anaesthesiol Scand"},{"key":"10.1093\/bja\/87.5.794_bib16","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/S0952-8180(97)00008-1","article-title":"Ritanserin attenuates the in-vitro effects of the 5-HT2 receptor agonist DOI on skeletal muscles from malignant hyperthermia susceptible patients","volume":"9","author":"Wappler","year":"1997","journal-title":"J Clin Anesth"},{"key":"10.1093\/bja\/87.5.794_bib17","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1007\/s002109900062","article-title":"Serotonin receptor antagonist-mediated inhibition of halothane-induced contractures in skeletal muscle specimens from malignant hyperthermia susceptible patients","volume":"360","author":"Wappler","year":"1999","journal-title":"Naunyn-Schmiedebergs Arch Pharmacol"},{"key":"10.1093\/bja\/87.5.794_bib18","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/S0140-6736(89)90182-7","article-title":"Inositol 1,4,5-trisphosphate phosphatase deficiency and malignant hyperpyrexia in swine","volume":"2","author":"Foster","year":"1989","journal-title":"Lancet"},{"key":"10.1093\/bja\/87.5.794_bib19","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1016\/0140-6736(91)93052-B","article-title":"Inositol-1,4,5-trisphosphate and malignant hyperthermia [letter]","volume":"337","author":"Scholz","year":"1991","journal-title":"Lancet"},{"key":"10.1093\/bja\/87.5.794_bib20","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1038\/342192a0","article-title":"Putative receptor for inositol 1,4,5-trisphosphate similar to ryanodine receptor","volume":"342","author":"Mignery","year":"1989","journal-title":"Nature"},{"key":"10.1093\/bja\/87.5.794_bib21","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1007\/BF00172783","article-title":"Hypersensitive response of malignant hyperthermia-susceptible skeletal muscle to inositol 1,4,5-trisphosphate induced release of calcium","volume":"352","author":"L\u00f3pez","year":"1995","journal-title":"Naunyn-Schmiedebergs Arch Pharmacol"},{"key":"10.1093\/bja\/87.5.794_bib22","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1093\/bja\/75.4.467","article-title":"Alterations of inositol polyphosphates in skeletal muscle during porcine malignant hyperthermia","volume":"75","author":"Tonner","year":"1995","journal-title":"Br J Anaesth"},{"key":"10.1093\/bja\/87.5.794_bib23","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1177\/026988119901300111","article-title":"The serotonin syndrome and its treatment","volume":"13","author":"Gillman","year":"1999","journal-title":"J Psychopharmacol"},{"key":"10.1093\/bja\/87.5.794_bib24","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1097\/00004714-199706000-00012","article-title":"Selective serotonin reuptake inhibitor-induced serotonin syndrome: review","volume":"17","author":"Lane","year":"1997","journal-title":"J Clin Psychopharmacol"}],"container-title":["British Journal of Anaesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0007091217366291?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0007091217366291?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/bja\/article-pdf\/87\/5\/794\/18265706\/794.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,11]],"date-time":"2019-04-11T12:57:59Z","timestamp":1554987479000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0007091217366291"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,11]]},"references-count":24,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2001,11]]}},"alternative-id":["S0007091217366291"],"URL":"https:\/\/doi.org\/10.1093\/bja\/87.5.794","relation":{},"ISSN":["0007-0912"],"issn-type":[{"value":"0007-0912","type":"print"}],"subject":[],"published":{"date-parts":[[2001,11]]}}}