{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T20:41:02Z","timestamp":1787863262286,"version":"build-2784847793"},"reference-count":65,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2003,2,1]],"date-time":"2003-02-01T00:00:00Z","timestamp":1044057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,12,4]],"date-time":"2017-12-04T00:00:00Z","timestamp":1512345600000},"content-version":"vor","delay-in-days":5420,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["British Journal of Anaesthesia"],"published-print":{"date-parts":[[2003,2]]},"DOI":"10.1093\/bja\/aeg040","type":"journal-article","created":{"date-parts":[[2003,1,21]],"date-time":"2003-01-21T22:53:30Z","timestamp":1043189610000},"page":"199-211","source":"Crossref","is-referenced-by-count":80,"title":["Differential interaction of anaesthetics and antiepileptic drugs with neuronal Na + channels, Ca 2+ channels, and GABA A receptors"],"prefix":"10.1016","volume":"90","author":[{"given":"R.","family":"Lingamaneni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.C.","family":"Hemmings Jr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1093\/bja\/aeg040_bib1","series-title":"Anesthesia: Biological Foundations","first-page":"277","article-title":"General anesthetic actions on transmission at glutamate and GABA synapses","author":"MacIver","year":"1997"},{"issue":"suppl 2","key":"10.1093\/bja\/aeg040_bib2","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1111\/j.1528-1157.1995.tb05996.x","article-title":"Antiepileptic drug mechanisms of action","volume":"36","author":"Macdonald","year":"1995","journal-title":"Epilepsia"},{"key":"10.1093\/bja\/aeg040_bib3","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1097\/00000542-199506000-00012","article-title":"Inhibition by volatile anesthetics of endogenous glutamate release from synaptosomes by a presynaptic mechanism","volume":"82","author":"Schlame","year":"1995","journal-title":"Anesthesiology"},{"key":"10.1093\/bja\/aeg040_bib4","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1097\/00000542-199610000-00018","article-title":"Volatile anesthetics depress glutamate transmission via presynaptic actions","volume":"25","author":"MacIver","year":"1996","journal-title":"Anesthesiology"},{"key":"10.1093\/bja\/aeg040_bib5","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1038\/sj.bjp.0701996","article-title":"Presynaptic and postsynaptic actions of halothane at glutamatergic synapses in the mouse hippocampus","volume":"124","author":"Kirson","year":"1998","journal-title":"Br J Pharmacol"},{"key":"10.1093\/bja\/aeg040_bib6","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1111\/j.1528-1157.1997.tb01728.x","article-title":"GABA and epileptogenesis","volume":"38","author":"Olsen","year":"1997","journal-title":"Epilepsia"},{"key":"10.1093\/bja\/aeg040_bib7","first-page":"S14","article-title":"The role of glutamate in epilepsy and other CNS disorders","volume":"44","author":"Meldrum","year":"1994","journal-title":"Neurology"},{"key":"10.1093\/bja\/aeg040_bib8","first-page":"303","article-title":"Pro- and anticonvulsant effects of anesthetics (Part I)","volume":"70","author":"Modica","year":"1990","journal-title":"Anesth Analg"},{"key":"10.1093\/bja\/aeg040_bib9","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1038\/367607a0","article-title":"Molecular and cellular mechanisms of general anesthesia","volume":"367","author":"Franks","year":"1994","journal-title":"Nature"},{"key":"10.1093\/bja\/aeg040_bib10","series-title":"Neural Mechanisms of Anesthesia","first-page":"299","article-title":"Actions of general anesthetics on voltage-gated ion channels","author":"Topf","year":"2003"},{"key":"10.1093\/bja\/aeg040_bib11","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S1054-3589(08)60069-1","article-title":"Sodium channels and therapy of central nervous system diseases","volume":"39","author":"Taylor","year":"1997","journal-title":"Adv Pharmacol"},{"key":"10.1093\/bja\/aeg040_bib12","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1111\/j.1528-1157.1997.tb01477.x","article-title":"Voltage-activated calcium channels: targets of antiepileptic drug therapy?","volume":"38","author":"Stefani","year":"1997","journal-title":"Epilepsia"},{"key":"10.1093\/bja\/aeg040_bib13","doi-asserted-by":"crossref","first-page":"8922","DOI":"10.1016\/S0021-9258(19)52487-5","article-title":"Binding of batrachotoxinin A 20-\u03b1-benzoate to a receptor site associated with sodium channels in synaptic nerve ending particles","volume":"256","author":"Catterall","year":"1981","journal-title":"J Biol Chem"},{"key":"10.1093\/bja\/aeg040_bib14","doi-asserted-by":"crossref","first-page":"5275","DOI":"10.1021\/bi00414a049","article-title":"Multiple calcium channels in synaptosomes: voltage dependence of 1,4-dihydropyridine binding and effects on function","volume":"27","author":"Dunn","year":"1988","journal-title":"Biochemistry"},{"key":"10.1093\/bja\/aeg040_bib15","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1111\/j.1476-5381.1995.tb16344.x","article-title":"Direct demonstration of sulphonylurea-sensitive KATP channels on nerve terminals of the rat motor cortex","volume":"115","author":"Lee","year":"1995","journal-title":"Br J Pharmacol"},{"key":"10.1093\/bja\/aeg040_bib16","first-page":"326","article-title":"[35S]t-Butylbicyclophosphorothionate binds with high affinity to brain-specific sites coupled to \u03b3-aminobutyric acid-A and ion recognition sites","volume":"23","author":"Squires","year":"1983","journal-title":"Mol Pharmacol"},{"key":"10.1093\/bja\/aeg040_bib17","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/0006-8993(86)91464-2","article-title":"A rapid method for isolation of synaptosomes on Percoll gradients","volume":"372","author":"Dunkley","year":"1986","journal-title":"Brain Res"},{"key":"10.1093\/bja\/aeg040_bib18","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal Biochem"},{"key":"10.1093\/bja\/aeg040_bib19","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1111\/j.1471-4159.1988.tb01102.x","article-title":"Modulation of the benzodiazepine\/\u03b3-aminobutyric acid receptor chloride channel complex by inhalation anesthetics","volume":"51","author":"Moody","year":"1988","journal-title":"J Neurochem"},{"key":"10.1093\/bja\/aeg040_bib20","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1111\/j.1476-5381.1996.tb16064.x","article-title":"Inhibition by propofol of [3H]batrachotoxinin-A 20-\u03b1-benzoate binding to voltage-dependent sodium channels in rat cortical synaptosomes","volume":"119","author":"Ratnakumari","year":"1996","journal-title":"Br J Pharmacolol"},{"key":"10.1093\/bja\/aeg040_bib21","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1213\/00000539-199205000-00023","article-title":"Depression of calcium channel blocker binding to rat brain membranes by halothane","volume":"74","author":"Drenger","year":"1992","journal-title":"Anesth Analg"},{"key":"10.1093\/bja\/aeg040_bib22","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1111\/j.1471-4159.1984.tb09721.x","article-title":"Binding characteristics and interactions of depressant drugs with [35S]t-butylbicyclophosphorothionate, a ligand that binds to the picrotoxinin site","volume":"42","author":"Ramanjaneyulu","year":"1984","journal-title":"J Neurochem"},{"key":"10.1093\/bja\/aeg040_bib23","first-page":"1162","article-title":"Characterization of binding of the ATP-sensitive potassium channel ligand, [3H]glyburide, to neuronal and muscle preparations","volume":"257","author":"Gopalakrishnan","year":"1991","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1093\/bja\/aeg040_bib24","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1097\/00000542-199804000-00025","article-title":"Inhibition of presynaptic sodium channels by halothane","volume":"88","author":"Ratnakumari","year":"1998","journal-title":"Anesthesiology"},{"key":"10.1093\/bja\/aeg040_bib25","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1146\/annurev.bi.64.070195.002425","article-title":"Structure and function of voltage-gated ion channels","volume":"64","author":"Catterall","year":"1995","journal-title":"Annu Rev Biochem"},{"key":"10.1093\/bja\/aeg040_bib26","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1097\/00000542-199211000-00015","article-title":"The general anesthetic potency of propofol and its dependence on hydrostatic pressure","volume":"77","author":"Tonner","year":"1992","journal-title":"Anesthesiology"},{"key":"10.1093\/bja\/aeg040_bib27","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/0014-2999(96)00066-0","article-title":"Interaction of allosteric ligands with GABAA receptors containing one, two, or three different subunits","volume":"301","author":"Zezula","year":"1996","journal-title":"Eur J Pharmacol"},{"key":"10.1093\/bja\/aeg040_bib28","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1097\/00000542-200106000-00020","article-title":"Anesthetic properties of 4-iodopropofol: Implications for mechanisms of anesthesia","volume":"94","author":"Lingamaneni","year":"2001","journal-title":"Anesthesiology"},{"key":"10.1093\/bja\/aeg040_bib29","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1097\/00000542-199702000-00018","article-title":"Effects of propofol on sodium channel-dependent sodium influx and glutamate release in rat cerebrocortical synaptosomes","volume":"86","author":"Ratnakumari","year":"1997","journal-title":"Anesthesiology"},{"key":"10.1093\/bja\/aeg040_bib30","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1097\/00000542-199908000-00026","article-title":"Suppression of central nervous system sodium channels by propofol","volume":"91","author":"Rehberg","year":"1999","journal-title":"Anesthesiology"},{"key":"10.1093\/bja\/aeg040_bib31","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0304-3940(98)00412-1","article-title":"Blocking effects of the anesthetic etomidate on human brain sodium channels","volume":"249","author":"Frenkel","year":"1998","journal-title":"Neurosci Lett"},{"key":"10.1093\/bja\/aeg040_bib32","first-page":"89","article-title":"Voltage- and frequency-dependent pentobarbital suppression of brain and muscle sodium channels expressed in a mammalian cell line","volume":"48","author":"Rehberg","year":"1995","journal-title":"Mol Pharmacol"},{"key":"10.1093\/bja\/aeg040_bib33","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1213\/00000539-197309000-00039","article-title":"Some pharmacologic similarities of ketamine, lidocaine and procaine","volume":"52","author":"Dowdy","year":"1973","journal-title":"Anesth Analg"},{"key":"10.1093\/bja\/aeg040_bib34","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1111\/j.1476-5381.1988.tb11599.x","article-title":"Interactions of benztropine, atropine and ketamine with veratridine-activated sodium channels: effects on membrane depolarization, K+-efflux and neurotransmitter amino acid release","volume":"94","author":"Erecinska","year":"1988","journal-title":"Br J Pharmacol"},{"key":"10.1093\/bja\/aeg040_bib35","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1038\/313479a0","article-title":"An N-methylaspartate receptor-mediated synapse in rat cerebral cortex: a site of action of ketamine?","volume":"313","author":"Thomson","year":"1985","journal-title":"Nature"},{"key":"10.1093\/bja\/aeg040_bib36","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1111\/j.1476-5381.1986.tb16265.x","article-title":"Augmentation by calcium channel antagonists of general anaesthetic potency in mice","volume":"88","author":"Dolin","year":"1988","journal-title":"Br J Pharmacol"},{"key":"10.1093\/bja\/aeg040_bib37","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1093\/bja\/77.2.248","article-title":"I.V. anaesthetic agents inhibit dihydropyridine binding to L-type voltage-sensitive Ca2+ channels in rat cerebrocortical membranes","volume":"77","author":"Hirota","year":"1996","journal-title":"Br J Anaesth"},{"key":"10.1093\/bja\/aeg040_bib38","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1093\/bja\/77.3.385","article-title":"I.V. anaesthetic agents do not interact with the verapamil binding site on L-type voltage-sensitive Ca2+ channels","volume":"77","author":"Hirota","year":"1996","journal-title":"Br J Anaesth"},{"key":"10.1093\/bja\/aeg040_bib39","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1097\/00000542-199605000-00025","article-title":"Central nervous system sodium channels are significantly suppressed at clinical concentrations of volatile anesthetics","volume":"84","author":"Rehberg","year":"1996","journal-title":"Anesthesiology"},{"key":"10.1093\/bja\/aeg040_bib40","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1097\/00000542-200002000-00037","article-title":"Differential effects of anesthetic and nonanesthetic cyclobutanes on neuronal voltage-gated sodium channels","volume":"92","author":"Ratnakumari","year":"2000","journal-title":"Anesthesiology"},{"key":"10.1093\/bja\/aeg040_bib41","first-page":"963","article-title":"Neurochemical actions of anesthetic drugs on the \u03b3-aminobutyric acid receptor-chloride channel complex","volume":"242","author":"Huidobro-Toro","year":"1987","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1093\/bja\/aeg040_bib42","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1097\/00000542-199407000-00018","article-title":"Inhibition of [3H]isradipine binding to L-type channels by the optical isomers of isoflurane: lack of stereospecificity","volume":"81","author":"Moody","year":"1994","journal-title":"Anesthesiology"},{"key":"10.1093\/bja\/aeg040_bib43","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1083\/jcb.123.4.949","article-title":"Identification and differential subcellular localization of the neuronal class C and class D L-type calcium channel \u03b11 subunits","volume":"123","author":"Hell","year":"1993","journal-title":"J Cell Biol"},{"key":"10.1093\/bja\/aeg040_bib44","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1097\/00000542-199407000-00016","article-title":"Isoflurane inhibits multiple voltage-gated calcium currents in hippocampal pyramidal neurons","volume":"81","author":"Study","year":"1994","journal-title":"Anesthesiology"},{"key":"10.1093\/bja\/aeg040_bib45","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1093\/bja\/82.3.402","article-title":"Isoflurane inhibits neuronal Ca2+ channels through enhancement of current inactivation","volume":"82","author":"Kameyama","year":"1999","journal-title":"Br J Anaesth"},{"key":"10.1093\/bja\/aeg040_bib46","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1523\/JNEUROSCI.11-05-01404.1991","article-title":"Halothane blocks low-voltage-activated calcium current in rat sensory neurons","volume":"11","author":"Takenoshita","year":"1991","journal-title":"J Neurosci"},{"key":"10.1093\/bja\/aeg040_bib47","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1152\/jn.1998.79.1.240","article-title":"Pharmacological properties of T-type Ca2+ current in adult rat sensory neurons: Effects of anticonvulsant and anesthetic agents","volume":"79","author":"Todorovic","year":"1998","journal-title":"J Neurophysiol"},{"key":"10.1093\/bja\/aeg040_bib48","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0006-8993(99)01401-8","article-title":"Volatile anesthetic inhibition of neuronal Ca channel currents expressed in Xenopus oocytes","volume":"831","author":"Kamatchi","year":"1999","journal-title":"Brain Res"},{"key":"10.1093\/bja\/aeg040_bib49","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/0028-3908(96)84641-7","article-title":"CHEB, a convulsant barbiturate, evokes calcium-dependent spontaneous glutamate release from rat cerbrocortical synaptosomes","volume":"35","author":"Wei","year":"1996","journal-title":"Neuropharmacology"},{"key":"10.1093\/bja\/aeg040_bib50","first-page":"627","article-title":"Inhibition of binding of [3H]batrachotoxinin-A 20-\u03b1-benzoate to sodium channels by the anticonvulsant drugs diphenylhydantoin and carbamazepine","volume":"22","author":"Willow","year":"1982","journal-title":"Mol Pharmacol"},{"key":"10.1093\/bja\/aeg040_bib51","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0304-3940(99)00810-1","article-title":"Effects of anticonvulsants on veratridine- and KCl-evoked glutamate release from rat cortical synaptosomes","volume":"276","author":"Lingamaneni","year":"1999","journal-title":"Neurosci Lett"},{"key":"10.1093\/bja\/aeg040_bib52","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1016\/0006-2952(85)90416-2","article-title":"Effects of dihydropyridine derivatives and anticonvulsant drugs on [3H]nitrendipine binding and calcium and sodium fluxes in brain","volume":"34","author":"Harris","year":"1985","journal-title":"Biochem Pharmacol"},{"key":"10.1093\/bja\/aeg040_bib53","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1097\/00000542-199004000-00022","article-title":"Molecular mechanisms of local anesthesia","volume":"72","author":"Butterworth","year":"1990","journal-title":"Anesthesiology"},{"key":"10.1093\/bja\/aeg040_bib54","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1111\/j.1399-6576.1986.tb02388.x","article-title":"Changes in CMRO2, EEG and concentration of etomidate in serum and brain tissue during craniotomy with continuous etomidate supplemented with N2O and fentanyl","volume":"30","author":"Cold","year":"1986","journal-title":"Acta Anaesthesiol Scand"},{"key":"10.1093\/bja\/aeg040_bib55","first-page":"1085P","article-title":"The relationship between the peak of the cerebral function monitor trace, consciousness and concentration of alphaxalone","volume":"50","author":"Savege","year":"1978","journal-title":"Br J Anaesth"},{"key":"10.1093\/bja\/aeg040_bib56","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1097\/00000542-198003000-00008","article-title":"Pharmacology of ketamine isomers in surgical patients","volume":"52","author":"White","year":"1980","journal-title":"Anesthesiology"},{"key":"10.1093\/bja\/aeg040_bib57","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1213\/00000539-199105000-00010","article-title":"What solvent best represents the site of action of inhaled anesthetics in humans, rats, and dogs?","volume":"72","author":"Taheri","year":"1991","journal-title":"Anesth Analg"},{"key":"10.1093\/bja\/aeg040_bib58","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1111\/j.1528-1157.1987.tb03661.x","article-title":"Common anticonvulsants inhibit Ca2+ uptake and amino acid neurotransmitter release in vitro","volume":"28","author":"Crowder","year":"1987","journal-title":"Epilepsia"},{"key":"10.1093\/bja\/aeg040_bib59","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1093\/bja\/38.8.596","article-title":"Dosage of lignocaine in epidural block in relation to toxicity","volume":"38","author":"Braid","year":"1966","journal-title":"Br J Anaesth"},{"key":"10.1093\/bja\/aeg040_bib60","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/0006-8993(91)91571-H","article-title":"Neurochemical action of the general anesthetic propofol on the chloride ion channel coupled with GABAA receptors","volume":"542","author":"Concas","year":"1991","journal-title":"Brain Res"},{"key":"10.1093\/bja\/aeg040_bib61","first-page":"346","article-title":"Structure-activity relationships for steroid interaction with the \u03b3-aminobutyric acidA receptor complex","volume":"241","author":"Harrison","year":"1987","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1093\/bja\/aeg040_bib62","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/BF00165807","article-title":"Affinities of barbiturates for the GABA-receptor complex and A1 adenosine receptors: a possible explanation of their excitatory effects","volume":"336","author":"Lohse","year":"1987","journal-title":"Naunyn-Schmiedeberg's Arch Pharmacol"},{"key":"10.1093\/bja\/aeg040_bib63","first-page":"219","article-title":"Inhibition of binding of [3H]batrachotoxinin A 20-\u03b1-benzoate to sodium channels by local anesthetics","volume":"25","author":"Postma","year":"1984","journal-title":"Mol Pharmacol"},{"key":"10.1093\/bja\/aeg040_bib64","first-page":"350","article-title":"Batrachotoxin-induced depolarization and [3H]batrachotoxinin-A 20-\u03b1-benzoate binding in a vesicular preparation from guinea pig cerebral cortex","volume":"23","author":"Creveling","year":"1983","journal-title":"Mol Pharmacol"},{"key":"10.1093\/bja\/aeg040_bib65","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/0006-2952(91)90705-A","article-title":"Interactions of local anesthetics with neuronal 1,4-dihydropyridine binding sites","volume":"42","author":"Kwon","year":"1991","journal-title":"Biochem Pharmacol"}],"container-title":["British Journal of Anaesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0007091217368940?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0007091217368940?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/bja\/article-pdf\/90\/2\/199\/683388\/aeg040.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,3]],"date-time":"2021-06-03T11:07:11Z","timestamp":1622718431000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0007091217368940"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,2]]},"references-count":65,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2003,2]]}},"alternative-id":["S0007091217368940"],"URL":"https:\/\/doi.org\/10.1093\/bja\/aeg040","relation":{},"ISSN":["0007-0912"],"issn-type":[{"value":"0007-0912","type":"print"}],"subject":[],"published":{"date-parts":[[2003,2]]}}}