{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T14:19:10Z","timestamp":1782569950948,"version":"3.54.5"},"reference-count":27,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2004,4,1]],"date-time":"2004-04-01T00:00:00Z","timestamp":1080777600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,12,4]],"date-time":"2017-12-04T00:00:00Z","timestamp":1512345600000},"content-version":"vor","delay-in-days":4995,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["British Journal of Anaesthesia"],"published-print":{"date-parts":[[2004,4]]},"DOI":"10.1093\/bja\/aeh089","type":"journal-article","created":{"date-parts":[[2004,3,4]],"date-time":"2004-03-04T21:20:28Z","timestamp":1078435228000},"page":"475-484","source":"Crossref","is-referenced-by-count":48,"title":["The two-compartment recirculatory pharmacokinetic model'an introduction to recirculatory pharmacokinetic concepts"],"prefix":"10.1016","volume":"92","author":[{"given":"R.N.","family":"Upton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1093\/bja\/aeh089_bib1","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1213\/00000539-199611000-00002","article-title":"(Almost) everything you learned about pharmacokinetics was (somewhat) wrong!","volume":"83","author":"Fisher","year":"1996","journal-title":"Anesth Analg"},{"key":"10.1093\/bja\/aeh089_bib2","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1093\/bja\/70.3.243","article-title":"Why not model physiologically?","volume":"70","author":"Sear","year":"1993","journal-title":"Br J Anaesth"},{"key":"10.1093\/bja\/aeh089_bib3","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1023\/A:1025788214777","article-title":"Errors in clearance estimation after bolus injection and arterial sampling: nonexistence of a central compartment","volume":"25","author":"Weiss","year":"1997","journal-title":"J Pharmacokinet Biopharm"},{"key":"10.1093\/bja\/aeh089_bib4","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1023\/A:1020903315017","article-title":"A compartmental analysis of the pharmacokinetics of propofol in sheep","volume":"27","author":"Ludbrook","year":"1999","journal-title":"J Pharmacokinet Biopharm"},{"key":"10.1093\/bja\/aeh089_bib5","series-title":"Uptake and Distribution of Anesthetic Agents","first-page":"59","article-title":"Role of lung factors","author":"Severinghaus","year":"1963"},{"key":"10.1093\/bja\/aeh089_bib6","series-title":"Uptake and Distribution of Anesthetic Agents","first-page":"104","article-title":"Uptake and distribution of anesthetic agents","author":"Mapleson","year":"1963"},{"key":"10.1093\/bja\/aeh089_bib7","series-title":"Uptake and Distribution of Anesthetic Agents","first-page":"72","article-title":"A mathematical model of uptake and distribution","author":"Eger","year":"1963"},{"key":"10.1093\/bja\/aeh089_bib8","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1093\/bja\/70.3.248","article-title":"A physiological model for the distribution of injected agents, with special reference to pethidine","volume":"70","author":"Davis","year":"1993","journal-title":"Br J Anaesth"},{"key":"10.1093\/bja\/aeh089_bib9","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/BF00608408","article-title":"Pharmacokinetic model based on circulatory transport","volume":"16","author":"Weiss","year":"1979","journal-title":"Eur J Clin Pharmacol"},{"key":"10.1093\/bja\/aeh089_bib10","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/BF01059445","article-title":"A linear recirculation model for drug disposition","volume":"7","author":"Cutler","year":"1979","journal-title":"J Pharmacokinet Biopharm"},{"key":"10.1093\/bja\/aeh089_bib11","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1002\/jps.2600710421","article-title":"Determination of tissue to blood partition coefficients in physiologically-based pharmacokinetic studies","volume":"71","author":"Lam","year":"1982","journal-title":"J Pharm Sci"},{"key":"10.1093\/bja\/aeh089_bib12","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1093\/bja\/79.4.497","article-title":"A physiological model of induction of anaesthesia with propofol in sheep. 1. Structure and estimation of variables","volume":"79","author":"Upton","year":"1997","journal-title":"Br J Anaesth"},{"key":"10.1093\/bja\/aeh089_bib13","first-page":"609","article-title":"A recirculatory pharmacokinetic model describing the circulatory mixing, tissue distribution and elimination of antipyrine in the dog","volume":"269","author":"Krejcie","year":"1994","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1093\/bja\/aeh089_bib14","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1023\/A:1025780012960","article-title":"A recirculatory pharmacokinetic model of the pulmonary uptake and pharmacokinetics of lidocaine based on analysis of arterial and mixed venous data from dogs","volume":"25","author":"Krejcie","year":"1997","journal-title":"J Pharmacokinet Biopharm"},{"key":"10.1093\/bja\/aeh089_bib15","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1213\/00000539-199909000-00002","article-title":"Cardiac output is a determinant of the initial concentrations of propofol after short-infusion administration","volume":"89","author":"Upton","year":"1999","journal-title":"Anesth Analg"},{"key":"10.1093\/bja\/aeh089_bib16","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1046\/j.1440-1681.1999.03048.x","article-title":"Kinetic aspects of drug disposition in the lungs","volume":"26","author":"Upton","year":"1999","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"10.1093\/bja\/aeh089_bib17","series-title":"Basic Principles of the Tracer Method","first-page":"176","author":"Sheppard","year":"1962"},{"key":"10.1093\/bja\/aeh089_bib18","series-title":"Fundamentals of Clinical Pharmacokinetics","first-page":"82","author":"Wagner","year":"1975"},{"key":"10.1093\/bja\/aeh089_bib19","series-title":"Fundamentals of Clinical Pharmacokinetics","first-page":"231","author":"Wagner","year":"1975"},{"key":"10.1093\/bja\/aeh089_bib20","first-page":"291","article-title":"The systemic and cerebral kinetics of thiopental in sheep: enantiomeric analysis","volume":"279","author":"Mather","year":"1996","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1093\/bja\/aeh089_bib21","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1093\/bja\/82.6.890","article-title":"A model of the kinetics and dynamics of induction of anaesthesia in sheep: variable estimation for thiopental and comparison with propofol","volume":"82","author":"Upton","year":"1999","journal-title":"Br J Anaesth"},{"key":"10.1093\/bja\/aeh089_bib22","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1007\/BF02353481","article-title":"Use of parallel Erlang density functions to analyze first-pass pulmonary uptake of multiple indicators in dogs","volume":"24","author":"Krejcie","year":"1996","journal-title":"J Pharmacokinet Biopharm"},{"key":"10.1093\/bja\/aeh089_bib23","first-page":"360","article-title":"Uptake, metabolism and efflux of methadone in \u2018single pass\u2019 isolated perfused rabbit lungs","volume":"199","author":"Wilson","year":"1976","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1093\/bja\/aeh089_bib24","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1211\/0022357001773832","article-title":"Development and validation of a recirculatory physiological model of the myocardial concentrations of lignocaine after intravenous administration in sheep","volume":"52","author":"Upton","year":"2000","journal-title":"J Pharm Pharmacol"},{"key":"10.1093\/bja\/aeh089_bib25","first-page":"1048","article-title":"The enantiomer-specific kinetics and dynamics of verapamil after rapid intravenous administration to sheep: physiological analysis and modeling","volume":"284","author":"Huang","year":"1998","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1093\/bja\/aeh089_bib26","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1046\/j.1365-2125.1996.03121.x","article-title":"Effects of cardiac output on disposition kinetics of sorbitol: recirculatory modelling","volume":"41","author":"Weiss","year":"1996","journal-title":"Br J Clin Pharmacol"},{"key":"10.1093\/bja\/aeh089_bib27","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1002\/1099-081X(200003)21:2<69::AID-BDD218>3.0.CO;2-L","article-title":"Relationships between steady state blood concentrations and cardiac output during intravenous infusions","volume":"21","author":"Upton","year":"2000","journal-title":"Biopharm Drug Dispos"}],"container-title":["British Journal of Anaesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0007091217361056?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0007091217361056?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/bja\/article-pdf\/92\/4\/475\/698143\/aeh089.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T02:02:10Z","timestamp":1682647330000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0007091217361056"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,4]]},"references-count":27,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2004,4]]}},"alternative-id":["S0007091217361056"],"URL":"https:\/\/doi.org\/10.1093\/bja\/aeh089","relation":{},"ISSN":["0007-0912"],"issn-type":[{"value":"0007-0912","type":"print"}],"subject":[],"published":{"date-parts":[[2004,4]]}}}