{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T20:31:57Z","timestamp":1790195517152,"version":"4.1.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2005,4,1]],"date-time":"2005-04-01T00:00:00Z","timestamp":1112313600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,12,4]],"date-time":"2017-12-04T00:00:00Z","timestamp":1512345600000},"content-version":"vor","delay-in-days":4630,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["British Journal of Anaesthesia"],"published-print":{"date-parts":[[2005,4]]},"DOI":"10.1093\/bja\/aei077","type":"journal-article","created":{"date-parts":[[2005,2,11]],"date-time":"2005-02-11T20:13:15Z","timestamp":1108152795000},"page":"486-491","source":"Crossref","is-referenced-by-count":17,"title":["Anoxic depolarization of rat hippocampal slices is prevented by thiopental but not by propofol or isoflurane"],"prefix":"10.1016","volume":"94","author":[{"given":"R.","family":"Sasaki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Hirota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.H.","family":"Roth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Yamazaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1093\/bja\/aei077_bib1","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1152\/jn.1944.7.6.359","article-title":"Spreading depression of activity in the cerebral cortex","volume":"7","author":"Leao","year":"1944","journal-title":"J Neurophysiol"},{"key":"10.1093\/bja\/aei077_bib2","series-title":"The Mechanism and Applications of Leao's Spreading Depression of Electroencephalographic Activity","author":"Bures","year":"1974"},{"key":"10.1093\/bja\/aei077_bib3","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/0165-0270(94)00199-Q","article-title":"Pathophysiology of anoxic depolarization: new findings and a working hypothesis","volume":"59","author":"Balestrino","year":"1995","journal-title":"J Neurosci Methods"},{"key":"10.1093\/bja\/aei077_bib4","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1097\/00001756-199306000-00027","article-title":"Correlation between peri-infarct DC shifts and ischaemic neuronal damage in rats","volume":"4","author":"Mies","year":"1993","journal-title":"Neuroreport"},{"key":"10.1093\/bja\/aei077_bib5","first-page":"75","article-title":"Spreading depression as a contributor to ischemic brain damage","volume":"71","author":"Nedergaard","year":"1996","journal-title":"Adv Neurol"},{"key":"10.1093\/bja\/aei077_bib6","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1080\/01616412.1998.11740529","article-title":"Anoxic depolarization determines ischemic brain injury","volume":"20","author":"Kaminogo","year":"1998","journal-title":"Neurol Res"},{"key":"10.1093\/bja\/aei077_bib7","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1152\/jn.2001.85.1.414","article-title":"Imaging anoxic depolarization during ischemia-like conditions in the mouse hemi-brain slice","volume":"85","author":"Joshi","year":"2001","journal-title":"J Neurophysiol"},{"key":"10.1093\/bja\/aei077_bib8","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1097\/00000542-198602000-00006","article-title":"Neuropsychiatric complications after cardiopulmonary bypass: cerebral protection by a barbiturate","volume":"64","author":"Nussmeier","year":"1986","journal-title":"Anesthesiology"},{"key":"10.1093\/bja\/aei077_bib9","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0749-0704(05)70301-8","article-title":"Intravenous agents and intraoperative neuroprotection","volume":"13","author":"Cheng","year":"1997","journal-title":"Crit Care Clin"},{"key":"10.1093\/bja\/aei077_bib10","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1213\/00000539-199804000-00018","article-title":"Isoflurane and pentobarbital reduce the frequency of transient ischemic depolarizations during focal ischemia in rats","volume":"86","author":"Patel","year":"1998","journal-title":"Anesth Analg"},{"key":"10.1093\/bja\/aei077_bib11","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1097\/00000542-200005000-00024","article-title":"Anesthetics and mild hypothermia similarly prevent hippocampal neuron death in an in vitro model of cerebral ischemia","volume":"92","author":"Popovic","year":"2000","journal-title":"Anesthesiology"},{"key":"10.1093\/bja\/aei077_bib12","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1007\/BF03016699","article-title":"Thiopentone and methohexital, but not pentobarbitone, reduce early focal cerebral ischemic injury in rats","volume":"48","author":"Cole","year":"2001","journal-title":"Can J Anaesth"},{"key":"10.1093\/bja\/aei077_bib13","first-page":"426","article-title":"The effects of sevoflurane on population spikes in CA1 and dentate gyrus of the rat hippocampus in vitro","volume":"85","author":"Hirota","year":"1997","journal-title":"Anesth Analg"},{"key":"10.1093\/bja\/aei077_bib14","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1213\/00000539-199903000-00039","article-title":"The effects of general anesthetics on excitatory and inhibitory synaptic transmission in area CA1 of the rat hippocampus in vitro","volume":"88","author":"Wakasugi","year":"1999","journal-title":"Anesth Analg"},{"key":"10.1093\/bja\/aei077_bib15","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1097\/00000542-199410000-00008","article-title":"The interaction of fentanyl on the CP50 of propofol for loss of consciousness and skin incision","volume":"81","author":"Smith","year":"1994","journal-title":"Anesthesiology"},{"key":"10.1093\/bja\/aei077_bib16","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/0304-3940(93)90312-9","article-title":"Power spectral analysis of the electroencephalographic and hemodynamic correlates of propofol anesthesia in the rat: Intravenous bolus administration","volume":"153","author":"Shyr","year":"1993","journal-title":"Neurosci Lett"},{"key":"10.1093\/bja\/aei077_bib17","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1097\/00000542-199512000-00016","article-title":"Propofol reduces neuronal transmission damage and attenuates the changes in calcium, potassium, and sodium during hyperthermic anoxia in the rat hippocampal slice","volume":"83","author":"Amorim","year":"1995","journal-title":"Anesthesiology"},{"key":"10.1093\/bja\/aei077_bib18","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1097\/00000542-199310000-00021","article-title":"Propofol activates GABAA receptor-chloride ionophore complex in dissociated hippocampal pyramidal neurons of the rat","volume":"79","author":"Hara","year":"1993","journal-title":"Anesthesiology"},{"key":"10.1093\/bja\/aei077_bib19","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1126\/science.6093256","article-title":"Blockade of N-methyl-D-aspartate receptors may protect against ischemic damage in the brain","volume":"226","author":"Simon","year":"1984","journal-title":"Science"},{"key":"10.1093\/bja\/aei077_bib20","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/35002090","article-title":"Glutamate release in severe brain ischaemia is mainly by reversed uptake","volume":"403","author":"Rossi","year":"2000","journal-title":"Nature"},{"key":"10.1093\/bja\/aei077_bib21","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/S0006-8993(99)01141-5","article-title":"Real-time monitoring of glutamate transmitter release with anoxic depolarization during anoxic insult in rat striatum","volume":"822","author":"Satoh","year":"1999","journal-title":"Brain Res"},{"key":"10.1093\/bja\/aei077_bib22","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/0166-2236(94)90040-X","article-title":"Triggering and execution of neuronal death in brain ischaemia: two phases of glutamate release by different mechanisms","volume":"17","author":"Szatkowski","year":"1994","journal-title":"Trends Neurosci"},{"key":"10.1093\/bja\/aei077_bib23","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1097\/00000542-199512000-00014","article-title":"Volatile and intravenous anesthetics decrease glutamate release from cortical brain slices during anoxia","volume":"83","author":"Bickler","year":"1995","journal-title":"Anesthesiology"},{"key":"10.1093\/bja\/aei077_bib24","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1097\/00000542-199808000-00023","article-title":"Thiopental inhibits increases in [Ca2+]i induced by membrane depolarization, NMDA receptor activation, and ischemia in rat hippocampal and cortical slices","volume":"89","author":"Zhan","year":"1998","journal-title":"Anesthesiology"},{"key":"10.1093\/bja\/aei077_bib25","doi-asserted-by":"crossref","first-page":"2400","DOI":"10.1161\/01.STR.30.11.2400","article-title":"Thiopental attenuates hypoxic changes of electrophysiology, biochemistry, and morphology in rat hippocampal slice CA1 pyramidal cells","volume":"30","author":"Wang","year":"1999","journal-title":"Stroke"},{"key":"10.1093\/bja\/aei077_bib26","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/0304-3940(88)90379-5","article-title":"NMDA antagonists: lack of protective effect against hypoxic damage in CA1 region of hippocampal slices","volume":"89","author":"Aitken","year":"1988","journal-title":"Neurosci Lett"},{"key":"10.1093\/bja\/aei077_bib27","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1093\/cercor\/11.3.249","article-title":"Anoxic depolarization mediates acute damage independent of glutamate in neocortical brain slices","volume":"11","author":"Jarvis","year":"2001","journal-title":"Cereb Cortex"},{"key":"10.1093\/bja\/aei077_bib28","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1152\/physrev.2001.81.3.1065","article-title":"Mechanisms of spreading depression and hypoxic spreading depression-like depolarization","volume":"81","author":"Somjen","year":"2001","journal-title":"Physiol Rev"},{"key":"10.1093\/bja\/aei077_bib29","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1097\/00008506-199707000-00015","article-title":"The effect of isoflurane on biochemical changes during and electrophysiological recovery after anoxia in rat hippocampal slices","volume":"9","author":"Kass","year":"1997","journal-title":"J Neurosurg Anesthesiol"},{"key":"10.1093\/bja\/aei077_bib30","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1002\/jnr.10237","article-title":"Hypothermia and thiopentone sodium: individual and combined neuroprotective effects on cortical cultures exposed to prolonged hypoxic episodes","volume":"68","author":"Varathan","year":"2002","journal-title":"J Neurosci Res"}],"container-title":["British Journal of Anaesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0007091217356696?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0007091217356696?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/bja\/article-pdf\/94\/4\/486\/826596\/aei077.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,1,28]],"date-time":"2019-01-28T13:29:45Z","timestamp":1548682185000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0007091217356696"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,4]]},"references-count":30,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2005,4]]}},"alternative-id":["S0007091217356696"],"URL":"https:\/\/doi.org\/10.1093\/bja\/aei077","relation":{},"ISSN":["0007-0912"],"issn-type":[{"value":"0007-0912","type":"print"}],"subject":[],"published":{"date-parts":[[2005,4]]}}}