{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:17:23Z","timestamp":1790381843005,"version":"4.1.0"},"reference-count":42,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2006,11,1]],"date-time":"2006-11-01T00:00:00Z","timestamp":1162339200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,12,4]],"date-time":"2017-12-04T00:00:00Z","timestamp":1512345600000},"content-version":"vor","delay-in-days":4051,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["British Journal of Anaesthesia"],"published-print":{"date-parts":[[2006,11]]},"DOI":"10.1093\/bja\/ael220","type":"journal-article","created":{"date-parts":[[2006,8,17]],"date-time":"2006-08-17T00:13:30Z","timestamp":1155773610000},"page":"658-665","source":"Crossref","is-referenced-by-count":148,"title":["Dexmedetomidine as an anaesthetic adjuvant in patients undergoing intracranial tumour surgery: a double-blind, randomized and placebo-controlled study \u2020"],"prefix":"10.1016","volume":"97","author":[{"given":"P.E.","family":"Tanskanen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.V.","family":"Kytt\u00e4","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.T.","family":"Randell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.E.","family":"Aantaa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1093\/bja\/ael220_bib1","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1097\/00000542-200007000-00012","article-title":"Relation between perioperative hypertension and intracranial hemorrhage after craniotomy","volume":"93","author":"Basali","year":"2000","journal-title":"Anesthesiology"},{"key":"10.1093\/bja\/ael220_bib2","series-title":"Anesthesia and Neurosurgery","first-page":"129","article-title":"Effects of anesthetic agents and other drugs on cerebral blood flow, metabolism, and intracranial pressure","author":"Sakabe","year":"2001"},{"key":"10.1093\/bja\/ael220_bib3","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1097\/00000542-199103000-00029","article-title":"Alpha-2 adrenergic agonists: defining the role in clinical anesthesia","volume":"74","author":"Maze","year":"1991","journal-title":"Anesthesiology"},{"key":"10.1093\/bja\/ael220_bib4","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1097\/00000542-200008000-00016","article-title":"The effects of increasing plasma concentrations of dexmedetomidine in humans","volume":"93","author":"Ebert","year":"2000","journal-title":"Anesthesiology"},{"key":"10.1093\/bja\/ael220_bib5","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1097\/00000539-200003000-00035","article-title":"Sedative, amnestic, and analgesic properties of small-dose dexmedetomidine infusions","volume":"90","author":"Hall","year":"2000","journal-title":"Anesth Analg"},{"key":"10.1093\/bja\/ael220_bib6","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1093\/bja\/68.2.126","article-title":"Dexmedetomidine attenuates sympathoadrenal responses to tracheal intubation and reduces the need for thiopentone and peroperative fentanyl","volume":"68","author":"Scheinin","year":"1992","journal-title":"Br J Anaesth"},{"key":"10.1093\/bja\/ael220_bib7","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1097\/00000542-199404000-00017","article-title":"Anesthetic and hemodynamic interactions of dexmedetomidine and fentanyl in dogs","volume":"80","author":"Salmenper\u00e4","year":"1994","journal-title":"Anesthesiology"},{"key":"10.1093\/bja\/ael220_bib8","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1097\/00000542-199108000-00022","article-title":"Dexmedetomidine improves neurologic outcome from incomplete ischemia in the rat. Reversal by the alpha 2-adrenergic antagonist atipamezole","volume":"75","author":"Hoffman","year":"1991","journal-title":"Anesthesiology"},{"key":"10.1093\/bja\/ael220_bib9","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1097\/00000542-199308000-00016","article-title":"Neuroprotection by the alpha 2-adrenoreceptor agonist dexmedetomidine in a focal model of cerebral ischemia","volume":"79","author":"Maier","year":"1993","journal-title":"Anesthesiology"},{"key":"10.1093\/bja\/ael220_bib10","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1097\/00000542-198802000-00013","article-title":"Testing computer-controlled infusion pumps by simulation","volume":"68","author":"Shafer","year":"1988","journal-title":"Anesthesiology"},{"key":"10.1093\/bja\/ael220_bib11","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1097\/00000542-199305000-00003","article-title":"Computer-controlled infusion of intravenous dexmedetomidine hydrochloride in adult human volunteers","volume":"78","author":"Dyck","year":"1993","journal-title":"Anesthesiology"},{"key":"10.1093\/bja\/ael220_bib12","first-page":"812","article-title":"The pharmacokinetics and hemodynamic effects of intravenous and intramuscular dexmedetomidine hydrochloride in adult human volunteers","volume":"78","author":"Dyck","year":"1993","journal-title":"Anesthesiology"},{"key":"10.1093\/bja\/ael220_bib13","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/BF03008142","article-title":"A comparison of morphine-perphenazine and midazolam on preoperative sedation and arterial oxygen saturation","volume":"38","author":"Hudes","year":"1991","journal-title":"Can J Anaesth"},{"key":"10.1093\/bja\/ael220_bib14","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1097\/00000542-199212000-00013","article-title":"Effects of intravenous dexmedetomidine in humans. I. Sedation, ventilation, and metabolic rate","volume":"77","author":"Belleville","year":"1992","journal-title":"Anesthesiology"},{"key":"10.1093\/bja\/ael220_bib15","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1213\/00000539-199212000-00012","article-title":"Dexmedetomidine infusion for maintenance of anesthesia in patients undergoing abdominal hysterectomy","volume":"75","author":"Aho","year":"1992","journal-title":"Anesth Analg"},{"key":"10.1093\/bja\/ael220_bib16","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1097\/00000542-199705000-00008","article-title":"Reduction of the minimum alveolar concentration of isoflurane by dexmedetomidine","volume":"86","author":"Aantaa","year":"1997","journal-title":"Anesthesiology"},{"key":"10.1093\/bja\/ael220_bib17","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1093\/bja\/83.3.372","article-title":"Effects of dexmedetomidine on isoflurane requirements in healthy volunteers. 1: Pharmacodynamic and pharmacokinetic interactions","volume":"83","author":"Khan","year":"1999","journal-title":"Br J Anaesth"},{"key":"10.1093\/bja\/ael220_bib18","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/clpt.1989.103","article-title":"Effects of dexmedetomidine, a selective alpha 2-adrenoceptor agonist, on hemodynamic control mechanisms","volume":"46","author":"Kallio","year":"1989","journal-title":"Clin Pharmacol Ther"},{"key":"10.1093\/bja\/ael220_bib19","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1097\/00000542-199212000-00014","article-title":"Effects of intravenous dexmedetomidine in humans. II. Hemodynamic changes","volume":"77","author":"Bloor","year":"1992","journal-title":"Anesthesiology"},{"key":"10.1093\/bja\/ael220_bib20","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1212\/WNL.18.12.1166","article-title":"Derangement of regional cerebral blood flow and of its regulatory mechanisms in acute cerebrovascular lesions","volume":"18","author":"Fieschi","year":"1968","journal-title":"Neurology"},{"key":"10.1093\/bja\/ael220_bib21","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1177\/0310057X9202000312","article-title":"Oral clonidine pretreatment for haemodynamic stability during craniotomy","volume":"20","author":"Chadha","year":"1992","journal-title":"Anaesth Intensive Care"},{"key":"10.1093\/bja\/ael220_bib22","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1213\/00000539-199805000-00017","article-title":"Clonidine premedication decreases hemodynamic responses to pin head-holder application during craniotomy","volume":"86","author":"Costello","year":"1998","journal-title":"Anesth Analg"},{"key":"10.1093\/bja\/ael220_bib23","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1111\/j.1365-2044.1997.169-az0303.x","article-title":"Effects of a single pre-operative dexmedetomidine dose on isoflurane requirements and peri-operative haemodynamic stability","volume":"52","author":"Lawrence","year":"1997","journal-title":"Anaesthesia"},{"key":"10.1093\/bja\/ael220_bib24","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1097\/00000542-199409000-00022","article-title":"Potentiation of the analgesic properties of fentanyl-like opioids with alpha 2-adrenoceptor agonists in rats","volume":"81","author":"Meert","year":"1994","journal-title":"Anesthesiology"},{"key":"10.1093\/bja\/ael220_bib25","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1213\/00000539-200004000-00011","article-title":"The hemodynamic and adrenergic effects of perioperative dexmedetomidine infusion after vascular surgery","volume":"90","author":"Talke","year":"2000","journal-title":"Anesth Analg"},{"key":"10.1093\/bja\/ael220_bib26","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1097\/00000542-199306000-00002","article-title":"A prospective, comparative trial of three anesthetics for elective supratentorial craniotomy. Propofol\/fentanyl, isoflurane\/nitrous oxide, and fentanyl\/nitrous oxide","volume":"78","author":"Todd","year":"1993","journal-title":"Anesthesiology"},{"key":"10.1093\/bja\/ael220_bib27","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1097\/00000542-198905000-00022","article-title":"Cerebrovascular responsiveness to carbon dioxide in dogs with 1.4% and 2.8% isoflurane","volume":"70","author":"McPherson","year":"1989","journal-title":"Anesthesiology"},{"key":"10.1093\/bja\/ael220_bib28","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1213\/00000539-199908000-00023","article-title":"Intravenous dexmedetomidine inhibits cerebrovascular dilation induced by isoflurane and sevoflurane in dogs","volume":"89","author":"Ohata","year":"1999","journal-title":"Anesth Analg"},{"key":"10.1093\/bja\/ael220_bib29","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1213\/00000539-200007000-00030","article-title":"A comparison of remifentanil and fentanyl in patients undergoing surgery for intracranial mass lesions","volume":"91","author":"Balakrishnan","year":"2000","journal-title":"Anesth Analg"},{"key":"10.1093\/bja\/ael220_bib30","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1097\/00000542-199703000-00002","article-title":"Comparison of remifentanil and fentanyl in patients undergoing craniotomy for supratentorial space-occupying lesions","volume":"86","author":"Guy","year":"1997","journal-title":"Anesthesiology"},{"key":"10.1093\/bja\/ael220_bib31","doi-asserted-by":"crossref","first-page":"2188","DOI":"10.1007\/s00134-004-2417-z","article-title":"Dexmedetomidine infusion for more than 24 hours in critically ill patients: sedative and cardiovascular effects","volume":"30","author":"Shehabi","year":"2004","journal-title":"Intensive Care Med"},{"key":"10.1093\/bja\/ael220_bib32","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1097\/00000542-200411000-00005","article-title":"Dexmedetomidine pharmacodynamics: Part 1: Crossover comparison of the respiratory effects of dexmedetomidine and remifentanil in healthy volunteers","volume":"101","author":"Hsu","year":"2004","journal-title":"Anesthesiology"},{"key":"10.1093\/bja\/ael220_bib33","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1097\/00000542-200005000-00028","article-title":"Intrathecal dexmedetomidine attenuates hypercapnic but not hypoxic cerebral vasodilation in anesthetized rabbits","volume":"92","author":"Takenaka","year":"2000","journal-title":"Anesthesiology"},{"key":"10.1093\/bja\/ael220_bib34","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1097\/00000542-199705000-00008","article-title":"Reduction of the minimum alveolar concentration of isoflurane by dexmedetomidine","volume":"86","author":"Aantaa","year":"1997","journal-title":"Anesthesiology"},{"key":"10.1093\/bja\/ael220_bib35","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1213\/00000539-199903000-00029","article-title":"Dexmedetomidine modulates cardiovascular responses to stimulation of central nervous system pressor sites","volume":"88","author":"Farber","year":"1999","journal-title":"Anesth Analg"},{"key":"10.1093\/bja\/ael220_bib36","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1097\/00000542-199503000-00003","article-title":"Effects of perioperative dexmedetomidine infusion in patients undergoing vascular surgery","volume":"82","author":"Talke","year":"1995","journal-title":"Anesthesiology"},{"key":"10.1093\/bja\/ael220_bib37","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1213\/00000539-199903000-00031","article-title":"The effects of dexmedetomidine on neuromuscular blockade in human volunteers","volume":"88","author":"Talke","year":"1999","journal-title":"Anesth Analg"},{"key":"10.1093\/bja\/ael220_bib38","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1097\/00000542-200202000-00034","article-title":"Effect of the alpha2-agonist dexmedetomidine on cerebral neurotransmitter concentrations during cerebral ischemia in rats","volume":"96","author":"Engelhard","year":"2002","journal-title":"Anesthesiology"},{"key":"10.1093\/bja\/ael220_bib39","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1097\/00000542-199802000-00022","article-title":"In vivo effects of dexmedetomidine on laser-doppler flow and pial arteriolar diameter","volume":"88","author":"Ganjoo","year":"1998","journal-title":"Anesthesiology"},{"key":"10.1093\/bja\/ael220_bib40","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1213\/00000539-200210000-00048","article-title":"Dexmedetomidine-induced sedation in volunteers decreases regional and global cerebral blood flow","volume":"95","author":"Prielipp","year":"2002","journal-title":"Anesth Analg"},{"key":"10.1093\/bja\/ael220_bib41","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1097\/00008506-200401000-00005","article-title":"Dexmedetomidine and neurocognitive testing in awake craniotomy","volume":"16","author":"Mack","year":"2004","journal-title":"J Neurosurg Anesthesiol"},{"key":"10.1093\/bja\/ael220_bib42","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1097\/00008506-200404000-00004","article-title":"Dexmedetomidine for awake carotid endarterectomy: efficacy, hemodynamic profile, and side effects","volume":"16","author":"Bekker","year":"2004","journal-title":"J Neurosurg Anesthesiol"}],"container-title":["British Journal of Anaesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0007091217353680?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0007091217353680?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/bja\/article-pdf\/97\/5\/658\/915257\/ael220.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T14:56:15Z","timestamp":1683557775000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0007091217353680"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,11]]},"references-count":42,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2006,11]]}},"alternative-id":["S0007091217353680"],"URL":"https:\/\/doi.org\/10.1093\/bja\/ael220","relation":{},"ISSN":["0007-0912"],"issn-type":[{"value":"0007-0912","type":"print"}],"subject":[],"published":{"date-parts":[[2006,11]]}}}